Abstract：Objective To explore the clinical effect of Intravenous Gamma Globulin in the prevention and treatment of recurrent abortion （RSA）.Methods A total of 90 patients with RSA who were treated in our hospital from September 2014 to December 2017 were selected as observation group，46 patients who were treated with Intravenous Gamma Globulin according to their own willingness were selected as observation group 1，44 patients who chose traditional conservative treatment were selected as observation group 2，and the clinical treatment effects and adverse reactions of the two groups were observed.At the same time，90 healthy women who did pregnancy check-up in the hospital during the same period were selected as the control group.The level of gamma globulin in patients with RSA and healthy women were observed.Results The success rate of pregnancy and full term yield in the observation group 1 were significantly higher than those in the observation group 2 （P＜0.05）.The mortality of premature infant and abortion rate in the observation group 1 were significantly lower than those in the observation group 2 （P＜0.05），and the total incidence of adverse reactions in the two groups was not significantly different（P＞0.05）and the level of gamma interferon （IFN-γ）and natural killer （NK）in the observation group were significantly lower than those in the control group （P＜0.05）.The level of interleukin-10 （IL-10）in the observation group was significantly higher than that in the control group，the differences were statistically significant （P＜0.05）.Conclusion The level of IFN-γ in RSA patients is significantly different from that in healthy women.It can be used as an effective index to prevent RSA.Intravenous Gamma Globulin in the treatment of RSA can significantly improve the success rate of pregnancy and full term yield，and it has high safety and high clinical value.
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