限时进食对2 型糖尿病糖代谢影响及机制的研究进展

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Abstract The high incidence rate and mortality rate of type 2 diabetes mellitus have caused huge social and economic losses worldwide,and are still on the rise.Lifestyle intervention may be the most practical and cost-effective way to deal with this persistent epidemic.Time-restricted feeding,as an emerging dietary intervention measure,refers to limit the daily food consumption window within 4-10 hours,which is a special form of intermittent fasting.Recently,a series of studies have proved that time-restricted feeding can effectively prevent and alleviate the progress of type 2 diabetes mellitus and the occurrences of complications through circadian clock,intestinal microbes,skeletal muscle mitochondria,inflammation,lipid circulation and other ways,with high compliance and no serious side-effects.However,there is still no relevant summary regarding the specific mechanism of its effects in China.Therefore,this article reviews the impact of time-restricted feeding on glucose metabolism in type 2 diabetes mellitus and its mechanism of action,providing reference for the clinical application of diet programs and the formulation of the best diet program suitable for the current situation in China.

Key words： Type 2 diabetes mellitus Time-restricted feeding Circadian clock Gut microbiota Inflammatory factor Oxidative stress Lipid circulation

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[1]	张慧，宋明明，张雯翔等.限时进食与代谢综合征的研究进展[J].生命科学，2022，34（4）：376-384.
[2]	Grajower MM，Horne BD.Clinical management of intermittent fasting in patients with diabetes mellitus[J].Nutrients，2019，11（4）：873.
[3]	Sutton EF，Beyl R，Early KS，et al.Early Time-Restricted Feeding Improves Insulin Sensitivity，Blood Pressure，and Oxidative Stress Even without Weight Loss in Men with Prediabetes[J].Cell Metab，2018，27（6）：1212-1221.e3.
[4]	Andriessen C，Fealy CE，Veelen A，et al.Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity：a randomised crossover trial[J].Diabetologia，2022，65（10）：1710-1720.
[5]	Cienfuegos S，McStay M，Gabel K，et al.Time Restricted Eating for the Prevention of Type 2 Diabetes[J].Physiol，2022，600，1253-1264.
[6]	Jamshed H，Steger FL，Bryan DR，et al.Effectiveness of Early Time-Restricted Eating for Weight Loss，Fat Loss，and Cardiometabolic Health in Adults With Obesity：A Randomized Clinical Trial[J].JAMA Intern Med，2022，182（9）：953-962.
[7]	Yun N，Nah J，Lee MN，et al.Post-Effects of Time-Restricted Feeding against Adipose Tissue Inflammation and Insulin Resistance in Obese Mice[J].Nutrients，2023，15（11）：2617.
[8]	Tsitsou S，Zacharodimos N，Poulia KA，et al.Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight，Body Composition，Glucose Responses，and Insulin Resistance：A Systematic Review of Randomized Controlled Trials[J].Nutrients，2022，14（22）：4778.
[9]	Ramanathan C，Johnson H，Sharma S，et al.Early Time-Restricted Feeding Amends Circadian Clock Function and Improves Metabolic Health in Male and Female Nile Grass Rats[J].Medicines（Basel），2022，9（2）：15.
[10]	Xie Z，Sun Y，Ye Y，et al.Randomized controlled trial for time-restricted eating in healthy volunteers without obesity[J].Nat Commun，2022，13（1）：1003.
[11]	Che T，Yan C，Tian D，et al.Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes：a randomised controlled trial[J].Nutr Metab（Lond），2021，18（1）：88.
[12]	Chaix A，Zarrinpar A，Miu P，et al.Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges[J].Cell Metab，2014，20（6）：991-1005.
[13]	Kim BH，Joo Y，Kim MS，et al.Effects of Intermittent Fasting on the Circulating Levels and Circadian Rhythms of Hormones[J].Endocrinol Metab（Seoul），2021，36（4）：745-756.
[14]	Chaix A，Rynders CA.Time restricted feeding plus exercise：could two be better than one for metabolic health?[J].Physiol，2022，600（4）：699-700.
