中国当代医药
      Home                              中文
中国当代医药
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2022 Vol. 29, No. 17
Published: 2022-06-18
 
 
5 Incidence and related factors of perforation during endoscopic submucosal dissection in patients with early gastric cancer
ZHONG Zhuluan LIU Fang
Objective To investigate the incidence and related factors of perforation during endoscopic submucosal dissection (ESD) in patients with early gastric cancer.Methods The clinical data of 48 patients with early gastric cancer who received ESD treatment from April 2021 to December 2021 in Shangrao Municipal Hospital were retrospectively analyzed,they were divided into the occurrence group (n=10) and the non-occurrence group (n=38) according to whether intraoperative perforation occurred.Compare the incidence of perforation during ESD in patients with early gastric cancer.The basic data of the two groups were statistically compared,including age,sex,operation time,lesion diameter,degree of differentiation,lesion site,digestive tract operation history,tumor invasion depth and platelet count.The differenct information between the two groups was incorporated into the logistic regression analysis model,quantified and assigned,so as to clarify the influencing factors of perforation during ESD operation in patients with early gastric cancer.Results Among 48 patients with early gastric cancer,perforation occurred in 10 cases,accounting for 20.83% (10/48),and 38 cases had no perforation occurred,accounting for 79.17% (38/48).Univariate analysis showed that there was no significant differences in age,sex,operation time and differentiation degree between the two groups (P＞0.05).The occurrence of perforation during ESD operation in patients with early gastric cancer is related to the lesion diameter ≥2 cm,the lesion site at the cardia and fundus of stomach,the history of digestive tract operation,the depth of tumor invasion at the deep lamina propria,and the platelet count ≥400×109/L,the differences were statistically significant (P＜0.05).Taking the incidence of perforation during ESD as the dependent variable,and taking the lesion diameter,lesion location,gastrointestinal surgery history,tumor infiltration depth and platelet count as independent variables,the logistic regression model was used for multivariate analysis.The results showed that the lesion diameter(β=0.221,OR=1.247,95%CI=1.021-1.523),lesion location (β=0.436, OR=1.546,95%CI=1.152-2.075),history of gastrointestinal surgery (β=0.450, OR=1.569,95%CI=1.152-2.137),depth of tumor invasion (β=0.393, OR=1.481,95%CI=1.037-2.115),platelet count (β=0.730, OR=2.075,95%CI=1.080-3.987) were independent risk factors for perforation during ESD in patients with early gastric cancer (P＜0.05).Conclusion When the lesion diameter is ≥2 cm,the lesion site is cardia and fundus of stomach,with history of digestive tract operation,the depth of tumor invasion is deep lamina propria and the platelet count is ≥400×109/L,the incidence of perforation during ESD operation in patients with early gastric cancer is higher.
2022 Vol. 29 (17): 5-8 [Abstract] ( 34 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
9 Application effect of dual long-acting bronchodilators in stable chronic obstructive pulmonary disease
PENG Xue
Objective To investigate the application effect of double long-acting bronchodilator in the stable stage of chronic obstructive pulmonary disease (COPD).Methods A total of 78 COPD stable patients admitted to Suqian Hospital of Traditional Chinese Medicine from January 2019 to March 2021 were selected and divided into observation group and control group by random number table method,with 39 cases in each group.Patients in control group were treated with Tiotropium Bromide Inhalation Powder,and patients in observation group were treated with Umeclidinium Bromide and Vilanterol Trifenatate Powder for Inhalation.Serum levels of tumor necrosis factor α (TNF-α),interleukin (IL)-8,IL-10,C1q tumor necrosis factor associated protein 9 (CTRP-9),soluble late glycation end product receptor (sRAGE),forced expiratory volume in 1 second (FEV1),forced vital capacity (FVC),peak expiratory flow rate (PEF) and the incidence of adverse reactions were compared between two groups.Results There were no significant differences in TNF-α,IL-8 and IL-10 levels between two groups before treatment (P＞0.05).After treatment,the levels of TNF-α,IL-8 in the two groups were lower than those before treatment,and the observation group was lower than that in the control group,the levels of IL-10 in the two groups were higher than those before treatment,and the observation group was higher than that in control group,the differences were statistically significant (P＜0.05).There were no significant differences in FEV1,FVC and PEF between the two groups before treatment (P＞0.05).After treatment,FEV1,FVC and PEF in the two groups were higher than those before treatment,and the observation group was higher than the control group,the differences were statistically significant (P＜0.05).There were no significant differences in serum CTRP-9 and sRAGE between the two groups before treatment (P＞0.05).After treatment,the CTRP-9 of the two groups were lower than those before treatment,and the sRAGE of the observation group was lower than that in the control group,and the sRAGE was higher than that in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Treatment with dual longacting bronchial dilator Umeclidinium Bromide and Vilanterol Trifenatate Powder for Inhalation can reduce the release of inflammatory factors in stable COPD patients and improve lung function,with high safety.At the same time,it can also reduce the level of serum CTRP-9,improve the level of serum sRAGE and improve the symptoms of disease.
2022 Vol. 29 (17): 9-12 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
13 Meta-analysis of the correlation between the deficient DNA mismatch repair protein and clinicopathological features of gastric cancer
YE Chuan LIANG Peng HE Zhengyue ZHANG Weishan LIU Zhi▲
Objective To comprehensively evaluate the correlation between the deficient DNA mismatch repair protein(dMMR) and clinicopathological features of gastric cancer using meta-analysis.Methods Keywords were searched from PubMed,Web of Science,Embase database,CNKI,WanFang and VIP database for relevant studies on DNA mismatch repair (MMR) protein expression and clinicopathological features of gastric cancer from the database construction to June 2021.Cochrane was used to screen the literature and extract data,and the quality of the included literature was evaluated according to the Newcastle-Ottawa scale (NOS).Finally,meta-analysis was performed using Review Manager 5.4.1.Results A total of 13 studies were included,including 5075 gastric cancer patients,530 of whom were dMMR patients,accounting for 10.44%.Meta-analysis showed that tumor location was significantly correlated with dMMR(OR=0.60,95%CI=0.47-0.76, P＜0.0001).Lauren typing was significantly correlated with dMMR (OR=2.56,95%CI=1.49-4.39, P=0.0007).dMMR was significantly correlated with gastric cancer without lymph node metastasis (OR=1.40,95%CI=1.12-1.75, P=0.003).There was no significant correlation between TNM staging and dMMR (OR=1.47,95%CI=0.88-2.44,P=0.14).dMMR was significantly associated with gastric cancer with lymphatic infiltration (OR=1.70,95%CI=1.23-2.36, P=0.001).There was no publication bias in all subgroups (P＞0.05).Conclusion dMMR has significant clinicopathological features in gastric cancer patients,which is of great value for diagnosis and clinical treatment.
2022 Vol. 29 (17): 13-17 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
18 Study on the compatibility of Dexmedetomidine Hydrochloride Injection with drug delivery equipment
GUO Xiaopeng1 WEI Junling2
Objective To establish the content determination method of Dexmedetomidine Hydrochloride Injection,and study its compatibility with clinical syringes and infusion tubes,so as to provide basis for drug quality in in the process ofclinicaluse.Methods High performance liquid chromatography was used.The chromatographic column was kromasil entity-5-C18 column (250 mm×4.6 mm,5 m),the mobile phase was 0.01 mol/L sodium dihydrogen phosphate solution acetonitrile (60∶40),and the column temperature was 30℃.The detection wavelength is 210 nm.The compatibility of glass syringe,natural rubber piston syringe,synthetic rubber piston syringe,piston free syringe,infusion tube and Dexmedetomidine Hydrochloride Injection at different time points at room temperature was analyzed.Results The established content determination method was verified,and the change of its content could be determined accurately.The syringe of natural rubber had great adsorption on Dexmedetomidine Hydrochloride.The content of Dexmedetomidine Hydrochloride retained in the syringe for 24 h decreases to about 81%,and the compatibility was poor.The synthetic rubber syringe had a certain adsorption of dexmedetomidine hydrochloride.The content was retained in the syringe for 24 h,and the adsorption drops to about 93%,with general compatibility.The syringe and infusion tube without rubber plug had good compatibility with Dexmedetomidine Hydrochloride,and the content remained in the syringe or infusion tube for 24 h without adsorption (＜2%).Conclusion When Dexmedetomidine Hydrochloride Injection is used clinically,syringes without rubber stopper or syringes with synthetic rubber stopper should be preferred.
2022 Vol. 29 (17): 18-21 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
22 Research progress of ultrasound-guided thermal ablation combined with programmed death-1 inhibitor in the treatment of colorectal cancer liver metastases
REN Jianwei ZHOU Zubang▲ MA Wenjuan
More than half of colorectal cancer (CRC) patients have liver metastases in the whole course of the disease.Most of the metastases cannot be radically removed and are prone to recurrence,which is the main factor for the poor prognosis of colorectal cancer patients.Thermal ablation therapy has become an alternative treatment for patients with inoperable colorectal cancer liver metastases.It can not only eliminate local lesions,but also enhance the patients′ anti-tumor immune response,but in the long run,it is not enough to prevent tumor progression.Ultrasound has many advantages such as real-time imaging,accurate guidance,simplicity and convenience, etc.,and is the usual guidance method for thermal ablation therapy.Today,immunotherapy for cancer is emerging,and breakthroughs have been made in the treatment of various cancers,such as immune checkpoint inhibitors (ICIs).Many basic studies have found that thermal ablation combined with immunotherapy can activate the immunosuppressive state of patients,providing a sufficient theoretical basis for further clinical applications.This article mainly describes the research progress of ultrasound-guided thermal ablation therapy of colorectal cancer liver metastases (CRLM),immunotherapy of PD-1 inhibitors,and their combined application.
2022 Vol. 29 (17): 22-27 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
28 Textual research on compatibility of Radix Aconite Lateralis Preparata and Fructus Trichosanthis
ZENG Siming1 MO Yawei2 YANG Hui3▲
Although Radix Aconite Lateralis Preparata and Fructus Trichosanthis are considered as anti-drugs,it is generally believed that there is a taboo of compatibility between them,but there are still some records that the two can be used together to treat some diseases,and there are some typical cases of compatibility therapy in modern medicine.In this paper,the pharmacological effect of Radix Aconite Lateralis Preparata and Fructus Trichosanthis were studied,and their applications in Chinese medicine were analyzed.This paper studies the origin of the contraindications of Radix Aconite Lateralis Preparata and Fructus Trichosanthis,and puts forward a challenge to this theory.It is believed that Radix Aconite Lateralis Preparata and Fructus Trichosanthis are not absolutely incompatible,but can treat some difficult diseases under certain conditions.To investigate the compatibility of Radix Aconite Lateralis Preparata and Fructus Trichosanthis in the treatment of diseases and adverse reactions over the years.It is suggested that the combination of Radix Aconite Lateralis Preparata and Fructus Trichosanthis can be used to treat heart disease,lung disease,gastritis,gallstones and other diseases,and will not cause serious adverse reactions as long as the combination is appropriate.
