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Quick Search     Adv Search 2022 Vol. 29, No. 8 Published: 2022-03-18   7 Comparison of clinical effect of transcatheter arterial chemoembolization combined with microwave ablation and Apatinib Mesylate in treatment of intermediate and advanced primary liver cancer DENG Zefeng Objective To investigate the clinical effect of transcatheter arterial chemoembolization (TACE) combined with microwave ablation and Apatinib Mesylate in the treatment of intermediate and advanced primary liver cancer.Methods A total of 92 patients with primary liver cancer who were treated in the Department of Oncology of Jiujiang Third People′s Hospital from January 2018 to May 2019 were selected as subjects. They were divided into the microwave ablation group and the Apatinib Mesylate group according to random number table method, with 46 cases in each group. The microwave ablation group was given TACE combined with microwave ablation, and the Apatinib Mesylate group was given TACE combined with Apatinib Mesylate. The disease control rate (DCR), serum marker levels(serum alpha-fetoprotein [AFP], vascular endothelial growth factor [VEGF], matrix metalloproteinase-9 [MMP-9], cysteine aspartic proteinase-8 [caspase-8]), adverse events, and short-term survival rate were compared between the two groups. Results The DCR in the microwave ablation group was higher than that in the Apatinib Mesylate group, and the total incidence of adverse events in the microwave ablation group was lower than that in the Apatinib Mesylate group,with statistically significant differences (P<0.05). After treatment, the levels of serum AFP, VEGF and MMP-9 in the microwave ablation group were lower than those in the Apatinib Mesylate group, and the level of caspase-8 in the microwave ablation group was higher than that in the Apatinib Mesylate group, with statistically significant differences (P<0.05). There was no statistically significant difference in the one-year survival rate between the two groups (P>0.05).Conclusion TACE combined with Apatinib Mesylate or microwave ablation has a certain effect in the treatment of intermediate and advanced primary liver cancer. The two therapies have similar short-term survival rate, but TACE combined with microwave ablation has a better effect and the advantage of improving serum marker levels. 2022 Vol. 29 (8): 7-10 [Abstract] ( 48 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 11 Hemostatic effect of injecting Longxuejie Powder dissolving solution into medical swelling sponge on patients of chronic sinusitis with nasal polyps resection under nasal endoscopy WU Weikun CAO Jian XIONG Meihua WAN Jinhua FU Huanhuan Objective To evaluate the hemostatic effect of injecting Longxuejie Powder dissolving solution into medical swelling sponge on patients of chronic sinusitis with nasal polyps resection under nasal endoscopy. Methods From October 2014 to May 2021, 40 patients of bilateral chronic sinusitis with nasal polyps resection under nasal endoscopy who were treated in Jiangxi Province Hospital of Chinese and Western Combination were used as research subjects.They were divided into observation group and control group by random number table method, 20 cases in each group.Observation group was treated with injecting Longxuejie Powder dissolving solution into medical swelling sponge for hemostasis. Patients in control group were treated with 0.9% normal saline injection of medical expandable sponge for hemostasis. The curative effect of nasal hemostasis and nasal mucosahealing were observed and compared between the two groups. Results The total effective rate of hemostasis in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the scores of symptoms and signs between the two groups before treatment (P>0.05). The improvement of symptoms and signs in the observation group was better than that in the control group after treatment, and the difference was statistically significant (P<0.05). After treatment, the amount and frequency of bleeding, nasal congestion, dizziness, nasal mucosa, secretions, polyps, scars, scabs scores and total scores of the two groups were lower than those before treatment, and the differences were statistically significant (P<0.05). The scores of amount and frequency of bleeding, nasal congestion, dizziness, nasal mucosa, secretions and polyps in the observation group were lower than those in the control group after treatment, and the differences were statistically significant (P<0.05). However, there were no significant differences between the two groups in the scores of changes in scars and scabs after treatment (P>0.05). Conclusion After polyps resection of chronic sinusitis under nasal endoscopy, nasal injection of Longxuejie Powder dissolving solution for medical expansion and packing to stop bleeding has high clinical value, and the postoperative nasal mucosa healed well, which is worthy of clinical application and promotion. 2022 Vol. 29 (8): 11-14转20 [Abstract] ( 37 ) HTML (1 KB)  PDF (705 KB)  ( 50 ) 15 Preparation and in vitro transdermal penetration of oil-in-oil capsaicin emulsion ZHONG Zhong1 Yang Dihua2 MAI Yunhua1 Objective To prepare oil-in-oil capsaicin emulsion to control the release rate of capsaicin and prolong the latent itching time. Methods The oil-in-oil capsaicin emulsion was prepared by high pressure homogenization using orthogonal test, and transdermal test was conducted in vitro using modified Franz diffusion cell. The optimal formulation was selected by using the steady-state diffusion rate (Js) and centrifugal stability as indexes. The effect of dextran induced pruritus in mice was determined. The experimental group (n=8) and the commercial sale group (n=8) were given oil-in-oil capsaicin emulsion and commercial capsaicin ointment, respectively, and the blank control group (n=8) were given equal volume of normal saline. The latency time and itching times of each group were compared. Results The optimal formula of oil-in-oil capsaicin emulsion was 0.5 phase volume ratio, 500 mPa·s viscosity of silicone oil and 2%dosage of Triton X100. The transdermal rate of oil-in-oil capsaicin emulsion was lower than that of hydrophilic pepper cream. The latency time of the experimental group was longer than that of the blank control group and the commercial sale group, and the itching frequency was less than that of the blank control group and the commercial sale group, the differences were statistically significant (P<0.05). Conclusion The oil-in-oil capsaicin emulsion have good sustained release effect, high drug loading and little irritation. It is hopeful to be used in the treatment of chronic pruritus. 2022 Vol. 29 (8): 15-20 [Abstract] ( 40 ) HTML (1 KB)  PDF (827 KB)  ( 97 ) 21 Predictive value of N-terminal pro brain natriuretic peptide combined with neutrophil lymphocyte ratio in intravenous immunoglobulin unresponsive Kawasaki disease DENG Jianrong； LIN Xiaoqin； RUAN Yucai；PENG Lijun； NIE Yuzhe； XIAO Xiaobing Objective To investigate the predictive value of N-terminal pro brain natriuretic peptide combined with the ratio of neutrophils to lymphocytes in intravenous immunoglobulin unresponsive Kawasaki disease. Methods A total of 120 children with Kawasaki disease treated in pediatrics of North Guangdong People′s Hospital from January 2019 to July 2021 were selected as the research objects. According to whether they responded to gamma globulin, they were divided into non response group and sensitive group, with 60 cases in each group. At the same time, 30 healthy children were collected as the control group. The three groups of research objects were tested by serum and color Doppler echocardiography. The levels of amino terminal brain natriuretic peptide precursor, neutrophil lymphocyte ratio, leukocyte count, C-reactive protein, platelet, erythrocyte sedimentation rate, albumin and blood sodium of the three groups were compared. Pearson correlation analysis was used to analyze the correlation between amino terminal brain natriuretic peptide precursor and leukocyte count, C-reactive protein, platelet, erythrocyte sedimentation rate, albumin and blood sodium, ROC curve analysis of the predictive value of amino terminal pro brain natriuretic peptide and the ratio of neutrophils to lymphocytes in the diagnosis of Kawasaki disease alone and in combination. Results The amino terminal brain natriuretic peptide precursors, neutrophil to lymphocyte ratio, white blood cell count, C-reactive protein,platelet and erythrocyte sedimentation rate were higher in non-reactive group and sensitive group than those in control group, while the levels of albumin and serum sodium were lower than those in control group, the differences were statistically significant (P<0.05). There were no significant differences in amino terminal brain natriuretic peptide precursors, neutrophil to lymphocyte ratio, white blood cell count, C-reactive protein, platelet, erythrocyte sedimentation rate, albumin and serum sodium levels between non-reaction group and sensitive group (P>0.05). The amino terminal brain natriuretic peptide precursors were positively correlated with white blood cell count count and C-reactive protein (P<0.05). The amino terminal brain natriuretic peptide precursors were negatively correlated with albumin and serum sodium levels (P<0.05). There was no correlation between amino terminal brain natriuretic peptide precursor and platelet and erythrocyte sedimentation rate (P>0.05). The sensitivity and specificity of N-terminal pro brain natriuretic peptide in the diagnosis of gamma globulin unresponsive Kawasaki disease were 66.67% and 80.00%, and the sensitivity and specificity of their combined detection in the diagnosis of gamma globulin unresponsive Kawasaki disease were 91.67% and 96.67%. Conclusion N-terminal pro brain natriuretic peptide combined with neutrophil lymphocyte ratio is not only helpful for the diagnosis of intravenous gamma globulin unresponsive Kawasaki disease, but also has a good value in predicting coronary artery damage. 2022 Vol. 29 (8): 21-24 [Abstract] ( 42 ) HTML (1 KB)  PDF (699 KB)  ( 31 ) 25 Relationship between vulnerability of asymptomatic carotid artery plaque,laboratory indicators and its influence on the occurrence of cerebrovascular ischemic events in patients at high risk of stroke HU Binbin LUO Chenghong LU Weiheng LIU Qun Objective To investigate the relationship between vulnerability of asymptomatic carotid artery plaque, laboratory indicators and influence on the occurrence of cerebrovascular ischemic events in high-risk patients with stroke.Methods The clinical data of 120 patients with asymptomatic carotid plaque who underwent stroke screening in Dongguan Songshan Lake Central Hospital from June 2017 to June 2020 were retrospectively reviewed. According to the results of carotid ultrasound, all patients with high risk of stroke were divided into stable plaque group (n=71) and vulnerable plaque group (n=49). The basic data and laboratory index levels of the two groups were compared, and the risk factors of cerebral ischemic events in the high-risk population of stroke were analyzed. Results There were no significant differences in levels of fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and homocysteine (Hcy) in peripheral blood between stable plaque group and vulnerable plaque group (P>0.05). The levels of low-density lipoprotein cholesterol (LDL-C) and cystatin C (CysC) in peripheral blood in vulnerable plaque group were higher than those in stable plaque group, and the differences were statistically significant (P<0.05). Univariate analysis showed that there were no significant differences in gender, age, body mass index, FPG, TC, TG, HDL-C and Hcy between two groups (P>0.05). There were statistically significant differences in plaque properties, LDL-C and CysC levels (P<0.05). Multivariate analysis showed that the levels of vulnerable plaques(β=1.784, OR=2.546, 95%CI=1.734-2.996), LDL-C (β=1.695, OR=2.198, 95%CI=1.453-2.760) and CysC (β=1.564,OR=1.754, 95%CI=1.176-2.488) were independent risk factors for cerebral ischemic events in high-risk stroke population (P<0.05). Conclusion Patients at high risk of stroke complicates with vulnerable asymptomatic carotid artery plaque have abnormal levels of LDL-C and CysC, which are independent risk factors for subsequent cerebral ischemic events. 