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2024 Vol. 31, No. 13 Published: 2024-05-08

	4	Construction and preliminary evaluation of a thermostatic amplification detection system for miRNA-21-5p
		ZENG Yuanqing DENG Ningbo▲
		Objective To establish a fluorescence detection method for miRNA-21-5p based on rolling ring amplification and CRISPR-Cas9 system,and to preliminarily evaluate the detection performance.Methods A specific lock-in probe was designed to identify the target miRNA-21-5p,and rolled loop amplification was performed under the action of Escherichia coli DNA ligase and Phi29 DNA polymerase to form a long repeat single strand.With the help of Cas9 enzyme,the specificity is identified and double-stranded DNA is formed,and then the fluorescence intensity of the fluorescence signal was proportional to the concentration of the double-stranded DNA product by adding SYBR Green Ⅰfluorescent dye.The constructed method was used to detect miRNA in serum of patients with gastric cancer and serum of healthy people.Whether miRNA was successfully detected and the levels of pepsinogen Ⅰ/pepsinogen Ⅱ (PGⅠ/Ⅱ)in serum of the two groups were detected at the same time,and receiver operating characteristic(ROC)curve was drawn.The diagnostic value of miRNA-21-5p and pepsinogen in gastric cancer was analyzed according to area under the curve (AUC).Results The constructed amplification system could detect miRNA in serum,and the fluorescence intensity of mirNA-21-5P in serum of gastric cancer was higher than that in healthy control group,the difference was statistically significant(P＜0.05).ROC curve results showed that the AUC of miRNA-21-5p and PGⅠ/Ⅱalone in the diagnosis of gastric cancer was 0.72 and 0.80,respectively,and the AUC of combined detection was 0.85,higher than that of any single index.Conclusion Using this method to directly detect miR-21-5p has convenient and fast operation,no need for complex thermal cycling instruments,and a wide range of applications.
		2024 Vol. 31 (13): 4-09 [Abstract] ( 17 ) HTML (1 KB) PDF (1092 KB) ( 21 )

	10	Expression changes of human epidermal growth factor receptor 2 and epithelial growth factor receptor in the patients with human papilloma virus related cervical adenocarcinoma and correlation with clinicopathological characteristics
		ZENG Fansheng LIAO Linhong WANG Qian SU Hui YE Qianqian HUANG Lijuan
		Objective To explore the expression changes of human epidermal growth factor receptor 2 (HER2)and epithelial growth factor receptor (EGFR)in human papilloma virus (HPV)related cervical adenocarcinoma and their correlation with clinicopathological characteristics.Methods A total of 120 patients with HPV related cervical adenocarcinoma from January 2016 to June 2023 in Ganzhou Women and Children's Health Care Hospital were selected as the observation group,and 40 patients with chronic cervicitis were selected as the control group.The expression of HER2 and EGFR in the tissues of the two groups were compared,and the test results of patients with different ages,silva classification,FIGO stage,histological grade,lymph node metastasis,vascular involvement and vaginal wall involvement in the observation group were compared.Spearman correlation was used to analyze the relationship between the expression of HER2 and EGFR and the clinicopathological characteristics of HPV related cervical adenocarcinoma.Results The positive expression rates of HER2 and EGFR in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were significant differences in the positive rate of HER2 among different silva classification,FIGO stage,histological grade,lymph node metastasis,vascular and vaginal wall involvement(P＜0.05).There were significant differences in EGFR positive rates between silva type C and other types,different FIGO stages,lymph node metastasis,vascular and vaginal wall involvement in the observation group (P＜0.05).Correlation analysis showed that the expression of HER2 in HPV related cervical adenocarcinoma was correlated with silva classification,FIGO stage,histological grade,lymph node metastasis,vascular and vaginal wall involvement(P＜0.05).EGFR expression was correlated with silva classification,FIGO stage,lymph node metastasis,vascular and vaginal wall involvement (P＜0.05).Conclusion HER2 and EGFR are highly expressed in HPV related cervical adenocarcinoma and HER2 expression is related to silva classification,FIGO stage,histological grade,lymph node metastasis,vascular and vaginal involvement.EGFR expression is related to silva classification,FIGO stage,lymph node metastasis,vascular and vaginal involvement,and has high detection value in patients with this disease.
		2024 Vol. 31 (13): 10-14 [Abstract] ( 15 ) HTML (1 KB) PDF (545 KB) ( 27 )

	15	Effect evaluation of Shuxuetong Injection in the treatment of ischemic stroke
		DENG Yongxiong1 BI Haiquan2
		Objective To explore the effect of Shuxuetong Injection in the treatment of ischemic stroke.Methods From January 2019 to May 2023,a total of 49 patients with ischemic stroke in Yongchuan Huimin Traditional Chinese Medicine Hospital of Chongqing City were selected as the research objects,and they were divided into control group (24 cases) and observation group (25 cases) according to random number table method.The control group were treated with Aspirin and Clopidogrel,while the observation group were treated with Shuxuetong Injection on the basis of the treatment of the control group.The clinical efficacy and the incidence of bleeding during treatment were compared between the two groups,and the coagulation function and disease-related scores before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,and the total incidence of bleeding was lower than that of the control group,and the differences were statistically significant (P＜0.05).After treatment,the activated partial thromboplastin time (APTT)and prothrombin time (PT)of the two groups were longer than those before treatment,the international normalized ratio (INR) and Barthel index (BI) score of the two groups were higher than those before treatment,the D-dimer(D-D)level,the national institutes of health stroke scale(NIHSS)score and the traditional Chinese medicine symptom score of the two groups were lower than those before treatment,and the differences were statistically significant (P＜0.05).After treatment,the APTT and PT of the observation group were longer than those of the control group,the INR value and BI score of the observation group were higher than those of the control group,and the D-D level,the NIHSS score and the traditional Chinese medicine symptom score of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).Conclusion Shuxuetong Injection can effectively improve the clinical efficacy,improve the coagulation function and neurological function,reduce the incidence of bleeding and improve the daily living ability of patients.
		2024 Vol. 31 (13): 15-18转23 [Abstract] ( 16 ) HTML (1 KB) PDF (873 KB) ( 102 )

	19	Clinical effect and mechanism of Wuling Capsules combined with Tenofovir in the treatment of hepatitis B cirrhosis
		SHENG Fanxiu1 XIA Jinrong1 LU Ren2
		Objective To investigate the clinical effect and mechanism of Wuling Capsules combined with Tenofovir in the treatment of hepatitis B cirrhosis.Methods A total of 64 patients with hepatitis B cirrhosis who were diagnosed and treated in Shangrao Second People's Hospital from January 2022 to March 2023 were selected as the study subjects.They were divided into the control group and the observation group using the random number table method,with 32 patients in each group.The control group was treated with Tenofovir,and the observation group was treated with Wuling Capsules combined with Tenofovir.The two groups were compared in terms of clinical efficacy,liver function and liver fibrosis indicators.Immune function and levels of inflammatory factors in the two groups were observed.Results The total effective rate in the observation group (96.87%) was higher than that in the control group (81.25%),and the difference was statistically significant (P＜0.05).After 6 months of treatment,the levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,serum hyaluronic acid,laminin and type Ⅲprocollagen in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).After 6 months of treatment,the levels of CD3+,CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).After 6 months of treatment,serum tumor necrosis factor-α (TNF-α),interleukin 6(IL-6)and transforming growth factor-β1 (TGF-β1)levels in observation group were lower than those in the control group,and the differences were statistically significant (P ＜0.05).Conclusion Wuling Capsules combined with Tenofovir is effective in the treatment of hepatitis B cirrhosis,which can effectively improve liver function,relieve cirrhosis,reduce liver damage,enhance immunity and alleviate inflammatory reactions.
		2024 Vol. 31 (13): 19-23 [Abstract] ( 14 ) HTML (1 KB) PDF (472 KB) ( 90 )

	24	Application of oscillating sieve atomization in patients undergoing mechanical ventilation
		QIU Xinliang LIU Yuebo LYU Zhiqiang ZHONG Jianrong
		Objective To analyze the impact of implementing an oscillating sieve atomization device in the nebulization administration of mechanically ventilated patients on their respiratory system status.Methods A total of 62 patients with respiratory diseases who underwent mechanical ventilation support in the Department of Critical Care Medicine,Xingguo Hospital Affiliated to Gannan Medical College from September 2020 to December 2022 were selected as the study objects,and they were divided into control group and observation group according to the odd-even method,with 31 patients in each group.The control group received conventional oxygen drive atomization medication,while the observation group received oscillating sieve atomization medication.The respiratory parameters,atomization indicators,and blood gas indicators of the two groups of patients were compared under different medication regimens Serum inflammatory markers.Results The tidal volume and dynamic compliance of the observation group were higher than those of the control group,and the airway peak pressure and respiratory rate were lower than those of the control group,and the differences were statistically significant (P＜0.05).The atomization preparation time,atomization administration time,residual amount of atomization administration,and ventilator alarm times after atomization in the observation group were lower than those in the control group (P＜0.05).The arterial partial pressure of oxygen,oxygenation index and pH value of the observation group after treatment were higher than those of the control group,while arterial partial pressure of carbon dioxide and respiratory rate were lower than those of the control group,the arterial partial pressure of oxygen,oxygenation index and pH value of the two groups after treatment were higher than those before treatment,while arterial partial pressure of carbon dioxide and respiratory rate were lower than those before treatment,and the differences were statistically significant (P＜0.05).The levels of interleukin-13,procalcitonin,human soluble intercellular adhesion molecule,granulocyte-macrophage colony-stimulating factor,C-reactive protein in the observation group after treatment were lower than those in the control group,and the inflammatory indexes in the two groups after treatment were higher than those before treatment,the differences were statistically significant(P＜0.05).Conclusion The implementation of an oscillating sieve atomization device in the atomization administration of mechanically ventilated patients can enhance the efficacy of the medication,shorten the administration time,improve the patient's respiratory indicators,and promote the regression of inflammation,which has important application value.
		2024 Vol. 31 (13): 24-28 [Abstract] ( 11 ) HTML (1 KB) PDF (469 KB) ( 56 )

