改良宫颈环形电切术与传统宫颈环形电切术在宫颈高度鳞状上皮内瘤变患者中的效果比较

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Abstract Objective To compare the effects of modified loop electrosurgical excision procedure (LEEP) and traditional LEEP in women with cervical high-grade squamous intraepithelial lesions (HSIL).Methods A total of 60 women of childbearing age with HISL,which was diagnosed in Department of Vaginoscopy in Macare Women's Hospital from June 2021 to June 2022,received LEEP as the first time were enrolled.They were divided into the modified LEEP group (30 cases)and the traditional LEEP group(30 cases)according to the different operative methods.The amount of vaginal hemorrhage during and after the operation,the operation time,the cervix length after surgery and cervical regeneration rate were recorded and compared between the two groups.Results The operation time in the modified LEEP group was shorter than that in the traditional LEEP group,the difference was statistically significant(P＜0.05).The amount of vaginal hemorrhage during the operation in the modified LEEP group was less than that in the traditional LEEP group,the difference was statistically significant(P＜0.05).The post operation vaginal hemorrhage at day one to a week in the modified LEEP group was lower than that in the traditional LEEP group,the difference was statistically significant (P＜0.05).At 12 months after surgery,the cervix length in the modified LEEP group was longer than that in the traditional LEEP group,the difference was statistically significant (P＜0.05).The postoperative cervical regeneration rate in the modified LEEP group was better than that in the traditional LEEP group,the difference was statistically significant(P＜0.05).Conclusion In the treatment of the women with HSIL,the modified LEEP can effectively reduce the amount of vaginal hemorrhage during and after operation,shorten the operation time,and increase the postoperative cervix regeneration rate,which is worthy of its promotion and application.

Key words： Loop electrosurgical excision procedure High-grade squamous intraepithelial lesions Cervix regeneration Vaginal hemorrhage Effect

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LIN Peixuan. Comparison on the effect of modified loop electrosurgical excision procedure and traditional loop electrosurgical excision procedure in women with cervical high-grade squamous intraepithelial lesions[J]. 中国当代医药, 2024, 31(13): 58-62.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2024/V31/I13/58

