氨基末端脑钠肽前体联合中性粒细胞与淋巴细胞比值对静脉丙种球蛋白无反应性川崎病预测价值

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Abstract Objective To investigate the predictive value of N-terminal pro brain natriuretic peptide combined with the ratio of neutrophils to lymphocytes in intravenous immunoglobulin unresponsive Kawasaki disease. Methods A total of 120 children with Kawasaki disease treated in pediatrics of North Guangdong People′s Hospital from January 2019 to July 2021 were selected as the research objects. According to whether they responded to gamma globulin, they were divided into non response group and sensitive group, with 60 cases in each group. At the same time, 30 healthy children were collected as the control group. The three groups of research objects were tested by serum and color Doppler echocardiography. The levels of amino terminal brain natriuretic peptide precursor, neutrophil lymphocyte ratio, leukocyte count, C-reactive protein, platelet, erythrocyte sedimentation rate, albumin and blood sodium of the three groups were compared. Pearson correlation analysis was used to analyze the correlation between amino terminal brain natriuretic peptide precursor and leukocyte count, C-reactive protein, platelet, erythrocyte sedimentation rate, albumin and blood sodium, ROC curve analysis of the predictive value of amino terminal pro brain natriuretic peptide and the ratio of neutrophils to lymphocytes in the diagnosis of Kawasaki disease alone and in combination. Results The amino terminal brain natriuretic peptide precursors, neutrophil to lymphocyte ratio, white blood cell count, C-reactive protein,platelet and erythrocyte sedimentation rate were higher in non-reactive group and sensitive group than those in control group, while the levels of albumin and serum sodium were lower than those in control group, the differences were statistically significant (P<0.05). There were no significant differences in amino terminal brain natriuretic peptide precursors, neutrophil to lymphocyte ratio, white blood cell count, C-reactive protein, platelet, erythrocyte sedimentation rate, albumin and serum sodium levels between non-reaction group and sensitive group (P>0.05). The amino terminal brain natriuretic peptide precursors were positively correlated with white blood cell count count and C-reactive protein (P<0.05). The amino terminal brain natriuretic peptide precursors were negatively correlated with albumin and serum sodium levels (P<0.05). There was no correlation between amino terminal brain natriuretic peptide precursor and platelet and erythrocyte sedimentation rate (P>0.05). The sensitivity and specificity of N-terminal pro brain natriuretic peptide in the diagnosis of gamma globulin unresponsive Kawasaki disease were 66.67% and 80.00%, and the sensitivity and specificity of their combined detection in the diagnosis of gamma globulin unresponsive Kawasaki disease were 91.67% and 96.67%. Conclusion N-terminal pro brain natriuretic peptide combined with neutrophil lymphocyte ratio is not only helpful for the diagnosis of intravenous gamma globulin unresponsive Kawasaki disease, but also has a good value in predicting coronary artery damage.

Key words： Kawasaki disease Gamma globulin Amino terminal pro brain natriuretic peptide Ratio of neutrophils to lymphocytes

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	Articles by authors
	DENG Jianrong
	LIN Xiaoqin
	RUAN Yucai
	PENG Lijun
	NIE Yuzhe
	XIAO Xiaobing

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DENG Jianrong,LIN Xiaoqin,RUAN Yucai, et al. Predictive value of N-terminal pro brain natriuretic peptide combined with neutrophil lymphocyte ratio in intravenous immunoglobulin unresponsive Kawasaki disease[J]. 中国当代医药, 2022, 29(8): 21-24.

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