	29	Study on the prognosis of stroke patients with different risk factors based on lipotomic method
		LIU Jianping GAO Hui▲ ZHANG Lianhong
		Objective To investigate the prognostic of stroke patients with different risk factors based on lipotomic method.Methods The clinical data of 120 patients with acute ischemic stroke(AIS)admitted to Jiujiang First People's Hospital from February 2021 to February 2023 were retrospectively analyzed,after 3 months of treatment,the patients were divided into good group(n=82)and bad group(n=38)according to prognosis.The effects of age,gender,smoking history,drinking history,hypertension,hyperlipidemia,diabetes,family history of stroke,total cholesterol (TC),triglyceride (TG),glycated hemoglobin(HbA1c)and low-density lipoprotein cholesterol(LDL-C)levels on the poor prognosis of AIS patients were analyzed.Results Among all 120 AIS patients included in the study,38 patients had poor prognosis,with an incidence of 31.67%,and 82 patients had good prognosis,with an incidence of 68.33%.The results of univariate analysis showed that there were no significant differences in gender,smoking history,drinking history,hypertension,hyperlipidemia,diabetes and family genetic history of stroke between the two groups(P＞0.05).There were significant differences in age,TC,TG,HbA1c and LDL-C between the two groups(P＜0.05).Multiple factors analysis results suggest that age(β=0.266,OR=1.304,95%CI=1.136-1.498),HbA1c (β=0.838,OR=2.312,95%CI=1.269-4.212),LDL-C (β=1.662,OR=5.269,95%CI=2.178-12.745) were risk factors for poor prognosis in AIS patients,and the differences were statistically significant (P＜0.05).Conclusion Age,HbA1c and LDL-C are risk factors for poor prognosis of AIS patients.Targeted interventions can be carried out according to the above factors to reduce the incidence of poor prognosis in AIS patients.
		2024 Vol. 31 (13): 29-32 [Abstract] ( 18 ) HTML (1 KB) PDF (433 KB) ( 0 )

	33	Effects of functional electrical stimulation combined with mirror therapy on lower limb function,balance function and serum irisin level in stroke patients with hemiplegia
		WU Lina1 XU Gui1 YU Xiujie2
		Objective To investigate the effects of functional electrical stimulation (FES)combined with mirror therapy on lower limb function,balance function and serum irisin level in stroke patients with hemiplegia.Methods A total of 84 stroke patients with hemiplegia admitted to Foresea Life Insurance Nanning Hospital from January 2022 to June 2023 were selected as the research objects.They were divided into control group (42 cases)and FES group (42 cases)by random number table method.On the basis of routine rehabilitation,the control group was given mirror therapy,and the FES group was given FES combined with mirror therapy.Both groups were intervened for 4 weeks.The lower limb motor function (Fugl-Meyer assessment lower limb part[FMA-L]),balance function (berg balance scale [BBS]),walking ability (10 m walking time test[10MWT],functional walking ability classification [FAC]),daily living ability ([modified Barthel index MBI]) and serum irisin levels were compared between the two groups before and after treatment.Results After 4 weeks of treatment,the FMA score,BBS score and MBI score of the lower limbs in the FES group were higher than those in the control group,and the 10MWT and FAC were better than those in the control group,the differences were statistically significant(P＜0.05).After 4 weeks of treatment,the serum irisin level in the FES group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion FES combined with mirror therapy can better improve lower limb function and balance function,increase serum irisin level and promote walking ability of patients.
		2024 Vol. 31 (13): 33-36 [Abstract] ( 15 ) HTML (1 KB) PDF (436 KB) ( 0 )

	37	Effect of acupoint application of traditional Chinese medicine on gastrointestinal reaction caused by chemotherapy for cervical cancer
		LI Hua1 ZHANG Fangfang2▲
		Objective To explore the effect of acupoint application of traditional Chinese medicine on gastrointestinal reaction caused by chemotherapy of cervical cancer.Methods A total of sixty cervical cancer patients admitted to the Department of Gynecological Oncology,Jiujiang Third People's Hospital from June 2022 to May 2023 were selected as the study objects.They were divided into control group (30 cases)and treatment group (30 cases)according to the random number table method.The control group patients were treated with routine nursing methods,the patients in the treatment group were given traditional Chinese medicine acupoint patches on the basis of the treatment of the control group.The toxic side effects,gastrointestinal intervention effects,and quality of life between two groups were compared.Results The gastrointestinal response of the treatment group patients on the last day of chemotherapy was lower than that of the control group,with a statistically significant difference(P＜0.05).The intervention effect on gastrointestinal reactions in the treatment group was better than that in the control group,and the difference was statistically significant(P＜0.05).The psychological function,physical function,social function,common symptoms and adverse reactions,psychological burden,and total score of the the quality of life instrument for cervical cancer patients (QLICP-CE) cervical cancer scale system for cancer patients in the treatment group on the last day of chemotherapy were higher than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Acupoint application of traditional Chinese medicine can effectively reduce the gastrointestinal reactions caused by chemotherapy in cervical cancer,has a reliable preventive effect on related toxic and side effects,and can actively alleviate the degree of toxic and side effects in patients,so as to improve the quality of life of patients.
		2024 Vol. 31 (13): 37-40转44 [Abstract] ( 15 ) HTML (1 KB) PDF (644 KB) ( 1 )

	41	Cause analysis and prevention strategies of postoperative anastomotic fistula in laparoscopic colorectal cancer
		CHEN Yuanjian
		Objective To study and analyze the causes of anastomotic leakage after laparoscopic surgery for colorectal cancer,and explore corresponding preventive measures.Methods A total of 676 patients with colorectal cancer who underwent laparoscopic surgery at the Department of Gastroenterology Surgery,Liuzhou People's Hospital from January 2018 to December 2022 were selected as the study objects.They were divided into a study group (49 cases with anastomotic leakage)and a control group (627 cases without anastomotic leakage)based on whether they experienced anastomotic leakage after surgery.Retrospective analysis was conducted on the clinical data of two groups of cases,and logistic regression analysis was used to analyze the influencing factors of anastomotic fistula after laparoscopic surgery for colorectal cancer.Results The results of single factor analysis showed that there were significant differences between the study group and the control group in gender,age,body mass index,diabetes,preoperative serum albumin,and operation time(P＜0.05).The results of multiple factor analysis suggest that males (β=0.335,OR=2.561,95%CI:1.489-3.082),age ≥60 years old (β=0.361,OR=2.457,95%CI: 1.193-3.107),body mass index ≥24.9 kg/m2 (β=0.329,OR=2.379,95%CI:1.140-3.278),combined with diabetes(β=0.328,OR=2.369,95%CI: 1.207-3.114),preoperative serum albumin＜35 g/L (β=0.357,OR=2.418,95%CI:1.245-3.098),surgery time ≥3.5 hours(β=0.348,OR=2.406,95%CI:1.352-3.069)were the risk factors for anastomotic fistula after laparoscopic colorectal cancer surgery (P＜0.05).Conclusion Patients with colorectal cancer after laparoscopic surgery are affected by gender,age,body mass index,diabetes and other factors,and are prone to anastomotic leakage.
		2024 Vol. 31 (13): 41-44 [Abstract] ( 15 ) HTML (1 KB) PDF (621 KB) ( 22 )

