DNA错配修复蛋白表达缺失与胃癌临床病理特征相关性的meta分析

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Abstract Objective To comprehensively evaluate the correlation between the deficient DNA mismatch repair protein(dMMR) and clinicopathological features of gastric cancer using meta-analysis.Methods Keywords were searched from PubMed,Web of Science,Embase database,CNKI,WanFang and VIP database for relevant studies on DNA mismatch repair (MMR) protein expression and clinicopathological features of gastric cancer from the database construction to June 2021.Cochrane was used to screen the literature and extract data,and the quality of the included literature was evaluated according to the Newcastle-Ottawa scale (NOS).Finally,meta-analysis was performed using Review Manager 5.4.1.Results A total of 13 studies were included,including 5075 gastric cancer patients,530 of whom were dMMR patients,accounting for 10.44%.Meta-analysis showed that tumor location was significantly correlated with dMMR(OR=0.60,95%CI=0.47-0.76, P＜0.0001).Lauren typing was significantly correlated with dMMR (OR=2.56,95%CI=1.49-4.39, P=0.0007).dMMR was significantly correlated with gastric cancer without lymph node metastasis (OR=1.40,95%CI=1.12-1.75, P=0.003).There was no significant correlation between TNM staging and dMMR (OR=1.47,95%CI=0.88-2.44,P=0.14).dMMR was significantly associated with gastric cancer with lymphatic infiltration (OR=1.70,95%CI=1.23-2.36, P=0.001).There was no publication bias in all subgroups (P＞0.05).Conclusion dMMR has significant clinicopathological features in gastric cancer patients,which is of great value for diagnosis and clinical treatment.

Received: 01 November 2021

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	YE Chuan LIANG Peng HE Zhengyue ZHANG Weishan LIU Zhi▲

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YE Chuan LIANG Peng HE Zhengyue ZHANG Weishan LIU Zhi▲. Meta-analysis of the correlation between the deficient DNA mismatch repair protein and clinicopathological features of gastric cancer[J]. 中国当代医药, 2022, 29(17): 13-17.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I17/13

[12]	Sugimoto R，Endo M，Osakabe M，et al.Immunohistochemical Analysis of Mismatch Repair Gene Proteins in Early Gastric Cancer Based on Microsatellite Status[J].Digestion，2021，102（5）：691-700.
[13]	屈重行，刘艳红，葛瑞瑞，等.胃癌组织中p53 蛋白表达和微卫星不稳定及其与预后的相关性研究[J].肿瘤学杂志，2019，25（8）：698-702.
[14]	麻婧，钱美睿，李建辉，等.微卫星不稳定型胃癌及微卫星稳定型胃癌的免疫分型及预后分析[J].西安交通大学学报（医学版），2019，40（6）：927-932.
[1]	Baretti M，Le DT.DNA mismatch repair in cancer[J].Pharmacol Ther，2018，189：45-62.
[2]	Jiricny J.The multifaceted mismatch-repair system[J].Nat Rev Mol Cell Biol，2006，7（5）：335-346.
[3]	Cho J，Kang SY，Kim KM.MMR protein immunohistochemistry and MSI in gastric cancers[J].Pathology，2019，51（1）：110-113.
[4]	McCarthy AJ，Capo-Chichi JM，Spence T，et al.Heterogenous loss of mismatch repair（MMR）protein expression：a challenge for immunohistochemical interpretation and microsatellite instability （MSI）evaluation[J].J Pathol Clin Res，2019，5（2）：115-129.
[5]	Inada R，Sekine S，Taniguchi H，et al.ARID1A expression in gastric adenocarcinoma：Clinicopathological significance and correlation with DNA mismatch repair status[J].World J Gastroenterol，2015，21（7）：2159-2168.
[6]	Zhang L，Wang Y，Li Z，et al.Clinicopathological features of tumor mutation burden，Epstein-Barr virus infection，MSI and PD-L1 status in Chinese patients with gastric cancer[J].Diagn Pathol，2021，16（1）：38.
[7]	Tanabe H，Mizukami Y，Takei H，et al.Clinicopathological characteristics of Epstein-Barr virus and microsatellite instability subtypes of early gastric neoplasms classified by the Japanese and the World Health Organization criteria[J].J Pathol Clin Res，2021，7（4）：397-409.
[8]	Miceli R，An J，Di Bartolomeo M，et al.Prognostic Impact of MSI in Asian Gastric Cancer Patients Enrolled in the ARTIST Trial[J].Oncology，2019，97（1）：38-43.
[9]	Park JH，Kim EK，Kim YH，et al.Epstein-Barr virus positivity，not mismatch repair-deficiency，is a favorable risk factor for lymph node me tastasis in submucosa-invasive early gastric cancer[J].Gastric Cancer，2016，19（4）：1041-1051.
[10]	Salari S，Ghadyani M，Karimi M，et al.Immunohistochemical Expression Pattern of MLH1，MSH2，MSH6，and PMS2 in Tumor Specimen of Iranian Gastric Carcinoma Patients[J].J Gastrointest Cancer，2022，53（1）：192-196.
[11]	刘欢，孙丹，李文会，等.DNA 错配修复蛋白表达与胃腺癌临床病理特征的关系及意义[J].现代肿瘤医学，2019，27（15）：2702-2708.
[15]	Karpińska-Kaczmarczyk K，Lewandowska M，Lawniczak M，et al.Expression of Mismatch Repair Proteins in Early and Advanced Gastric Cancer in Poland[J].Med Sci Monit，2016，22：2886-2892.
[16]	Mathiak M，Warneke VS，Behrens HM，et al.Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited：Urgent Need for Standardization[J].Appl Immunohistochem Mol Morphol，2017，25（1）：12-24.
[17]	Pereira MA，Ramos MFKP，Faraj SF，et al.Clinicopathological and prognostic features of Epstein-Barr virus infection，microsatellite instability，and PD-L1 expression in gastric cancer[J].J Surg Oncol，2018，117（5）：829-839.
[18]	Choi YY，Kim H，Shin SJ，et al.Microsatellite Instability and PD-L1 Expression in Stage Ⅱ/ⅢGastric Cancer：Post Hoc Analysis of the Classic Randomized Controlled study[J].Ann Surg，2019，270（2）：309-316.
[19]	Schiefer AI，Schoppmann SF，Birner P.Lymphovascular invasion of tumor cells in lymph node metastases has a negative impact on survival in esophageal cancer[J].Surgery，2016，160（2）：331-340.
[20]	Sakuragi N，Takeda N，Hareyama H，et al.A multivariate analysis of blood vessel and lymph vessel invasion as predictors of ovarian and lymph node metastases in patients with cervical carcinoma[J].Cancer，2000，88（11）：2578-2583.
[21]	Mei D，Zhao B，Zhang J，et al.Impact of Lymphovascular Invasion on Survival Outcome in Patients With Gastric Cancer[J].Am J Clin Pathol，2020，153（6）：833-841.
[22]	Liu E，Zhong M，Xu F，et al.Impact of lymphatic vessel invasion on survival in curative resected gastric cancer[J].J Gastrointest Surg，2011，15（9）：1526-1531.