Abstract：Objective To explore the effect of Zoledronic Acid treatment on elderly patients with osteoporosis and its effect on bone pain relief.Methods Fifty-two elderly patients with osteoporosis admitted to our hospital from March 2015 to April 2017 were selected as the research objects，they were divided into control group （24 cases）and experimental group （28 cases）according to different treatment methods，the control group was treated with Calcium Cartonate and Vitamin D3Chewabie Tablets and Alfacalciferol soft Capsules，while the experimental group was treated with Calcium Carttonate and Vitamin D3Chewabie Tablets，Alfacalciferol soft Capsules and Zoledronic Acid.Pain score，serum calcium，phosphorus，alkaline phosphatase （ALP）levels and total incidence of adverse reactions were compared between the two groups.Results The pain score of the experimental group after 3 and 6 months of treatment was lower than that of the control group，the differences were statistically significant （P＜0.05）.After 6 months of treatment，the ALP level in the experimental group was （98.27±15.36）IU/L，which was lower than （142.27±19.36）IU/L in the control group，the difference was statistically significant （P＜0.05）.There were no significant differences in serum calcium and phosphorus levels between the two groups after 6 months of treatment （P＞0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups （P＞0.05）.Conclusion Zoledronic Acid has a good effect on elderly patients with osteoporosis.It can significantly alleviate bone pain and has high safety.
李堃宜. 唑来膦酸治疗老年骨质疏松症的效果及对骨痛缓解的影响[J]. 中国当代医药, 2019, 26(4): 124-126.
LI Kun-yi. Effect of Zoledronic Acid in the treatment of osteoporosis in the elderly and its effect on bone pain relief. 中国当代医药, 2019, 26(4): 124-126.
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