Effect comparison of non-invasive ventilation with Bi-level positive airway pressure ventilator and low-flow oxygen by nasal cannula in the treatment of elderly patients with chronic obstructive pulmonary disease and respiratory failure
YAO Shao-shu ZHONG Guan-jun HUANG Wei-xiaLI Shu-lan CHEN Wen-ying
The Second Department of Internal Medicine，Hospital of Traditional Chinese Medicine of Zengcheng District of Guangzhou City in Guangdong Province，Guangzhou 511300，China
Abstract：Objective To investigate the clinical application effect of non-invasive ventilation with Bi-level positive airway pressure （BiPAP）ventilator and nasal low-flow oxygen in the treatment of elderly patients with chronic obstructive pulmonary disease （COPD）and respiratory failure.Methods A total of 100 elderly patients with COPD and respiratory failure admitted to our hospital from April 2015 to April 2018 were enrolled as subjects.By a random number table method，all patients were divided into the study group and the control group，50 cases in each groups.Both groups were provided with basic treatment.In the control group，low-flow oxygen via nasal catheter was added，while in the study group，non-invasive ventilation with BiPAP ventilator was added.The clinical efficacy，acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ）score，arterial oxygen partial pressure （PaO2），potential of hydrogen （pH），arterial blood carbon dioxide partial pressure （PaCO2），respiratory rate （RR），heart rate （HR），and the incidence rate of complications were compared between the two groups.Results The total clinical effectiveness rate was 86.00%in the study group，which was higher than that of the control group accounting for 64.00%，with significant difference （P＜0.05）.There were no significant differences in the levels of pH，PaO2，PaCO2，HR，RR and APACHE Ⅱscores before intervention between the two groups （P＞0.05）.At 96 hours of intervention，the levels of pH and PaO2 between the two groups were higher than those before intervention，with significant differences （P＜0.05）.Meanwhile，the levels of PaCO2，HR，RR，and the APACHE Ⅱ scores of the two groups were lower than those before intervention，with statistical significance （P＜0.05）.After 96-hour intervention，the level of PaCO2，HR，RR and the APACHE Ⅱ score in the study group were lower than those in the control group，with statistical differences （P＜0.05）.The levels of pH and PaO2in the study group were higher than those in the control group at 96-hour intervention，which differed statistically（P＜0.05）.The total incidence rate of complications in the study group was 26.00%，which was higher than that in the control group accounting for 4.00%，with significant difference （P＜0.05）.Conclusion Non-invasive ventilation with BiPAP ventilator can obtain a definite effect on treating elderly patients with COPD and respiratory failure by significantly improving the clinical symptoms and blood gas indicators，but the incidence rate of complications is high，which should be paid attention for its complication management in clinical application.
姚绍枢;钟冠军;黄伟霞;李淑兰;陈文英. 双水平气道正压通气呼吸机无创通气和鼻导管低流量吸氧治疗老年慢性阻塞性肺疾病并呼吸衰竭的效果比较[J]. 中国当代医药, 2019, 26(4): 45-47.
YAO Shao-shu ZHONG Guan-jun HUANG Wei-xiaLI Shu-lan CHEN Wen-ying. Effect comparison of non-invasive ventilation with Bi-level positive airway pressure ventilator and low-flow oxygen by nasal cannula in the treatment of elderly patients with chronic obstructive pulmonary disease and respiratory failure. 中国当代医药, 2019, 26(4): 45-47.
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