2022 Vol. 29 (8): 25-28 [Abstract] ( 43 ) HTML (1 KB)  PDF (684 KB)  ( 28 ) 29 Application effect of volar locking plate internal fixation on wrist joint function in patients with distal radius fracture WU Jie Objective To investigate the application effect of palm locking plate fixation in distal radial fracture.Methods A total of 84 patients with distal radial fracture treated in Central Hospital of Shenyang Medical College from September 2019 to August 2020 were selected as the study subjects and divided into control group and observation group by random touching ball method, with 42 cases each. The control group used dorsal approach surgery, and the observation group used internal fixation of palm locking steel plate. the radial recovery, pain degree, wrist function, perioperative indicators and quality of life were compared between the two groups. Results The radial height, palm inclination angle and ultar deviation angle were bigger than those in the control group (P<0.05). Postoperative observation groups, grip force and wrist activity were higher than those in control groups, and the differences were statistically significant (P<0.05). The VAS score of the observation group at 1, 2 weeks and 1 month after operation were lower than those of the control group, the differences were statistically significant (P＜0.05). The VAS score of the control group after 1, 2 weeks and 1 month were compared, the differences were statistically significant (P<0.05). The VAS score of the control group at 2 weeks after the operation was lower than that at 1 week after operation, and the difference was statistically significant (P<0.05). The VAS score of the control group at 1 month after operation was lower than that at 1 weeks and 2 weeks after operation, the difference was statistically significant (P＜0.05). The VAS score of the observation group after 1, 2 weeks and 1 month were compared, the differences were statistically significant (P<0.05). The VAS score of the observation group at 2 weeks after the operation was lower than that of 1 week after operation, the difference was statistically significant (P<0.05); the VAS score of the observation group at 1 month after the operation was lower than that at 1, 2 weeks after operation, and the differences were statistically significant (P＜0.05). The operation time, hospitalization time and healing time of the observation group were shorter than those of the control group, the differences were statistically significant (P<0.05); the bleeding volume of the observation group was less than that of the control group, the difference was statistically significant (P<0.05). Conclusion In the treatment of patients with distal radius fractures with locking plate internal fixation, volar approach surgery can effectively improve the fracture reduction of the patients, increase the palmar and ulnar deflection angles, improve the wrist joint function of the patients, reduce the degree of pain, the operation time and blood loss. The effect is remarkable and it is worthy of promotion. 2022 Vol. 29 (8): 29-32 [Abstract] ( 44 ) HTML (1 KB)  PDF (637 KB)  ( 19 ) 33 Progress in the treatment of contrast nephropathy CHEN Yu QIN Yan ZENG Qing Contrast-induced nephropathy (CIN) is a common reversible acute renal failure in clinical practice. The incidence rate of CIN is increasing annually with the widely use of contrast agents such as angiography, coronary angiography, cerebral angiography, or other medical related radiography (urography and cholangiography). It has been an important cause of acute kidney injury after ischemia and drug injury. Nowadays, the mechanism of CIN induced by contrast agent is not completely clear, mainly including oxidative stress and apoptosis. In addition, many studies have also found that renal ischemia and tubular toxic injury are also the key pathological mechanisms of CIN. The occurrence of CIN is not only related to the increased medical expenses, but also leads to a significant increase in the risk of adverse outcomes (such as acute myocardial infarction, acute heart failure, dialysis and death). Therefore, early identification of risk factors for CIN and appropriate clinical intervention will help high-risk CIN patients benefit from early renal protection strategies and improve prognosis. This study reviews the diagnosis of CIN and the progress of current treatment measures, so as to provide basis for clinical practice. 2022 Vol. 29 (8): 33-36转41 [Abstract] ( 49 ) HTML (1 KB)  PDF (765 KB)  ( 105 ) 37 Research progress on application of three skin expanding methods in peripherally inserted central catheter WANG Hejin1 HE Jin′ai2▲ HE Jinwei1 LI Xiaoling1 Peripherally inserted central catheter (PICC) has the obvious advantages of reducing the pain caused by repeated venipuncture, protecting the patient′s blood vessels, avoiding drug extravasation caused by stimulating drug infusion through peripheral blood, and reducing the workload of nursing staff. At present, there are three methods of dilatation in clinical practice, they are, traditional dilatation knife method, blunt separation method and small incision combined with dilator blunt separation method. Thrombocytopenia is relatively contraindicated for PICC catheterization.Therefore, in the nursing process after catheterization, it is necessary to focus on key issues such as local bleeding and petechiae at the puncture point in patients with less platelets. This paper reviews the research progress of the application of three skin expansion methods in peripherally inserted central catheter, compares and analyzes their operation steps and the amount of bleeding, puts forward the enlightenment of PICC catheterization in patients with thrombocytopenia. Small incision combined with blunt separation of expander can effectively reduce the injury and bleeding of catheterization, it can play a better therapeutic effect and has important clinical application and research significance.However, in order to make the catheterization method widely used, for the special group of people with thrombocytopenia in vivo, more in-depth clinical exploration, improvement and optimization of the operation method are needed. This paper is expected to provide reference for further clinical research. 2022 Vol. 29 (8): 37-41 [Abstract] ( 44 ) HTML (1 KB)  PDF (764 KB)  ( 210 ) 42 Analysis of the clinical characteristics of 836 patients with pancytopenia WANG Huan YE Fang▲ LI Ningning SHU Ya′nan TONG Chun WANG Ling ZHANG Linan Objective To investigate the clinical characteristics of patients with pancytopenia in the third-class comprehensive hospital preliminarily. Methods A total of 836 patients with pancytopenia in our hospital from January 2016 to October 2020 were selected as the subjects, and divided into hemotopathy group (287 cases) and non-hemotopathy group (488 cases). The blood cell reduction degree were compared between the two groups. The distribution and cause of all patients were analyzed and summarized. Results Among the 836 patients, the degree of pancytopenia was mainly mild or moderate.There were 785 cases(93.9%)of mild and moderate anemia,Pations of platelet count([75-<125]×109/L)was 21 cases(62.32%),WBC count([2.0-<3.5]×109/L)was 763 cases(91.15%).Patients with pancytopenia were mainly distributed in Department of Haematology, Department of Emergency, Department of Respiratory Medicine, Department of General Surgery,Department of Gastroenterology,Department of Cardiology and other departments.According to the etiology, the 836 patients were divided into 287 cases (34.33%) of hemotopathy and 488 cases (58.37%) of non-hemotopathy.In hematopoietic system, megaloblastic anemia mainly accounted for 35.19%, followed by myelodysplastic syndrome(19.16%). In non-hematopoietic system, infection disease accounted for 34.06%, followed by metastatic tumor (18.5%).The decrease degree of leukocyte, hemoglobin and platelet in hemotopathy was higher than that in non-hemotopathy, the difference was statistically significant(P<0.05).Conclusion Clinicians of all specialties should pay attention to finding the etiology of pancytopenia,and improve the level of diagnosis and treatment. Pancytopenia is mainly caused by hematopoietic disorders, non-hematopoietic diseases also accounts for a certain percentage. Bone marrow cytology and laboratory tests should be actively performed to confirm the diagnosis and avoid missed diagnosis and misdiagnosis. 2022 Vol. 29 (8): 42-46 [Abstract] ( 46 ) HTML (1 KB)  PDF (577 KB)  ( 36 ) 47 Expression and clinicopathological analysis of protein gene product 9.5 in endometrioid carcinoma ZENG Fancheng1 LIU Lanlan2 YANG Jingzhen2 Objective To investigate the expression of protein gene product 9.5 (PGP 9.5) in endometrioid carcinoma and its relationship with clinicopathological characteristics. Methods From January 2017 to December 2020, 91 patients with endometrioid cancer and 20 healthy patients who were admitted to Ganzhou Maternity and Child Health Hospital were selected as the research objects, and their tissue specimens of endometrioid cancer and normal endometrium were collected.Tissue specimens were prepared and sectioned.PGP 9.5 was stained by immunohistochemical experiments and the results were interpreted. The expression of PGP 9.5 in normal endometrial tissue and endometrioid carcinoma tissue was compared. The cancer specimens were divided into high expression group and low expression group. The clinicopathological characteristics such as age, tumor diameter, histological grade, muscle invasion, cervical canal involvement, lymph node metastasis, vascular involvement, adnexal involvement, Federation International of Gynecology and Obstetrics (FIGO) staging, etc. were compared between the two groups. Results The results of immunohistochemical experiments showed that the positive expression rate of PGP 9.5 in normal endometrial tissues was lower than that in endometrioid carcinoma tissues, and the difference was statistically significant (P<0.05). The age of the two groups of patients were compared, and the difference was not statistically significant (P>0.05). The tumor diameter, histological grade, myometrial infiltration, cervical canal involvement, lymph node metastasis, vascular involvement, adnexal involvement, FIGO staging were compared between the two groups, and the differences were statistically significant(P<0.05).Conclusion The expression level of PGP 9.5 in endometrioid carcinoma tissues and normal endometrial tissues is different, indicating that the protein gene product has a role in the process of endometrial tissue transforming from normal to endometrioid carcinoma. Important regulatory role. Therefore, it can be used as an effective predictor of the prognosis of endometrioid carcinoma, providing new ideas and new methods for clinical treatment of endometrioid carcinoma, which can create certain social benefits. 2022 Vol. 29 (8): 47-50 [Abstract] ( 38 ) HTML (1 KB)  PDF (957 KB)  ( 123 ) 51 Effect of medical thoracoscopy combined with different schemes in the treatment of tuberculous encapsulated pleural and peritoneal effusion LIU Lu QIAN Xiaojun▲ JIE Yunyun Objective To evaluate the therapeutic effect and safety of three different treatment schemes of medical thoracoscopy, medical thoracoscopy combined with microcapsule vaccine and medical thoracoscopy combined with cryotherapy in the treatment of tuberculous encapsulated pleural and peritoneal effusion, so as to find out the best clinical treatment scheme. Methods A total of 60 patients with tuberculous encapsulated pleural and peritoneal effusion treated in Yichun People′s Hospital from January 2019 to December 2020 were selected as the research objects. They were divided into group X (20 cases), group W (20 cases) and group L (20 cases) according to random number table method. Group X used the medical thoracoscopy, group W used medical thoracoscopy combined with microcapsule vaccine, and group L used medical thoracoscopy combined with cryotherapy. The disappearance time of clinical symptoms,normal temperature, days of catheterization, the total amount of pleural fluid, the score of pleural encapsulation range,interleukine-2 (IL-27) value, CD3+ value and CD8+ value among the three groups were compared. Results The disappearance time of clinical symptoms, the normal time of normal temperature and the days of catheterization in group L were shorter than those in group X, group W, the total amount of pleural fluid in group L were less than those in group X and group W, the score of pleural encapsulation range in group L were lower than those in group X and group W, the level of IL-27 in group L were lower than those in group X and group W, and the levels of CD3+ and CD8+ in group L were higher than those in group X and group W, the differences were statistically significant (P＜0.05). The disappearance time of clinical symptoms, the normal time of body temperature and the days of catheterization in group X were shorter than those in group W, the total amount of pleural effusion in group X was less than that in group W, the score of pleural encapsulation range in group X was lower than that in group W, the level of IL-27 in group X was lower than that in group W, and the levels of CD3+ and CD8+ in group X were higher than those in group W, the differences were statistically significant (P＜0.05). Conclusion The effect of medical thoracoscopy combined with cryotherapy in the treatment of tuberculous encapsulated pleural and peritoneal effusion is better, which is worthy of further clinical promotion. 