超声造影联合术中快速免疫组化检测在乳腺癌前哨淋巴结活检中的应用研究

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Abstract Objective To investigate the effect of contrast-enhanced ultrasound(CEUS)combined with intraoperative rapid immunohistochemical detection in breast cancer sentinel lymph node (SLN).Methods Clinical data of 80 patients with breast cancer who received surgical treatment in Pingxiang Maternal and Child Health Hospital from January 2020 to June 2022 were retrospectively analyzed.All patients received preoperative CEUS and underwent merocyanine staining and intraoperative rapid immunohistochemistry detection,and postoperative pathological examination was used as the gold standard to analyze the application value of CEUS combined with intraoperative rapid immunohistochemistry detection in SLN metastasis of breast cancer.Results All 80 breast cancer patients were successfully implemented ultrasonography,ultrasound detected SLN was successfully stained with methylene blue,a total of 110 SLN were detected.110 SLN were metastasized 47 and not metastasized 63 after postoperative pathological examination.The sensitivity,specificity and accuracy of rapid immunohistochemical detection of SLN metastasis in combination with CEUS were 95.74%,100.00% and 98.18%,respectively,which were higher than single CEUS and intraoperative rapid immunohistochemical detection,and the differences were statistically significant (P＜0.017).Conclusion Ultrasonography combined with intraoperative rapid immunohistochemistry detection of SLN metastasis in breast cancer has high accuracy in the evaluation.

Key words： Breast cancer Sentinel lymph node Ultrasonography Immunohistochemistry

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