2022 Vol. 29 (17): 28-31 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
32 Research progress on the application of music intervention in senile chronic disease complicated with depression
CHEN Hao GAO Yuan▲
Depression in the elderly is a common and serious health problem,which usually co-exists with chronic diseases,which can easily lead to the deterioration of cognitive function and body function of the elderly.Due to the concomitant symptoms of chronic diseases,the depressive symptoms of the elderly are often ignored and inadequate treatment.Antidepressants and psychotherapy have shown effect on senile depression,but their limitations are more obvious in the elderly.Music-based intervention is a systematic intervention process that has a positive impact on depressive symptoms,and the elderly especially benefit from this non-invasive treatment.At present,a variety of music intervention methods have been explored,from music listening to leisure singing to music intervention by specially trained music therapists.They have the characteristics of non-invasive,high safety,good compliance and cost-effectiveness ratio.This paper summarizes the effect of different forms of music intervention in the treatment of common chronic diseases with depression in the elderly,and summarizes the problems and challenges that music intervention needs to face in the popularization and application of music intervention in domestic health care institutions.
2022 Vol. 29 (17): 32-36 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
37 Research about community family doctor responsibility system and disease control supervision on the prevention and treatment of pulmonary tuberculosis
LONG Ying1 LI Ying2 DENG Zhibin3 YI Chenggen4 WEI Xiongjie5 WAN Jiehua6
Objective To explore and analyze the value of community family doctor responsibility system and disease control supervision on the prevention and treatment of pulmonary tuberculosis.Methods A total of 120 patients with pulmonary tuberculosis reported by Fenghuang Street Community Health Service Center in Yuanzhou District of Yichun City were collected from December 2019 and November 2020.The patients were divided into observation group (n=60) and control group (n=60) according to random number table method.The control group was intervened by hospital continuous nursing regimen,and the observation group was intervened by community family doctor responsibility system combined with disease control supervision.The medication compliance and self-management level of the two groups were compared.Results The total medication compliance of observation group was higher than that of control group,the difference was statistically significant (P＜0.05).After intervention,the scores of self-management dimensions in the two groups were higher than those before intervention,and the scores in observation group were higher than those in control group,the differences were statistically significant (P＜0.05).Conclusion Community family doctor responsibility system combined with disease control supervision can enhance the medication compliance rate and improve the self-management level.
2022 Vol. 29 (17): 37-39 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
40 Application effect of Rhubarb in colonoscopy of patients with constipation
CHEN Fang1 YE Fan2▲ XU Dan2 YIN Lihong3 WANG Nongrong2

Objective To investigate the application effect of Rhubarb in colonoscopy of patients with constipation.Methods From January 2019 to June 2021,60 patients with constipation in the Department of Outpatient,the Fourth Affiliated Hospital of Nanchang University were selected as the research objects,and they were divided into group A(20 cases),group B (20 cases) and group C (20 cases) by random number table method.Patients in group A were given raw Rhubarb water 3 d before colonoscopy,and Compound Polyethylene Glycol Electrolyte Powder (PCEP) was taken orally at 8:00 PM 1 day before the examination,and PCEP was taken orally 5 h before the examination.In group B,PCEP was taken orally at 8:00 PM 1 day before the examination,PCEP was taken orally 5 hours in advance on the day of examination,and raw Rhubarb water was taken to enema 1 hour earlier.In group C,PCEP was taken orally at 8:00 PM 1 day before the examination,and PCEP was taken 5 h in advance on the day of examination.Boston bowel preparation scale (BBPS) scores and satisfaction scores were observed and compared among the three groups.The colonoscopy time of the three groups was compared.Results The BBPS score of group A was higher than that of group B and group C,the difference was statistically significant (P＜0.05).The satisfaction score of group A was higher than that of group B and group C,and the difference was statistically significant (P＜0.05).The colonoscopy time of patients in group A was shorter than that in group B and group C,and the difference was statistically significant (P＜0.05).Conclusion In intestinal preparation for patients with constipation before colonoscopy,PGEP combined with Rhubarb oral administration or enema can better achieve the purpose of intestinal moistening and defecation than PGEP alone,and ultimately improve the intestinal cleanliness of patients effectively.
2022 Vol. 29 (17): 40-43 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
44 Application value of flexible medical thoracoscopy in the treatment of unexplained pleural effusion and analysis of the characteristics of malignant pleural effusion under endoscopy
ZHU Yujun LI Ping LIANG Qiuhong
Objective To investigate the effect of flexible medical thoracoscopy in the diagnosis of unexplained pleural effusion and the characteristics of malignant pleural effusion.Methods From June 2017 to June 2020,58 patients with unexplained pleural effusion in Yichun People′s Hospital were selected as the research objects,and all patients underwent flexible medical thoracoscopy.The results of thoracoscopic examination were analyzed,and the differences between tuberculous pleural effusion and malignant pleural effusion were compared.Results A total of 57 cases of 58 patients were diagnosed by flexible medical thoracoscopy,1 case was misdiagnosed,there were 20 cases of malignant pleural effusion,37 cases of tuberculous pleurisy.The sensitivity of the standard pleural effusion was 100.00%(20/20),specificity of 97.37%(37/38),accuracy of 98.28%(57/58),positive predictive value of 95.24%(20/21) and negative predictive value of 100.00%(37/37).The main manifestations of tuberculous pleural effusion under thoracoscopy were white miliary nodules,pleural congestion and edema,nodular neobiotics,cellulose like adhesion,caseous necrosis and encapsulation;the main manifestations of malignant pleural effusion were white miliary nodules,pleural congestion and edema,cellulose like adhesions and nodular new organisms.The proportions of white miliary nodules,pleural congestion and edema,cellulose like adhesion,encapsulated effusion and caseous necrosis in tuberculous pleural effusion group were higher than those in malignant pleural effusion group,and the proportions of nodular neoplasms,hyperplasia and thickening,nodules of different sizes,leukoplakia-like changes,and masses were lower than those in malignant pleural effusion group,the differences were statistically significant (P＜0.05).Among the 58 patients,1 patient(1.67%) had severe chest pain,1 patient (1.67%) had dyspnea,and 6 patients (10.00%) had transient tachycardia during the operation.All the symptoms were relieved after psychological counseling,and the examination was continued.Postoperative subcutaneous emphysema occurred in 3 cases (5.00%),incision pain in 12 cases (20.00%) and low fever in 3 cases (5.00%),all of which were relieved by special treatment.Conclusion Flexible medical thoracoscopy can accurately identify the etiology of pleural effusion of unknown origin.There are obvious differences between malignant pleural effusion and tuberculous pleural effusion under the endoscope,which can guide the treatment and improve the prognosis of patients.
2022 Vol. 29 (17): 44-47 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
48 Analysis of influencing factors for postoperative recurrence of chronic subdural hematoma in elderly patients
MAO Mingli ZHANG Yueli SUN Qijun YUAN Jialong WANG Shangwu
Objective To investigate the influencing factors of postoperative recurrence of chronic subdural hematoma in the elderly patients.Methods The clinical data of 148 elderly patients with chronic subdural hematoma who underwent surgical treatment in the Department of Neurosurgery of Miyun Teaching Hospital of Capital Medical University from January 2015 to December 2020 were retrospectively analyzed,and the related risk factors were statistically analyzed by univariate factor analysis (χ2 test) and logistic regression analysis.Results Of the 148 elderly patients with chronic subhematoma,12 cases (8.11%) had recurrence.Univariate analysis showed that there were significant differences in postoperative widening of subarachnoid space ≥10 mm on one side of the surgical area and postoperative tension pneumocephalus (P＜0.05).While the general factors of patients included age,gender,body mass index,hypertension,diabetes,hyperlipidemia and history of cerebral infarction,perioperative drug-related factors included preoperative antiplatelet therapy,anticoagulant therapy and postoperative statin administration,and surgery-related factors included age,operation time,postoperative drainage volume,postoperative drainage time,and the maximum thickness of preoperative hematoma were not significantly correlated with postoperative hematoma recurrence (P＞0.05).Logistic regression analysis showed that postoperative widening of the submandibular space ≥10 mm on one side of the surgical area and postoperative tension pneumocephalus were closely related to postoperative hematoma recurrence,which were independent risk factors for postoperative hematoma recurrence (P＜0.05).Conclusion Postoperative recurrence in elderly patients with chronic subdural hematoma is associated with postoperative widening of subarachnoid space ≥10 mm on one side of the surgical area and postoperative tension pneumocephalus,both of which are independent risk factors.
2022 Vol. 29 (17): 48-51 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 16 )
52 Influence of standard control function of automatic blood component separator on the quality of platelet concentrate products
KANG Meiyan WU Xianbin LUO Manhua LI Jin YANG Zuohui
Objective To explore the influence of standard control function of automatic blood component separator on the quality of platelet concentrate products.Methods From September 2019 to June 2020,90 whole blood samples from Ganzhou City Center Blood Station were selected as research objects,and they were divided into the control group(45 cases)and the observation group(45 cases)according to the random number table method.The observation group used fully automatic blood component separator to separate and prepare white membrane layer and concentrated platelets in standard quantity,while the control group used fully automatic blood component separator to separate and prepare concentrated platelets in white membrane layer in standard quantity and manual method with plasma separation clamp.The preparation effects of the two groups was compared.Results The volume,the amount of red blood cells mixed and the amount of white blood cells mixed in the observation group were all less than those in the control group,the differences were statistically significant (P＜0.05).The platelets count and white blood cell count in the observation group were less than those in the control group,the hematocrit of the observation group was lower than that of the control group,the differences were statistically significant (P＜0.05).Conclusion Compared with the traditional manual separation of concentrated platelets,the automatic blood component separator can improve the quality of concentrated platelets by setting the standard control function,which is worthy of popularization and application.
2022 Vol. 29 (17): 52-54 [Abstract] ( 27 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
55 Effect of high uric acid on renal tubule-related indexes in patients with type 2 diabetes mellitus
GAO Yun；ZHANG Miao；LI Chuanyan；YU Yang；ZHANG Shuxia；LIN Shaozhi
Objective To investigate the effect of high uric acid on renal tubule-related indexes in patients with type 2 diabetes mellitus.Methods A total of 100 patients with type 2 diabetes who met the criteria were hospitalized in Weifang Endocrine and Metabolic Disease Hospital from June 2019 to May 2021 were selected as the research subjects.According to the blood uric acid level,they were divided into high uric acid group (n=50) and normal uric acid group (n=50).Urine was kept and the urine concentrations of β2-microglobulin (β2-MG),retinol-binding protein (RBP),N-acetyl-β-D-glucosidase (NAG),uric acid and osmotic pressure (UOSM) level in the two groups were measured.Results Urine retention,urine β2-MG and RBP of patients in the high uric acid group were higher than those in the normal uric acid group,the differences were statistically significant (P＜0.01).Urine NAG and uric acid in high uric acid group were higher than those in normal uric acid group,and the differences were statistically significant (P＜0.05).There was no significant difference in urinary UOSM level between the two groups (P＞0.05).Conclusions High uric acid has different degrees of damage to the proximal tubule in type 2 diabetes patients,especially the reabsorption function of the proximal tubule is obviously damaged,but the concentration and dilution function of the distal renal tubule is not affected.