2022 Vol. 29 (8): 51-54 [Abstract] ( 34 ) HTML (1 KB)  PDF (589 KB)  ( 23 ) 55 Application effect of vacuum sealing drainage in wound drainage of patients with anastomotic fistula after esophageal cancer surgery LIANG Qingmei HUANG Weizhao CHEN Binbin YE Cuiling Objective To study the effect of vacuum sealing drainage (VSD) in wound drainage of patients with anastomotic fistula after esophageal cancer surgery, and to provide reference basis for clinical therapy. Methods From January 2018 to December 2020, 60 patients with postoperative anastomotic fistula of esophageal cancer hospitalized in Zhongshan People′s Hospital were selected as the research objects. The patients were divided into the study group (n=30) and the control group (n=30) according to random number table method. The control group was treated with conventional anastomotic fistula drainage and wound oxygen therapy, and the study group was treated with VSD for fistula drainage on the basis of the control group. The leakage volume of fistula, fistula healing time, hospitalization time, hospitalization expenses and quality of life were compared between the two groups. Results The leakage volume of fistula of the study group was less than that of the control group, the difference was statistically significant (P<0.05). The fistula healing time and hospitalization time of the study group were shorter than those of the control group, and the hospitalization expenses of the study group was less than that of the control group, the differences were statistically significant (P<0.05). After the intervention, the quality of life of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion VSD is an effective method for postoperative anastomotic fistula wound drainage of esophageal cancer. It can reduce the amount of leakage, promote wound healing, shorten hospitalization time, reduce hospitalization expenses, and effectively improve the quality of life of patients. 2022 Vol. 29 (8): 55-58 [Abstract] ( 42 ) HTML (1 KB)  PDF (590 KB)  ( 33 ) 59 Application effect of Baixuan Xiata Hot Tablets combined with Triamcinolone Acetonide Econazole Cream in patients with rose furrrash ZHANG Tongwei1 ZHENG Wenjie2▲ Objective To explore the application effect of Baixuan Xiata Hot Tablets (BXHT) combined with Triamcinolone Acetonide Econazole Cream (TAEC) in patients with rose furrrash. Methods A total of 60 patients treated in the Seventh People′s Hospital of Shenyang city from April 2019 to March 2020 were selected as research objects, they were divided into the control group (30 cases) and the observation group (30 cases) according to random number table method. The control group was treated with BXHT. On this basis, the observation group was added TAEC. The improvement of skin lesions, cosmetic effect score and therapeutic effect were compared between the two groups. Results After treatment, the scorching, rash area and erythema symptom score of the two groups were lower than those before treatment, and the scorching, rash area and erythema symptom score of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). After 4 weeks of treatment, the cosmetic effect scores of the two groups were higher than those of the two weeks of treatment and before treatment, and the cosmetic effect scores of the observation group at 2 and 4 weeks after treatment were higher than those of the control group, the differences were statistically significant (P＜0.05). The total effective rate of the observation group was 92.50%, which was higher than 72.50% of the control group, the difference was statistically significant (P＜0.05). Conclusion Combined application of BXHE and TAEC in the treatment of patients with rose furrash can effectively improve their skin loss symptoms and cosmetic effect, improve clinical treatment efficiency, and deserve clinical promotion and application. 2022 Vol. 29 (8): 59-62 [Abstract] ( 39 ) HTML (1 KB)  PDF (559 KB)  ( 18 ) 63 Effect of α-lipoic Acid Injection combined with Mecobalamin Injection in the treatment of diabetic peripheral neuropathy SUN Chuang Objective To investigate the effect of α-lipoic Acid Injection combined with Mecobalamin Injection in the treatment of diabetic peripheral neuropathy. Methods A total of 110 patients with diabetic peripheral neuropathy who were admitted to Xincheng Hospital, Liaoyang Central Hospital from June 2018 to June 2020 were selected as subjects and divided into control group and observation group by the random number table method, with 55 cases in each group.The patients in the control group were provided with Mecobalamin Injection, and patients in the observation group were added with α-lipoic Acid Injection. The curative effect, neuropathy subjective symptom questionnaire (TSS) score, the motor nerve conduction velocity (MCV) of the common peroneal nerve and the median nerve, the sensory nerve conduction velocity (SCV) of the common peroneal nerve and the median nerve of the two groups were compared. The adverse reactions during the treatment of the two groups were observed. Results The total clinical effective rate of observation group was higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, the scores of pain, burning sensation, numbness, paresthesia and total score in observation group were lower than those in control group, the differences were statistically significant (P<0.05). The MCV of common peroneal nerve, MCV of median nerve, SCV of median nerve and SCV of common peroneal nerve in observation group were higher than those in control group after treatment, with statistical significances (P<0.05). There were no obvious adverse reactions such as abnormal blood routine, liver and kidney function and coagulation function in the two groups. Conclusion The combination of α-lipoic Acid Injection and Mecobalamin Injection has a significant clinical effect in the treatment of diabetic peripheral neuropathy,which can effectively help improve symptoms and signs,and regulate the conduction velocity of the common peroneal nerve and median nerve, and has a high safety, without obvious adverse reactions during treatment. 2022 Vol. 29 (8): 63-66 [Abstract] ( 38 ) HTML (1 KB)  PDF (413 KB)  ( 27 ) 67 Clinical effect of intensive insulin therapy in the treatment of diabetes complicated with acute cerebral infarction HUANG Liangzhi HUANG Zugui CHEN Ting Objective To study the clinical effect of intensive insulin therapy in the treatment of diabetes mellitus complicated with acute cerebral infarction. Methods A total of 80 patients with diabetes complicated with acute cerebral infarction in the First Hospital of Nanping City, Fujian Province from January 2019 to January 2021 were selected as the research subjects and divided into an observation group and a control group by the random number table method,with 40 patients in each group. Patients in the control group received conventional treatment, while patients in the observation group received intensive insulin therapy. Blood glucose level, insulin function indicators and neurological deficit were compared between the two groups. Results After treatment, the levels of fasting blood glucose, 2-hour postprandial blood glucose and glycosylated hemoglobin in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). After treatment, fasting insulin and insulin resistance levels in the observation group were lower than those in the control group, with statistically significant differences (P<0.05). The insulin β cells functional level in observation group was higher than that in the control group after treatment, and the difference was statistically significant (P<0.05). After treatment, the score of National Institutes of Health stroke scale in the observation group was lower than that in the control group, the difference was statistically significant (P<0.05).Conclusion Intensive insulin therapy for patients with diabetes complicated with acute cerebral infarction can not only stabilize the blood glucose level of patients, control their insulin resistance, but also improve neurological deficit of patients to a certain extent, with significant therapeutic effect. 2022 Vol. 29 (8): 67-70 [Abstract] ( 40 ) HTML (1 KB)  PDF (402 KB)  ( 34 ) 71 Effect of percutaneous forspinal endoscopy on cure rate and symptom improvement in patients with lumbar disc herniation ZHOU Youhua； WU Fangqian Objective To analyze the effect of percutaneous transforaminal spinal endoscopy on the cure rate and symptom improvement of patients with lumbar disc herniation. Methods A total of 60 patients with lumbar disc herniation admitted to Fuzhou First People′s Hospital from May 2019 to May 2021 were selected as the research objects, and they were divided into control group and observation group according to random number table method, with 30 cases in each group. The control group was treated with traditional operation, the observation group was treated with percutaneous transforaminal spinal endoscopy. The treatment effect, postoperative recovery and hospital stay were compared between the two groups. Results The total effective rate in observation group was higher than that in control group, and the difference was statistically significant (P<0.05). The operation time and hospital stay in the observation group were shorter than those in the control group, the amount of intraoperative blood loss was less than that in the control group, and the total incidence of complications was lower than that in the control group, and the differences were statistically significant (P<0.05). The improvement rate of clinical symptoms in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Percutaneous transforaminal spinal endoscopy in the treatment of patients with lumbar disc herniation, can effectively improve the treatment effect, high cure rate, good symptom improvement, less damage to the patient′s body, low total incidence of complications, effectively improve the quality of life and recovery speed of patients, it is worthy of wide application. 2022 Vol. 29 (8): 71-73转78 [Abstract] ( 50 ) HTML (1 KB)  PDF (472 KB)  ( 24 ) 74 Comparison of the application of different suture methods in the operation of Sanders Ⅲtype calcaneal fracture WEI Cheng； CHEN Youmin； CAO Yingwu； HUANG Yun； WU Fuhua Objective To compare the application value of three-layer tight suture method and Allgower-Donati suture method in patients with Sanders Ⅲtype calcaneal fracture. Methods A total of 83 patients with Sanders type Ⅲcalcaneal fractures from June 2017 to June 2020 in Lishui Branch Hospital of Zhongda Hospital Affiliated to Southeast University were selected as the research objects. According to the different surgical suture methods, they were divided into the observation group of 43 cases and the control group of 40 cases. The observation group was given three-layer tight suture method, and the control group was given Allgower-Donati suture method. The surgical efficacy, surgical related indicators, postoperative recovery and the total incidence of postoperative incision complications were compared between the two groups. The postoperative Maryland score, visual analog scale (VAS) score and changes in incision skin temperature were observed between the two groups. Results There was no statistically significant difference in the excellent and good rate between the two groups (P＞0.05). The Maryland score of the observation group at 1 month after surgery of the observation group was higher than that of the control group, and the VAS score at 3 days after surgery of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05).There were no significant differences in the operation time and postoperative drainage time between the two groups (P＞0.05). The skin incision suture time of the observation group was longer than that of the control group, and the area of skin inflammation around the incision of the observation group was smaller than that of the control group, and the healing time of incision of the observation group was shorter than that of the control group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in the fracture healing time between the two groups (P＞0.05). The incision skin temperature of the observation group at 2 and 3 days after surgery were higher than those of the control group, the differences were statistically significant (P＜0.05). There was no statistically significant difference in the total incidence of postoperative incision complications between the two groups (P ＞0.05). Conclusion Compared with the Allgower-Donati suture method, the three-layer tight suture method in Sanders type Ⅲcalcaneal fracture operation can promote the healing of the incision, reduce postoperative pain, and reduce the area of skin inflammation. 