LIU Dong-guo1ZHANG Li-wei2ZHANG Zhen3XIA Kun-gang1TAO Ying-xiu1WEI Jing-liang1LI De-zheng1▲
1.Department of Respiratory Medicine,Shouguang People′s Hospital Affiliated to Weifang Medical College,Shandong Province,Shouguang 262700,China;2.Department of Gastroenterology,Shouguang People′s Hospital Affiliated to Weifang Medical College,Shandong Province,Shouguang 262700，China;3.Department of Neurosurgery,Shouguang People′s Hospital Affiliated to Weifang Medical College,Shandong Province,Shouguang 262700,China
Abstract：Objective To investigate the changes of central respiratory drive during acute exacerbation in patients with chronic obstructive pulmonary disease (COPD)without respiratory failure.Methods A total of 88 patients with COPD treated in our hospital from April 2015 to May 2016 were selected as the subjects.None of the patients had respiratory failure.The patients′oral blocking pressure was measured on admission day and after remission,and data analysis was then performed.Results Both in awake and asleep states,the oral obstruction pressure (P0.1)of patients with COPD during acute exacerbation was significantly higher than that in remission,and the difference was statistically significant(P＜0.05).The P0.1 in sleep state was lower than that in awake state,and the difference was statistically significant(P＜0.05).Conclusion Central respiratory drive of patients with COPD is at a high output in the acute episode,meaning that central respiratory drive is increased in patients with COPD during acute exacerbations,and is weakened in sleep state.
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