[1]	陈晴，杜辉，王纯，等.阴道镜下隐匿子宫颈上皮内瘤变Ⅲ级病变的HPV 亚型感染特征及鳞状上皮厚度分析[J].中华妇产科杂志，2018，53（3）：172-177.
[2]	刘静云，刘艳秋，吕志红.CIN2-CIN3 宫颈电环锥切术后病变残留/复发的危险因素及预测指标[J].中国计划生育学杂志，2022，30（3）：699-702.
[3]	伊欣，张蕾，陈汶，等.高危型人乳头瘤病毒与女性下生殖道感染联合检测专家共识[J].中国实用妇科与产科杂志，2022，38（5）：524-528.
[4]	赵超，刘军，李明珠，等.子宫颈锥形切除术操作规范[J].中国妇产科临床，2021，22（2）：218-219.
[5]	Kyrgiou M，Athanasiou A，Kalliala IEJ，et al.Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease[J].Cochrane Database Syst Rev，2017，11（11）：CD012847.
[6]	Monti M，D'Aniello D，Scopelliti A，et al.Relationship between cervical excisional treatment for cervical intraepithelial neoplasia and obstetrical outcome[J].Minerva Obstet Gynecol，2021，73（2）：233-246.
[7]	冯力民，史小雨，李晶华.宫颈锥切除术及其相关问题[J].中华妇幼临床医学杂志，2015，11（5）：6.
[8]	Li K，Li Q，Song L，et al.The distribution and prevalence of human papillomavirus in women in mainland China[J].Cancer，2019，125（7）：1030-1037.
[9]	Bruni L，Albero G，Serrano B，et al.ICO/IARC Information Centre on HPV and Cancer（HPV Information Centre）.Human Papillomavirus and Related Diseases in China[R].Summary Report 10 March 2023.https://hpvcentre.net/statistics/reports/CHN.pdf
[10]	李风艳，郭晶，王朝霞.宫颈环形电切术术后宫颈粘连影响因素分析及预防研究[J].中国计划生育和妇产科，2018，10（8）：26-29.
[11]	李春梅，林琳.LEEP 手术在子宫颈/阴道病变中的治疗价值新探[J].实用妇产科杂志，2021，37（12）：898-900.
[12]	Ghaem-Maghami S，De-Silva D，Tipples M，et al.Determinants of success in treating cervical intraepithelial neoplasia[J].BJOG，2011，118（6）：679-684.
[13]	Wang Z，Wang J，Fan J，et al.Risk factors for cervical intraepithelial neoplasia and cervical cancer in Chinese women：large study in Jiexiu，Shanxi Province，China[J].J Cancer，2017，8（6）：924-932.
[14]	李道娟，师金，靳晶，等.宫颈癌的流行病学趋势[J].中华肿瘤杂志，2021，43（9）；912-916.
[15]	苏皖.宫颈癌的早期筛查与预防措施探析[J].实用妇科内分泌电子杂志，2021，8（35）：25-26.
[16]	Kumar R，Mandal S，Arora P，et al.The expression of p16 and galectin-3 in cervical intraepithelial neoplasia（CIN）and squamous cell carcinoma（SCC）uterine cervix[J].J Obstet Gynaecol，2021，41（5）：785-790.
[17]	Perkins RB，Guido RS，Castle PE，et al.2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors[J].Low Genit Tract Dis，2020，24（4）：102-131.
[18]	周晖，刘昀昀，罗铭，等.《2024 NCCN 子宫颈癌临床实践指南（第1 版）》更新解读[J].中国实用妇科与产科杂志，2023，39（11）：1119-1121.
[19]	Yang EJ，Kim NR，Choi JY，et al.Loop electrosurgical excision procedure combined with cold coagulation for cervical intraepithelial neoplasia and adenocarcinoma in-situ：a feasible treatment with a low risk of residual/recurrent disease[J].Infect Agent Cancer，2020，15：58.
[20]	林朝雅.阴道镜联合LEEP 术在子宫颈癌前病变患者中的应用及对局部创伤的控制效果观察[J].中外医学研究，2023，21（4）：26-29.
[21]	吴丽华，晏婷，胡江辉.不同宫颈锥切术对妊娠及妊娠结局的影响分析[J].浙江创伤外科，2023，28（2）：325-327.
[22]	Papoutsis D，Rodolakis A，Mesogitis S，et al.Regeneration of uterine cervix at 6 months after large loop excision of the transformation zone for cervical intraepithelial neoplasia[J].BJOG，2012，119（6）：678-684.
[23]	Song T，Seong SJ，Kim BG.Regeneration Process After CervicalConization for Cervical Intraepithelial Neoplasia[J].Obstet Gynecol，2016，128（6）：1258-1264.
[24]	张仕田，杨琴，赵红利.LEEP 术在宫颈病变中诊断及其术后联合不同药物治疗的应用[J].慢性病学杂志，2016（1）：4.
[25]	Cai L，Huang Y，Lin C，et al.A comparison study of post-operative infection analysis of cold-knife conization and loop electrosurgical excision procedure for cervical high-grade squamous intraepithelial lesion[J].Transl Cancer Res，2020，9（2）：949-957.
[26]	Rezniczek GA，Hecken JM，Rehman S，et al.Syringe or mask Loop electrosurgical excision procedure under local or general anesthesia：a randomized trial[J].Am J Obstet Gynecol，2020，223（6）：888.e1-888.e9.
[27]	林婧，吴丹，夏玮，等.宫颈环形电切术导致的宫颈黏连高危因素及预防措施[J].中华妇幼临床医学杂志：电子版，2016，12（4）：412-418.
[28]	王小芹，王晖，刘晓慧，等.宫颈上皮内瘤变患者LEEP 术后宫颈粘连的相关因素分析[J].宁夏医科大学学报，2019，41（6）：616-619.
[29]	段华.宫颈锥切术的并发症与处理[J].实用妇产科杂志，2009，25（7）：393-394.
[30]	Bozanovic T，Ljubic A，Momcilov P，et al.Cold-knife conization versus the loop electrosurgical excision procedure for treatment of cervical dysplasia[J].Eur J Gynaecol Oncol，2008，29（1）：83-85.
[31]	郝吉琴.宫颈环形电切术治疗宫颈病变300例的并发症分析和处理[J].实用妇科内分泌杂志，2018，5（35）：81，83.