2022 Vol. 29 (8): 74-78 [Abstract] ( 47 ) HTML (1 KB)  PDF (484 KB)  ( 23 ) 79 Comparison of two kinds of intramedullary nailing in the treatment of senile unstable intertrochanteric fractures WANG Haichuan； SANG Yuantian Objective To compare the efficacy of InterTAN intramedullary nail and proximal femoral anti-rotation intramedullary nail (PFNA) in the treatment of elderly unstable intertrochanteric fractures. Methods A retrospective analysis was performed on the clinical data of 76 elderly patients with unstable intertrochanteric fractures admitted to the Fifth People′s Hospital of Dalian City from March 2016 to June 2020. According to different internal fixation methods, they were divided into InterTAN group (39 cases) and PFNA group (37 cases). InterTAN group was fixed with InterTAN intramedullary nail, and PFNA group was fixed with anti-rotation femoral proximal intramedullary nail. All patients were followed up for at least 1 year after surgery, and the operative time, intraoperative blood loss, postoperative complications, ground time, bone union time and postoperative hip function of the two groups were compared. Results There were no significant differences in ground time, bone healing time and postoperative hip function between two groups (P>0.05). The operative time of PFNA group was shorter than that of InterTAN group, and the intraoperative blood loss was lower than that of InterTAN group, the differences were statistically significant (P<0.05). The incidence of thigh pain in InterTAN group was lower than that in PFNA group, the difference was statistically significant (P<0.05). Conclusion Both kinds of intramedullary nail fixation can achieve good efficacy in the treatment of unstable proximal femoral fracture. InterTAN has fewer postoperative complications, while PFNA is more convenient, shorter operation time and less injury, which may be more suitable for the surgical treatment of elderly patients with more medical complications and severe osteoporosis. 2022 Vol. 29 (8): 79-82 [Abstract] ( 38 ) HTML (1 KB)  PDF (494 KB)  ( 21 ) 83 Efficacy and safety of second-line treatment with Apatinib and Paclitaxel for HER-2 negative advanced gastric cancer HAN Yongqing； FU Feng； HUANG Kairong Objective To explore the effect of Apatinib combined with Paclitaxel in the second-line treatment of Her-2 negative advanced gastric cancer patients. Methods A total of 96 patients with Her-2 negative advanced gastric cancer who were treated at Shangrao People′s Hospital in Jiangxi from January 2018 to January 2021 were selected as the subjects of this study, and they were divided into the control group and the study group by simple randomization method, with 48 cases in each group. Patients in the control group were treated with Paclitaxel alone, and patients in the study group were treated with Apatinib combined with Paclitaxel as second-line treatment. The clinical efficacy,adverse reactions and progression-free survival time of the two groups of patients were compared. Results The total effective rate, disease control rate in the study group after treatment were higher than those in the control group, and progression-free survival time of the patients in the study group after treatment was longer than that in the control group,the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion The second-line treatment of Apatinib combined with Paclitaxel can significantly improve the clinical efficacy of HER-2 negative patients with advanced gastric cancer, effectively prolong the progression free survival time, and is conducive to the control of the disease. At the same time, there is a certain degree of safety and no serious adverse situation. It is worthy of widespread clinical promotion. 2022 Vol. 29 (8): 83-85转90 [Abstract] ( 39 ) HTML (1 KB)  PDF (488 KB)  ( 28 ) 86 Clinical effect of transbronchoscopic cryotherapy combined with thermal ablation in the treatment of airway stenosis caused by lung cancer WU Cili； ZHANG Minghua Objective To investigate the clinical effect of transbronchoscopic cryotherapy combined with thermal ablation in the treatment of airway stenosis caused by lung cancer. Methods Fifty-two patients with airway stenosis caused by lung cancer treated in Central Hospital of Enshi Tujia and Miao Autonomous Prefecture from January 2020 to June 2021 were retrospectively selected as the research subjects. According to different treatment methods, they were divided into observation group(26 cases)and control group(26 cases).The observer used cryotherapy combined with thermal ablation, and the control group used thermal ablation. The clinical efficacy, shortness of breath index, Karnofsky performance score (KPS)were compared between the two groups after treatment,and surgical complications was recorded. Results Before treatment, there were no significant differences in breathlessness index and KPS score between the two groups (P>0.05). After treatment, the breathlessness indexes of the two groups were lower than those before treatment, and the KPS scores were higher than those before treatment, and the breathlessness index of the observation group was lower than that in the control group, and the KPS score was higher than that in the control group, the differences were statistically significant (P<0.05). The total effective rate of observation group was higher than that in control group, the difference was statistically significant (P<0.05). No serious complications occurred in both groups. Conclusion transbronchoscopic cryotherapy combined with hot ablation in the treatment of airway stenosis caused by lung cancer can achieve satisfactory results, and it′s safe.It provides another treatment for patients who lose the opportunity of surgery or refuse surgery. 2022 Vol. 29 (8): 86-90 [Abstract] ( 41 ) HTML (1 KB)  PDF (509 KB)  ( 110 ) 91 Influence of laparoscopic complete mesocolic excision on tumor markers and peripheral blood T cell content in patients with right colon cancer ZHANG Xueyuan Objective To investigate the influence of laparoscopic complete mesocolic excision (CME) on tumor markers and peripheral blood T cell content in patients with right colon cancer. Methods A total of 80 patients with right colon cancer who were admitted to the First People′s Hospital of Jiujiang City in Jiangxi Province from January 2019 to February 2021 were selected and divided into the experimental group and the reference group according to random number table method, with 40 patients in each group. The reference group received open CME treatment, and the experimental group received laparoscopic CME treatment. The level of serum tumor markers, peripheral blood T cell subsets and complications were compared between the two groups. Results There was no significant difference in the level of soluble intercellular adhesion molecule-1 (SICAM-1), colon cancer specific antigen 2 (CCSA-2) and vascular endothelial growth factor (VEGF) between the two groups before surgery (P＞0.05). The levels of SICAM-1, CCSA-2 and VEGF in the two groups after surgery were higher than those before surgery, and the differences were statistically significant (P＜0.05). The levels of SICAM-1, CCSA-2 and VEGF in the experimental group were lower than those in the reference group, and the differences were statistically significant (P＜0.05). The levels of CD4+, CD3+ and CD8+ in the two groups after surgery were lower than those before surgery, and the level of CD4+/CD8+ in the reference group after surgery was lower than that before surgery, with statistical significances (P＜0.05). There was no significant difference in the levels of CD4+/CD8+ in the experimental group between after surgery and before surgery (P＞0.05). The levels of CD4+, CD3+ and CD4+/CD8+ in the experimental group after surgery were higher than those in the reference group, and the level of CD8+ in the experimental group after surgery was lower than that in the reference group, the differences were statistically significant (P＜0.05). The total incidence of postoperative complications in the experimental group was lower than that in the reference group, and the difference was statistically significant (P＜0.05). Conclusion Laparoscopic CME treatment for right colon cancer patients is safer, which can reduce the level of tumor markers, has little impact on immune function, and is conducive to postoperative rehabilitation. 2022 Vol. 29 (8): 91-94 [Abstract] ( 39 ) HTML (1 KB)  PDF (482 KB)  ( 21 ) 95 Significance of detecting peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning after antiplumbism WANG Zhi； HE Qin； LIN Yuanyuan； LIU Xiaohui Objective To explore the significance of detecting peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning after antiplumbism. Methods A total of 50 children with lead poisoning admitted in Jiangxi Children′s Hospital from June 2019 to December 2020 were selected as research subjects. The levels of peripheral blood immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), T-lymphocyte subsets (CD3+, CD4+, CD8+) and natural killer (NK) cells CD16+ were compared before and after treatment. The levels of IgA, IgG and IgM in children with different prognosis were compared before and after treatment. Results The levels of IgA, IgG and IgM after treatment were higher than those before treatment, the differences were statistically significant(P<0.05). The levels of CD3+, CD4+ and CD16+ after treatment were higher than those before treatment, while the levels of CD8+were lower than those before treatment, the differences were statistically significant (P<0.05). The levels of IgA,IgG and IgM in cured group and non-cure group after treatment were higher than those before treatment, and the levels of IgA, IgG and IgM in cured group before and after treatment were higher than those in non-cure group, the differences were statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+ and CD16+ in cured group and non-cure group were higher than those before treatment, while the levels of CD8+ were lower than those before treatment, and the levels of CD3+, CD4+ and CD16+ in cured group before and after treatment were higher than those in the non-cure group, while the levels of CD8+ was lower than those in the non-cure group, the differences were statistically significant (P<0.05). Conclusion Peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning have detection significance, and peripheral blood immunoglobulin level and cellular immune function closely relate to the prognosis of children. 2022 Vol. 29 (8): 95-98 [Abstract] ( 47 ) HTML (1 KB)  PDF (520 KB)  ( 22 ) 99 Application effect of nebulized inhalation of 3% Hypertonic Saline in children with moderate bronchiolitis LI Jinyan； LIANG Xiuye； LIANG Jinhong； ZHU Guanlan； PAN Changfan Objective To examine the application effect of atomizing inhalation of 3% Hypertonic Saline (HS) in children with moderate bronchiolitis. Methods A total of 72 children with moderate bronchiolitis who were hospitalized in the Department of Pediatrics of Maternal and Child Health Centre of Wuming District from July 2018 to October 2020 were selected as research objects. They were divided into 3% HS group and noral saline (NS) group according to random number table method, with 36 cases in each group. 3% HS 2 ml was used in 3%HS group and NS 2 ml was used in NS group. The clinical severity scores (CSS) and length of hospital stay in the pre-treatment phase, 24, 48, 72 h after treatment and at discharge of two groups were compared, and the adverse effect were observed. Results There were no significant differences in CSS between two groups at 24, 48, 72 h after treatment and at discharge (P>0.05).The CSS in the pre-treatment phase 24, 48, 72 h after treatment and at discharge were significantly decreased over time in 3% HS group, the differences were statistically significant (P<0.05). The CSS in the pre-treatment phase, 24,48, 72 h after treatment and at discharge were significantly decreased over time in NS group, the differences were statistically significant (P<0.05). There was no significant difference in length of hospital stay between groups (P>0.05). No adverse reaction occured in both groups. Conclusion Compared with NS, 3% HS combined with Budesonide, Salbutamol and Ipratropium Bromide Atomized Inhalation in the treatment of moderate bronchiolitis did not significantly reduce the CSS and shorten the length of hospital stay, requiring further study with HS alone. 