[15]	Papakonstantinou E，Oikonomou C，Nychas G，et al.Effects of Diet，Lifestyle，Chrononutrition and Alternative Dietary Interventions on Postprandial Glycemia and Insulin Resistance[J].Nutrients，2022，14（4）：823.
[16]	Jamshed H，Beyl RA，Della Manna DL，et al.Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock，Aging，and Autophagy in Humans[J].Nutrients，2019，11（6）：1234.
[17]	Ye Y，Xu H，Xie Z，et al.Time-Restricted Feeding Reduces the Detrimental Effects of a High-Fat Diet，Possibly by Modulating the Circadian Rhythm of Hepatic Lipid Metabolism and Gut Microbiota[J].Front Nutr，2020，7：596285.
[18]	Bitsanis D，Giannakou K，Hadjimbei E，et al.The Effect of Early Time-Restricted Feeding on Glycemic Profile in Adults：A Systematic Review of Interventional Studies[J].Rev Diabet Stud，2022，18（1）：10-19.
[19]	Zeb F，Osaili T，Obaid RS，et al.Gut Microbiota and Time-Restricted Feeding/Eating：A Targeted Biomarker and Approach in Precision Nutrition[J].Nutrients，2023，15（2）：259.
[20]	Zhao L，Hutchison AT，Liu B，et al.Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity[J].Obesity（Silver Spring），2023，31 Suppl 1（Suppl 1）：63-74.
[21]	Marcheva B，Ramsey KM，Buhr ED，et al.Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes[J].Nature，2010，466（7306）：627-631.
[22]	Wei F，Gong L，Lu S，et al.Circadian transcriptional pathway atlas highlights a proteasome switch in intermittent fasting[J].Cell Rep，2022，41（4）：111547.
[23]	Swiatkiewicz I，Wozniak A，Taub PR.Time-Restricted Eating and Metabolic Syndrome：Current Status and Future Perspectives[J].Nutrients，2021，13（1）：221.
[24]	Zouhal H，Bagheri R，Triki R，et al.Effects of Ramadan Intermittent Fasting on Gut Hormones and Body Composition in Males with Obesity[J].Int J Environ Res Public Health，2020，17（15）：5600.
[25]	Kim Y，Lee Y，Lee MN，et al.Time-restricted feeding reduces monocyte production by controlling hematopoietic stem and progenitor cells in the bone marrow during obesity[J].Front Immunol，2022，13：1054875.
[26]	Ella K，Südy AR，Búr Z，et al.Time restricted feeding modifies leukocyte responsiveness and improves inflammation outcome[J].Front Immunol，2022，13：924541.
[27]	Moon S，Kang J，Kim SH，et al.Beneficial Effects of Time-Restricted Eating on Metabolic Diseases：A Systemic Review and Meta-Analysis[J].Nutrients，2020，12（5）：1267.
[28]	Thankamony A，Capalbo D，Marcovecchio ML，et al.Low circulating levels of IGF-1 in healthy adults are associated with reducedβ-cell function，increased intramyocellular lipid，and enhanced fat utilization during fasting[J].Clin Endocrinol Metab，2014，99（6）：2198-2207.
[29]	Obradovic M，Sudar-Milovanovic E，Soskic S，et al.Leptin and Obesity：Role and Clinical Implication[J].Front Endocrinol（Lausanne），2021，12：585887.
[30]	Molina-Giraldo P，Murillo S，Meis L，et al.A time-restricted feeding intervention in children and adolescents with obesity：The TRansForm study protocol[J].Front Nutr，2022，9：1026694.
[31]	Mouzaki M，Comelli EM，Arendt BM，et al.Intestinal microbiota in patients with nonalcoholic fatty liver disease[J].Hepatology，2013，58（1）：120-127.
[32]	Hu X，Xia K，Dai M，et al.Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism[J].NPJ Biofilms Microbiomes，2023，9（1）：19.
[33]	Rust BM，Picklo MJ，Yan L，et al.Time-Restricted Feeding Modifies the Fecal Lipidome and the Gut Microbiota[J].Nutrients，2023，15（7）：1562.
