五灵胶囊联合替诺福韦治疗乙型肝炎肝硬化的临床疗效及作用机制

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Abstract Objective To investigate the clinical effect and mechanism of Wuling Capsules combined with Tenofovir in the treatment of hepatitis B cirrhosis.Methods A total of 64 patients with hepatitis B cirrhosis who were diagnosed and treated in Shangrao Second People's Hospital from January 2022 to March 2023 were selected as the study subjects.They were divided into the control group and the observation group using the random number table method,with 32 patients in each group.The control group was treated with Tenofovir,and the observation group was treated with Wuling Capsules combined with Tenofovir.The two groups were compared in terms of clinical efficacy,liver function and liver fibrosis indicators.Immune function and levels of inflammatory factors in the two groups were observed.Results The total effective rate in the observation group (96.87%) was higher than that in the control group (81.25%),and the difference was statistically significant (P＜0.05).After 6 months of treatment,the levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin,serum hyaluronic acid,laminin and type Ⅲprocollagen in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).After 6 months of treatment,the levels of CD3+,CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).After 6 months of treatment,serum tumor necrosis factor-α (TNF-α),interleukin 6(IL-6)and transforming growth factor-β1 (TGF-β1)levels in observation group were lower than those in the control group,and the differences were statistically significant (P ＜0.05).Conclusion Wuling Capsules combined with Tenofovir is effective in the treatment of hepatitis B cirrhosis,which can effectively improve liver function,relieve cirrhosis,reduce liver damage,enhance immunity and alleviate inflammatory reactions.

Key words： Wuling Capsules Tenofovir Hepatitis B cirrhosis Liver function Curative effect

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