2022 Vol. 29 (8): 99-102 [Abstract] ( 36 ) HTML (1 KB)  PDF (529 KB)  ( 35 ) 103 Application effect of traditional Chinese medicine acupoint massage combined with bioelectric stimulation breast nursing in postpartum breast dredging FENG Li′na； LIANG Jiefen； OU Liwen； WU Xuemei； WU Weixia Objective To explore the application effect of traditional Chinese medicine acupoint massage combined with bioelectrical stimulation breast nursing in postpartum breast dredging. Methods A total of 468 cases of postpartum women who had breast swelling and pain requiring breast dredging admitted to Zhaoqing Duanzhou Maternal and Child Health Hospital from January 2019 to June 2020 were selected as the research objects, they were divided into control group and observation group according to random number table method, with 234 cases in each group. The control group used conventional massage nursing and the observation group used traditional Chinese medicine acupoint massage nursing. Both groups were assisted with low-frequency pulse bioelectric stimulation in the process of breast dredging and massage. Three days after nursing intervention, the breast dredging effect and nursing effect of the two groups were compared. Results Before nursing intervention, there was no significant difference in the score of breast swelling and pain between the two groups (P>0.05). Three days after nursing intervention, the breast pain score of the observation group was lower than that of the control group, and the breast pain scores of two groups were also lower than those before intervention, the differences were statistically significant (P<0.05). In terms of nursing effect after 3 days of intervention, the total effective rate of nursing effect in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). Conclusion The combination of traditional Chinese medicine acupoint massage and bioelectrical stimulation can greatly improve the dredging degree of postpartum breast duct, and the nursing effect is worthy of affirmation. 2022 Vol. 29 (8): 103-106 [Abstract] ( 37 ) HTML (1 KB)  PDF (538 KB)  ( 55 ) 107 Effect of Budesonide atomization inhalation combined with Montelukast Sodium on acute attack of asthma in children FENG Yuling Objective To investigate the effect of Budesonide atomization inhalation combined with Montelukast Sodium in the treatment of acute attack of asthma in children. Methods A total of 120 children with acute attack of asthma treated in Department of Pediatrics of Hongjiang Municipal People′s Hospital from January 2020 to March 2021 were selected as the research objects, they were divided into two groups according to random number table method, with 60 cases in each group. The control group was treated with Budesonide atomization inhalation, the observation group was treated with Montelukast Sodium on the basis of the control group. The therapeutic effect, changes of pulmonary function, expression of serum inflammation and adverse drug reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The forced expiratory value (FEV1), peak respiratory flow rate (PEF) and forced vital capacity(FVC) in the observation group were higher than those in the control group, the differences were statistically significant(P<0.05). Serum interleukin-17 (IL-17) and transforming growth factor-β2 (TGF-β2) and matrix metalloproteinase-9(MMP-9) in the observation group after treatment were lower than those in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Budesonide atomization inhalation combined with Montelukast Sodium in the treatment of acute attack of childhood asthma has achieved significant results, the level of inflammation has been reduced, and there are no obvious adverse reactions. 2022 Vol. 29 (8): 107-110 [Abstract] ( 38 ) HTML (1 KB)  PDF (519 KB)  ( 21 ) 111 Study of inflammatory factors in implants gingival crevicular fluid and peri-implant health in patients with type 2 diabetes mellitus CHEN Jin； FANG Hui； KUANG Li； JIANG Yan Objective To explore the effects of inflammatory cytokines induced by type 2 diabetes mellitus (T2DM) on peri-implant tissues. Methods A total of 32 patients with T2DM undergoing implant implantation and upper all-ceramic crown repair in stomatology department of Pingxiang People′s Hospital were enrolled as observation group between August 2020 and August 2021, while other 32 patients with normal blood glucose during the same period were enrolled as control group. The probing depth (PD), sulcus bleeding index (SBI), volume of peri-implant sulcular fluid(PISF), expression levels of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in PISF of the two groups were statistically analyzed. Results There were no significant differences in PD and SBI between the two groups (P>0.05). After implantation, the PISF in observation group was lower than that in control group, expressions of IL-1β and TNF-α in PISF of observation group were higher than those in control group, the differences were statistically significant (P<0.05), but there was no significant difference in IL-6 between the two groups (P>0.05). PISF was significantly negatively correlated with IL-1β and TNF-α (r=-0.482,-0.436,P<0.05).Conclusion Compared with patients with healthy implant teeth, PISF volume is less, while expressions of IL-1β and TNF-α were higher in T2DM patients. 2022 Vol. 29 (8): 111-113 [Abstract] ( 43 ) HTML (1 KB)  PDF (431 KB)  ( 34 ) 114 Longitudinal monitoring of visual function development in children with spontaneous regression of retinopathy of prematurity MENG Senling； XIONG Yanli； CHEN Shaohong Objective To longitudinally monitor the development of visual function in children with retinopathy of prematurity (ROP) spontaneously resolved. Methods Retrospectivety selected premature infants who underwent fundus examination in the Department of Child Health, Jiangxi Maternity and Child Health Hospital from January 2019 to June 2019. According to whether ROP occurred and the follow-up status, 82 patients with ROP and followed up to natural regression were set as ROP group, 64 preterm infants without ROP were set as the non ROP group, and 59 full-term infants of the same month age who were examined in the Department of Child Health, Jiangxi Maternity and Child Health Hospital during the same period were selected as the control group. The refraction and eye position of the three groups were compared. Results There was no statistically significant difference in the incidence of hyperopia and astigmatism between the groups of different months of age (P>0.017). The myopia rate of ROP group at 6, 18 and 24 months were higher than those of non ROP group and control group, and the strabismus rate was higher than that of control group, the differences were statistically significant (P<0.017). The myopia rate in ROP group at 12 months was higher than that in control group, the difference was statistically significant (P<0.017). There was no significant difference in myopia rate between non ROP group and control group at different months (P>0.017). There was no significant difference in the incidence of strabismus between ROP group and non ROP group, non ROP group and control group (P>0.017). Conclusion The incidence of strabismus and myopia is higher in patients with spontaneous regression of ROP.Early clinical intervention is needed to avoid amblyopia. 2022 Vol. 29 (8): 114-117 [Abstract] ( 41 ) HTML (1 KB)  PDF (428 KB)  ( 26 ) 118 Clinical effect of Ketorolac Traminotriol combined with Sufentanil on postoperative analgesia in children undergoing orthopedic surgery LAI Jianhong；ZENG Fanying；LONG Yan Objective To investigate the clinical effect of Ketorolac Traminotriol combined with Sufentanil on postoperative analgesia in children undergoing orthopedic surgery. Methods A total of 60 children undergoing fracture reduction under general anesthesia in Ganzhou Hospital of Traditional Chinese Medicine from April 2017 to April 2019 were selected as the research objects. The patients were divided into observation group and control group by random number table method, 30 cases in each group. The control group was treated with Sufentanil for analgesia, and the observation group was treated with Ketorolac Traminotriol combined with Sufentanil for analgesia. Sufentanil dosage, press times,CRIES score, 5-hydroxytryptamine (5-HT) level, substance P (PS) level and adverse reactions were compared between the two groups at different time points. Results The dose of Sufentanil at 4, 8 and 24 h after operation showed an increasing trend in both groups, the number of analgesic pump compressions at 4 and 8 h after surgery was more than 1 h after surgery, and the number of analgesic pump compressions at 24 h after surgery was less than 1, 4 and 8 h after surgery, the differences were statistically significant (P<0.05). The dose and pressing times of Sufentanil in the observation group were lower than those in the control group at 1, 4, 8 and 24 h after operation, the differences were statistically significant (P<0.05). At 4, 8 and 24 h after surgery, the scores of the two groups decreased. There was no significant difference between the two groups at 1 h after surgery (P>0.05). The CRIES of the observation group were lower than those of the control group at 4, 8 and 24 h after surgery, the differences were statistically significant (P<0.05). The levels of 5-HT and PS in both groups were higher on postoperative day 2 than postoperative day 1, and higher on postoperative day 3 than postoperative day 1 and 2, the differences were statistically significant (P<0.05). The levels of 5-HT and PS in the observation group were lower than those in the control group on day 1, 2 and 3 after operation, the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of postoperative adverse reactions between the two groups(P>0.05). Conclusion Ketorolac Tromethamine combined with Sufentanil for pediatric orthopedic surgery has good analgesic effect, inhibits the increase of 5-HT and PS concentration, and has high safety. 2022 Vol. 29 (8): 118-121 [Abstract] ( 65 ) HTML (1 KB)  PDF (424 KB)  ( 28 ) 122 Comparison of continuous intravenous rehydration and open venous channel to encourage eating in labor analgesia DING Chengsheng； LIU Rong Objective To compare the application effect of continuous intravenous fluid infusion and open venous channel to encourage feeding in labor analgesia. Methods A total of 200 full-month-old parturient women who received analgesic delivery in Ganzhou Maternal and Child Health Hospital from January to October 2021 were selected as the research objects, and were divided into study group (100 cases) and control group (100 cases) by random number table method. The study group received continuous intravenous rehydration, and the control group received open venous channel to encourage feeding. Apgar scores and body weights at 1, 5 and 10 minutes after birth were compared between the two groups. The non stimulation test (NST) score, total labor process, adverse events of pregnancy and biophysical score (BPS) were compared between the two groups. Results There was no significant difference in Apgar score and birth weight at 1, 5 and 10 minutes between the two groups (P>0.05). The NST and BPS scores of the study group were higher than those of the control group, and the total labor course was shorter than that of the control group, the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse pregnancy events between the two groups(P>0.05).Conclusion Compared with open intravenous channels to encourage feeding, continuous intravenous fluid rehydration has higher application value in analgesic delivery, which can effectively reduce the impact on fetal heart rate and basic signs, improve NST, BPS scores and the quality of maternal and infant prognosis. 