酮咯酸氨丁三醇复合舒芬太尼对骨科手术患儿术后镇痛的临床效果

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Abstract Objective To investigate the clinical effect of Ketorolac Traminotriol combined with Sufentanil on postoperative analgesia in children undergoing orthopedic surgery. Methods A total of 60 children undergoing fracture reduction under general anesthesia in Ganzhou Hospital of Traditional Chinese Medicine from April 2017 to April 2019 were selected as the research objects. The patients were divided into observation group and control group by random number table method, 30 cases in each group. The control group was treated with Sufentanil for analgesia, and the observation group was treated with Ketorolac Traminotriol combined with Sufentanil for analgesia. Sufentanil dosage, press times,CRIES score, 5-hydroxytryptamine (5-HT) level, substance P (PS) level and adverse reactions were compared between the two groups at different time points. Results The dose of Sufentanil at 4, 8 and 24 h after operation showed an increasing trend in both groups, the number of analgesic pump compressions at 4 and 8 h after surgery was more than 1 h after surgery, and the number of analgesic pump compressions at 24 h after surgery was less than 1, 4 and 8 h after surgery, the differences were statistically significant (P<0.05). The dose and pressing times of Sufentanil in the observation group were lower than those in the control group at 1, 4, 8 and 24 h after operation, the differences were statistically significant (P<0.05). At 4, 8 and 24 h after surgery, the scores of the two groups decreased. There was no significant difference between the two groups at 1 h after surgery (P>0.05). The CRIES of the observation group were lower than those of the control group at 4, 8 and 24 h after surgery, the differences were statistically significant (P<0.05). The levels of 5-HT and PS in both groups were higher on postoperative day 2 than postoperative day 1, and higher on postoperative day 3 than postoperative day 1 and 2, the differences were statistically significant (P<0.05). The levels of 5-HT and PS in the observation group were lower than those in the control group on day 1, 2 and 3 after operation, the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of postoperative adverse reactions between the two groups(P>0.05). Conclusion Ketorolac Tromethamine combined with Sufentanil for pediatric orthopedic surgery has good analgesic effect, inhibits the increase of 5-HT and PS concentration, and has high safety.

Key words： Orthopedic surgery Ketorolac Tromethamine Sufentanil Serotonin Substance P

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	Articles by authors
	LAI Jianhong
	ZENG Fanying
	LONG Yan

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LAI Jianhong,ZENG Fanying,LONG Yan. Clinical effect of Ketorolac Traminotriol combined with Sufentanil on postoperative analgesia in children undergoing orthopedic surgery[J]. 中国当代医药, 2022, 29(8): 118-121.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I8/118

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