2022 Vol. 29 (17): 55-58 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
61 Application of positive pressure straight type indwelling needle in reducing sample hemolysis during phase Ⅰclinical trial
YAO Wei； HUANG Wei ；LAI Fengjiao； PENG Qinghai
Objective To explore the application of positive pressure straight type indwelling needle in reducing sample hemolysis during phase Ⅰclinical trial.Methods A total of 80 subjects who participated in phase Ⅰclinical trial from January 2020 to June 2021 in Pingxiang People′s Hospital were selected as the research subjects.According to the random number table method,they were divided into the experimental group (n=40) and the control group (n=40).The control group adopted ordinary disposable intravenous indwelling needle for blood collection,and the experimental group applied positive pressure straight type indwelling needle to collect blood.The hemolysis rate,blood return rate and the total incidence of complications were compared between the two groups.Results The hemolysis rate and blood return rate in the experimental group were lower than those in the control group,with statistically significant differences (P＜0.05).The total incidence rate of tube plugging,blood collection difficulty and super time window in the experimental group was lower than that in the control group,with statistically significant difference (P＜0.05).Conclusion Positive pressure straight type indwelling needle for blood collection can effectively reduce the hemolysis rate and blood return rate of blood samples.It has a high application value during phase Ⅰclinical trial and is helpful for the smooth progress of the trial.
2022 Vol. 29 (17): 61-61转65 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
62 Application effect of vitamin K2 combined with Midapril in patients with hypertension complicated with osteoporosis
ZHENG Yanliang
Objective To study the efficacy of vitamin K2 combined with Midapril in patients with hypertension complicated with osteoporosis and the influence on 25 hydroxy vitamin D [25(OH)D3],beta C-terminal cross-linked telopeptides of type Ⅰcollagen (β-CTX) and N-terminal-midfragment of osteocalcin (N-MID).Methods A total of 120 patients with hypertension and osteoporosis treated in Dalian Fourth People′s Hospital from September 2019 to January 2021 were selected as the research objects,they were divided into the control group (60 cases) and the observation group (60 cases) according to computer randomization.The control group was treated with Midapril,and the observation group was treated with combined vitamin K2 based on the control group.The efficacy and satisfaction of the two groups were compared,and the levels of 25(OH)D3 and β-CTX,N-MID and receptor activator of nuclear factor-κB ligand (RANKL) before and after treatment in the two groups was recorded.Results The total effective rate in the observation group after treatment was 95.00%,which was higher than 81.67% in the control group,the difference was statistically significant (P＜0.05).The 25(OH)D3 levels after treatment in the two groups were higher than those before treatment,the β-CTX levels after treatment in the two groups were lower than those before treatment,the differences were statistically significant (P＜0.05).The level of 25(OH)D3 in the observation group after treatment was higher than that in the control group,the level of β-CTX in the observation group after treatment was lower than that of the control group,the differences were statistically significant (P＜0.05).The levels of N-MID and RANKL after treatment in the two groups were higher than those before treatment,the differences were statistically significant (P＜0.05).After treatment,the levels of N-MID and RANKL in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).The total satisfaction of the observation group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Using vitamin K2 and Midapril in the treatment of hypertensive patients with osteoporosis can effectively improve the therapeutic effect,and improve the levels of 25(OH)D3,β-CTX,N-MID,and RANKL in the body.
2022 Vol. 29 (17): 62-65 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
66 Clinical effect of Tenofovir Dipivoxil combined with dual immunization regimen in blocking the transmission of mother-to-child virus from pregnant women with chronic hepatitis B virus
JIANG Xianxing；HONG Yongmeng ；CHEN Xing
Objective To investigate the clinical effect of Tenofovir Dipivoxil combined with dual immunization regimen in blocking the transmission of mother-to-child from pregnant women with chronic hepatitis B virus (HBV).Methods A total of 70 pregnant women with HBV who were admitted to Yangjiang Public Health Hospital from September 2019 to September 2020 were selected as the research subjects.They were divided into control group and observation group according to random number table method,with 35 cases in each group.The control group was not given anti-antibiotics during pregnancy.The observation group took Tenofovir Dipivoxil at 24 to 28 week of gestation until delivery.Both groups of newborns were given a dual immunization program after birth (Hepatitis B Human Immunoglobulin 200 μg intramuscular injection + Recombinant Hepatitis B Vaccine 20 μg intramuscular injection at 0,1 and 6 month).The liver function indexes,HBV DNA levels,newborn HBV infection status,newborn conditions and drug safety were compared between the two groups.Results There were no significant differences in the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) between the two groups before treatment and during delivery (P＞0.05).There was no significant difference in the HBV DNA between the two groups before treatment (P＞0.05).The HBV DNA level of the observation group was lower than that of the control group during delivery,and the difference was statistically significant (P＜0.05).At delivery,after 6 and 12 months of treatment,the positive rates of hepatitis B surface antigen (HBsAg) and HBV in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in Apgar score between the two groups(P＞0.05).No significant adverse reactions occurred in two groups.Conclusion Tenofovir Dipivoxil combine with dual immunization program has a significant effect in blocking the transmission of mother-to-child from pregnant women with HBV virus.It can effectively reduce the level of HBV DNA during delivery and reduce the rate of HBV infection in newborns with high safety.
2022 Vol. 29 (17): 66-69 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 11 )
70 Clinical effect of numerical control pressure air pump on prevention of deep venous thrombosis of lower extremity with spinal cord injury
HU Siyan；CHENG Ling；YUAN Juan；PENG Tianzhong
Objective To investigate the preventive effect of numerical control pressure air pump on deep venous thrombosis (DVT) of lower extremity with spinal cord injury.Methods From August 2020 to August 2021,120 patients with spinal cord injury who were admitted to Nanchang Hongdu Traditional Chinese Medicine Hospital were selected as the research objects,and they were divided into the control group (60 cases) and the experimental group (60 cases) by random number table method.The control group was treated with Low Molecular Weight Heparin,and the experimental group was intervened with a numerically controlled pressure air pump based on the control group.The lower extremity blood flow velocity,the levels of activated partial thromboplastin time (APTT),thrombin time (TT),D-Dimer (D-D),and the incidence of lower extremity DVT and pulmonary embolism were compared between the two groups.Results There was no significant difference in the lower extremity blood flow velocity between the two groups before intervention (P＞0.05).After intervention,the blood flow velocity of the left and right lower extremity in the experimental group were higher than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant differences in the levels of APTT,TT and D-D between the two groups before intervention (P＞0.05).After intervention,the levels of APTT and TT in the experimental group were higher than those in the control group,and the level of D-D in the experimental group was lower than that in the control group,the differences were statistically significant (P＜0.05).The incidence of lower extremity DVT in the experimental group was 1.67%,which was lower than 15.00% in the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of pulmonary embolism between the two groups (P＞0.05).Conclusion The application of numerical control pressure air pump in patients with spinal cord injury can improve the blood flow velocity of lower limbs,improve coagulation indexes,and effectively control the incidence of DVT of lower limbs.It is worth popularizing and promotion.
2022 Vol. 29 (17): 70-72转76 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 17 )
73 Analysis of influencing factors on the severity of acute pancreatitis
WANG Bin
Objective To investigate the relationship between C-reactive protein (CRP)/albumin (ALB) ratio and the severity of acute pancreatitis (AP),and the influencing factors of the severity of acute pancreatitis.Methods A total of 98 patients with AP in Beijing Chuiyangliu Hospital from January 2017 to February 2019 were selected as the research object.They were divided into MAP group (46 cases) and SAP group (52 cases) by light and heavy classification of AP.The levels of CRP and ALB in each group were detected by automatic biochemical analyzer.The general data,CRP,ALB and CRP/ALB levels of MAP group and SAP group were compared.Logistic regression was used to analyze the multiple factors affecting the severity of AP. Pearson method was used to analyze the correlation between serum CRP/ALB and APACHE Ⅱscore in patients with AP.Results The CRP,CRP/ALB,course of disease,APACHE Ⅱscores,and the proportions of liver dysfunction,renal dysfunction,ARDS and pancreatic necrosis in SAP group were higher than those in MAP group,and ALB level was lower than MAP group,the differences were statistically significant (P＜0.05).There was a positive correlation between serum CRP/ALB and APACHE Ⅱscore on the day of admission (r=0.651, P＜0.05).Multivariate logistic analysis showed that CRP/ALB (β=0.88, OR=2.42,95%CI=1.32-4.43) was independent risk factor for the development of severe AP,and ALB (β=-0.17, OR=0.85,95%CI=0.76-0.94) was the protective factor for the development of severe AP (P＜0.05).Conclusions The CRP/ALB ratio is related to the severity of AP,and it is an independent risk factor for the development of severe AP.
2022 Vol. 29 (17): 73-76 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
77 Application effect of EnCor rotary cutting system in the minimally invasive resection with ultrasound guidance in single nonpalpable BI-RADS category 4a breast tiny lesions
CHEN Fulong；CHEN Jishang； LI Xiaowen； LIN Xianjun； CHEN Lijia； LIN Zhaoling
 Objective To study the application effect of EnCor rotary cutting system in the minimally invasive resection with ultrasound guidance in single nonpalpable BI-RADS category 4a breast tiny lesions.Methods A total of 96 female patients with single nonpalpable BI-RADS category 4a breast tiny lesions treated in Yangjiang People′s Hospital from January 2019 to September 2020 were retrospectively selected as the study subjects.According to different treatment methods,the enrolled patients were divided into the observation group (47 cases) and the control group (49 cases).Patients in the observation group were treated with minimally invasive resection using EnCor rotary cutting system with ultrasound guidance,while those in the control group were treated with traditional open resection.The detection rate of malignant lesions,intraoperative effect,postoperative healing and complications after operation of the two groups were compared.Results There was no statistically significant difference in the detection rate of malignant lesions between the two groups(P＞0.05).The operation incision length of the observation group was shorter than that of the control group,the tissue excision amount and bleeding volume of the observation group were lower than those of the control group,and the operation time of the observation group was shorter than that of the control group,the differences were statistically significant (P＜0.05).The postoperative pain duration and postoperative recovery time of the observation group were shorter than those of the control group,and the scar length of the observation group was shorter than that of the control group,the differences were statistically significant (P＜0.05).The total incidence of complications including incision infection,local hematoma,subcutaneous congestion and breast deformity after operation in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion EnCor rotary cutting system in the minimally invasive resection with ultrasound guidance in single nonpalpable BI-RADS category 4a breast tiny lesions has accurate locating,short operation time,small trauma,short postoperative recovery time,good cosmetic effect and high safety and contributes to early detection of breast cancer,which is worthy of clinical promotion and application.
