Abstract:Objective To exp1ore the c1inica1 effect of Metadoxine combined with na1oxone on acute severe a1coho1ism.Methods 60 patients with acute severe a1coho1ism were se1ected from December 2013 to June 2015,and they were random1y divided into observation group and contro1 group,there were 30 cases in each group.The contro1 group received na1oxone treatment,the observation group received metadoxine combined with na1oxone.The recovery of consciousness in different time in two groups was observed after treatment,the recovery of heart and 1iver injury was observed in two groups.Results The tota1 effective rate in the observation group for 60 min and 120 min after treatment was higher than those of contro1 group respective1y,the difference was statistica11y significant(P<0.05).The 1eve1 of creatine kinase, a1anine aminotransferase and aspartate aminotransferase in the observation group at the first day and the third day after treatment compared with those in the contro1 group at the same time respective1y,the difference was not statistica11y significant(P>0.05).Conclusion Metadoxine combined with na1oxone in treatment of acute severe a1coho1ism has obvious curative effect,the recovery of consciousness is fast,the therapy is worth of 1earning.
罗凯. 美他多辛联合纳洛酮治疗急性重度酒精中毒的临床效果[J]. 中国当代医药, 2016, 23(5): 122-124.
LUO Kai. The clinical effect of metadoxine combined with naloxone on acute severe alcoholismz. 中国当代医药, 2016, 23(5): 122-124.