替诺福韦酯联合双重免疫方案阻断慢性乙型肝炎病毒携带孕妇母婴病毒传播的临床效果

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Abstract Objective To investigate the clinical effect of Tenofovir Dipivoxil combined with dual immunization regimen in blocking the transmission of mother-to-child from pregnant women with chronic hepatitis B virus (HBV).Methods A total of 70 pregnant women with HBV who were admitted to Yangjiang Public Health Hospital from September 2019 to September 2020 were selected as the research subjects.They were divided into control group and observation group according to random number table method,with 35 cases in each group.The control group was not given anti-antibiotics during pregnancy.The observation group took Tenofovir Dipivoxil at 24 to 28 week of gestation until delivery.Both groups of newborns were given a dual immunization program after birth (Hepatitis B Human Immunoglobulin 200 μg intramuscular injection + Recombinant Hepatitis B Vaccine 20 μg intramuscular injection at 0,1 and 6 month).The liver function indexes,HBV DNA levels,newborn HBV infection status,newborn conditions and drug safety were compared between the two groups.Results There were no significant differences in the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) between the two groups before treatment and during delivery (P＞0.05).There was no significant difference in the HBV DNA between the two groups before treatment (P＞0.05).The HBV DNA level of the observation group was lower than that of the control group during delivery,and the difference was statistically significant (P＜0.05).At delivery,after 6 and 12 months of treatment,the positive rates of hepatitis B surface antigen (HBsAg) and HBV in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).There was no significant difference in Apgar score between the two groups(P＞0.05).No significant adverse reactions occurred in two groups.Conclusion Tenofovir Dipivoxil combine with dual immunization program has a significant effect in blocking the transmission of mother-to-child from pregnant women with HBV virus.It can effectively reduce the level of HBV DNA during delivery and reduce the rate of HBV infection in newborns with high safety.

Key words： Chronic hepatitis B virus Tenofovir Disoproxil Hepatitis B Human Immunoglobulin Recombinant Hepatitis B Vaccine Mother-to-child transmission

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	JIANG Xianxing
	HONG Yongmeng
	CHEN Xing

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JIANG Xianxing,HONG Yongmeng,CHEN Xing. Clinical effect of Tenofovir Dipivoxil combined with dual immunization regimen in blocking the transmission of mother-to-child virus from pregnant women with chronic hepatitis B virus[J]. 中国当代医药, 2022, 29(17): 66-69.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I17/66

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