2022 Vol. 29 (17): 77-80转84 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
81 Application effect of splenic artery embolization in patients with traumatic splenic rupture
SUN Chaobing
Objective To explore the application effect of splenic artery embolization in patients with traumatic splenic rupture.Methods A total of 40 patients with traumatic splenic rupture admitted to Binhu Hospital of Hefei City from May 2020 to April 2021 were selected as the research objects.According to the random number table method,they were divided into the surgical group (20 cases) and the interventional group (20 cases).The surgical group was treated with surgery,the interventional group was treated with splenic artery embolization.The operative indexes,cellular immunity level before and after surgery and the incidence rate of total complication were compared between the two groups.Results The operation time,time to get out of bed and length of hospital stay in the interventional group were shorter than those in the surgical group,the intraoperative blood loss in the interventional group was less than that in the surgical group,the differences were statistically significant (P＜0.05).There were no statistically significant differences in the levels of CD3+,CD4+and CD4+/CD8+between the two groups before surgery (P＞0.05).The levels of CD3+,CD4+,and CD4+/CD8+ in the intervention group at 1 week after surgery were higher than those in the surgery group,with statistically significant differences (P＜0.05).The total incidence of complications in the interventional group was 5.00%,which was lower than 35.00% in the surgical group,and the difference was statistically significant (P＜0.05).Conclusion Splenic artery embolization in the treatment of traumatic splenic rupture can effectively stop bleeding,preserve spleen and its function,compared with surgical treatment,the operative time is shorter and the trauma is less,it can promote the recovery of immune function of patients,effectively reduce the incidence of related complications,safety is higher,which can help to shorten the hospitalization time,and there is higher value of clinical application and popularization.
2022 Vol. 29 (17): 81-84 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )
85 Therapeutic effect of nano-silver antibacterial hydrogel dressing combined with recombinant human basic fibroblast growth factor on patients with open ankle fracture
ZHANG Shigang
Objective To study the therapeutic effect of nano-silver antibacterial hydrogel dressing (NSAHD) combined with recombinant human basic fibroblast growth factor (RHBFGF) on patients with open ankle fracture.Methods A total of 100 patients with open ankle fractures treated in Shenyang Jishuitan Hospital from March 2019 to May 2020 were selected as research objects,they were divided into the control group and the observation group according to random number table method,with 50 cases in each group.The control group was treated with vaseline and sterile gauze,while the observation group was treated with NSAHD combined with RHBFGF.The total effective rate of wound healing,the levels of malondialdehyde (MDA),superoxide dismutase (SOD),interleukin-6 (IL-6),C-reactive protein (CRP),and tumor necrosis factor-α (TNF-α) were compared between the two groups.Results The total effective rate of wound healing after treatment in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The levels of MDA in the two groups after treatment were lower than those before treatment,and the levels of SOD in the two groups after treatment were higher than those before treatment,and the differences were statistically significant (P＜0.05).The level of MDA in the observation group after treatment was lower than that in the control group,and the level of SOD in the observation group after treatment was higher than that in the control group,and the differences were statistically significant (P＜0.05).The levels of IL-6,CRP and TNF-α in the two groups after treatment were lower than those before treatment,the levels of IL-6,CRP and TNF-α in the observation group after treatment were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion The combination of NSAHD and RHBFGF can achieve better effects in patients with open ankle fractures,and can improve oxidative stress and inflammation.
2022 Vol. 29 (17): 85-88 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
89 Application effect of bone island technique in posterior cruciate ligament preserving knee arthroplasty
HE Junyuan ；TANG Jianbang ；WU Ziguang
Objective To study the application effect of bone island technique in posterior cruciate ligament preserving knee arthroplasty.Methods A total of 120 patients with knee osteoarthritis admitted to the Department of Arthrosis,Zhongshan Hospital of Traditional Chinese Medicine from November 2019 to March 2020 were selected as the research subjects.The patients were divided into stable prosthesis (PS) group,traditional posterior cruciate ligament (CR) prosthesis group and bone island osteotomy CR prosthesis group accordin to the random number table method,with 40 patients in each group.Hospital for special surgery knee (HSS) score,visual analogue scale (VAS) score,femoral condyle retrorolling degree and knee motion were compared among the three groups.Results One month after surgery,HSS score of bone island osteotomy CR prosthesis group was higher than that of CR prosthesis group and PS group,and HSS score of CR prosthesis group was higher than that of PS group,the differences were statistically significant (P＜0.05).One month after surgery,there was no significant difference in VAS scores among the three groups (P＞0.05).One month after surgery,there were no significant differences in femoral condyle retrorolling distance and knee motion among the three groups (P＞0.05).Conclusion The three methods for the treatment of knee osteoarthritis have the same degree of postoperative pain,knee range of motion and femoral condyle roll back,but knee function of bone island osteotomy CR prosthesis is better,clinical worthy of promotion.
2022 Vol. 29 (17): 89-91转96 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 17 )
92 Effect comparison of minimally invasive plate internal fixation and intramedullary nail in the treatment of 42A1 and 42B1 tibial shaft fractures
QIN Huiyong； WANG Junsheng ；SONG Xiaoliang
Objective To compare the efficacy of intramedullary nail (IMN) and minimally invasive plate osteosynthesis(MIPO) in the treatment of 42A1 and 42B1 tibial shaft fractures classified by Arbeitsgemeinschaftfür OsteSyntheefragen(AO).Methods The clinical data of 52 patients with AO type 42A1 and 42B1 tibial shaft fractures treated in the Second People′s Hospital of Changzhi City from January 2007 to January 2017 were retrospectively analyzed.According to different treatment methods,they were divided into MIPO group and IMN group,with 26 cases in each group.The methods of anesthesia,operation time and the time of callus formation were compared between the two groups.The infection,malunion and delayed healing of the two groups were compared,and the lower limb function score (LEFS) of the two groups were compared after 6 months and 2 years of follow-up.Results There was no significant difference in anesthesia mode between two groups (P＞0.05).The operation time of MIPO group was longer than that of IMN group,the difference was statistically significant (P＜0.05).There were no significant differences in the follow-up time and the time of callus formation between the two groups (P＞0.05).There were no significant differences in infection,malunion and delayed union between the two groups (P＞0.05).The postoperative anatomical reduction rate of MIPO group was higher than that of IMN group,and the incidence of anterior knee pain was lower than that of IMN group,the difference was statistically significant (P＜0.05).After 6 months of follow-up,the LEFS score of MIPO group was lower than that of IMN group,the difference was statistically significant (P＜0.05),but there was no significant difference of LEFS score between the two groups after 2 years of follow-up (P＞0.05).Conclusion MIPO and IMN are similar in clinical and functional results,and MIPO can effectively avoid specific complications caused by IMN in some aspects,MIPO is recommended as an alternative to IMN in the treatment of AO type 42A1 and 42B1 tibial shaft fractures.
2022 Vol. 29 (17): 92-96 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
97 Analysis of influencing factors of old anterior cruciate ligament injury with medial meniscus tear
ZHOU Pu ；YAN Fang ；HE Yunheng； LI Qian
Objective To analyze the influencing factors of old anterior cruciate ligament (ACL) injury with medial meniscus tear.Methods The clinical data of 200 patients with old ACL injury in Changde First Hospital of Traditional Chinese Medicine from September 2018 to October 2021 were analyzed retrospectively.The patients were divided into study group (with medial meniscus tear) and control group (with normal medial meniscus),with 100 cases in each group.All patients were scanned by magnetic resonance imaging to measure the anatomical parameters of the knee joint(knee varus angle,ACL tibial stop width,medial tibial plateau retroversion angle,tibial coronal inclination angle,medial tibial plateau depth).The anatomical parameters of knee joint were compared between the two groups,and the influencing factors of medial meniscus tear were analyzed by logistic regression model.Results The knee varus angle,medial tibial plateau retroversion angle and tibial coronal inclination angle of the study group were greater than those of the control group,and the ACL tibial insertion width and medial tibial plateau depth were less than those of the control group,the differences were statistically significant (P＜0.05).Multivariate logistic analysis showed that the decrease of medial tibial plateau depth (OR=1.152),the increase of tibial coronal inclination angle (OR=1.279),the decrease of ACL tibial stop width (OR=1.346),the increase of knee varus angle (OR=1.769) and the increase of medial tibial plateau caster angle (OR=1.957) were the risk factors of medial meniscus tear in patients with old ACL injury (P＜0.05).Conclusion There is an influence mechanism between medial meniscus tear and tibial plateau caster.The increase of medial tibial caster is a risk factor for medial meniscus tear in patients with old ACL injury.
2022 Vol. 29 (17): 97-99转115 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 15 )
100 Effect of drug combined with physical therapy in the prevention of venous thromboembolism after thoracoscopic radical resection of lung cancer
JIANG Wentan； WU Jiayun ；WU Jingyang ；LIN Xianbin； LIN Liang′an ；YANG Jiansheng▲
Objective To explore the effect of drug combined with physical therapy in the prevention of venous thromboembolism after thoracoscopic radical resection of lung cancer.Methods A total of 300 patients after thoracoscopic radical resection of lung cancer in the Second Affiliated Hospital of Fujian Medical University from January 2016 to December 2020 were selected as the research objects.According to the random number table method,they were divided into combined group (n=150) and physical group (n=150).The physical group used physical prevention,and the combined group used drug prevention on the basis of the physical group.The changes of blood related indexes(hemoglobin [Hb],D-dimer,fibrinogen [FIB]) before and after treatment and the incidence of venous thromboembolism and bleeding were compared between the two groups.Results There were no significant differences between the two groups in chest tube drainage volume and chest tube retention time (P＞0.05).The postoperative hospital stay in the combined group was shorter than that in the physical group,and the difference was statistically significant (P＜0.05).There was no significant difference in Hb level between the two groups after treatment (P＞0.05).The levels of D-dimer and FIB in the combined group were lower than the physical group,the differences were statistically significant (P＜0.05).The total incidence of venous thromboembolism was lower than the physical group,and the difference was statistically significant (P＜0.05).There was no significant difference in the incidence of bleeding between the two groups (P＞0.05).Conclusion Drug combined with physical therapy can reduce the incidence of venous thromboembolism in patients with radical thoracoscopic pulmonary cancer and shorten the postoperative hospitalization time,do not increase postoperative flow and prolong the retention of thoracic tube,which can serve as an important measure to prevent pulmonary cancer.