2022 Vol. 29 (8): 122-124 [Abstract] ( 38 ) HTML (1 KB)  PDF (410 KB)  ( 24 ) 125 Changes and influencing factors of ultrasonic blood flow parameters of renal segmental artery before and after coronary angiography HUANG Shuang； HAO Jiping； GAO Yuqin； LIANG Oujing；TIAN Feng Objective To investigate the influencing factors and the changes of ultrasonic blood flow parameters of renal segmental artery before and after coronary angiography. Methods A total of 46 patients undergoing coronary angiography or percutaneous coronary intervention (PCI) in Ninth Hospital of Xi′an from July 2020 to April 2021 were selected as the study subjects. The peak systolic velocity (PSV),end diastolic velocity (EDV)and resistance index (RI) of bilateral renal segmental arteries were measured before angiography and the 3rd day and the 10th day after angiography.The influencing factors of renal blood flow parameters after radiography were also discussed by multiple linear regression analysis. Results The PSV on the 3rd day and 10th day after angiography were higher than that before angiography,the EDV on the 10th day after angiography was higher than that before angiography and on the 3rd day after angiography,the RI on the 3rd day after angiography was higher than that before angiography, the differences were statistically significant (P＜0.05). On the 3rd day after angiography, PSV was related to age and gender, EDV was correlated with age and the using of Calcium Channel Blockers (CCB). While on the 10th day after angiography, PSV was only related to age,EDV was correlated with age, the dose of contrast medium and body mass index. On the 3rd day and 10th day after angiography, RI was related to age and diabetes. Conclusion PSV, EDV and RI of segmental renal arteries show a trend of deterioration and subsequent improvement. After angiography, age and gender are the influencing factors of PSV.Age, CCB, contrast agent volume and body mass index are the influencing factors of EDV, then age and diabetes are the influencing factors of RI. Among them, age is the most significant influencing factor for renal blood flow parameters, regardless of the contrast agent itself. 2022 Vol. 29 (8): 125-129 [Abstract] ( 44 ) HTML (1 KB)  PDF (897 KB)  ( 17 ) 130 Clinical value and imaging analysis of susceptibility weighted imaging on reperfusion hemorrhage of hemorrhagic cerebral infarction CHEN Suwen； LONG Guangfeng； WU Zhuobin； REN Yongji Objective To study the clinical application value of susceptibility weighted imaging (SWI) for reperfusion hemorrhage in patients with hemorrhagic cerebral infarction and perform imaging analysis on the results. Methods From January 2016 to March 2021, a total of 70 patients with hemorrhagic cerebral infarction who were treated in the Department of Radiology, Jiangmen People′s Hospital were selected as the research objects. All patients were examined with a 1.5T superconducting MR imager, followed by regular MRI scans and magnetic sensitivity weighted imaging examinations. With digital subtraction angiography (DSA) as the diagnostic gold standard, the diagnostic efficiency and bleeding volume of different MRI technologies were compared, and the imaging characteristics of the two technologies were analyzed. Results There was no statistically significant difference in sensitivity between susceptibility weighted imaging and conventional MRI scans (P>0.05). The accuracy of susceptibility weighted imaging for hemorrhage, cerebral infarction, reperfusion, hemorrhage and specificity was higher than that of the accuracy of conventional MRI scans and the difference was statistically significant (P<0.05). The bleeding volume of magnetically weighted imaging was greater than that of conventional MRI scans the mean volume was, and the difference was statistically significant (P<0.05). Conclusion Susceptibility weighted imaging examination has high accuracy and specificity for reperfusion bleeding in patients with hemorrhagic cerebral infarction. It can scan the range of intracerebral hemorrhage as completely as possible, and provide more reliable diagnostic results for clinical treatment. It is clinically worthy of promotion. 2022 Vol. 29 (8): 130-132转136 [Abstract] ( 39 ) HTML (1 KB)  PDF (552 KB)  ( 26 ) 133 Application value of multi-slice spiral CT in diagnosis and follow-up of non-tuberculous mycobacterium lung disease MEI Jufang； HUANG Xianping； ZENG Zhong； ZHONG Wan； WU Bang； LIU Xiazhen Objective To explore the application value of multi-slice spiral computed tomography (CT) in the diagnosis and treatment follow-up of non-tuberculous mycobacterial lung disease. Methods Eighty patients with suspected nontuberculous mycobacterial lung disease admitted to Ganzhou Fifth People′s Hospital from February 2019 to August 2020 were selected as the research subjects. All subjects received conventional CT examination and multi-slice spiral CT. Using pathological results as the gold standard, the detection rate, detection of different signs, diagnostic efficacy and follow-up results of the two examination methods were compared. Results The detection rate of multi-slice spiral CT was higher than that of conventional CT, and the difference was statistically significant (P<0.05). The detection rate of upper lobe cavity type, nodular bronchiectasis type, mixed type, and difficult to be classified by multi-slice spiral CT were higher than those of conventional CT, and the differences were statistically significant (P<0.05). The diagnostic sensitivity and accuracy of multi-slice spiral CT were higher than those of conventional CT, and the differences were statistically significant (P<0.05). The specificity of the two inspection methods was compared, and the difference was not statistically significant (P>0.05). Followed up for six months, a total of 24 patients showed no obvious changes in multi-slice spiral CT images, a total of 18 patients improved, the patch shadow area was reduced and the number was reduced, the cavity was reduced, the tree-in-bud sign and nodular shadow were reduced, and the patch shadow area was reduced in 28 patients. Enlarged and increased number, tree-in-bud sign and nodular shadows increased, of which 9 cases of cavities were reduced, and 19 cases of nodules and patchy shadows evolved into cavities. Conclusion Multislice spiral CT has a significant effect in the diagnosis of non-tuberculous mycobacterial pulmonary disease. It can judge different signs more accurately, improve the clinical detection rate, and has high diagnostic sensitivity. It plays an important role in the follow-up evaluation of treatment. It is recommended to be promoted use. 2022 Vol. 29 (8): 133-136 [Abstract] ( 37 ) HTML (1 KB)  PDF (601 KB)  ( 37 ) 137 Clinical study on self-made Shoutai Pills combined with Western medicine in the treatment of uterine effusion in the first and second trimesters of pregnancy GONG Xue； WU Huiping Objective To study the clinical effect of self-made Shoutai Pills combined with Western medicine in the treatment of patients with uterine effusion in the first and second trimesters of pregnancy. Methods A total of 100 patients with uterine effusion in the first and second trimesters of pregnancy who were given medication in Jingdezhen Hospital of Chinese Medicine from March 2020 to March 2021 were retrospectively analyzed. According to the different medication regimens, they were divided into control group (50 cases) and treatment group (50 cases). The control group was treated with Western medicine, and the treatment group was treated with self-made Shoutai Pills combined with Western medicine. The total effective rate of drug treatment and the incidence of adverse drug reactions were compared between the two groups. The levels of hypersensitive C-reactive protein, tumor necrosis factor α, interleukin 6 and quality of life score were compared between the two groups before and after treatment. The disappearance time of uterine effusion was compared between the two groups. Results The total effective rate of drug therapy in treatment group was higher than that in the control group, the difference was statistically significant (P<0.05). The incidence of adverse reaction in the treatment group was lower than that in the control group, and the difference was statistically significant(P<0.05). There were no significant differences in the levels of hypersensitive C-reactive protein, tumor necrosis factor α, interleukin 6 and quality of life score between the two groups before treatment (P<0.05). After treatment, the levels of hypersensitive C-reactive protein, tumor necrosis factor α and interleukin 6 in the treatment group were lower than those in the control group, the differences were statistically significant (P<0.05). The quality of life score of the treatment group was higher than that of the control group, and the difference was statistically significant (P<0.05). The disappearance time of uterine effusion in treatment group was shorter than that in control group, and the difference was statistically significant (P<0.05). Conclusion Self-made Shoutai Pills combined with Western medicine in the treatment of patients with uterine effusion in the first and second trimesters of pregnancy can greatly improve the levels of inflammatory factors, shorten the control time of the disease, reduce adverse drug reactions, enhance the quality of life and improve the overall effective rate of treatment. 2022 Vol. 29 (8): 137-140 [Abstract] ( 34 ) HTML (1 KB)  PDF (423 KB)  ( 46 ) 141 Clinical effect of Maxing Shigan Decoction in the trteatment of chronic cough after respiratory tract infection YANG Meiyu Objective To investigate the clinical effect of Maxing Shigan Decoction in the trteatment of chronic cough after respiratory tract infection. Methods A total of 60 patients with chronic cough after respiratory tract infection who were admitted to the Second Section of Department of Respiratory, Tongzhou District of Dongzhimen Hospital from April 2020 to May 2021 were selected as the research objects. They were divided into the control group and the observation group by the random number table method, with 30 patients in each group. The control group was treated with conventional Western medicine treatment, and the observation group was treated with conventional Western medicine treatment + Maxing Shigan Decoction treatment. The total effective rate, disappearance time of symptoms and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was 93.33%,which was higher than that of the control group (66.67%), the difference was statistically significant (P<0.05). The disappearance time of cough in observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The total incidence of adverse reactions in the observation group was 3.33%, lower than 30.00% in the control group, and the difference was statistically significant (P<0.05). Conclusion Maxing Shigan Decoction can be used in the treatment of chronic cough after respiratory tract infection, which can promote the disappearance of symptoms and stabilize the internal environment of the body, with high safety. 2022 Vol. 29 (8): 141-143 [Abstract] ( 43 ) HTML (1 KB)  PDF (415 KB)  ( 10 ) 144 Investigation on the eating habits of 1520 residents aged 35 and above in Hefei City FENG Rui； SHEN Xingrong； WANG Debin Objective To explore the differences of dietary habits among urban and rural residents aged 35 and above in Hefei city. Methods A total of 1520 permanent residents in urban and rural areas aged 35 and in urban and rural areas in Hefei city from June to September 2017 were selected as the research objects by stratified random sampling method. The general sociological demographic characteristics, dietary structure and habits and other information were collected through questionnaires, and the collected data were analyzed. Results The proportion of rural residents often eat pickled and sun-dried food and leftovers was higher than that of urban residents, the proportion of people who often eat smoked, fried, spicy food and leftovers was lower than that of urban residents, the differences were statistically significant (P<0.05). The proportion of rural residents often eat garlic, soy products, seafood, freshwater fish and shrimp,milk, vegetables, fruits, whole grains and livestock meat was lower than that of urban residents, while the proportion of rural residents the high daily intake of staple foods, hot diet, partial oil, fast eating speed, regular meals Irregularities were higher than in urban residents, the differences were statistically significant (P<0.05). Conclusion There are big differences in the eating habits of residents aged 35 and above in urban and rural areas in Hefei, and the situation is not optimistic, and relevant departments should pay attention. 