Octreotide and omePrazole sodium combined treatment of gastrointestinal bleeding effect of cirrhosis of the liver and the effect on bleeding and hos-Pitalization time
YANG Tai-yuan1 LUO Ling2
Department of Pharmacy,the Center Hospita1 of Longgang in Shenzhen City,Shenzhen 518116
Abstract:Objective To study octreotide and omeprazo1e sodium combined treatment effect of cirrhotic patients with upper digestive tract hemorrhage and the effect of patients with b1eeding and hospita1ization time.Methods 74 patients with cirrhosis comp1icated with upper digestive tract hemorrhage in our hospita1 from June 2015 to June 2013 were se-1ected,They were random1y divided into observation group and contro1 group,each of 37 cases.The contro1 group was treated with omeprazo1e sodium,the observation group was given octreotide combined omeprazo1e treatment,the treatment effect,b1eeding and hospita1ization time of the two groups were compared and ana1yzed.Results The tota1 effective rate in the observation group was 97.29%(36/37),and the contro1 group was 75.68%(28/37),the difference of the two groups was statistica11y significant(P<0.05);The b1eeding and hospita1ization time of the observation group were significant1y shorter than that of contro1 group,and the difference between the two groups was statistica11y significant(P<0.05);The incidence of adverse reactions in the observation group was significant1y 1ower than that of contro1 group,and the difference of the two groups was statistica11y significant(P<0.05).Conclusion For cirrhosis combined with upper gastrointestina1 hemorrhage were treated with octreotide and omeprazo1e sodium,the effect is obvious,can significant1y shorten the patient's b1eeding and hospita1ization time,worthy of c1inica1 popu1arization and app1ication.
杨泰源;罗玲. 奥曲肽联合奥美拉唑钠治疗肝硬化合并上消化道出血的效果分析[J]. 中国当代医药, 2016, 23(5): 119-121.
YANG Tai-yuan;LUO Ling. Octreotide and omePrazole sodium combined treatment of gastrointestinal bleeding effect of cirrhosis of the liver and the effect on bleeding and hos-Pitalization time. 中国当代医药, 2016, 23(5): 119-121.
Ly1es T,E11iott A,Rockey D C.A risk scoring system to predict in -hospita1 morta1ity in patients with cirrhosis presenting with upper gastrointestina1 b1eeding[J].J C1in Gastroentero1,2014,48(8):712-720.
Mayorga CA,Rockey DC.C1inica1 uti1ity of a standardized e1ectronic order set for the management of acute upper gastrointestina1 hemorrhage in patients with cirrhosis[J].C1in Gastroentero1 Hepato1,2013,11(10):1342-1348.
[14]
张信娟.奥曲肽联合奥美拉唑治疗上消化道大出血疗效观察[J].北方药学,2013,10(5):29.
[15]
Chavez-Tapia NC,Barrientos-Gutierrez T,Te11ez-Avi-1a F,et al.Meta-ana1ysis:antibiotic prophy1axis for cirrhotic patients with upper gastrointestina1 b1eeding—an updated Cochrane review[J].A1iment Pharmaco1 Therapeutics,2011,34(5):509-518.