2022 Vol. 29 (17): 100-103 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
104 Risk factors for recurrence after endoscopic submucosal dissection in patients with early gastric cancer
ZHONG Bibo ；ZHONG Fang
Objective To investigate the risk factors of recurrence in patients with early gastric cancer after endoscopic submucosal dissection (ESD).Methods The clinical data of 176 patients with early gastric cancer admitted to Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from June 2019 to June 2021 were retrospectively analyzed.All patients successfully completed ESD.They were followed up for 1 year,and were divided into recurrence group (n=25) and non-recurrence group (n=151) according to the presence or absence of recurrence.General information of two groups including gender,age,tumor location,diabetes mellitus,tumor diameter,degree of differentiation,depth of tumor invasion,smoking history,whether endoscopy was performed before surgery,the nature of surgical margins,the number of positive lymph nodes were statistically analyzed,and the related risk factors for recurrence after ESD were analyzed.Results After ESD treatment,25 of 176 patients with gastric cancer recurred,and the recurrence rate was 14.20%.The univariate analysis showed that the tumor diameter≥3 cm,the depth of tumor invasion was submucosal,no preoperative endoscopy,positive surgical margins,and the number of positive lymph nodes ≥6 were related to the recurrence of early gastric cancer after ESD,and the differences were statistically significant (P＜0.05).Gender,age,tumor location,combined diabetes,degree of differentiation,smoking history were not related to the recurrence of early gastric cancer after ESD,and the differences were not statistically significant (P＞0.05).Multivariate analysis of the logistic regression model showed that the tumor diameter≥3 cm (β=2.512, OR=12.324,95%CI=4.322-35.141),the depth of tumor invasion was submucosal (β=1.947, OR=7.007,95%CI=2.629-18.677),no preoperative endoscopy (β=2.215, OR=9.164,95%CI=2.992-28.070),positive surgical margins (β=2.080, OR=8.005,95%CI=3.170-20.212),the number of positive lymph nodes≥6 (β=1.898, OR=6.673,95%CI=2.600-17.132) were independent risk factors for early gastric cancer recurrence after ESD (P＜0.05 and OR≥1).Conclusion Patients with early gastric cancer have a higher risk of recurrence after ESD,which is mainly affected by factors such as tumor diameter ≥3 cm,the depth of tumor invasion was submucosal,no preoperative endoscopy,positive surgical margins,and number of positive lymph nodes ≥6.Great attention should be paid in clinical practice.
2022 Vol. 29 (17): 104-107 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 17 )
108 Clinical efficacy of bioelectric technology in the perioperative period of gynecological total pelvic floor reconstruction based on enhanced recovery after surgery
CHEN Chunxia ；FANG Qiaochan； LI Guihong
Objective To evaluate the efficacy of biomimetic technology in perioperative period of gynecological total pelvic floor reconstruction based on enhanced recovery after surgery (ERAS).Methods A total of 60 patients in the perioperative period of gynecological whole basin reconstruction treated from May 2020 to August 2021 in Houjie Hospital of Gongguan City,Guangdong Province were selected as the research object.They were divided into control group and observation group by random number table method,with 30 cases in each group.The control group received ERAS concept intervention,and the observation group received bioelectric technology intervention on the basis of the control group.The postoperative bowel sound recovery,perioperative indexes,postoperative pain and complications were compared between the two groups.Results The occurrence rate of regular bowel sounds at 12,24 and 48 h in the observation group were higher than those in the control group,and the number of bowel sounds at 12,24 and 48 h were more than those in the control group,the differences were statistically significant (P＜0.05).There were no statistically significant differences in operation time and intraoperative bleeding between the two groups (P＞0.05).The first defecation time,first exhaust time and first eating time in the observation group were shorter than those in the control group,the differences were statistically significant (P＜0.05).The visual analogue scale (VAS) scores in the observation group were lower than those in the control group at 12,24 and 48 h after operation,the differences were statistically significant (P＜0.05).The incidence of complications in the observation group (10%) was lower than that in the control group (33.33%),and the difference was statistically significant (P＜0.05).Conclusion Perioperative patients with gynecological total pelvic floor reconstruction can significantly alleviate postoperative pain symptoms,reduce complications and promote postoperative recovery on the basis of eras intervention.
2022 Vol. 29 (17): 108-111 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
112 Application effect of Feike Granule and Omeprazole in children with gastroesophageal reflux disease complicated with pneumonia
ZHAO Jing
Objective To investigate the application effect of Feike Granule and Omeprazole in children with gastroesophageal reflux disease complicated with pneumonia.Methods A total of 86 children with gastroesophageal reflux disease complicated with pneumonia treated in pediatrics of Changping District Hospital of Beijing from April 2020 to May 2021 were selected as the research objects and randomly divided into the control group and the observation group,with 43 cases in each group.The control group was treated with Omeprazole,and the observation group was treated with Feike Granule and Omeprazole.The curative effect,regression time of various clinical symptoms,hospitalization time,the quality of life score (QOL) before and after treatment,the high-sensitivity C-reactive protein (hs-CRP),interleukin-6 (IL-6) and tumor necrosis factor were detected-α (TNF-α) and the adverse reactions of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The remission time of dyspnea,lung sounds and hospitalization time in the observation group were shorter than those of the control group,the differences were statistically significant (P＜0.05).Before treatment,there were no statistically significant differences in the QOL scores and level of hs-CRP,IL-6 and TNF-α of the two groups (P＞0.05).After one month of treatment,the QOL score of the observation group was higher than that of the control group,the hs-CRP,IL-6 and TNF-α levels were lower than those of the control group,the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The use of Feike Granule and Omeprazole in children with gastroesophageal reflux complicated with pneumonia can achieve better therapeutic effect,which can quickly alleviate their clinical symptoms,reduce inflammatory injury,improve the quality of life,and have less adverse reactions.It has the value of clinical promotion.
2022 Vol. 29 (17): 112-115 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
116 Analysis of clinical factors for endometrial polyps and canceration
WANG Lili； YANG Shanshan； XUE Jie ；ZHENG Wei
Objective To investigate the clinical factors of endometrial polyps (EP) and canceration,to provide evidence for clinical prevention and treatment.Methods From January 2018 to December 2020,the ultrasound examination in Integrated Traditional Chinese and Western Medicine Hospital of Daxing District showed 243 patients with suspected EP were selected as the research objects.All patients underwent hysteroscopy.The clinical symptoms,signs,age,body mass index (BMI),intrauterine device,gravidity and parity,cervical polyp,hysteromyoma,adenomyosis,diabetes,hypertension of the patients were recorded.According to pathological results,they were divided into control group (24 cases),benign EP group (197 cases) and malignant EP group (22 cases).The single-factor,multi-factor logistic regression analysis were used to investigate the risk factors of EP.Results Univariate analysis results showed that the differences in intrauterine device,cervical polyp,hysteromyoma,obesity,diabetes between benign EP group and control group were statistically significant (P＜0.05).The differences in hysteromyoma,obesity and menstruation is not clean between benign EP group and malignant EP group were statistically significant (P＜0.05).Multivariate logistic regression analysis showed that cervical polyp (β=2.19, OR=3.47,95%CI=1.552-7.181),hysteromyoma (β=1.83, OR=2.30,95%CI=0.691-7.660) and obesity (β=1.91, OR=2.02,95%CI=0.082-10.157) were risk factors of the onset of EP(P＜0.05).Obesity (β=2.96, OR=2.45,95%CI=1.552-7.088) and menstruation is not clean (β=1.53, OR=2.39,95%CI=1.240-8.871) were risk factors of the malignant transformation of EP (P＜0.05).Conclusion Cervical polyp,hysteromyoma and obesity are independent factors of EP.Obesity and menstruation is not clean are independent factors of EP malignant transformation.
2022 Vol. 29 (17): 116-118 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
119 Application effect of Xiyanping in children with acute respiratory tract infection
LU Mingcheng； QIN Xuan； XUE Hongyan
Objective To explore the application effect of Xiyanping in children with acute respiratory tract infection.Methods From February 2020 to May 2021,96 children with acute respiratory infection admitted to the Department of Pediatrics of Tianshui Maternal and Child Health Hospital were selected as the research objects,and they were divided into the experimental group (n=48) and the control group (n=48) using the random number table method (n=48).The experimental group was treated with Xiyanping Injection,and the control group was treated with Clohexine Dry Suspension.The treatment effect,clinical symptoms,inflammatory indicators and incidence of adverse reactions between the two groups were compared.Results The total effective rate of treatment in children in the experimental group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The disappearance time of cough,fever,sore throat,nasal congestion,and pulmonary rales in the experimental group were shorter than those in the control group,the differences were statistically significant (P＜0.05).After treatment,the levels of serum interleukin-6 (IL-6),interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were lower than those of the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Xiyanping Injection is effective in the treatment of children with acute respiratory tract infection and can quickly curb children′s cough and other clinical symptoms.The mechanism of action may be related to the reduction of inflammatory factors IL-6,IL-1β and TNF-α levels in children.
2022 Vol. 29 (17): 119-122 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
123 Effect of Carboprost Ambutritol combined with Misoprostol on clinical efficacy and oxidative stress indexes in patients with postpartum hemorrhage of placenta previa
YE Hongli ；CHENG Kang ；GAO Chang
 Objective To investigate the effect of Carboprost Ambutritol combined with Misoprostol on clinical efficacy and oxidative stress indexes in patients with postpartum hemorrhage of placenta previa.Methods A total of 92 patients with postpartum hemorrhage from placenta previa who were admitted in Huanggang Maternal and Child Health Hospital from September 2019 to October 2020 were selected as the research objects.They were divided into the observation group and the control group according to the random number table method,each group with 46 cases.The observation group was treated with Carboprost Ambutritol combined with Misoprostol,and the control group was treated with Misoprostol.The related clinical indicators and oxidative stress indicators were compared between the two groups.Results The 24 h postpartum blood loss in the observation group was less than that in the control group,and the hemostasis time and hospitalization time were shorter than those in the control group,with statistically significant differences (P＜0.05).After treatment,the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the two groups were higher than those before treatment,and the levels of lipid peroxide (LPO) in the two groups were lower than those before treatment,the levels of SOD and GSH-Px in observation group after treatment were higher than those in the control group,and the level of LPO in observation group after treatment was lower than that in the control group,the differences were statistically significant (P＜0.05).Conclusion Carboprost Ambutritol combined with Misoprostol for postpartum hemorrhage patients with placenta previa can improve relevant clinical indicators and significantly regulate the level of oxidative stress indicators.
2022 Vol. 29 (17): 123-125转129 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
126 Application effect of Houttuynia Qinlan Mixture in the treatment of acute suppurative tonsillitis of upper respiratory tract in children
XIA Li
Objective To investigate the application effect of Houttuynia Qinlan Mixture in the treatment of acute suppurative tonsillitis in the upper respiratory tract in children.Methods A total of 68 children with acute suppurative upper respiratory tonsillitis admitted to the First Hospital of Shanxi Medical University from May 2020 to May 2021 were selected as the study subjects.They were divided into observation group (34 cases) and control group (34 cases) by random number table method.The control group was treated with conventional Western medicine therapy,and the observation group was treated with conventional Western medicine therapy combined with Houttuynia Qinlan Mixture.The treatment effect,symptom relief time,improvement of inflammatory factors and incidence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group (94.12%) was higher than that in the control group (76.47%),and the difference was statistically significant (P＜0.05).The time of fever reduction,disappearance of hyperemia,relief of sore throat and disappearance of purulent secretions in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).The levels of interleukin-6 (IL-6),serum high sensitive C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) in observation group were lower than those in control group after treatment,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Houttuynia Qinlan Mixture can significantly improve the condition of children with acute suppurative tonsillitis of upper respiratory tract,and the safety of the treatment is high,this treatment plan is worth promoting in clinical application.
