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| Diagnostic value of serum prostate specific antigen,prostate specific antigen density,soluble epithelial cadherin levels in prostate cancer |
| XIANG Tianhe |
| Department of Laboratory,Jianli Hospital of Traditional Chinese Medicine |
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Abstract Objective To investigate the serum prostate-specific antigen (PSA),prostate specific antigen density(PSAD) and soluble epithelial cadherin (sE-cad) in the diagnosis of prostate cancer.Methods A total of 300 prostate cancer patients admitted to Jianli Hospital of Traditional Chinese Medicine from April 2020 to April 2021 were selected as the research group,and 280 healthy male from Jianli Hospital of Traditional Chinese Medicine during the same period were selected as the control group.Serum Levels of PSA,PSAD and sE-cad were compared between the two groups.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of serum PSA,PSAD and sE-cad single and combined detection were analyzed by receiver operating characteristic (ROC) curve.Results The levels of serum PSA,PSAD and sE-cad in the study group were higher than those in the control group,and the differences were statistically significant (P＜0.05).The sensitivity,specificity and accuracy of PSA in the diagnosis of prostate cancer were 80.00%,90.00% and 84.43%.The sensitivity,specificity and accuracy of PSAD in the diagnosis of prostate cancer were 83.33%,92.86% and 87.93%.The sensitivity,specificity and accuracy of sE-cad were 66.67%,71.42% and 68.97%.The sensitivity,specificity and accuracy of combined detection were 96.67%,98.21%and 97.41%.The diagnostic value of combined detection was higher than that of single detection,and the difference was statistically significant (P＜0.05).ROC curve results showed that the areas under curve of serum PSA,PSAD and sE-cad single and combined detection were 86.2,87.6,68.2 and 96.8 respectively,95%CI were 0.829-0.894,0.845-0.907,0.638-0.727 and 0.957-0.980,respectively.The diagnostic efficacy of serum PSA,PSAD and sE-cad combined detection was higher than that of single detection,and the difference was statistically significant (P＜0.05).Conclusion The levels of serum PSA,PSAD and sE-cad in patients with prostate cancer are significantly increased.The combined detection of prostate cancer has high diagnostic value and is worthy of clinical application.
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| [1] |
徐静，徐艳艳，于成勇.血清PSA、PSAD、ALP 联合检测对前列腺癌骨转移的临床诊断价值[J].癌症进展，2018，16（7）：121-123.
|
| [2] |
黄聪，林文强，林腾.PSA 和PA 比值、PSAD 对低水平PSA前列腺癌的诊断价值[J].汕头大学医学院学报，2018，31（4）：206-210.
|
| [3] |
郭放，刘兆喆，谢晓冬.NCCN 前列腺癌临床治疗指南更新要点解读与探讨[J].中华泌尿外科杂志，2013，34（12）：949-951.
|
| [4] |
匡小跟，张晖辉，许韩峰，等.钙黏蛋白E、桥粒芯糖蛋白2、磷酸化Akt 和转录因子Snail 在侵袭性前列腺癌中的作用[J].中国现代医学杂志，2016，26（8）：38-43.
|
| [5] |
黄顺坛，潘楚灶，唐顺利.前列腺特异性抗原密度结合游离前列腺特异抗原比值在灰区前列腺癌的鉴别诊断价值[J].齐齐哈尔医学院学报，2019，40（1）：56-57.
|
| [6] |
高国栋，张庆云，易利，等.Cyr61 在前列腺癌组织中的表达及其对前列腺癌细胞增殖、上皮间质转化和自噬的影响[J].广东医学，2019，40（11）：35-41.
|
| [7] |
陈志远，张艳，周懂晶，等.PSA 密度与PI-RADS（第二版）对各PSA 区间前列腺癌的诊断价值[J].中国医学计算机成像杂志，2018，24（2）：147-151.
|
| [9] |
古志聪，陈南辉，杨日辉，等.前列腺PI-RADSV2.1 评分联合血清PSA 相关指标对灰区前列腺癌的诊断价值研究[J].现代生物医学进展，2021，21（7）：5.
|
| [10] |
周毅，姚远，杨剑文，等.上皮-间质转化调控蛋白在前列腺癌侵袭、转移中的作用及其临床预后诊断价值[J].华中科技大学学报（医学版），2017，46（4）：397-403.
|
| [11] |
胡新红，张涛.血清相关因子对前列腺癌病理分期的预测价值[J].中国肿瘤临床与康复，2020，27（11）：4.
|
| [12] |
孙珂，高佃军.tPSA 灰区f/tPSA 与PSAD 对前列腺癌与前列腺增生伴前列腺炎的诊断价值[J].临床医学，2019，39（4）：3.
|
| [8] |
陈文颖，陈磊，郭倩，等.不同血清前列腺特异抗原水平下超声引导经会阴前列腺系统穿刺与认知融合多参数磁共振成像经会阴靶向穿刺对前列腺癌诊断价值的比较[J].中华超声影像学杂志，2021，30（3）：243-248.
|
| [13] |
侯传胜，马强，贾国金，等.PI3K/AKT 途径在调节侵袭性前列腺癌中的E-钙黏蛋白和桥粒芯糖蛋白2 中的作用[J].解剖学研究，2019，41（1）：57-62.
|
| [14] |
王士锋，王健.血清学检测联合前列腺超声造影对老年患者前列腺癌的诊断价值分析[J].中国性科学，2020，29（2）：4.
|
| [15] |
杨春华，刘宁，曹航，等.特异性核基质结合区结合蛋白1与E-钙黏蛋白、波形蛋白在前列腺癌组织的表达及相关性[J].中华实验外科杂志，2015，32（12）：2950-2952.
|
| [16] |
黄国权，蔡二朋，徐芳.PI-RADSv2 评分联合PSA，PSAD检测在有临床意义前列腺癌中的诊断价值[J].医学影像学杂志，2020，30（8）：5.
|
| [17] |
范润萍，包叶江，张毅敏，等.NLR 联合T-PSA 检测在前列腺癌诊断中的应用价值[J].中国医师杂志，2018，20（12）：1837.
|
| [18] |
陈燕君.研究fPSA/tPSA、PSAD、PSATZ 对前列腺癌诊断的意义[J].外科研究与新技术，2018，7（1）：3.
|
|
|
|