	45	Clinical observation of self-made Tongguan Decoction combined with sitz bath in the treatment of tubal infertility
		ZHU Ying ZHOU Yanmei ZHENG Guilian LI Ying ZHAO Xin LUO Yanqin
		Objective To explore the clinical effect of self-made Tongguan Decoction combined with sitz bath in the treatment of tubal infertility.Methods A total of 60 patients with tubal infertility admitted to Yichun Hospital of Traditional Chinese Medicnine from October 2020 to October 2022 were selected as the study subjects.They were divided into control group(30 cases)and treatment group(30 cases)according to random number table method.The patients in the control group were treated with routine tubal patency therapy,while the patients in the treatment group were treated with self-made Tongguan Decoction combined with sitz bath therapy on the basis of the treatment of the control group.The clinical efficacy,traditional Chinese medicine syndrome scores,local signs scores,inflammatory factor levels,uterine artery blood flow parameters,tubal patency,and natural conception rate between the two groups were compared.Results The total effective rate of the treatment group was higher than that of the control group,with a statistically significant difference (P＜0.05).Before treatment,there were no statistically significant differences in traditional Chinese medicine syndrome score,local sign score,tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),interleukin-8 (IL-8),uterine artery resistance index (RI),peak systolic velocity/end diastolic velocity (S/D) between the two groups (P＞0.05).After treatment,the traditional Chinese medicine syndrome score,local sign score,TNF-α,IL-6,IL-8,uterine artery RI,S/D of the two groups were lower than those before treatment,and the above in the treatment group were lower than those in the control group,and the differences were statistically significant (P＜0.05).After treatment,the tubal patency of the treatment group was better than that of the control group,and the natural pregnancy rate of the treatment group was higher than that of the control group,and the differences were statistically significant (P＜0.05).Conclusion The combination of self-made Tongguan Decoction and sitz bath can improve uterine artery blood flow,clinical symptoms and signs,reduce inflammatory factor levels,facilitate the recanalization of the fallopian tubes,and increase the natural conception rate,which is worthy of clinical promotion.
		2024 Vol. 31 (13): 45-48转53 [Abstract] ( 18 ) HTML (1 KB) PDF (568 KB) ( 3 )

	49	Effect of low-dose heparin sodium combined with mechanical assisted expectoration in the treatment of bronchopneumonia in children
		WAN Fang HUANG Bin CHEN Si
		Objective To investigate the effect of low-dose heparin sodium combined with mechanical assisted expectoration in the treatment of bronchopneumonia in children.Methods The clinical data of 100 children with bronchopneumonia who were treated in the Department of Pediatrics,Pingxiang People's Hospital,from April 2018 to November 2022 were retrospectively analyzed.According to the different treatment methods,they were divided into the conventional group (34 cases),heparin sodium group (33 cases),and combination group (33 cases).The conventional group was treated with symptomatic treatment such as fluid replacement,anti-infection,and relieving cough.The heparin sodium group was treated with low-dose heparin sodium,and the combination group was treated with mechanical expectoration on the basis of the above.The disappearance time of clinical symptoms,hospital stay and clinical efficacy of the three groups were compared.Results The cough disappearance time,lung rales disappearance time,hospitalization time and antipyretic time in the combination group were shorter than those in the conventional group and the heparin sodium group,and the cough disappearance time,lung rales disappearance time,hospitalization time and antipyretic time in the heparin sodium group were shorter than those in the conventional group,and the differences were statistically significant(P＜0.05).After 7 days of treatment,the effective rate of the combination group was higher than that of the conventional group,and the difference was statistically significant (P ＜0.017).After treatment,the levels of partial pressure of oxygen in arterial blood (PaO2),oxygenation index(OI)and arterial oxygen saturation(SpO2)in the three groups were higher than those before treatment,and the level of partial pressure of carbon dioxide in arterial blood (PaCO2) in the three groups were lower than those before treatment,and the levels of PaO2,OI and SpO2 in the combination group were higher than those in the heparin sodium group and the conventional group,and the level of PaCO2 in the heparin sodium group was lower than that in the heparin sodium group and the conventional group,the levels of PaO2,OI and SpO2 in the heparin sodium group were higher than those in the conventional group,and the level of PaCO2 in the heparin sodium group was lower than that in the conventional group,and the differences were statistically significant(P＜0.05).After treatment,the white blood cell count and neutrophil percentage levels of the three groups were lower than those before treatment,the white blood cell count and neutrophil percentage level of the combination group were lower than those of the heparin sodium group and the conventional group,and the white blood cell count and neutrophil level of the heparin sodium group were lower than those of the conventional group,and the differences were statistically significant(P＜0.05).Conclusion Low-dose heparin sodium combined with mechanical-assisted expectoration is effective in treating children with bronchopneumonia,which can effectively improve clinical symptoms and shorten treatment time.
		2024 Vol. 31 (13): 49-53 [Abstract] ( 16 ) HTML (1 KB) PDF (594 KB) ( 19 )

	54	Analysis of the influencing factors of adverse pregnancy outcomes in patients with gestational hypertension
		CHEN Jinghua ZHOU Qianjun▲ LIU Yingfeng LUN Guihuan
		Objective To explore the influencing factors of adverse pregnancy outcomes in patients with gestational hypertension.Methods A total of 71 patients with gestational hypertension admitted to Dongguan People's Hospital from April 2020 to June 2022 were selected as the study subjects.The levels of vitamin A,vitamin D,and vitamin E in the patients were measured using mass spectrometry.Single and multiple factor analyses were conducted to investigate the possible influencing factors of adverse pregnancy outcomes in patients with gestational hypertension.Results After follow-up,it was found that 19 out of 71 patients with gestational hypertension had poor pregnancy outcomes,while 52 had good pregnancy outcomes.The univariate results showed that the prognosis of patients with gestational hypertension was not related to age,pregnancy and childbirth history,family history of hypertension,adverse pregnancy history,high-sensitivity C-reactive protein (hs-CRP),D-dimer (D-D),vitamin D,and total bilirubin,and the differences were not statistically significant (P＞0.05).Compared with pre-pregnancy body mass index (BMI),severity of the condition,blood uric acid,24-hour urine protein quantification,vitamin A,and vitamin E,the differences were statistically significant (P＜0.05).The results of multiple logistic regression indicate that pre-pregnancy BMI (β=1.213,OR=3.582,95%CI=2.482-6.313),severity of the condition(β=1.563,OR=6.413,95%CI=5.682-8.452),blood uric acid(β=1.456,OR=4.083,95%CI=3.235-4.572),24-hour urine protein quantification(β=2.938,OR=1.434,95%CI=1.283-4.394),vitamin A(β=1.691,OR=1.593,95%CI=1.241-1.786),vitamin E (β=1.336,OR=1.246,95%CI=1.187-1.583) were independent risk factors for poor prognosis in patients with gestational hypertension,and the differences were statistically significant(P＜0.05).Conclusion The levels of vitamin A,D,and E are abnormally expressed in patients with gestational hypertension,and their expression levels can reflect the severity of the disease.Adverse pregnancy outcomes in patients are influenced by multiple factors,and different factors can interact and intervene.Therefore,interventions should be targeted at the controllable factors mentioned above.
		2024 Vol. 31 (13): 54-57 [Abstract] ( 17 ) HTML (1 KB) PDF (556 KB) ( 4 )

	58	Comparison on the effect of modified loop electrosurgical excision procedure and traditional loop electrosurgical excision procedure in women with cervical high-grade squamous intraepithelial lesions
		LIN Peixuan
		Objective To compare the effects of modified loop electrosurgical excision procedure (LEEP) and traditional LEEP in women with cervical high-grade squamous intraepithelial lesions (HSIL).Methods A total of 60 women of childbearing age with HISL,which was diagnosed in Department of Vaginoscopy in Macare Women's Hospital from June 2021 to June 2022,received LEEP as the first time were enrolled.They were divided into the modified LEEP group (30 cases)and the traditional LEEP group(30 cases)according to the different operative methods.The amount of vaginal hemorrhage during and after the operation,the operation time,the cervix length after surgery and cervical regeneration rate were recorded and compared between the two groups.Results The operation time in the modified LEEP group was shorter than that in the traditional LEEP group,the difference was statistically significant(P＜0.05).The amount of vaginal hemorrhage during the operation in the modified LEEP group was less than that in the traditional LEEP group,the difference was statistically significant(P＜0.05).The post operation vaginal hemorrhage at day one to a week in the modified LEEP group was lower than that in the traditional LEEP group,the difference was statistically significant (P＜0.05).At 12 months after surgery,the cervix length in the modified LEEP group was longer than that in the traditional LEEP group,the difference was statistically significant (P＜0.05).The postoperative cervical regeneration rate in the modified LEEP group was better than that in the traditional LEEP group,the difference was statistically significant(P＜0.05).Conclusion In the treatment of the women with HSIL,the modified LEEP can effectively reduce the amount of vaginal hemorrhage during and after operation,shorten the operation time,and increase the postoperative cervix regeneration rate,which is worthy of its promotion and application.
		2024 Vol. 31 (13): 58-62 [Abstract] ( 15 ) HTML (1 KB) PDF (567 KB) ( 66 )

	63	Application of contrast-enhanced ultrasound combined with intraoperative rapid immunohistochemical detection in sentinel lymph node biopsy of breast cancer
		LIU Ying HE Rong XIE Zijian LIU Xiaojuan
		Objective To investigate the effect of contrast-enhanced ultrasound(CEUS)combined with intraoperative rapid immunohistochemical detection in breast cancer sentinel lymph node (SLN).Methods Clinical data of 80 patients with breast cancer who received surgical treatment in Pingxiang Maternal and Child Health Hospital from January 2020 to June 2022 were retrospectively analyzed.All patients received preoperative CEUS and underwent merocyanine staining and intraoperative rapid immunohistochemistry detection,and postoperative pathological examination was used as the gold standard to analyze the application value of CEUS combined with intraoperative rapid immunohistochemistry detection in SLN metastasis of breast cancer.Results All 80 breast cancer patients were successfully implemented ultrasonography,ultrasound detected SLN was successfully stained with methylene blue,a total of 110 SLN were detected.110 SLN were metastasized 47 and not metastasized 63 after postoperative pathological examination.The sensitivity,specificity and accuracy of rapid immunohistochemical detection of SLN metastasis in combination with CEUS were 95.74%,100.00% and 98.18%,respectively,which were higher than single CEUS and intraoperative rapid immunohistochemical detection,and the differences were statistically significant (P＜0.017).Conclusion Ultrasonography combined with intraoperative rapid immunohistochemistry detection of SLN metastasis in breast cancer has high accuracy in the evaluation.
		2024 Vol. 31 (13): 63-66 [Abstract] ( 15 ) HTML (1 KB) PDF (440 KB) ( 29 )