2022 Vol. 29 (17): 126-129 [Abstract] ( 25 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
130 Application of ultrasound-guided type-2 of pectoral nerve block in patients undergoing modified radical mastectomy
LIN Xinqiang； CHEN Yuren；LIN Jianxin；CHEN Xiao； XIE Lijin； HE Yingxi
Objective To evaluate the perioperative analgesic effect of ultrasound-guided type-2 of pectoral nerve（Pecs Ⅱ） block in patients undergoing modified radical mastectomy.Methods A total of 100 elective breast surgery patients admitted to the Affiliated Hospital of Putian College from December 2019 to December 2020 were selected as the research objects,and were divided into P group and G group according to the random number table method,with 50 patients in each group.P group was treated with general anesthesia combined with Pecs Ⅱblock,and G group was treated with general anesthesia alone.The total amount of perioperative anesthesia,postoperative visual analogue scale（VAS） score,the number of patient controlled analgesia （PCA）compression,time of first postoperative pain,incidence of postoperative nausea and vomiting after MRM were compared between the two groups.The analgesic efficacy of 30 min after Pecs Ⅱblock for respective quadrant of breast in P group were evaluated.Results The consumption of Propofol and Remifentanil in P group were less than those in G group,and the differences were statistically significant(P＜0.05).VAS scores at 2,4 and 6 h after surgery in P group were lower than those in G group,the differences were statistically significant (P＜0.05).The first postoperative pain time in P group was longer than that in G group,the number of PCA compression in P group was lower than that in G group,and the occurrence of postoperative nausea and vomiting in P group was lower than that in G group,and the differences were statistically significant (P＜0.05).In P group,VAS scores of the axillary and outer quadrant of breast were lower than those of inner quadrant of breast,the differences were statistically significant (P＜0.05).Conclusion Ultrasound-guided Pecs Ⅱblock can provide effective analgesia for modified radical mastectomy,reduce the consumption of anesthesia in perioperative period,reduce postoperative VAS score,and reduce the incidence of postoperative nausea and vomiting.Meanwhile,the analgesic efficacy of Pecs Ⅱblock on outer quadrant of breast has better than inner quadrant of breast.
2022 Vol. 29 (17): 130-133转138 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
134 Effect of Dexmedetomidine combined with Ropivacaine ultrasound-guided nerve block on serum pain levels in patients undergoing thoracoscopic surgery
ZHANG Yilong
 Objective To investigate the effect of Dexmedetomidine combined with Ropivacaine ultrasound-guided nerve block on the level of serum pain indexes in patients undergoing thoracoscopic surgery.Methods From February 2019 to October 2020,93 patients who underwent thoracoscopic surgery in the Department of Anesthesiology,Longyan First Hospital Affiliated to Fujian Medical University were selected as research objects.They were divided into the control group (46 cases) and the observation group (47 cases) by random number table method.Patients in the control group were treated with Ropivacaine sound-guided nerve block,while patients in the observation group were treated with Dexmedetomidine combined with Ropivacaine sound-guided nerve block.The serum pain index,pain degree,sedation effect,comfort and the total incidence of complications were compared between the two groups.Results Prostaglandin E2 (PGE2),substance P (SP),interleukin-17 (IL-17) and high mobility cluster protein (HMGB1) in the observation group after operation were lower than those in the control group,and the differences were statistically significant (P＜0.05).There were no statistically significant differences between the two groups in the scores of resting and exercise visual analogue scale (VAS) scores at 8 hours after operation (P＞0.05).The scores of resting and exercise VAS at 16 and 24 hours after operation in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).There were no statistically significant differences between the Ramsay score and Bruggrmann comfort scale (BCS) score at 8 hours after operation between the two groups (P＞0.05).The Ramsay score and BCS score at 16 and 24 hours after operation in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of complications in observation group (10.61%) was lower than that in control group (28.24%),and the difference was statistically significant (P＜0.05).Conclusion Dexmedetomidine combined with Ropivacaine ultrasound-guided nerve block can reduce the level of serum pain in patients undergoing thoracoscopic surgery,improve the degree of pain,enhance the sedation effect and comfort,and the incidence of complications is lower.
2022 Vol. 29 (17): 134-138 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
139 Analysis of risk factors of hypotension after spinal anesthesia for elective cesarean section
TIAN Huanhuan
 Objective To explore the risk factors of hypotension after spinal anesthesia for elective cesarean section.Methods A total 261 parturients with elective cesarean section and spinal anesthesia who gave birth in the Affiliated Hospital of Xuzhou Medical University from June 2019 to August 2020 were selected as the research objects.According to whether hypotension occurred,they were divided into hypotension group (110 cases) and normal group (151 cases),and conduct univariate analysis and logistic regression analysis were used to explore the risk factors of hypotension after spinal anesthesia for elective cesarean section.Results A total of 110 cases of 261 parturients had hypotension,with an incidence rate of 42.15%.Univariate analysis showed that the differences of body mass index (BMI)≥28 kg/m2,anterior pain index (ANI)＞70,giant infants and the supine position of the hypotension group and the normal group were statistically significant (P＜0.05).The results of multivariate logistic analysis showed that BMI≥28 kg/m2 (β=1.739,OR=2.893,95%CI=1.386-7.415),ANI＞70 (β=1.549, OR=3.979,95%CI=2.157-10.323),giant infants (β=1.357, OR=4.523,95%CI=2.476-16.361),supine position (β=1.165, OR=10.298,95%CI=1.873-14.257) were independent risk factors for hypotension after elective cesarean section spinal anesthesia (P＜0.05).Conclusion BMI,ANI,macrosomia and supine position are risk factors for complicated hypotension in women with spinal anesthesia during elective cesarean section,and timely intervention should be carried out.
2022 Vol. 29 (17): 139-141 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
142 Research on the quality control status and countermeasures of decoction preparations of Chinese medicine decoction pieces
MENGXiangyun ；WANGYuan； HUBo； WANGXinghui
ThequalityofdecoctionpiecesoftraditionalChinesemedicinedirectlyaffectsthequalityofdecoction preparations and clinical efficacy. By establishing and improving the quality control system of traditional Chinese medicinedecoctionpiecesandtheirdecoctionpreparations,improvingtherelevantprofessionalandtechnicallevelof employees,andusingInternettechnologytoassistqualitysupervision,strengthensupervisiononthesupply,acceptance andstorageofrawmaterialsoftraditionalChinesemedicinedecoctionpieces,aswellastheproductionoftraditional Chinesemedicinedecoctionpreparations,soastoensurethesafetyandreliabilityoftraditionalChinesemedicinede- coctionpiecesandtheirdecoctionpreparationsfromthesource,thenimprovetheclinicaltherapeuticeffectoftradi- tionalChinesemedicine.
2022 Vol. 29 (17): 142-145转149 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 17 )
146 Clinical effect of different bloodletting volumes on the middle finger micro-collateral in the treatment of acute pharyngitis and sore throat
LIU Jiao ；HU Jielin； GUO Yanqing
Objective To investigate the clinical effect of different bloodletting volumes on the micro-collateral of the middle finger in patients with acute pharyngitis and sore throat.Methods A total of 60 patients with acute pharyngitis and sore throat who were treated in the Pingxiang People′s Hospital from January 2020 to November 2021 were selected as the research objects,they were divided into three groups according to random number table method,with 20 cases in each group.All patients were treated with bloodletting.The 4.5-gauge needle bloodletting group bleeds 4-5 drops,the 6-gauge needle bloodletting group bleeds 10-12 drops,and the 8-gauge needle bloodletting group bleeds more than 20 drops.The effect of the treatment was evaluated after 3 treatments.The visual analogue scale (VAS),the present pain intensity (PPI) score,the traditional Chinese medical symptom score and the incidence of adverse reactions were compared among the three groups.Results After 3 treatments,the VAS and PPI scores of the three groups were lower than those before treatment,the VAS and PPI scores of 8-gauge needle bloodletting group were lower than those of 4.5-gauge needle bloodletting group and 6-gauge needle bloodletting group,the differences were statistically significant (P＜0.05).After 3 treatments,the scores of pharyngeal pain,burning,pharyngeal dryness,fever and chills in the three groups were lower than those before treatment,the scores of pharyngeal pain,burning,pharyngeal dryness,fever and chills in the 8-gauge needle bloodletting group were lower than those in the 4.5-gauge needle bloodletting group and 6-gauge needle bloodletting group,the differences were statistically significant (P＜0.05).Conclusion The bloodletting volume of the middle finger micro-collateral more than 20 drops used in patients with acute pharyngitis and sore throat can help reduce the pain and improve the symptoms of patients,which is worthy of popularization and application.
2022 Vol. 29 (17): 146-149 [Abstract] ( 19 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
150 Effect of acupoint application of traditional Chinese medicine combined with anti-tuberculosis drugs in the treatment of tuberculosis of lung-yin deficiency type and its influence on immune function of patients
LI Jianpeng；XIE Feilong；LI Chaojie
Objective To explore the effect of acupoint application of traditional Chinese medicine combined with antituberculosis drugs in the treatment of tuberculosis of lung-yin deficiency type and its influence on the immune function of patients.Methods A total of 104 patients with of lung-yin deficiency type tuberculosis admitted to the Third People′s Hospital of Wuzhou City from August 2020 to May 2021 were selected as the research objects,and they were divided into the observation group (n=52) and the control group (n=52) using random number table method.The control group was treated with conventional anti-tuberculosis drugs,and the observation group was treated with acupoint application of traditional Chinese medicine on the basis of the control group.Both groups continued treatment for 8 weeks.The clinical treatment effect,pulmonary function indexes (forced expiratory volume in 1 second [FEV1],forced vital capacity[FVC]),traditional Chinese medicine syndrome scores,quality of life scores and immune function indicators (CD4+,CD8+,CD4+/CD8+,CD3+) before and after treatment of the two groups were compared.Results The clinical efficacy of the observation group was significantly better than that of the control group,and the difference was statistically significant (P＜0.05).Before treatment,there were no statistically significant differences in the lung function indexes,traditional Chinese medicine syndrome scores,quality of life scores and immune function indexes between the two groups(P＞0.05).After treatment,the levels of FEV1 and FVC of the observation group were higher than those of the control group,and the differences were statistically significant (P＜0.05).The traditional Chinese medicine syndrome score of the observation group was lower than that of the control group,and the quality of life score of the observation group was higher than that of the control group,and the differences were statistically significant (P＜0.05).The levels of CD4+,CD4+/CD8+ and CD3+ of the observation group were higher than those of the control group,and the level of CD8+ of the observation group was lower than that of the control group,and the differences were statistically significant (P＜0.05).Conclusion Acupoint application of traditional Chinese medicine combined with anti-tuberculosis drugs has a definite curative effect in the treatment of tuberculosis of lung-yin deficiency type,which can further improve the clinical treatment effect,effectively improve lung function,significantly alleviate the clinical symptoms of patients,improve their quality of life,and significantly improve immune function.