2022 Vol. 29 (8): 144-147 [Abstract] ( 37 ) HTML (1 KB)  PDF (610 KB)  ( 33 ) 148 Preoperative anxiety state and influencing factors of patients undergoing transurethral resection of prostate HUANG Qing； HU Caihong； PAN Hongshen； LIANG Zhengbo Objective To analyze the preoperative anxiety state of patients who need to undergo transurethral resection of prostate (TURP) before surgery and its influencing factors, so as to provide a theoretical basis for formulating clinical nursing strategies to alleviate patient′s preoperative anxiety. Methods From September 2019 to November 2020, 210 patients who were diagnosed as benign prostatic hyperplasia (BPH) in Deyang People′s Hospital and Chengdu Fifth People′s Hospital and planned to undergo TURP surgery were selected as the research subjects. Before the operation, the S-AI state anxiety subscale was used to measure the psychological indicators, to design a questionnaire about anxietyrelated factors, to collect relevant data and analyze. Results The results of univariate analysis suggested that the S-AI score of TURP patients was (56.01±6.89) points, compared with the domestic norm (50.00 points), and the difference was statistically significant (P<0.001). The results of multivariate analysis suggested that quite familiar with the hospital environment (β=-0.128, odds ratio [OR]=0.769, P<0.001), surgical procedures (β=0.076, OR=0.304, P<0.001), and good family financial status (β=-0.029, OR=0.453, P<0.001) were protective factors for high levels of preoperative anxiety. Fear of pain was an independent risk factor for patients with preoperative anxiety (β=0.116, OR=2.675, P<0.001).Conclusion Patients with TURP have varying degrees of anxiety before surgery. Effective clinical nursing interventions can be established based on common anxiety influencing factors. 2022 Vol. 29 (8): 148-150转154 [Abstract] ( 41 ) HTML (1 KB)  PDF (588 KB)  ( 47 ) 151 Analysis and evaluation of anesthetic drugs used in Donggang Central Hospital from Januray to June 2021 WANG Xinxin Objective To investigate the utilization of anesthetic drugs in Donggang Central Hospital from Januray to June 2021. Methods A total of 2562 anesthetic drugs prescriptions collected from Januray to June 2021 in Donggang Central Hospital were retrospective statistical analyzed and evaluated, including defined daily dose system, daily drug cost, drug utilization index, order ratio (B/A) and so on. Results Fourteen kinds of anesthetic drugs were mainly used in Donggang Central Hospital. The defined daily dose system (DDDs) of the top five were Morphine Sulfate Zyban, 10 mg Oxycodone Zyban, Fentanyl Transdermal Stick, 40 mg Oxycodone Zyban and Morphine Hydrochloride Tablets. The daily drug cost (DDC) of the top five were 2 mg Remifentanil, Morphine Sulfate Bolt, Sufentanil Injection, 1 mg Remifentanil and Fentanyl Injection. The varieties of drug utilization index (DUI) values ＞1 were Morphine Hydrochloride Tablets, Morphine Sulfate Zyban and Morphine Hydrochloride Injection. The B/A values of Codeine Phosphate, Morphine Hydrochloride Tablets, Morphine Sulfate had a poor synchronization. Conclusion The use of narcotic drugs in Donggang Central Hospital from Januray to June 2021 is unreasonable. It is necessary to continue to strengthen the narcotics training of medical staff and pharmacists intervention, and to further promote the clinical rational use of drugs. 2022 Vol. 29 (8): 151-154 [Abstract] ( 47 ) HTML (1 KB)  PDF (551 KB)  ( 103 ) 155 Correlation of anxiety or depression and medication compliance in patients with multidrug-resistant tuberculosis GUI Min；CHEN Jingfang； DENG Guofang；ZENG Guqing Objective To explore the correlation of anxiety or depression and medication compliance in patients with multidrug-resistant tuberculosis. Methods A total of 91 patients with multidrug-resistant tuberculosis (MDR-TB) who were treated in Shenzhen Third People′s Hospital from December 2020 to May 2021 were selected as the research subjects. The patient′s anxiety/depression score was evaluated by the Hospital Anxiety and Depression Scale, and the patient′s medication adherence score was evaluated by the Morisky Medication Adherence Scale. There were three groups of symptoms and use analysis of variance to compare the medication adherence scores of patients with different anxiety/depression symptoms in the three groups, and use Pearson linear correlation analysis to explore the correlation between anxiety/depression and medication adherence in patients. Results The average score of medication compliance in multidrug tuberculosis patients was (6.15±1.09) points, 12 patients (13.2%) had good medication compliance, 37 patients(40.7%) were moderate, and 42 patients (46.1%) were poor. The mean score of the condition was (9.11±3.26) points, and the mean score of the depression condition was (10.06±3.26) points. Comparing the compliance scores of the three groups of patients with different anxiety status, the differences were statistically significant (P<0.05). Comparing the compliance scores of the three groups of patients with different depression status, the differences were statistical ly significant (P<0.05). The results of multiple comparisons showed that there were significant differences in the compliance scores of the three groups of patients with different anxiety/depression conditions (P<0.05). The results of Pearson linear correlation analysis showed that the scores of anxiety and medication compliance were negatively correlated (r=-0.785, P＜0.05). The scores of depression were negatively correlated with medication compliance (r=-0.930, P＜0.05). Conclusion MDR-TB patients have poor medication compliance, and patients with more severe anxiety/depression have poor medication compliance. 2022 Vol. 29 (8): 155-158 [Abstract] ( 45 ) HTML (1 KB)  PDF (543 KB)  ( 19 ) 159 Investigation and research on cognition status of group standard for nurses on auricular Sticking technique of Constipation ZHANG Linyu； WANG Xiaohong； SHI Fuxia； LI Li； WU Xinyuan； ZHANG Suqiu Objective To provide reference for the promotion and revision of the group standard by understanding the status quo of nurses′ cognition of the group standard of Auricular Sticking technique for Constipation (hereinafter referred to as group standard). Methods From June 2021 to July 2021, 70 nurses in the Specialty Department of Traditional Chinese Medicine Nursing in Guang′anmen Hospital of China Academy of Traditional Chinese Medicine were selected as the research objects, and their cognitive status was investigated, including the nurses′ knowledge of group standards, their use and the reasons influencing their use. The survey was conducted in the form of questionnaire star and self-designed questionnaire. Results In terms of group standard cognition, 51% of nurses did not know the group standard, 49% of nurses knew the group standard, 27% of nurses had received the training of the group standard, 23%of nurses believed that the basic acupoints in the group standard could meet clinical needs. In terms of regimental standard implementation, 15% of nurses used the regimental standard frequently and all the time to relieve patients′ constipation. In terms of the reasons for influencing the implementation, 23% of nurses believed that the low compliance of patients or their family members would affect the implementation of the target, 19% thought that the expected effect of the target was uncertain, and 13% thought that the working time and energy were not allowed. Conclusion At present,the group standard of auricular acupoint pressing technique for constipation needs further practice and improvement,and the promotion of this group standard should be further strengthened, and the standard technical standard should be widely used in clinical practice. 2022 Vol. 29 (8): 159-162 [Abstract] ( 34 ) HTML (1 KB)  PDF (569 KB)  ( 15 ) 163 Influence of nursing intervention based on the concept of rapid rehabilitation surgery on postoperative pain and rehabilitation effect of patients undergoing endoscopic sinus surgery FAN Liu； LI Wei Objective To explore the influence of nursing intervention based on the concept of rapid rehabilitation surgery on patients undergoing endoscopic sinus surgery. Methods A total of 120 patients who underwent endoscopic sinus surgery in Yichun People′s Hospital from March 2020 to March 2021 were selected and divided into the control group and the experimental group according to random number table method, with 60 cases in each group. The control group received routine nursing, and the experimental group received nursing based on the concept of rapid rehabilitation surgery, and continued nursing until the patient was discharged. The scores of psychological stress, postoperative pain, the incidence of complications and postoperative hospital stay were compared between the two groups before and after intervention. Results Before intervention, there were no significant differences in the scores of depression screening scale of patient health questionnaire 9 (PHQ-9) and simple generalized anxiety disorder score 7 (GAD-7) between the two groups (P＞0.05). After the intervention, the scores of PHQ-9 and GAD-7 in the two groups were lower than those before the intervention, and the scores of PHQ-9 and GAD-7 in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). At 6, 24 h and 72 h after operation, the visual analogue scale (VAS) score of the experimental group was lower than that of the control group, the total incidence of complications after intervention of the experimental group was lower than that of the control group, and the postoperative hospital stay of the experimental group was shorter than that of the control group, the differences were statistically significant (P＜0.05). Conclusion Nursing intervention based on the concept of rapid rehabilitation surgery is helpful to reduce postoperative pain, which can reduce negative emotion and accelerate postoperative rehabilitation. 2022 Vol. 29 (8): 163-165转169 [Abstract] ( 42 ) HTML (1 KB)  PDF (665 KB)  ( 33 ) 166 Application research of Orem self-care theory in the nursing of patients with acute cerebral infarction after arterial thrombosis YU Rongyan； DUAN Tiantian； ZHANG Fang； KANG Feifei； HU Yiting； LUO Ruixia； ZHANG Lihua Objective To study and analyze the application effect of Orem self-care theory in the nursing of patients with acute cerebral infarction after arterial thrombosis. Methods A total of 96 patients with acute cerebral infarction after arterial thrombosis who were admitted to the Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University from June 2019 to December 2020 were selected as the research subjects. The patients were divided into control group and study group by grouping method of random dice roll, with 48 cases in each group. Patients in the control group were treated with conventional care, and patients in the study group were treated with conventional care and Orem self-care. The coma, neurological impairment, and ability to take care of themselves in daily life were compared between the two groups. Results The Glasgow coma scale (GCS) scores of patients in the study group at 3, 7 and 14 days after thrombolytic therapy were higher than those in the control group, and the differences were statistically significant (P<0.05). The scores of National Institutes of Health stroke scale (NIHSS) in the study group at 24 h and 14 d after thrombolytic therapy were lower than those in the control group, and the differences were statistically significant(P<0.05). Barther index (BI) scores of patients in the study group at 7 and 14 days after thrombolytic therapy were higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application of Orem self-nursing theory to the nursing of patients with acute cerebral infarction after arterial thrombosis can effectively improve the coma of patients, reduce the degree of nerve damage, improve the self-care ability of patients. 2022 Vol. 29 (8): 166-169 [Abstract] ( 36 ) HTML (1 KB)  PDF (662 KB)  ( 42 ) 170 Application effect of extended rehabilitation intervention in family rehabilitation of discharged children with cerebral palsy WU Xiaoyuan； DU Chuance； WENG Liping；WU Guihua；ZHU Zhenxing Objective To explore the application effect of extended rehabilitation intervention in family rehabilitation of discharged children with cerebral palsy. Methods From December 2018 to December 2020, 200 children with cerebral palsy who received routine treatment in Ganzhou People′s Hospital of Jiangxi Province were retrospectively analyzed.They were divided into the control group (100 cases) and the observation group (100 cases) according to different rehabilitation intervention methods after discharge. The control group received rehabilitation intervention with traditional methods after discharge, and the observation group received rehabilitation intervention with extended rehabilitation intervention mode after discharge. The motor function and intelligence-related scores, the total effective rate of disease control and the satisfaction of parents with the rehabilitation intervention mode after discharge were compared between the two groups before and after the intervention. Results After intervention, the motor function and intelligence-related scores of the children in the observation group were higher than those in the control group, with statistical significance(P＜0.05). The total effectiveness rate of disease control in the observation group was higher than that of the control group, with statistical significance (P＜0.05). The satisfaction of parents with the rehabilitation intervention mode after discharge in the observation group was higher than that in the control group, with statistical significance (P＜0.05).Conclusion Extended rehabilitation intervention for children with cerebral palsy during family rehabilitation after discharge can reduce the occurrence of adverse events, greatly improve their motor ability and intelligence level, and improve the effect of rehabilitation intervention and parental satisfaction simultaneously. 