	67	Observation on the effect of Neixiao Luoli Pills combined with Western medicine in the treatment of cavitary nontuberculous mycobacteria lung disease
		HUANG He1 XIE Wei2 ZENG Yunlong3
		Objective To investigate the effect of Neixiao Luoli Pills combined with western medicine in the treatment of cavitary nontuberculous mycobacterium (NTM) lung disease,and to provide a new therapeutic idea for clinical treatment.Methods Sixty-three patients with cavitary NTM lung disease admitted to Chest Hospital of Jiangxi Province from July 2020 to April 2023 were retrospectively analyzed,and divided into western medicine group (35 cases) and combined group (28 cases) according to treatment regimen.The western medicine group was treated with basic treatment,and the combined group was treated with Neixiao Luoli Pills.The main clinical manifestations and the changes of lesion extent and cavity in chest CT signs were observed in the two groups after intervention for 3 months.Results The treatment effect of cough and hemoptysis in combination group was better than that in western medicine group,and the total effective rate was higher than that in Western medicine group,the difference was statistically significant (P＜0.05).There was no significant difference in the treatment effect and total effective rate of chest tightness between the two groups (P＞0.05).Among the chest CT signs,the absorption of lung lesions and closure of cavity lesions in the combined group were better than those in the western medicine group,and the differences were statistically significant (P＜0.05).Conclusion Neixiao Luoli Pills combined with western medicine in the treatment of NTM lung disease can accelerate the remission of clinical symptoms and shorten the course of disease.The results of chest CT provide data support for the curative effect,which is worthy of clinical promotion and application.
		2024 Vol. 31 (13): 67-70 [Abstract] ( 18 ) HTML (1 KB) PDF (480 KB) ( 2 )

	71	Analysis on the application of Xiaobugan Decoction in cancer-related insomnia based on the theory of“Liver Storing Soul”
		WANG Jialing1 Luo Ling2 LIU Yong3
		Cancer-related insomnia is one of the common complications in clinical oncology patients,can appear after tumorigenesis and development and anti-tumor therapy,which often affects the quality of life of oncology patients，the efficacy of oncology treatment and the prognosis of oncology diseases.For its treatment,Western medicine often relies drugs such as benzodiazepines,and long-term use of which has problems such as dependence,addiction and poor efficacy,so it is necessary to seek the help of traditional Chinese medicine.Cancer-related insomnia belongs to the category of＂insomnia＂in Chinese medicine.Combined with the theory of ＂liver storing blood and blood shed soul＂ in the basic theory of Chinese medicine,it is believed that＂insomnia＂is closely related to the liver and its etiology and pathogenesis lies in＂liver does not store the soul＂.In this paper,we discuss the etiology and pathogenesis of insomnia from the perspective of ＂five viscera storing five spirit＂,＂spirit with soul＂,and analyzes that＂liver storing soul＂is closely related to Cancer-related insomnia.It also introduces the clinical efficacy of treating Cancer-related insomnia with Xiaobugan Decoction from the perspective of＂liver＂,thus providing ideas for the clinical application of the theory of ＂liver storing soul＂ in the treatment of Cancer-related insomnia.
		2024 Vol. 31 (13): 71-75 [Abstract] ( 15 ) HTML (1 KB) PDF (573 KB) ( 194 )

	76	Clinical effect of Du moxibustion combined with microwave in the treatment of tuberculous pleurisy with yang deficiency constitution
		GUO Qingjuan1 MA Xiaoman2 WANG Jie3 LIU Xiao4 REN Quanzhong4
		Objective To observe the clinical effect of moxibustion combined with microwave in the treatment of tuberculous pleurisy(TP)patients with Yang deficiency and its influence on adenosine deaminase(ADA)and lactate dehydrogenase(LDH).Methods A total of 80 patients admitted to the tuberculosis Department of Shandong Public Health Clinical Center from January to December 2023 were selected as the study objects and divided into the Western medicine group (40 cases)and the traditional Chinese medicine (TCM) group (40 cases) using computer random number method.The Western medicine group was treated with oral quadruple anti-tuberculosis drugs,while the TCM group was treated with moxibustion and microwave.The pleural thickness,pleural effusion,ADA and LDH contents and clinical efficacy were compared before and after treatment.Results After treatment,the pleural thickness and pleural effusion in TCM group were lower than those in Western medicine group,and the differences were statistically significant (P＜0.05).ADA and LDH in TCM group were lower than those in Western group after treatment,and the differences were statistically significant (P＜0.05).The total effective rate of TCM group was higher than that of Western group,and the difference was statistically significant (P＜0.05).Conclusion Du moxibustion combined with microwave in the treatment of tuberculous pleurisy patients with Yang deficiency constitution has definite clinical efficacy,which can be promoted as a green therapy of TCM.
		2024 Vol. 31 (13): 76-79 [Abstract] ( 16 ) HTML (1 KB) PDF (566 KB) ( 93 )

	80	Clinical effect of modified Ganlu Xiaodu Micropills in the treatment of intrahepatic cholestasis of pregnancy
		PENG Yao XIA Xiaojian CHEN Jin LIANG Yan YANG Qi
		Objective To explore the clinical effect of modified Ganlu Xiaodu Micropills in the treatment of intrahepatic cholestasis of pregnancy (ICP).Methods A total of 60 patients with ICP treated in Jiangxi Maternal and Child Health Hospital were selected as the research objects from October 2021 to June 2022,and they were divided into control group and study group according to random number table method,with 30 cases in each group.The control group was treated with conventional western medicine,and the study group was treated with modified Ganlu Xiaodu Micropills.The scores of pruritus degree,bilirubin (total bilirubin [TBil],indirect bilirubin [IBil],direct bilirubin [DBil]) and liver function (alanine aminotransferase[ALT],aspartate aminotransferase[AST])in the two groups were compared.And the adverse pregnancy outcomes in the two groups were observed.Results After treatment,the score of pruritus degree,levels of TBil,IBil and DBil in study group were lower than those in control group,and the differences were statistically significant (P＜0.05).The levels of ALT and AST in study group were lower than those in control group,and the differences were statistically significant (P＜0.05).and the total incidence of adverse pregnancy outcomes was lower than that in control group,and the difference was statistically significant (P＜0.05).Conclusion Modified Ganlu Xiaodu Micropills can improve clinical symptoms and liver function,relieve pruritus and reduce the occurrence of adverse pregnancy outcomes in ICP patients.
		2024 Vol. 31 (13): 80-83 [Abstract] ( 15 ) HTML (1 KB) PDF (563 KB) ( 36 )

	84	False -positive analysis of human Immunodeficiency virus antibody screening methods in Ganzhou
		GAO Qian LIAO Yong HU Xiaojun SU Junzhi▲ LIU Junjie TANG Manmei
		Objective To investigate the false positives of 4 697 samples from the human immunodeficiency virus(HIV)antibody screening laboratory in Ganzhou Center for Disease Control and Prevention from January 2015 to December 2022.Methods Western blotting was used to confirm 4 697 positive samples in Ganzhou.The false positive rate of each county and each year was obtained by statistical analysis.Results Through demographic analysis,it was found that the false positive rate of females was higher than that of males,and the false positive rate of prenatal testing and blood donor testing were higher than the other sample source,and the differences were statistically significant (P＜0.05),indicating the need to pay attention to special populations during clinical testing.The total false positive rate of 4 697 samples collected from January 2015 to December 2022 was as high as 12.14%,and showed a growing trend.There were significant differences in the false positive rate between years (P＜0.05).The false positive rate was greater than 10% in 10 of the 18 counties.CDC all use third-generation enzyme-linked immunosorbent assay reagents,while medical institutions mainly use chemiluminescence reagents.Conclusion When HIV antibody screening is positive,it is still very necessary to conduct confirmatory test to further confirm HIV infection and provide reference for clinical diagnosis.
		2024 Vol. 31 (13): 84-87 [Abstract] ( 14 ) HTML (1 KB) PDF (543 KB) ( 29 )