2022 Vol. 29 (17): 150-153 [Abstract] ( 30 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
154 Effect of Modified Gualou Xiebai Banxia Decoction combined with Western medicine in the treatment of coronary heart disease with turbid phlegm and internal obstruction and its influence on indexes of cardiac function
XIANG Li ；CHEN Qiu； WANG Jianhua
Objective To explore the clinical effect of Modified Gualou Xiebai Banxia Decoction combined with Western medicine in the treatment of coronary heart disease with turbid phlegm and internal obstruction.Methods A total of 84 patients with turbid phlegm and internal obstruction coronary heart disease who were admitted to the Lichuan National Hospital of Traditional Chinese Medicine in Enshi Prefecture of Hubei Province from October 2018 to June 2020 were selected,and they were divided into the study group (42 cases) and the control group (42 cases) according to random number table method.The ontrol group was treated with Western medicine,while the study group was treated with Modified Gualou Xiebai Banxia Decoction on the basis of the control group.Both groups were treated continuously for 30 days.The clinical efficacy,traditional Chinese medicine syndrome scores before and after treatment,cardiac function indexes and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 95.24%,which was higher than 80.95% in the control group,and the difference was statistically significant (P＜0.05).The traditional Chinese medicine syndromes score of chest tightness,chest pain,shortness of breath,body weight,body fat and phlegm after treatment in the two groups were lower than those before treatment,and the traditional Chinese medicine syndromes score of chest tightness,chest pain,shortness of breath,body fatness and phlegm after treatment in the study group were lower than those in the control group,the differences were statistically significant (P＜0.05).The left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter(LVESD) after treatment in the two groups were lower than those before treatment,and the left ventricular ejection fraction (LVEF) after treatment in the two groups were higher than those before treatment,the differences were statistically significant (P＜0.05).After treatment,the levels of LVEDD and LVESD in the study group were lower than those in the control group,and the levels of LVEF in the study group was higher than that in the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion Modified Gualou Xiebai Banxia Decoction combined with Western medicine has achieved good results in the treatment of turbid phlegm and internal obstruction coronary heart disease.The clinical symptoms of the patients have been effectively improved,the level of cardiac function is improved,the side effects are few,the safety is high,and it is good for prognosis and worth popularizing.
2022 Vol. 29 (17): 154-157 [Abstract] ( 17 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
158 Effect of Irbesartan combined with Jianpi Yishen Decoction in the treatment of IgA ephritis
CHEN Kangyu；CHEN Jinran；YE Hang
Objective To explore the effect of Irbesartan combined with Jianpi Yishen Decoction in the treatment of IgA nephritis.Methods A total of 50 patients with IgA nephritis treated in the Department of Nephrology and Rheumatology of the Fourth People′s Hospital of Nanhai District in Foshan City from December 2019 to December 2020 were selected as the research objects.They were divided into the reference group and the study group according to random number table method,with 25 cases in each group.The study group was treated with Irbesartan combined with Jianpi Yishen Decoction,the reference group was treated with Irbesartan alone.The levels of serum C-reactive protein,quality of life and treatment effect were compared between the two groups.Results There was no significant difference in the level of serum C-reactive protein between the two groups before treatment (P＞0.05).The level of serum C-reactive protein in the study group after treatment was lower than that in the reference group,and the difference was statistically significant (P＜0.05).The incidence of complications after treatment in the study group was lower than that in the reference group,and the difference was statistically significant (P＜0.05).The quality of life in the study group was higher than that in the reference group,and the difference was statistically significant (P＜0.05).The total effective rate of the study group after treatment was higher than that of the reference group,and the difference was statistically significant(P＜0.05).Conclusion Irbesartan combined with Jianpi Yishen Decoction has a significant effect in the treatment of IgA nephritis.It can stabilize the level of serum C-reactive protein,reduce the incidence of complications,improve the safety of treatment,and ensure the final treatment effect of the disease.It has ideal clinical value.
2022 Vol. 29 (17): 158-161 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
162 Effect of capillary hemoglobin electrophoresis combined with mean erythrocyte volume for couples of childbearing age β-thalassemia screening
HE Rongkui ；PAN Shaoyin ；HUANG Yanjuan
 Objective To investigate the effect of capillary hemoglobin electrophoresis combined with mean corpuscular volume (MCV) in couples of childbearing age β-thalassemia screening.Methods From August 2019 to September 2020,1508 couples of childbearing age (3016 people) who did pre-pregnancy β-thalassemia screening in Maternal and Child Health Hospital of Qingxin District,Qingyuan City were selected as the research objects.Fasting venous blood was collected,and the distribution of hemoglobin (Hb) was detected by capillary hemoglobin electrophoresis and MCV was detected by blood cell analyzer for β-thalassemia screening.Polymerase chain reaction/reverse dot blot (PCR/RDB) was used for gene diagnosis.The gene diagnosis result was took as the gold standard,the diagnostic efficacy of capillary hemoglobin electrophoresis and MCV alone and combined in screening β-thalassemia in couples of childbearing age was analyzed,and the Hb distribution of different clinical types of β-thalassemia was analyzed.Results The results of gene diagnosis showed that 174 of 3016 samples were β-thalassemia gene positive,with a positive rate of 5.77%,including 168 cases of mild type and 6 cases of intermediate type.The content of Hb-A in patients with intermediate βthalassemia was lower than that in patients with mild β-thalassemia,the difference was statistically significant (P＜0.05).The sensitivity,specificity and accuracy of β-thalassemia screening by capillary hemoglobin electrophoresis combined MCV were 95.98%,91.86% and 92.09% respectively.Conclusion The combination of capillary hemoglobin electrophoresis and MCV detection for prenatal β-thalassemia screening of couples of childbearing age can improve the sensitivity and accuracy of screening to a certain extent,and has certain guiding significance for their clinical typing.
2022 Vol. 29 (17): 162-165 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 10 )
166 Relationship between total cholesterol and lipoprotein-associated phospholipase A2 in 29 846 cheek-up crowd
WANG Zhixue； CHEN Jide
Objective To investigate the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and total cholesterol (TC) in cheek-up crowd.Methods From November 2017 to November 2019,29 846 people who underwent physical examination in People′s Hospital of Bishan District were selected as research subjects.General information,including age,sex,height,weight,hip circumference,waist circumference,systolic blood pressure (SBP),diastolic blood pressure (DBP),body mass index (BMI),serum TC,triglyceride (TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol (LDL-C) levels and Lp-PLA2 activity were detected.The collected population data were divided into normal control group (16 192 cases),elevated TC margin group (9452 cases),elevated TC group (4202 cases) according to TC concentration.Patients with hypercholesterolemia who met the standard were selected as the follow-up group (114 cases).Pearson test was used to analyze the correlation between Lp-PLA2 activity and age,height,weight,waist circumference,SBP,DBP,BMI,TG,HDL-C and LDL-C.The differences in age,body weight,hip circumference,waist circumference,SBP,DBP,BMI,Lp-PLA2,TG,HDL-C and LDL-C were compared among the normal TC control group,TC edge elevation group and TC elevation group.The changes of Lp-PLA2 activity and TC concentration in the hypercholesterolemia follow-up group before and after treatment were compared.Results The Lp-PLA2,TG and LDL-C of TC edge elevation group were higher than those of normal TC control group,while HDL-C was lower than that of normal TC control group,the differences were statistically significant (P＜0.05).The Lp-PLA2,TG and LDL-C of TC increased group were higher than those of TC normal control group,the differences were statistically significant (P＜0.05).The Lp-PLA2,TG and LDL-C in TC increased group were higher than those in TC edge increased group,while HDL-C was lower than that in TC edge increased group,the differences were statistically significant (P＜0.05).Lp-PLA2 activity was positively correlated with age,height,weight,waist circumference,SBP,DBP,BMI,TC,TG and LDL-C (P＜0.05),while Lp-PLA2 activity was negatively correlated with HDL-C (P＜0.05),but had no significant correlation between Lp-PLA2 activity and hip circumference (P＞0.05).After regular treatment for 4 weeks,serum Lp-PLA2 activity and TC concentration in the follow-up group were lower than those before treatment,the differences were statistically significant (P＜0.05).Conclusion The activity of different concentrations of TC and Lp-PLA2 was statistically significant,and reducing the concentration of TC in hypercholesterolemia was of great significance for reducing the activity of Lp-PLA2.
2022 Vol. 29 (17): 166-169 [Abstract] ( 17 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
170 Comparison of thromboelastogram and routine coagulation test in the guidance of clinical rational blood use
GU Ruilin
Objective To compare the application value of thromboelastogram (TEG) and routine coagulation test (CCT)in the guidance of clinical rational blood use.Methods A total of 83 patients with indications for blood transfusion who underwent TEG and CCT in Xiamen Fifth Hospital from March 2020 to March 2021 were selected.All patients underwent TEG,CCT and blood plate count (PLTs).The TEG and CCT results and there correlation were analyzed and the application value of TEG and CCT in the guidance of clinical rational blood use were compared.Results The blood clot formation time (K) was (3.92±1.08) min,reaction time (R) was (10.58±4.16) min,maximum amplitude (MA) was (42.34±10.92) mm,α-Angle (Angle) was (50.76±9.05)°,fibrinogen (FIB) was (2.03±0.85) g/L,prothrombin time (PT) was(16.41±5.36) s,activated partial prothrombin time (APTT) was (42.59±17.74) s,PLTs was (123.58±41.62)×109/L of 83 patients.K value was negatively correlated with FIB (P＜0.05).R was negatively correlated with FIB and positively correlated with PT and APTT (P＜0.05).MA was positively correlated with FIB and PLTs (P＜0.05).Angle was positively correlated with FIB and PLTs (P＜0.05).Under the guidance of TEG,platelet volume,plasma volume and cryoprecipitate volume were less than those of CCT,and the differences were statistically significant (P＜0.05).Conclusion There is a correlation between TEG and CCT.TEG examination is conducive to the complete and dynamic evaluation of the whole process of coagulation and the guidance of clinical rational blood use.In clinical work,TEG and CCT can be combined to objectively and accurately evaluate the coagulation state of patients and optimize the blood transfusion scheme of patients.
2022 Vol. 29 (17): 170-172转176 [Abstract] ( 18 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
173 Diagnostic value of serum prostate specific antigen,prostate specific antigen density,soluble epithelial cadherin levels in prostate cancer
XIANG Tianhe
Objective To investigate the serum prostate-specific antigen (PSA),prostate specific antigen density(PSAD) and soluble epithelial cadherin (sE-cad) in the diagnosis of prostate cancer.Methods A total of 300 prostate cancer patients admitted to Jianli Hospital of Traditional Chinese Medicine from April 2020 to April 2021 were selected as the research group,and 280 healthy male from Jianli Hospital of Traditional Chinese Medicine during the same period were selected as the control group.Serum Levels of PSA,PSAD and sE-cad were compared between the two groups.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of serum PSA,PSAD and sE-cad single and combined detection were analyzed by receiver operating characteristic (ROC) curve.Results The levels of serum PSA,PSAD and sE-cad in the study group were higher than those in the control group,and the differences were statistically significant (P＜0.05).The sensitivity,specificity and accuracy of PSA in the diagnosis of prostate cancer were 80.00%,90.00% and 84.43%.The sensitivity,specificity and accuracy of PSAD in the diagnosis of prostate cancer were 83.33%,92.86% and 87.93%.The sensitivity,specificity and accuracy of sE-cad were 66.67%,71.42% and 68.97%.The sensitivity,specificity and accuracy of combined detection were 96.67%,98.21%and 97.41%.The diagnostic value of combined detection was higher than that of single detection,and the difference was statistically significant (P＜0.05).ROC curve results showed that the areas under curve of serum PSA,PSAD and sE-cad single and combined detection were 86.2,87.6,68.2 and 96.8 respectively,95%CI were 0.829-0.894,0.845-0.907,0.638-0.727 and 0.957-0.980,respectively.The diagnostic efficacy of serum PSA,PSAD and sE-cad combined detection was higher than that of single detection,and the difference was statistically significant (P＜0.05).Conclusion The levels of serum PSA,PSAD and sE-cad in patients with prostate cancer are significantly increased.The combined detection of prostate cancer has high diagnostic value and is worthy of clinical application.
