Abstract：Objective To compare the c1inica1 effect of esomeprazo1e and omeprazo1e in treating ref1ux esophagitis,and to provide some theory basis for promoting the treatment deve1opment of digestive system department.Methods 100 ref1ux esophagitis patients of digestive system department in our hospita1 from January to December 2014 were se1ected as study object.On the condition of our hospita1 ethics committee approva1 and got patients agreement,patients were divided into observation group and contro1 group according to different treatment method,and each group was 50 cases.Patients in contro1 group were given omeprazo1e,and patients in observation group were given esomeprazo1e.Symptoms improved conditions after treatment in two groups were compared.Results The symptoms improved conditions and tota1 effective rate of treatment in observation group were better than that of contro1 group,and the difference was statistica1 significance（P＜0.05）.Conclusion Using esomeprazo1e in treating ref1ux esophagitis can obvious improve c1inica1 symptoms of patients and enhance treatment tota1 effective rate.It is worth to popu1arize in the future.
Shin JS，Lee JY，Cho KH，et al.The pharmacokinetics，pharmacodynamics and safety of ora1 doses of i1aprazo1e 10，20 and 40 mg and esomeprazo1e 40 mg in hea1thy subjects：a randomised，open-1abe1 crossover study[J].A1iment Pharmaco1 Ther，2014，40（5）：548-561.
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