	88	Distribution characteristics and drug sensitivity of pathogenic bacteria in patients with human immunodeficiency virus combined with Mycobacterium tuberculosis infection
		ZHOU Huan YU Huangpeng▲
		Objective To explore the distribution characteristics and drug sensitivity of pathogenic bacteria in patients with human immunodeficiency virus(HIV)combined with Mycobacterium tuberculosis(MTB)infection.Methods A total of 142 HIV and MTB infected patients admitted to Jiujiang Third People's Hospital from January 2021 to May 2023 were selected as the study objects.They were divided into a simple HIV infection group(42 cases),a simple MTB infection group(42 cases),and a HIV combined with MTB infection group (58 cases) according to their infection status.The distribution of pathogenic bacteria and initial resistance to anti tuberculosis drugs in three groups of patients were recorded.Results Fungi were the most common in the HIV combined with MTB infection group,followed by Gram negative bacteria.Gram negative bacteria were the most common in the HIV infected group and MTB infected group.The proportion of fungal distribution in the HIV combined with MTB infection group was higher than that in the pure HIV infection group and the pure MTB group,and the difference was statistically significant(P＜0.017).There were no statistically significant differences among the three groups of Gram positive bacteria,Gram negative bacteria,and other pathogens (P＞0.05).The proportion of first-line anti tuberculosis drugs resistant to isoniazid(INH),streptomycin(SM),initial multidrug resistance,and total initial resistance in the HIV combined with MTB infection group were higher than those in the MTB alone group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference between the two groups in terms of resistance to second-line anti tuberculosis drugs such as rifampicin (RFP),ethambutol (EMB),and resistance to second-line anti tuberculosis drugs (P＞0.05).Conclusion Patients with HIV combined with MTB infection carry more fungi than those with only two infections,and the patients with combined infections is high in INH,SM,and overall initial drug resistance.Clinical attention should be paid to this issue.
		2024 Vol. 31 (13): 88-91 [Abstract] ( 18 ) HTML (1 KB) PDF (441 KB) ( 1 )

	92	Effect of social support and general self-efficacy on social participation of bladder cancer patients undergoing urinary diversion through abdominal wall stoma
		MA Sihui LIU Fei▲
		Objective To explore the effects of social support and general self-efficacy on social participation in bladder cancer patients undergoing urinary diversion through abdominal wall stoma,and to verify the mediating effects of general self-efficacy on social support and social participation.Methods A total of 145 bladder cancer patients undergoing urinary diversion through abdominal wall stoma and discharged 6 months after surgery from the Department of Urology of the Second Hospital of Dalian Medical University,the First Affiliated Hospital of Dalian Medical University and Dalian Municipal Central Hospital from November 2019 to December 2020 were selected as the research objects.Social support rating scale,general self-efficacy scale,social dysfunction screening list and general situation questionnaire were used to investigate the effects of social support and general self-efficacy on social participation in bladder cancer patients undergoing urinary diversion through abdominal wall stoma.Results The total scores of social participation,social support and general self-efficacy were(5.98±4.12),(31.10±5.43)and(2.24±0.64)points in patients with bladder cancer.Correlation analysis showed that the total score of social participation,total score of social support and general self-efficacy were negatively correlated (P＜0.001).Regression analysis showed that the total score of social support and general self-efficacy were the influencing factors of social participation score (P＜0.01).Pathway analysis showed that general self-efficacy had partial mediating effect between social support and social participation in bladder cancer patients undergoing urinary diversion through abdominal wall stoma,and the mediating effect accounted for 50.088%of the total effect.Conclusion Both social support and general self-efficacy can significantly affect social participation in bladder cancer patients undergoing urinary diversion through abdominal wall stoma.General self-efficacy has partial mediating role in the influence of social support on social participation.
		2024 Vol. 31 (13): 92-96 [Abstract] ( 16 ) HTML (1 KB) PDF (547 KB) ( 30 )

	97	Detection and epidemiological analysis of serum allergen specific immunoglobulin E in 370 patients with allergic diseases in Liaocheng City
		HAN Yumin ZHONG Qianqian MA Miao LIU Ligang LI Wenling LIU Bo HAN Lifen▲
		Objective The detection results of serum specific immunoglobulin E(sIgE)in patients with allergic diseases and the characteristics of allergens were analyzed.Methods Serum sIgE of 370 patients with allergic diseases admitted to Department of Anaphylaxis in Materal and Child Health Care Hospital of Dongchangfu County from April to June 2022 and July to September 2022 was detected,and the characteristics and allergens of the cases were analyzed.Results The sIgE positive rates of dust mite,wheat flour,house dust mite,pineapple and strawberry were 70.00%,65.14%,62.43%,45.68%and 44.32% respectively.There were 227 patients with allergic diseases in spring and 143 in autumn.Wheat flour,house dust mite,house dust mite,pineapple and strawberry were common allergens in spring,while dust mite,house dust mite,egg,humulus scandens and wheat flour were common allergens in autumn.Except mugwormwood,sycamore,birch,peach,apple,mango,cashew and cypress,the immunoglobulin E(IgE)positive rates of other 17 allergens were higher in spring than in autumn,and the differences were statistically significant (P＜0.05).The top 5 inhaled allergens in spring and autumn were dust mites,house dust mites,humulus scandens,common ragweed,willow (spring)and mugwormwood (autumn).The top 5 food allergens in spring were wheat flour,pineapple,strawberry,egg and soybean.The top 5 food allergens in autumn were egg,wheat flour,pineapple,milk and strawberry,and the positive rate of serum sIgE in spring was higher than that in autumn,the differences were statistically significant (P＜0.05).There were no significant differences in the types and incidence of major allergens between different genders(P＞0.05).Conclusion Dust mite,wheat flour,house dust mite,pineapple and strawberry were the main allergens in patients with sIgE positive allergic diseases.Dust mite was the main inhalation allergen,wheat flour and egg were the main food allergens.The positive rate of sIgE was different in different seasons.The results of this study provide certain reference for the prevention and treatment of allergic diseases in this area.
		2024 Vol. 31 (13): 97-100 [Abstract] ( 18 ) HTML (1 KB) PDF (493 KB) ( 9 )

	101	Analysis of current situation and influencing factors of medication compliance in non-dialysis patients with chronic kidney disease
		PENG Yingqian WAN Yanping
		Objective To investigate the current situation of medication compliance in non-dialysis patients with chronic kidney disease (CKD)and analyze its influencing factors.Methods A total of 220 non-dialysis patients with CKD admitted to the Department of Renal Medicine of the First Affiliated Hospital of University of South China from October 2022 to May 2023 were selected by convenience sampling method.The general data,medication compliance,self-efficacy of rational drug use,medication belief and other relevant scales of patients were collected.The factors related to medication compliance were analyzed.Results A total of 220 non-dialysis patients with CKD were included.The score of Morisky-8 medication compliance scale was (2.96±1.20)points,which was at a low level.The results of univariate analysis showed that gender,education level,occupational status and payment method of patients were related to medication compliance,and the differences were statistically significant (P＜0.05).Multivariate linear regression model was used to analyze the factors,and the results showed that patients' occupation,payment method,drug self-efficacy and general medication belief were the influencing factors of patients'drug compliance(P＜0.05).In addition,medication compliance was positively correlated with drug self-efficacy to a certain extent (r=0.558),and general medication belief was negatively correlated to a certain extent(r=-0.510).Conclusion The medication compliance of non-dialysis patients with CKD is poor.It is suggested that the medical staff should take corresponding nursing measures to improve the medication self-efficacy and medication compliance of patients.
		2024 Vol. 31 (13): 101-105 [Abstract] ( 15 ) HTML (1 KB) PDF (527 KB) ( 3 )

	106	Application effect of ＂one-to-one＂ precise teaching in standardized training operation skills of pediatric surgery residents
		HUANG Hua1 YUAN Yang1 MA Ling2
		Objective To explore the application effect of ＂one to one＂ precise teaching combined with problem-based learning (PBL)teaching method in improving the clinical operation skills of standardized training for residential physicians.Methods A total of 64 residents adopted standardized training for residential physicians (including professional master's students) in Department of General Pediatric Surgery in the Third Affiliated Hospital of Zhengzhou University from July 2020 to July 2023 were selected as the study objects,and they were divided into experimental group (22 cases),control group 1 (20 cases)and control group 2 (22 cases)by drawing lot method.The experimental group adopted ＂one-to-one＂precise teaching method combined with PBL teaching method,control group 1 only adopted traditional teaching method,control group 2 only adopted PBL teaching method,and the clinical operation skills test scores and random questionnaire survey results of the three groups of students were analyzed.Results There were significant differences in the scores of surgical operation assessment and total scores among the three groups (P＜0.05).The scores of surgical operation assessment and total scores of experimental group were higher than those of control group 1 and control group 2,and the differences were statistically significant (P＜0.05).There were no significant differences in skill scores between control group 1 and control group 2 (P＞0.05).The results of the questionnaire showed that the experimental group was better than the control group 1 in improving the self-learning ability and self-learning consciousness of standardized training for residential physicians,and the number of people in favor of this teaching method was higher than that in the control group 1,the differences were statistically significant (P＜0.017).Conclusion＂One to one＂precise teaching combined with PBL teaching method is worth popularizing to improve the operation skills of standardized training for clinical pediatric surgery residents.
		2024 Vol. 31 (13): 106-109转122 [Abstract] ( 17 ) HTML (1 KB) PDF (859 KB) ( 25 )

