Clinical effect of Tiotropium Bromide combined with Salmeterol and Fluticasone Inhalation in the treatment of silicosis complicated with chronic obstructive pulmonary disease
LI Ming1 ZHANG Zu-hua2
1.Department of Respiratory Medicine,Ping Mine General Hospital of Pingxiang City in Jiangxi Province (Xiangya Ping Mine Collaborative Hospital),Pingxiang 337000,China;2.Department of Respiratory Medicine,People′s Hospital of Pingxiang City in Jiangxi Province,Pingxiang 337000,China
摘要目的 探讨噻托溴铵联合沙美特罗替卡松吸入治疗矽肺并发慢性阻塞性肺疾病的临床效果。结果 选择2017年1月～2018年10月于江西省萍乡市萍矿总医院接受治疗并确诊为矽肺合并慢性阻塞性肺疾病稳定期的60 例患者，按照随机数字表法分为对照组、观察组、治疗组，各20 例。对照组予以对症治疗，观察组在以上治疗基础上再加用噻托溴铵粉吸入剂，治疗组在观察组治疗的基础上联合沙美特罗替卡松粉吸入剂规律吸入。3 个月后所有对象均再次完成肺功能[用力肺活量（FVC）、第1 秒用力呼气量（FEV1）、FEV1/FVC、第1 秒用力呼气容积占正常预计值百分比（FEV1%）]检测及6 min 步行实验行走距离的测量。结果 治疗组患者干预后的FVC、FEV1、FEV1/FVC、FEV1%水平以及6 min 步行实验结果均高于观察组和对照组，差异有统计学意义（P＜0.05）；观察组患者干预后的FVC、FEV1、FEV1/FVC、FEV1%水平以及6 min 步行实验结果均高于对照组，差异有统计学意义（P＜0.05）。结果 噻托溴铵配合沙美特罗替卡松治疗矽肺并发慢性阻塞性肺疾病的效果显著，患者肺功能恢复较好，6 min 步行实验的行走距离较远，可作为优选治疗方案。
Abstract：Objective To investigate the clinical efficacy of Tiotropium Bromide combined with Salmeterol and Fluticasone Inhalation in the treatment of silicosis complicated with chronic obstructive pulmonary disease.Methods From January 2017 to October 2018,60 patients with silicosis and chronic obstructive pulmonary disease in stable stage treated in Ping Ming General Hospital of Pingxiang City in Jiangxi Province were selected.They were divided into the control group,the observation group and the treatment group according to random number table methods.The control group was given symptomatic treatment,while the observation group was given Tiotropium Bromide Powder inhalation on the basis of the above treatment.On the basis of the observation group,the treatment group received regular inhalation of Salmeterol and Roticasone Inhalation.After 3 months,all subjects completed lung function detection again,such as forced vital capacity (FVC),forced expiratory volume (FEV1),FEV1/FVC,the percentage of forced expiratory volume in the first second to the normal predicted value (FEV1%),and the walking distance of the 6-minute walking test was measured.Results The results of FVC,FEV1,FEV1/FVC,FEV1% and 6-minute walking test in the treatment group after intervention were higher than those in the observation group and the control group,the differences were statistically significant (P＜0.05).The results of FVC,FEV1,FEV1% and 6-minute walking test in the observation group after intervention were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Tiotropium Bromide combined with Salmeterol and Fluticasone Inhalation is effective in the treatment of silicosis complicated with chronic obstructive pulmonary disease.The pulmonary function of patients recovers better.The walking distance of 6-minute walking test is longer,which can be used as the optimal treatment.
李鸣;张祖华. 噻托溴铵联合沙美特罗替卡松吸入治疗矽肺并发慢性阻塞性肺疾病的临床效果[J]. 中国当代医药, 2019, 26(27): 47-50.
LI Ming;ZHANG Zu-hua. Clinical effect of Tiotropium Bromide combined with Salmeterol and Fluticasone Inhalation in the treatment of silicosis complicated with chronic obstructive pulmonary disease. 中国当代医药, 2019, 26(27): 47-50.
Rando RJ，Vacek PM，Glenn RE，et al.Retrospective assessment of respirable quartz exposure for a silicosis study of the industrial sand industry[J].Ann Work Expo Health，2018，62（8）：1021-1032.
Nandi S，Burnase N，Barapatre A，et al.Assessment of silicosis awareness among stone mine workers of rajasthan state[J].Indian J Occup Environ Med，2018，22（2）：97-100.
[5]
樊乃根.矽肺发病及治疗研究的最新进展[J].职业与健康，2016，32（8）：1140-1142.
[6]
Volobaev VP，Larionov AV，Kalyuzhnaya EE，et al.Associations of polymorphisms in the cytokine genes IL-1β （rs169 44），IL-6 （rs1800795），IL-12b （rs3212227）and growth factor VEGFA （rs2010963） with anthracosilicosis in coal miners in Russia and related genotoxic effects[J].Mutagenesis，2018，33（2）：129-135.
Panev NI，Zakharenkov VV，Korotenko OY，et al.Diagnostic features of atherosclerosis development in miners having anthracosilicosis[J].Med Tr Prom Ekol，2016，9（5）：16-20.
[8]
Spalgais S，Gothi D，Jaiswal A，et al.Nonoccupational anthracofibrosis/anthracosilicosis from Ladakh in Jammu and Kashmir，India：a case series[J].Indian J Occup Environ Med，2015，19（3）：159-166.
Alaya Z，Braham M，Aissa S，et al.A case of Caplan syndrome in a recently diagnosed patient with silicosis：a case report[J].Radiol Case Rep，2018，13（3）：663-666.
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