2022 Vol. 29 (17): 173-176 [Abstract] ( 32 ) HTML (1 KB)  PDF  (0 KB)  ( 17 )
177 Nursing research of integrated traditional Chinese and Western medicine in the concept of enhanced recovery after surgery in cesarean section
LIU Lan ；WAN Yan； WANG Mei； DING Lu； XIONG Xuelian； LONG Yajuan； CHEN Lingyan
 Objective To explore the application effect of integrated traditional Chinese and Western medicine nursing in the concept of enhanced recovery after surgery (ERAS) in cesarean section.Methods A total of 120 puerpera who underwent cesarean section in the Department of Obstetrics of Jiangxi Maternal and Child Health Hospital from January to October 2021 were selected as the research subjects,they were divided into intervention group and control group according to random number table method,with 60 cases in each group.The control group was treated with traditional nursing,and the intervention group was treated with integrated traditional Chinese and Western medicine nursing.Compare the self-rating anxiety scale (SAS),self-rating depression scale (SDS),pregnancy outcomes,neonatal outcomes,and puerpera′s satisfaction of two groups.Results Before nursing,there were no significant differences in SAS and SDS scores between the two groups (P＞0.05).After nursing,the SAS score and SDS score in two groups were lower than those before nursing,and the SAS and SDS scores of the intervention group were lower than those of the control group,the differences were statistically significant (P＜0.05).At 5,10 min and 1 d after delivery,the Apgar scores of the intervention group were higher than those of the control group,and the differences were statistically significant (P＜0.05).The Apgar score of newborns in the two groups at 10 min and 1 d after delivery was higher than that at 5 min after delivery,and the Apgar score at 1 d after delivery was higher than that at 10 min after delivery,the differences were statistically significant (P＜0.05).The total nursing satisfaction of the intervention group was 95.00%,which was higher than 80.00% of the control group,and the difference was statistically significant (P＜0.05).Conclusion The implementation of integrated traditional Chinese and Western medicine nursing in ERAS nursing for cesarean section can reduce maternal negative emotions,improve maternal and neonatal outcomes,and make maternal and family members recognize the hospital nursing mode and content,which is worthwhile in the clinical cesarean section process.
2022 Vol. 29 (17): 177-180 [Abstract] ( 21 ) HTML (1 KB)  PDF  (0 KB)  ( 13 )
181 Application effect of predictive nursing based on the Autar risk assessment scale in patients with coronary heart disease after percutaneous coronary intervention
XIONG Lina
Objective To investigate the application effect of predictive nursing based on the Autar risk assessment scale in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods A total of 80 patients with coronary heart disease who underwent PCI in Nanchang Third Hospital from September 2019 to September 2021 were selected as research objects.They were divided into the control group and the observation group according to random number table method,with 40 cases in each group.The control group received routine nursing,and the observation group received predictive nursing based on the Autar risk assessment scale.The incidence of postoperative deep venous thrombosis (DVT) was compared between the two groups,and the coagulation indexes (prothrombin time[PT],activated partial thromboplastin time [APTT],thrombin receptor [Tr],fibrinogen [Fbg]) before and after the intervention of the two groups were observed.The quality of life of the two groups before and after the intervention was evaluated by generic quality of life inventory 74(GQOLI-74),and the self-made Nursing Satisfaction Questionnaire was used to evaluate the nursing satisfaction of the two groups.Results The incidence of DVT in the observation group was 5.00%,which was lower than 25.00% in the control group,the difference was statistically significant (P＜0.05).The total satisfaction of nursing in the observation group was higher than that in the control group,the difference was statistically significant (P＜0.05).Before intervention,there were no significant differences in the levels of PT,APTT,Tr and Fbg between the two groups (P＞0.05).The levels of PT,APTT and Fbg in the two groups after intervention were higher than those before intervention,and the level of Tr in the two groups after intervention was lower than that before intervention,the differences were statistically significant(P＜0.05).After the intervention,the levels of PT,APTT and Fbg in the observation group were higher than those in the control group,and the level of Tr in the observation group was lower than that in the control group,the differences were statistically significant (P＜0.05).There were no significant differences in the scores of physical function,psychological function,life function and social function between the two groups before intervention (P＞0.05).After the intervention,the scores of physical function,psychological function,life function and social function in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Predictive nursing based on the Autar risk assessment scale can significantly reduce the incidence of DVT of patients with coronary heart disease after PCI,and improve coagulation indicators and quality of life
2022 Vol. 29 (17): 181-184 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
185 Application of cluster nursing in perioperative nursing of non inflatable transaxillary total endoscopic thyroidectomy
WU Yunyun； MAO Xiulian； CHEN Xiaomei； LIU Pinqian； LIU Huimin
Objective To analyze the effect of cluster nursing in perioperative nursing of non inflatable transaxillary total endoscopic thyroidectomy.Methods A total of 88 patients who underwent total endoscopic thyroidectomy without inflatable through axillary approach in the Department of Thoracic Surgery,Guangdong Nongken Central Hospital from May 2020 to May 2021 were selected as the research subjects.They were divided into the reference group and the intervention group by random number table method,with 44 cases in each group.Patients in the reference group were treated with routine intervention,and patients in the intervention group were treated with cluster nursing.Psychological status,total incidence of complications,nursing comfort,nursing satisfaction score,length of stay and treatment cost were compared between the two groups before and after nursing.Results The scores of self-rating anxiety scale (SAS)and self-rating depression scale (SDS) in the intervention group were higher than those in the reference group,and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of complications between the two groups (P＞0.05).The duration of hospitalization in the intervention group was shorter than that in the reference group,and the treatment cost was less than that in the reference group,the differences were statistically significant (P＜0.05).Kolcabal score and nursing satisfaction score of patients in the intervention group were higher than those in the reference group,the differences were statistically significant (P＜0.05).Conclusion For patients treated with non inflatable transaxillary total endoscopic thyroidectomy,actively carrying out cluster nursing in their perioperative nursing intervention is more conducive to improve their negative psychology.It can not only reduce the occurrence of postoperative complications and shorten the length of hospital stay,but also effectively improve patients′nursing comfort and satisfaction and reduce treatment costs.
2022 Vol. 29 (17): 185-188 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 14 )
189 Application effect of sleep psychological behavior mode in middle-aged and elderly patients with chronic insomnia
JIANG Qing ；HUANG Helong ；ZHANG Sairong
Objective To explore the application effect of sleep psychological behavior mode in middle-aged and elderly patients with chronic insomnia.Methods From April 2019 to December 2020,60 middle-aged and elderly patients with chronic insomnia treated in Jingdezhen Fourth People′s Hospital were selected as the research objects.They were divided into the control group and the observation group according to random number table method,30 cases in each group.The control group was implemented with routine nursing,the observation group was performed with sleep psychological behavior nursing on this basis.Pittsburgh sleep quality index (PSQI) and the self-report symptom inventory,symptom checklist-90 (SCL-90) were used to compare the sleep quality and mental health of the two groups before and after the intervention.Results Before intervention,there were no significant differences in the factor scores of PSQI scale between the two groups (P＞0.05).After 4 weeks of intervention,the factor scores of sleep quality,sleep time,length of sleep,sleep efficiency,sleep disorder,hypnotic drugs and daytime dysfunction and the total scores in the two groups were lower than those before intervention,the differences were statistically significant (P＜0.05).The factor scores of sleep quality,sleep time,length of sleep,sleep efficiency,sleep disorder,hypnotic drugs and daytime dysfunction and the total scores in the observation group after 4 weeks of intervention were lower than those in the control group,the differences were statistically significant (P＜0.05).Before intervention,there were no significant differences in SCL-90 factor scores between the two groups (P＞0.05).The scores of somatization,anxiety,depression and panic in the control group after 4 weeks of intervention were higher than those before intervention,while the scores of compulsion,interpersonal sensitivity,hostility,paranoia,psychosis of other 6 factors in the control group after 4 weeks of intervention were lower than those before intervention,the differences were statistically significant (P＜0.05).There was no significantly difference in the total score of SCL-90 between the control group after 4 weeks of intervention and before intervention (P＞0.05).The factor scores of somatization,anxiety,depression,panic,compulsion,interpersonal sensitivity,hostility,paranoia,psychosi of SCL-90 and the total scores of the observation group after 4 weeks of intervention were lower than those before intervention,the differences were statistically significant (P＜0.05).The factor scores of somatization,anxiety,depression,panic,compulsion,interpersonal sensitivity,hostility,paranoia and psychosis of SCL-90 and the total scores of in the observation group after 4 weeks of intervention were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion Sleep psychological behavior intervention is helpful to improve sleep quality,mental health and life quality of elderly patients with chronic insomnia.
2022 Vol. 29 (17): 189-192转196 [Abstract] ( 19 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
193 Effect of Chinese medicine directed drug penetration therapy on postoperative rehabilitation and bladder spasm in patients with benign prostatic hyperplasia
LIAO Yongqiang ；ZHANG Yuehong
Objective To explore the effect of Chinese medicine directed drug penetration therapy on postoperative rehabilitation and bladder spasm in patients with benign prostatic hyperplasia (BPH).Methods A total of 80 patients with BPH who underwent transurethral resection of the prostate (TURP) at No.909 Hospital of Joint Logistics Support Forces from January 2019 to December 2020 were selected and divided into two groups according to random number table method,with 40 cases in each group.The control group was given routine nursing intervention,and the observation group was treated with Chinese medicine directed drug penetration therapy,and the intervention continued until discharge.The postoperative rehabilitation,pain,quality of life,traditional Chinese medicine syndrome score and incidence of bladder spasm were compared between the two groups.Results The time of indwelling catheter,disappearance of hematuria and dilution of bladder flushing fluid in the observation group were shorter than those in the control group,the differences were statistically significant (P＜0.05).After the intervention,the scores of visual analogue scale (VAS),quality of life scale (QOL) and traditional Chinese medicine syndrome score in the observation group were lower than those in the control group,and the incidence of bladder spasm was lower than that in the control group,the differences were statistically significant (P ＜0.05).Conclusion The directional drug penetration therapy of traditional Chinese medicine can speed up the postoperative recovery of BPH patients,reduce body pain,reduce the occurrence of bladder spasm,and improve the quality of life of patients.
2022 Vol. 29 (17): 193-196 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )
Copyright © Editorial Board of 中国当代医药
Supported by:Beijing Magtech