	110	Research on ideological and political education in the courses for Pharmaceutical Analysis
		LIN Meiyu LIAO Yingyan ZHOU Jin XIAO Meifeng ZHAO Biqing XU Guangming
		No one can be established without virtue,and the root of educating people lies in establishing virtue.Under the new situation,＂moral cultivation＂is the fundamental task of higher education.Integrating ideological and political education into the teaching of professional courses has become the main way to achieve collaborative education.Pharmaceutical Analysis is one of the compulsory courses in the undergraduate training program of pharmacy and related majors in China.In order to profoundly explore the elements of political thinking in the course of Pharmaceutical Analysis,to better bring into play the effect of collaborative education through the course,and to respond to the call of General Secretary XI Jinping to＂carry out ideological and political work throughout the whole process of education and teaching,so as to realize the whole process of educating people and educating people in all aspects＂.Based on the current situation of ideological and political education in the course of Pharmaceutical Analysis,this paper discusses the necessity of carrying out ideological and political education in the course,then condenses the ideological elements in the course by chapter,and finally explores the implementation of the ideological construction of the course,in order to cultivate more high-quality pharmacy talents with ideals,morality,culture and discipline,and contribute to the development of the health of the society.
		2024 Vol. 31 (13): 110-113 [Abstract] ( 14 ) HTML (1 KB) PDF (538 KB) ( 14 )

	114	Implementation and exploration of integrating curriculum ideology and politics into the instruction of rehabilitation therapy technology specialty
		WANG Liya ZHANG Xiaochen SUN Xiaoyan SHI Xiaofeng
		At present,the construction of curriculum ideology and politics is the focus and hot spot of the reform of educational teaching mode in colleges and universities.Medicine is a subject related to life and people's health,and the importance of strengthening morality and cultivating people in medical education can be highlighted.Clinical medicine introduction is an important course in rehabilitation therapy technology,which provides information and knowledge support for the cross penetration of clinical discipline and rehabilitation therapy technology.This paper analyzes the characteristics of clinical medicine introduction course and the current situation of rehabilitation therapy technology specialty,through reform and innovation of teaching methods,deeply excavates and extracts the ideological and spiritual connotation of the course knowledge system,integrates ideological and political elements in line with the characteristics of rehabilitation therapy technology specialty,and carries out beneficial exploration and practice for the realization of the education model of integrating medical ethics.Through the integration of ideological and political teaching,the boring traditional classroom is enriched,while improving students'interest in learning,training their ability to communicate with others,allowing students to internalize noble moral character in the mind and externalize in the practice,implementing the goal of strengthening morality and cultivating people,and providing references for better training high-quality and skilled rehabilitation talents with both moral and technical training.
		2024 Vol. 31 (13): 114-117 [Abstract] ( 18 ) HTML (1 KB) PDF (561 KB) ( 1 )

	118	Analysis of drug therapy for 1 case of torsade de pointes caused by drug combination
		FENG Jiayuan
		The possibility that several widely used drugs can cause or exacerbate arrhythmia has become a focus of drug risk management in recent years.Amiodarone and Levofloxacin are widely used drugs that are known to prolong the QT interval,while their combined use is a major risk factor for inducing torsade de pointes (TdP).TdP occurred after Amiodarone combined with Levofloxacin treatment in patients with arrhythmia complicated with urinary tract infection.Clinical pharmacists' comprehensive drug correlation evaluation,drug mechanism of action and analysis of relevant literature at home and abroad determined that TdP was mainly caused by the combined effect of Amiodarone and Levofloxacin.It was recommended to stop the drug and give Magnesium Sulfate,Lidocaine,Potassium Chloride and other drugs.Finally,the patient was treated with implantable cardioverter defibrillator(ICD)and discharged.
		2024 Vol. 31 (13): 118-122 [Abstract] ( 17 ) HTML (1 KB) PDF (473 KB) ( 76 )

	123	A case of microsurgical varicocelectomy combined with traditional Chinese and western medicine in the treatment of natural pregnancy of nonobstructive azoospermia spouse
		WU Xiaolin1 WU Jinggen2▲
		This paper reports a male infertility patient with non-obstructive azoospermia and varicocele who underwent microsurgical varicocelectomy (preoperative monitoring and evaluation of the spermatic artery to protect the spermatic artery).During the operation,6 left pampiniform spermatic veins were ligated,3 pampiniform veins were ligated and the spermatic arteries were protected.After the surgery,the patient was treated with traditional Chinese and western medicine(Letrozole+Xianlu Oral Liquid),and enough ejaculated sperm was obtained,so that his spouse had a natural pregnancy and live birth of a female infant.This case shows that in addition to assisted reproductive technology,minimally invasive urological surgery combined with traditional Chinese and western medicine treatment is also an effective treatment strategy for such patients.This method can not only reduce the surgical trauma of the patient,but also reduce the economic cost and help to promote eugenics.
		2024 Vol. 31 (13): 123-126 [Abstract] ( 14 ) HTML (1 KB) PDF (452 KB) ( 48 )

	127	Application effect of the new simple transfer pad in the operating room
		GUO Xiaoju ZHANG Qiuxiang TU Pinghua
		Objective To explore the application effect of the new simple transfer pad in the operating room.Methods A total of 100 surgical patients from Nanchang First Hospital from August 2022 to February 2023 were selected as the study objects and divided into control group (50 cases)and observation group (50 cases)according to random number table.The control group was carried by traditional transport method,and the observation group was carried by a new type of simple transport pad.The incidence of adverse events,patients' comfort satisfaction,post-bed transport time and the incidence of psoas muscle injury were compared between the two groups.Results The incidence of adverse events in the observation group was lower than that in the control group,the difference was statistically significant (P＜0.05).Patient comfort in the observation group than the control group,the difference was statistically significant (P＜0.05).The handling time in the observation group was lower than the control group,the difference was statistically significant(P＜0.05).The total incidence of psoas muscle injury in observation group was lower than that in control group,the difference was statistically significant(P＜0.05).Conclusion Through the application of the new simple transfer pad in the post-operative operating room and clinical departments,it can avoid the occurrence of adverse events such as falling,pipe shedding or entanglement during the handling process,increase the comfort and security of patients,improve the comfort satisfaction of patients,and reduce the incidence of lumbar muscle strain caused by clinical medical staff during handling,which is worthy of clinical promotion.
		2024 Vol. 31 (13): 127-130转134 [Abstract] ( 16 ) HTML (1 KB) PDF (824 KB) ( 63 )

	131	Nursing intervention of Sihuangmi traditional Chinese medicine rubbing combined with traditional Chinese medicine fumigation and washing in postoperative limb swelling
		LIU Jiaona XIE Juan
		Objective To explore the nursing effect of Sihuangmi traditional Chinese medicine application combined with traditional Chinese medicine fumigation and washing on postoperative limb swelling after limb fracture surgery.Methods Sixty patients with postoperative limb swelling after limb fracture surgery admitted to Pingxiang Traditional Chinese Medicine Hospital from June 2021 to January 2023 were selected as the research subjects.They were randomly divided into a control group (30 cases)and an observation group (30 cases)using random number table method.The control group was treated with traditional Chinese medicine fumigation and washing of the affected limbs.On the basis of the control group,the observation group was treated with self-made Sihuangmi and applied with traditional Chinese medicine.Limb swelling degree,pain score,swelling relief time,pain relief time and nursing satisfaction were compared between the two groups.Results The limb swelling degree scores and pain scores of the two groups at 1,3 and 5 days after intervention were lower than those before intervention,and the limb swelling degree scores of the observation group were lower than those of the control group,with statistical significances (P＜0.05).The duration of swelling relief and pain relief in the observation group were shorter than those in the control group,the differences were statistically significant (P＜0.05).The total nursing satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).Conclusions The combination of Sihuangmi traditional Chinese medicine application and traditional Chinese medicine fumigation has a significant nursing effect on limb swelling after limb fracture surgery,which can be attributed to the degree of limb swelling and pain score of patients,shortening the time for swelling and pain relief,and improving patient nursing satisfaction.
		2024 Vol. 31 (13): 131-134 [Abstract] ( 17 ) HTML (1 KB) PDF (680 KB) ( 0 )

	135	Application effect of rapid rehabilitation surgical nursing in the perioperative period of pediatric appendicitis
		CHEN Pei CHENG Wen WU Pingping CHEN Hui TANG Le
		Objective To study the application effect of perioperative rapid rehabilitation surgical nursing in the clinical treatment of pediatric appendicitis.Methods A total of 76 children with appendicitis admitted to Jiujiang Maternal and Child Health Hospital from August 2021 to September 2022 were selected as the research objects.They were divided into a control group (38 cases) and an observation group (38 cases) according to the random number table method.The control group received routine perioperative care,while the observation group received rapid recovery surgical care during the perioperative period.The rehabilitation indicators,total incidence of complications,and level of stress indicators between the two groups were compared.Results The recovery time of bowel sounds,anal exhaust time,first defecation time,and first bedtime activity time in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).The postoperative C-reactive protein(CRP),interleukin-6(IL-6),cortisol,and norepinephrine levels in the observation group were lower than those in the control group,with statistically significant differences(P＜0.05).Conclusion The application of perioperative rapid rehabilitation surgical nursing in children with appendicitis has achieved ideal results,which can effectively reduce the risk of related complications and have a positive effect on the physical recovery of children.
		2024 Vol. 31 (13): 135-138 [Abstract] ( 13 ) HTML (1 KB) PDF (681 KB) ( 27 )

