鳞状细胞癌抗原及白介素-38在宫颈癌患者外周血的表达水平及诊断价值

Abstract
Figure/Table
References (19)
Related Citation (15)

Download: PDF (594 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the expression level and diagnostic value of squamous cell carcinoma antigen(SCC) and interleukin-38 (IL-38) in peripheral blood of patients with cervical cancer. Methods A total of 52 cases of cervical cancer patients admitted to Gaozhou People′s Hospital in February 2019 to May 2021 were selected as the study group, 50 patients with uterine intraepithelial neoplasia admitted to Gaozhou People′s Hospital in the same period were selected as the neoplastic group, and 50 normal healthy women examined in Gaozhou People′s Hospital in the same period were selected as the control group. The expression levels of SCC and IL-38 in the three groups were detected and compared on admission. The expression levels of IL-38 and SCC in patients with different pathological factors were compared. After treatment, IL-38 and SCC of patients in the study group were detected and compared with the results on admission. Finally, the diagnostic efficacy of each index was evaluated by receiver operating characteristic (ROC) curve. Results The expression levels of IL-38 and SCC in the study group were higher than those in the neoplastic group and control group, the differences were statistically significant (P＜0.05). The two indexes in the neoplastic group were also higher than those in the control group, the differences were statistically significant (P＜0.05). After treatment, IL-38 and SCC expression levels of the study group were lower than those before treatment, the differences were statistically significant (P＜0.05). IL-38, SCC expression levels of Ⅲ/Ⅳstage were higher than those of theⅠ/Ⅱstage, IL-38 expression level of high degree of differentiation was higher than that of low, medium degree of differentiation, IL-38 expression level of medium degree of differentiation was higher than that of low degree of differentiation, the differences were statistically significant (P＜0.05). ROC curve showed that the area under curve (AUC) of serum IL-38 and SCC in the diagnosis of cervical cancer was 0.729 and 0.748, while the AUC of combined diagnosis was 0.826, with a sensitivity of 82.32% and specificity of 76.37%, both higher than single indexes. Conclusion SCC and IL-38 are related to the incidence and progression of cervical cancer. The combination of SCC and IL-38 as diagnostic indicators can improve the accuracy of cervical cancer diagnosis, which has great clinical guiding significance and diagnostic value for the disease, and is worthy of popularization and application.

Key words： Squamous cell carcinoma associated antigen Interleukin-38 Cervical cancer Diagnosis Diagnostic value

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	QIN Caifeng
	YANG Jinqiong
	XU Xuezhen

Cite this article:

QIN Caifeng,YANG Jinqiong,XU Xuezhen. Expression level and diagnostic value of squamous cell carcinoma antigen and interleukin-38 in peripheral blood of patients with cervical cancer[J]. 中国当代医药, 2022, 29(15): 23-26.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I15/23

[1]	张燕，刘艺璇，尹德财，等.胰岛素样生长因子2 mRNA 结合蛋白3 在CIN 及宫颈癌患者中的表达及其在宫颈病变筛查中的意义[J].临床和实验医学杂志，2020，19（9）：988-991.
[3]	孙晓东，刘敏，鲍慧，等.不同年龄段宫颈癌患者的病理特点及预后分析[J].现代肿瘤医学，2018，26（11）：1766-1769.
[2]	Muhammad SB，Hassan F，Bhowmik KK，et al.Detection of association of IL-1β，IL-4R，and IL-6 gene polymorphisms with cervical cancer in the Bangladeshi women by tetraprimer ARMS-PCR method[J].Int Immunopharmacol，2021，90：107131.
[4]	王燕，舒月红，丁叔波，等.MR 联合血清SSCA 检测对宫颈癌患者疗效及预后预测分析[J].中华肿瘤防治杂志，2018，25（21）：1522-1527.
[5]	Ye S，Sun X，Kang B，et al.The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay：a prospective observational study[J].BMC Cancer，2020，20（1）：138.
[6]	Zhong Y，Yu K，Wang X，et al.Elevated Plasma IL-38 Concentrations in Patients with Acute ST-Segment Elevation Myocardial Infarction and Their Dynamics after Reperfusion Treatment[J].Mediators Inflamm，2015，2015：490120.
[7]	林仲秋，王丽娟，刘龙阳.国际妇产科联盟2012 宫颈癌诊治指南解读[J].中国实用妇科与产科杂志，2013，29（5）：323-325.
[8]	周滢，姜继勇.早期宫颈癌淋巴脉管间隙浸润与临床病理因素及预后的关系[J].实用妇产科杂志，2018，34（3）：203-207.
[9]	周海萍，谢丽丹，涂晓波.宫颈癌患者超声造影特征与患者临床预后因素关系的分析[J].中国妇幼保健，2018，33（3）：695-698.
[10]	柴春晶.80 例年轻宫颈癌患者临床特征及术后复发和预后相关因素分析[J].中外女性健康研究，2018（14）：118，143.
[11]	陈莉萍，曹婷，李素芬，等.Hsp90α 及SCC 在宫颈癌早期诊断及预后监测中的价值[J].西部医学，2020，32（1）：76-80.
[12]	陶晓军，赵芳，葛学顺，等.血清SCCA、AFP、ProGRP 对肺癌早期诊断及预后评价的意义研究[J].中国实验诊断学，2018，22（5）：849-851.
[13]	李薇薇.血清甲胎蛋白、甲胎蛋白异质体、异常凝血酶原、鳞状细胞癌抗原联合检测对肝细胞癌的诊断价值[J].中国当代医药，2020，27（22）：94-96，100.
[14]	林晓燕，曾芸珠，林雪琼.八项肿瘤标志物在肺癌早期诊断的临床研究[J].中国医药科学，2021，11（11）：142-145，156.
[15]	崔桐，韩存芝.血清鳞状细胞癌抗原和癌胚抗原联合检测对子宫颈癌的诊断及疗效评价[J].肿瘤研究与临床，2016，28（8）：513-518.
[16]	Yu H，Liu Y，Xie W，et al.IL-38 alleviates the inflammatory response and the degeneration of nucleus pulposus cells via inhibition of the NF-κB signaling pathway in vitro[J].Int Immunopharmacol，2020，85：106592.
[17]	张瑜，金建军，田笑笑.IL-38 及其受体IL-36R mRNA 在结直肠癌中的表达及意义[J].胃肠病学和肝病学杂志，2018，27（12）：1383-1385.
[18]	赵先文，平翠香，荆结线，等.宫颈癌患者CEA 和SCCAg 血清水平联合检测的临床应用价值[J].现代肿瘤医学，2013，21（10）：2316-2318.
[19]	邵丹，朱峰.宫颈癌患者血清鳞状细胞癌抗原，白细胞介素-6 及转化生长因子水平变化及相关性[J].国际检验医学杂志，2018，39（4）：432-434.