Application value of combination of rapid shallow breathing index and N-terminal-pro-brain natriuretic peptide for ventilator weaning to chronic obstructive pulmonary disease patients with respiratory failure
LIU LingWU Wen-jieWANG Yan-xin YANG JiXIONG Xin ZHAO Hui-min CHEN YangXUE Bin
Department of Respiratory，Chuiyangliu Hospital of Beijing City，Beijing 100022，China
Abstract：Objective To assess the value of combination of rapid shallow breathing index （RSBI）and plasma N-terminal-pro-brain natriuretic peptide （NT-proBNP）for ventilator weaning to chronic obstructive pulmonary disease （COPD）patients with respiratory failure.Methods A total of 78 COPD patients with respiratory failure admitted in our hospital from 1 January 2015 to 1 January 2018 were selected as the research objects，they were divided into the success group（61 cases）and the failure group （17 cases）according to the weaning outcome at the first time.The difference of RSBI and plasma NT-proBNP were compared between the two groups when offline conditions were reached.Logistic multiple regression analysis was used to analyze the significance of RSBI，NT-proBNP and their combined detection in guiding ventilator evacuation in COPD patients with respiratory failure.Results The RSBI of the success group and the failure group were （81.25±10.12）times/（min·L），（110.01±20.13）times/（min·L），respectively.The level of NT-proBNP in the success group and the failure group were （299.26±131.62）pg/ml and （1286.29±256.16）pg/ml，respectively.The levels of RSBI and NT-proBNP in the successful group were lower than those in the failure group，and the difference was statistically significant （P＜0.05）.Logistic multivariate regression analysis showed that the relative risks OR of RSBI，NT-proBNP and their combination for successful ventilator evacuation were 5.236，2.762 and 6.785，respectively （P＜0.05）.The combination of the two methods was more valuable in predicting ventilator evacuation.Conclusion Respiratory muscle reserve function measured by RSBI and cardiac function assessed by NT-proBNP can improve the success rate of ventilator evacuation in COPD patients with respiratory failure and mechanical ventilation.
刘领;吴文杰;王艳新;杨霁;熊鑫;赵惠敏;陈杨;薛兵. 浅快指数与N端脑钠素前体结合在指导慢性阻塞性肺疾病呼吸衰竭患者呼吸机撤离中的应用价值[J]. 中国当代医药, 2019, 26(4): 51-53.
LIU LingWU Wen-jieWANG Yan-xin YANG JiXIONG Xin ZHAO Hui-min CHEN YangXUE Bin. Application value of combination of rapid shallow breathing index and N-terminal-pro-brain natriuretic peptide for ventilator weaning to chronic obstructive pulmonary disease patients with respiratory failure. 中国当代医药, 2019, 26(4): 51-53.
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