	139	Design and application of structured peripherally inserted central catheter specialist nursing record sheet under hospital information system
		LIU Yan LIANG Fang LI Hongqun
		Objective To explore the design and application of structured peripherally inserted central catheter(PICC)specialist nursing record sheet under hospital information system (HIS)so as to provide high-level and professional services for patients.Methods A total of 60 outpatients in JiuJiang NO.1 People's Hospital were enrolled as the research objects between January and March 2023.According to the admission order,they were divided into control group(n=30)and observation group(n=30).Based on HIS design and the advanced nursing practice mode in nurse-led clinics,structured PICC specialized nursing record sheets under HIS were designed and compared with the traditional outpatient medical record mode.The record time,data quality and data statistics convenience of the two groups were compared.Results The recording time of PICC nursing (writing time,examination time)in observation group were shorter than those in control group,the differences were statistically significant(P＜0.05).The scores of integrity,legibility and traceability,and total score of data quality were higher than those in control group,the differences were statistically significant (P＜0.05).The scores of PICC nursing data convenience(local skin conditions,needle eye conditions,catheter calibration,catheter sealing conditions and dressing conditions)were higher than those in control group,the differences were statistically significant(P＜0.05).Conclusion The application of structured PICC specialist nursing record sheet under HIS in PICC nursing record is beneficial to improve data quality and data statistics convenience,and shorten nursing record time.
		2024 Vol. 31 (13): 139-142 [Abstract] ( 14 ) HTML (1 KB) PDF (676 KB) ( 68 )

	143	Analysis of the effect of doctor-nurse collaborative management combined with dietary intervention based on fast track surgery concept in patients undergoing laparoscopic radical resection of colorectal cancer
		YAO Sisi GUAN Guiqing WANG Xiao WANG Huiling YU Ming
		Objective To explore the effects of doctor-nurse collaborative management combined with dietary intervention based on fast track surgery (FTS)concept in patients undergoing laparoscopic radical resection of colorectal cancer.Methods A total of 30 patients undergoing laparoscopic radical resection of colorectal cancer between March and August 2022 and 30 patients undergoing the same surgery between September 2022 and March 2023 in Shangrao Municipal Hospital were enrolled as control group and study group.The study group was given doctor-nurse collaborative management combined with dietary intervention based on FTS concept,while control group was given routine nursing.The nutritional status(hemoglobin [Hb],prealbumin [PA],transferrin [TRF]) and psychological state (self-rating anxiety scale [SAS],self-rating depression scale[SDS])before and after intervention,perioperative indexes(recovery time of bowel sound,anal exhaust time,the first eating time,the first leaving bed time,hospitalization time)and postoperative complications (vomiting,incision infection,bleeding,hypothermia) in the two groups were compared.Results After intervention,Hb,PA and TRF in study group were higher than those in control group,the differences were statistically significant(P＜0.05).The scores of SAS and SDS were lower than those in control group,the differences were statistically significant (P＜0.05).The recovery time of bowel sound,anal exhaust time,the first eating time,first leaving bed time and hospitalization time were shorter than those in control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of postperative complications between the two groups(P＞0.05).Conclusion The application of doctor-nurse collaborative management combined with dietary intervention based on FTS concept can significantly improve nutritional status and shorten hospitalization time in patients after laparoscopic radical resection of colorectal cancer.
		2024 Vol. 31 (13): 143-147 [Abstract] ( 16 ) HTML (1 KB) PDF (686 KB) ( 55 )

	148	Influence of narrative management on the occupational value identification and negative emotions of nursing staffs in emergency department
		CHEN Haizhu ZHANG Lili
		Objective To explore the influence of narrative management on the occupational value identification and negative emotions of nursing staffs in emergency department.Methods A total of 86 nursing staffs working in the Department of Emergency of Jiujiang University Affiliated Hospital from May 2020 to June 2022 were retrospectively selected as the research objects,and 43 nursing staffs received routine management from May 2020 to May 2021 were set as the control group,43 nursing staffs who received narrative management from June 2021 to June 2022 were included in the observation group.The sense of professional value,negative emotion,professional self-efficacy and nursing satisfaction were compared between the two groups.Results Before intervention,there were no significant differences in occupational value identity,negative emotion and occupational self-efficacy between the two groups(P＞0.05).After intervention,the scores of nurses professional values scale-reviced (NPVS-R)in all dimensions of the observation group were higher than those of the control group,the scores of self-rating depression scale (SDS)and self-rating anxiety scale (SAS)were lower than those of the control group,and the scores of nursing students in all dimensions of the professional self-efficacy scale were higher than those of the control group,with statistical significances (P＜0.05).The nursing satisfaction of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion The application of narrative management in emergency department nursing staffs can effectively enhance occupational self-efficacy,improve the sense of professional value,reduce negative emotions,and obtain higher nursing satisfaction.
		2024 Vol. 31 (13): 148-151 [Abstract] ( 13 ) HTML (1 KB) PDF (681 KB) ( 0 )

	152	Application effect of collaborative nursing mode combined with phased functional rehabilitation training in postoperative rehabilitation of elderly patients with femoral neck fractures
		YU Yating1 CAO Jingjing1 SUN Lingzhi2 SU Zhonglei1
		Objective To explore the application effect of collaborative nursing mode combined with phased functional rehabilitation training in postoperative rehabilitation of elderly patients with femoral neck fractures.Methods Retrospective analyzed the general data of 107 elderly patients with femoral neck fractures admitted to the Eighth People's Hospital of Jinan from September 2021 to October 2022.According to different nursing methods,they were divided into a control group(53 cases)and an observation group (54 cases).The control group received collaborative care,while the observation group received collaborative care and phased functional rehabilitation training.The joint function,pain level,quality of life,self-care ability,and stress indicators between two groups before and after nursing care,and postoperative complications between two groups were compared.Results After 3 months of discharge,the scores of the Numeric Rating Scale (NRS)of the observation group were lower than those of the control group,while the scores of Harris hip score (HHS),modified Barthel index (MBI),and the MOS 36-item short form health survey (SF-36)were higher than those of the control group,with statistically significant differences (P＜0.05).At discharge,the levels of cortisol (COR),adrenocorticotropic hormone(ACTH),and norepinephrine (NE)in the observation group were lower than those in the control group,with statistically significant differences (P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The collaborative nursing mode combined with phased functional rehabilitation training can improve joint function in elderly patients with femoral neck fractures and promote postoperative recovery.
		2024 Vol. 31 (13): 152-155 [Abstract] ( 16 ) HTML (1 KB) PDF (724 KB) ( 19 )

	156	Effect of improved nursing pants on the comfort of bedridden patients with indwelling catheters
		CAI Yanhua LI Zheng HUANG Yanming
		Objective To evaluate the effect of modified nursing pants on the comfort of patients with indwelling catheter in bed.Methods A total of 124 bedridden patients who needed catheterization and indwelling catheterization in the Fuzhou Eighth Hospital from July to December 2022 were selected as the study objects,with 62 cases in each group.The patients in the control group were treated with uniform pants for general patients in hospital,and the patients in the observation group were treated with special pants for patients with improved indwelling catheter.The comfort degree and cooperation degree of the two groups were compared,the adverse events of ureter fixation (ureter folding,ureter pollution,urine extravasation,pulling and pulling the tube off) and the pressure of skin and mucosa (urethra mucosa swelling,thigh impression) were compared between the two groups.Results The comfort score of observation group was higher than that of control group after wearing modified nursing pants for 1 week,and the difference was statistically significant(P＜0.05).The nursing cooperation evaluation results of the observation group after wearing the modified nursing pants for 1 week were better than those of the control group,the differences were statistically significant (P＜0.05).The incidence of adverse events and skin and mucosa compression during urinary catheter wearing in the observation group were lower than that in the control group,with statistical significances(P＜0.05).Conclusion The application of improved nursing pants can improve the comfort degree of patients and enhance the cooperation degree of clinical nursing operation for patients lying in bed during urethral catheterization and indwelling urethral catheterization,at the same time,it is beneficial to reduce the occurrence of adverse reactions during catheterization and indwelling catheterization,and is of great significance to the bedridden patients during catheterization and indwelling catheterization.
		2024 Vol. 31 (13): 156-160 [Abstract] ( 14 ) HTML (1 KB) PDF (944 KB) ( 12 )

	161	Progress of etiology and immunotherapy of dilated cardiomyopathy
		SHEN Qiming1 WANG Hui1 ZHANG Jianzhong1 MA Lihong2 ZHANG Yihong3▲
		Dilated cardiomyopathy (DCM) is a disease that seriously endangers human health.It is characterized by left ventricular systolic dysfunction and left ventricular enlargement,with a high incidence rate and poor prognosis.The pathogenesis of DCM is multifactorial,including genetic and acquired factors.Genetic factors mainly refer to gene mutations,with Titin(TTN)gene mutations and Lamin AC(LMNA)gene mutations being the most common types of mutations in the genetic etiology of DCM.Acquired factors include infection,alcohol,and immune mediation.Existing research has shown that viral infection and immune response cause myocardial damage and produce anti automyocardial antibodies,which play an important role in the occurrence and development of DCM.Specific treatment for related causes has gradually become one of the research hotspots.On the basis of conventional treatment methods such as diuresis,vasodilation,and delayed ventricular remodeling,immunotherapy can be used to remove anti myocardial antibodies from patients with positive anti myocardial antibodies,which can reduce myocarditis in patients with dilated cardiomyopathy,improve heart function,and prognosis.However,currently immunotherapy lacks evidence from large-scale clinical trials to support it,and is only an experimental treatment option for DCM patients.
		2024 Vol. 31 (13): 161-164 [Abstract] ( 16 ) HTML (1 KB) PDF (691 KB) ( 36 )