2022 Vol. 29 (8): 170-173 [Abstract] ( 39 ) HTML (1 KB)  PDF (650 KB)  ( 14 ) 174 Application effect of traditional Chinese medicine evidence-based mode plus ear acupoint compression in patients with gastrointestinal ulcer SHI Ruhui； BIN Juexiu Objective To explore the intervention effect of traditional Chinese medicine evidence-based mode plus ear acupoint compression in patients with gastrointestinal ulcer. Methods A total of 104 patients with gastrointestinal ulcer in the Department of Gastroenterology, the Second Affiliated Hospital of Guangdong Pharmaceutical University (Yunfu Hospital of Traditional Chinese Medicine) from February 2019 to March 2021 were selected as the research subjects,and they were divided into the conventional treatment group and the combined traditional Chinese medicine group using the "drawing method", with 52 patients in each group. The routine intervention was used in the routine group, and the evidence-based mode of traditional Chinese medicine plus auricular point sticking was used in the combined group on the basis of routine intervention. The acid reflux, abdominal pain, Hamilton anxiety acale (HAMA), Hamilton depression scale (HAMD) and quality of life after intervention were compared between the two groups. At the same time,the total compliance rate and bleeding rate after one month of treatment were compared between the two groups. Results Before the intervention, there were no significant differences in the scores of acid reflux and abdominal pain between the two groups (P>0.05). The scores of abdominal pain and abdominal pain were lower than those of the routine group, and the differences were statistically significant (P<0.05). Before the intervention, there were no significant differences in the HAMA and HAMD scores between the two groups (P>0.05). The scores of HAMD and HAMD in the two group were lower than those before the intervention, and the scores of HAMA and HAMD in the traditional Chinese medicine combination group were lower than those in the routine group, and the differences were statistically significant(P<0.05). After the intervention, the scores of physiological condition, family situation, cognition and role function in the combination group of traditional Chinese medicine were higher than those in the routine group, and the differences were statistically significant (P<0.05). One month after the intervention, the bleeding rate in the traditional Chinese medicine combination group was lower than that in the routine group, and the difference was statistically significant (P<0.05). Conclusion Through the evidence-based mode of traditional Chinese medicine and auricular plaster intervention in patients with peptic ulcer, it can significantly improve the clinical symptoms of patients, regulate anxiety and depression, improve the living standards of patients, strengthen the overall compliance behavior, reduce the bleeding rate, and help to accelerate the recovery of patients, which is worthy of promotion. 2022 Vol. 29 (8): 174-177转181 [Abstract] ( 37 ) HTML (1 KB)  PDF (634 KB)  ( 27 ) 178 Application of continuous nursing in patients with peritoneal dialysis CAI Minhua； OU Meiqiong； LI Aiqun Objective To explore the application of continuing nursing in patients with peritoneal dialysis. Methods A total of 60 patients undergoing peritoneal dialysis in the Department of Nephrology, Yunfu People′s Hospital, Guangdong Province from June 2020 to May 2021 were selected as the study subjects. They were divided into observation group and control group by random number table method, with 30 patients in each group. Continuous nursing intervention was used in the observation group and routine nursing intervention was used in the control group. The medical compliance behavior, quality of life and complications of patients in the two groups were compared. Results After intervention, the compliance rate of the observation group was 93.33% (28/30), which was higher than that of the control group of 63.33% (19/30), and the difference was statistically significant (P<0.05). The scores of the MOS item short form health survey (SF-36) in observation group were higher than those in control group, and the differences were statistically significant (P<0.05). The total incidence of complications in the observation group was 10.00% (3/30), which was lower than 30.33% (10/30) in the control group, and the difference was statistically significant (P<0.05). Conclusion Continuous nursing in patients with peritoneal dialysis can improve their medical compliance behavior, improve their quality of life and reduce the incidence of complications. 2022 Vol. 29 (8): 178-181 [Abstract] ( 40 ) HTML (1 KB)  PDF (650 KB)  ( 76 ) 182 Application of graded management midwifery nursing model in advanced second-born mothers ZHANG Yingzi； LI Zhiping Objective To explore the application effect of graded management midwifery nursing model in advanced second-born mothers. Methods A total of 180 elderly women with two births who delivered in Fuzhou Maternal and Child Health Hospital from February 2019 to February 2021 were selected as the research objects. They were randomly divided into control group (90 cases) and study group (90 cases). The control group received routine nursing, and the study group implemented the intervention of hierarchical management midwifery nursing mode. The mode of delivery,duration of labor, incidence of adverse events and nursing satisfaction were compared between the two groups. Results The rate of natural delivery in the study group was higher than that in the control group, and the rate of cesarean section was lower than that in the control group, the mode of delivery the two groups were compared, the difference was statistically significant (P<0.05). The first stage of labor, the second stage of labor and the third stage of labor in the study group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The total incidence of adverse events in the study group was lower than that in the control group, and the total nursing satisfaction was higher than that in the control group, and the differences were statistically significant (P<0.05). Conclusion The hierarchical management midwifery nursing model can improve the natural delivery rate of elderly second child pregnant women, shorten the time of each stage of labor, reduce the occurrence of adverse events and improve nursing satisfaction. 2022 Vol. 29 (8): 182-184 [Abstract] ( 47 ) HTML (1 KB)  PDF (603 KB)  ( 31 ) 185 Application effect of secondary prevention management mode based on"Internet+" in patients with coronary heart disease LI Yuling； CHEN Haihong；JIAN Xiangyu Objective To explore the effect of secondary prevention management mode based on "Internet+" in patients with coronary heart disease. Methods A total of 120 patients with coronary heart disease treated in Foshan Second People′s Hospital from August 2019 to March 2021 were selected as the research subjects, and were divided into control group (60 cases) and observation group (60 cases) by random number table method. The control group received routine follow-up management plan, while the observation group adopted the secondary prevention management mode based on "Internet+". The disease self-management ability (CSMs), quality of life (SAQ) before and after intervention,incidence of adverse cardiovascular events and rehospitalization rate were compared between the two groups. Results There were no significant differences between the two groups in the scores of CSMS and SAQ before intervention (P>0.05). The scores of CSMS and SAQ in the observation group were higher than those in the control group after intervention, the differences were statistically significant (P<0.05). The incidence of adverse cardiovascular events and rehospitalization rate in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion The secondary prevention management mode based on "Internet+" can improve the selfmanagement ability and quality of life of patients with coronary heart disease, reduce the incidence of cardiovascular adverse events and relapse rate. 2022 Vol. 29 (8): 185-188 [Abstract] ( 39 ) HTML (1 KB)  PDF (626 KB)  ( 27 ) 189 Application effect of systemic pain nursing model in patients with cancer pain at home HE Xiaofang； ZENG Liyin；ZENG Qiuping； LYU Jinfeng Objective To explore the application effect of systematic pain nursing model in patients with cancer pain at home. Methods From March to December 2020, 130 patients with cancer pain at home admitted to the Eighth Affiliated Hospital of Sun Yat-sen University (Shenzhen Futian) were selected as the research objects, and they were divided into the control group (65 cases) and the observation group (65 cases) by random number table method. The control group received routine pain nursing, and the observation group received systematic pain nursing on this basis. The two groups of patients were compared with the numerical rating scale (NRS) score, the number of burst pain, Pittsburgh sleep quality index (PSQI) score, cancer fatigue scale (CFS) score and the satisfaction rate of pain control. Results There were no statistically significant differences in NRS score, burst pain time, PSQI score, and CFS score between the two groups before intervention (P>0.05). The NRS score of the two groups after intervention was lower than those before intervention, the burst pain time was less than that before intervention, and the PSQI and CFS scores were lower than those before intervention, the differences were statistically significant (P<0.05). The NRS score of the observation group after intervention was lower than that of the control group, the burst pain time was less than that of the control group, the PSQI score and CFS score were lower than those in the control group, and the total pain control satisfaction rate was higher than that of the control group, the differences were statistically significant (P<0.05). Conclusion The systematic pain nursing model can effectively reduce the pain degree and burst pain frequency of patients with cancer pain at home, reduce the degree of cancer-related fatigue, and improve the patient′s sleep quality and pain control satisfaction rate. 2022 Vol. 29 (8): 189-192 [Abstract] ( 36 ) HTML (1 KB)  PDF (649 KB)  ( 37 ) 193 Application effect of early enteral nutrition nursing in diabetic patients with severe cerebral infarction GU Xiaoyan；YI Chaoqun Objective To explore the effect of early enteral nutrition nursing in diabetic patients with severe cerebral infarction. Methods A total of 78 patients with severe diabetic cerebral infarction admitted to the Fifth Affiliated Hospital of Guangzhou Medical University from July 2020 to June 2021 were selected as research objects. They were divided into control group (routine nursing) and research group (early enteral nutrition) by drawing lot method, with 39 cases in each group. The control group using routine nursing method and research group using early enteral nutrition method.The adverse reactions, nutritional status (arm circumference [AC], serum albumin [ALB], arm muscle circumference[AMC] and triceps skinfold thickness [TST] of upper limb on non paralyzed side) and nursing satisfaction of two groups were observed. Results After treatment, AC and AMC in the study group were longer than those in the control group,ALB was higher than that in the control group, and TST was thicker than that in the control group, the differences were statistically significant (P<0.05). The nursing satisfaction rate of the study group was higher than that of the control group, the difference was statistically significant (P<0.05). The total incidence of the study group was lower than that in the control group, the difference was statistically significant (P<0.05). Conclusion The application of early enteral nutrition in severe diabetic cerebral infarction has a high value, can improve the satisfaction and nutritional status of patients, reduce the total incidence of adverse reactions, and it′s worthy of promotion and application. 2022 Vol. 29 (8): 193-196 [Abstract] ( 39 ) HTML (1 KB)  PDF (610 KB)  ( 18 )

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