[34]	Feyzioglu BS，Güven CM，Avul Z.Eight-Hour Time-Restricted Feeding：A Strong Candidate Diet Protocol for First-Line Therapy in Polycystic Ovary Syndrome[J].Nutrients，2023，15（10）：2260.
[35]	Pan C，Herrero-Fernandez B，Borja Almarcha C，et al.Time-Restricted Feeding Enhances Early Atherosclerosis in Hypercholesterolemic Mice[J].Circulation，2023，147（9）：774-777.
[36]	Mulas A，Cienfuegos S，Ezpeleta M，et al.Effect of intermittent fasting on circulating inflammatory markers in obesity：A review of human trials[J].Front Nutr，2023，10：1146924.
[37]	Brownstein AJ，Veliova M，Acin-Perez R，et al.ATP-consuming futile cycles as energy dissipating mechanisms to counteract obesity[J].Rev Endocr Metab Disord，2022，23（1）：121-131.
[38]	Kang J，Ratamess NA，Faigenbaum AD，et al.Effect of Time-Restricted Feeding on Anthropometric，Metabolic，and Fitness Parameters：A Systematic Review[J].Am Nutr Assoc，2022，41（8）：810-825.
[39]	Bushman T，Lin TY，Chen X.Depot-Dependent Impact of Time-Restricted Feeding on Adipose Tissue Metabolism in High Fat Diet-Induced Obese Male Mice[J].Nutrients，2023，15（1）：238.
[40]	Charlot A，Hutt F，Sabatier E，et al.Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases：Importance of Aligning Food Habits with the Circadian Clock[J].Nutrients，2021，13（5）：1405.
[41]	Xu H，Shi C，Ye Y，et al.Time-Restricted Feeding Could Not Reduce Rainbow Trout Lipid Deposition Induced by Artificial Night Light[J].Metabolites，2022，12（10）：904.
[42]	Endo S，Uto A，Miyashita K，et al.Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation[J].Endocr Soc，2023，7（7）：bvad082.
[43]	de Goede P，Wüst RCI，Schomakers BV，et al.Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle[J].FASEB J，2022，36（2）：e22133.
[44]	Sun J，She Y，Fang P，et al.Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice[J].Eat Weight Disord，2022，27（4）：1415-1425.
[45]	Liu Z，Patil IY，Jiang T，et al.High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity[J].PLoS One，2015，10（5）：e0128274.
[46]	Currenti W，Buscemi S，Cincione RI，et al.Time-Restricted Feeding and Metabolic Outcomes in a Cohort of Italian Adults[J].Nutrients，2021，13（5）：1651.
[47]	Zeb F，Osaili T，Obaid RS，et al.Gut Microbiota and Time-Restricted Feeding/Eating：A Targeted Biomarker and Approach in Precision Nutrition[J].Nutrients，2023，15（2）：259.
[48]	Kitada M，Koya D.Autophagy in metabolic disease and ageing[J].Nat Rev Endocrinol，2021，17（11）：647-661.
[49]	Parr EB，Devlin BL，Lim KHC，et al.Time-Restricted Eating as a Nutrition Strategy for Individuals with Type 2 Diabetes：A Feasibility Study[J].Nutrients，2020，12（11）：3228.
[50]	Boyd P，O'Connor SG，Heckman-Stoddard BM，et al.Time-Restricted Feeding Studies and Possible Human Benefit[J].JNCI Cancer Spectr，2022，6（3）：pkac032.
[51]	Cienfuegos S，Gabel K，Kalam F，et al.Effects of 4-and 6-h time-restricted feeding on weight and cardiometabolic health：a randomized controlled trial in adults with obesity[J].Cell Metab，2020，32：366-378.e3.
[52]	Arciero PJ，Poe M，Mohr AE，et al.Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss[J].Obesity（Silver Spring），2023，31 Suppl 1（Suppl 1）：139-149.
[53]	Yun N，Nah J，Lee MN，et al.Post-Effects of Time-Restricted Feeding against Adipose Tissue Inflammation and Insulin Resistance in Obese Mice[J].Nutrients，2023，15（11）：2617.
[54]	Teong XT，Liu K，Vincent AD，et al.Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes：a randomized controlled trial[J].Nat Med，2023，29（4）：963-972.