	165	Research Progress in practical teaching of diagnostic physical examination
		ZENG Xiangli LIN Chunyan HE Xu LI Xiaodan
		The operation of physical examination in diagnostics is the first basic clinical skill for medical students,and also the fastest and most convenient way for clinicians to obtain clinical diagnosis.Due to its importance and difficulty,various colleges and universities have actively carried out teaching reform.According to its practical characteristics,increase the proportion of practical teaching,pay attention to the combination of theory and practice.Combined with the development of information,it breaks through the traditional classroom teaching,constructs the student-centered teaching mode,expands the limitations of classroom teaching,connects pre-class-during-after-class,and cultivates students' independent learning ability and habits.Give full play to the role of peer supervision,implement team assessment,change the final evaluation of one test,and build a formative evaluation system.This article focuses on the above reform measures of the physical examination practice teaching,and explores the reform results,in order to provide some reform ideas for the general medical educators in the physical examination practice teaching.
		2024 Vol. 31 (13): 165-169 [Abstract] ( 13 ) HTML (1 KB) PDF (650 KB) ( 6 )

	170	Research progress in clinical diagnosis and treatment drug of osteoporosis in the elderly
		YU Lu ZHANG Yan WEI Zhongfei ZHANG Kai
		Osteoporosis is currently the most common chronic metabolic bone disease in clinical practice,with a particularly high incidence in the elderly.The trigger for osteoporosis is an imbalance between bone resorption and bone formation in the patient's body.Aging,end of menstruation,nutritional disorders,and medication use can all trigger osteoporosis.Osteoporosis patients often have a series of symptoms such as fractures,systemic pain,impaired mobility,functional impairment,and susceptibility to infection.Because of its high incidence rate and high mortality rate,osteoporosis has become a very serious health problem in China and even the world.There is still some controversy regarding the clinical diagnostic criteria for elderly patients with osteoporosis.New diagnostic technologies,including X-ray computed tomography,high-resolution peripheral quantitative X-ray computed tomography,and quantitative ultrasound,have gradually been applied in clinical practice.At present,the main clinical drug choices for osteoporosis are anti resorption and anabolic drugs.In addition,combination therapy and new drugs are also steadily advancing.There are a wide variety of drugs for this disease,with new and old ones varying,and the advantages and disadvantages coexist,making it very difficult to identify patients.This article is based on the latest progress in research on elderly osteoporosis,focusing on its clinical diagnosis and drug treatment.
		2024 Vol. 31 (13): 170-174 [Abstract] ( 15 ) HTML (1 KB) PDF (702 KB) ( 0 )

	175	Research progress on modernized treatment of spinal cord injury in traditional chinese medicine
		WEI Yanmian1 ZHOU Meitong2
		Spinal cord injury is a common traumatic disease in spinal surgery,often accompanied by severe functional impairment of limbs below the injury level,and even life-threatening respiratory complications.Extensive research data from both domestic and international sources have investigated the pathological and regenerative mechanisms of spinal cord injury.Traditional Chinese medicine (TCM)has a long history of treating spinal cord injury,with its independent dialectical thinking mode,emphasis on individualized treatment,and irreplaceable role of herbal medicine and acupuncture therapy in the treatment of spinal cord injury.This article systematically reviews the pathogenesis of spinal cord injury,from ancient understanding to modern clinical and experimental research,summarizes the etiology and pathogenesis of spinal cord injury,TCM diagnostic key points,various treatment mechanisms and current status,and summarizes the modernized treatment of spinal cord injury in TCM,aiming to explore new ideas for the future development of TCM-based treatment for spinal cord injury.
		2024 Vol. 31 (13): 175-179 [Abstract] ( 19 ) HTML (1 KB) PDF (647 KB) ( 19 )

	180	Research progress on sleep disorders inpatients with cerebral infarction
		WU Shijun TANG Ling
		Sleep disorder is a common complication in patients with acute cerebral infarction,which is closely related to neurological recovery,quality of life,physical and mental health,hypertension,diabetes and other basic diseases.Some severe cases may increase the risk of cerebral infarction.Therefore,how to prevent and treat sleep disorders after acute cerebral infarction and understand the pathogenesis of sleep disorders after acute ischemic stroke are very important.This paper briefly reviewed the pathogenesis of sleep disorders complicated by acute cerebral infarction,understood the clinical characteristics of sleep disorders after acute cerebral infarction,including increased sleep time,wake disorders and insomnia,and analyzed the related factors of sleep disorders in patients with acute cerebral infarction,hoping to provide references for the clinical diagnosis and treatment of patients with cerebral infarction accompanied by sleep disorders,in order to improve patients'sleep quality and promote patients'good recovery.
		2024 Vol. 31 (13): 180-184 [Abstract] ( 14 ) HTML (1 KB) PDF (650 KB) ( 24 )

	185	Progress in clinical research of pediatric bipolar disorder
		LIU Tao CHEN Tianming FENG Zihang WANG Huan
		Bipolar disorder is a mental disease with complex course and multiple influencing factors.It can be caused by biochemical,neuroendocrine,neuroimmune,brain structural abnormalities,heredity,psychosocial environment and other factors.Its episodic,circulatory,mixed and ebb and flow course varies,and its onset will involve impulsive and aggressive behavior.Such behavior will have a serious impact on the patient's life and social function,and will also cause a lot of inconvenience for subsequent treatment.This article summarizes the existing literature and systematically reviews the clinical manifestations and course of pediatric bipolar disorder,as well as the multifaceted influences of genetic,environmental and psychosocial factors.At the same time,the present diagnostic criteria and tools for this disorder are described in detail,as well as the integrated application of medication,psychotherapy,and lifestyle intervention in the treatment of bipolar disorder.In addition,this paper discusses the importance of risk assessment and attention to prodromal symptoms for offspring of people with bipolar disorder.The paper also looks forward to the challenges and opportunities in the field of bipolar disorder research in the future,with a view to providing useful guidance for clinical practice and scientific research.
		2024 Vol. 31 (13): 185-189 [Abstract] ( 14 ) HTML (1 KB) PDF (652 KB) ( 31 )

	190	The significance of circRNA-miRNA in pulpitis and apical periodontitis
		LIU Xiaochuan LAI Yanlin CHEN Binghua LIU Fuyu ZHANG Jingying▲
		Pulpitis and apical periodontitis are two stages of development of dental pulp disease.The former is an inflammatory reaction that occurs in the pulp tissue,while the latter is an inflammatory disease that stimulates the periapical tissue after further progression of pulpitis.The occurrence of inflammation causes significant pain in patients,which can be accompanied by bite pain and affect eating.Over time,it can affect overall health and seriously reduce quality of life.CircRNA is a type of biologically active nucleic acid molecule that belongs to endogenous non coding RNA,while miRNA is a highly conserved single stranded RNA sequence synthesized by processing hair clip precursors,both of which are widely present in organisms.CircRNA has complementary miRNA binding sites and can serve as a miRNA sponge.Through competitive endogenous RNA mechanisms,it regulates the expression of downstream target genes and is closely related to the occurrence of inflammatory diseases in the body.CircRNA can regulate dental pulp stem cells,apoptosis,and inflammatory response,promoting their osteogenesis and differentiation;And miRNA has been confirmed to play an important role in the pathogenesis of apical periodontitis.This review elucidates the widespread involvement of circRNA miRNA in numerous inflammatory reactions in the body,elucidates the role of miRNA and circRNA in pulpitis and periapical periodontitis,and hopes to provide a basis for the development of new prevention,diagnosis,and treatment methods.
		2024 Vol. 31 (13): 190-193 [Abstract] ( 17 ) HTML (1 KB) PDF (656 KB) ( 20 )

	194	Research progress on the effect and mechanism of time-restricted feeding on type 2 diabetes mellitus
		LU Yanxi LI Guiqiong
		The high incidence rate and mortality rate of type 2 diabetes mellitus have caused huge social and economic losses worldwide,and are still on the rise.Lifestyle intervention may be the most practical and cost-effective way to deal with this persistent epidemic.Time-restricted feeding,as an emerging dietary intervention measure,refers to limit the daily food consumption window within 4-10 hours,which is a special form of intermittent fasting.Recently,a series of studies have proved that time-restricted feeding can effectively prevent and alleviate the progress of type 2 diabetes mellitus and the occurrences of complications through circadian clock,intestinal microbes,skeletal muscle mitochondria,inflammation,lipid circulation and other ways,with high compliance and no serious side-effects.However,there is still no relevant summary regarding the specific mechanism of its effects in China.Therefore,this article reviews the impact of time-restricted feeding on glucose metabolism in type 2 diabetes mellitus and its mechanism of action,providing reference for the clinical application of diet programs and the formulation of the best diet program suitable for the current situation in China.
		2024 Vol. 31 (13): 194-198 [Abstract] ( 16 ) HTML (1 KB) PDF (667 KB) ( 19 )

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