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| Effect of α-lipoic Acid Injection combined with Mecobalamin Injection in the treatment of diabetic peripheral neuropathy |
| SUN Chuang |
| Department of Endocrinology, Xincheng Hospital, Liaoyang Central Hospital, Liaoning Province, Liaoyang 111000,China |
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Abstract Objective To investigate the effect of α-lipoic Acid Injection combined with Mecobalamin Injection in the treatment of diabetic peripheral neuropathy. Methods A total of 110 patients with diabetic peripheral neuropathy who were admitted to Xincheng Hospital, Liaoyang Central Hospital from June 2018 to June 2020 were selected as subjects and divided into control group and observation group by the random number table method, with 55 cases in each group.The patients in the control group were provided with Mecobalamin Injection, and patients in the observation group were added with α-lipoic Acid Injection. The curative effect, neuropathy subjective symptom questionnaire (TSS) score, the motor nerve conduction velocity (MCV) of the common peroneal nerve and the median nerve, the sensory nerve conduction velocity (SCV) of the common peroneal nerve and the median nerve of the two groups were compared. The adverse reactions during the treatment of the two groups were observed. Results The total clinical effective rate of observation group was higher than that in the control group, the difference was statistically significant (P<0.05). After treatment, the scores of pain, burning sensation, numbness, paresthesia and total score in observation group were lower than those in control group, the differences were statistically significant (P<0.05). The MCV of common peroneal nerve, MCV of median nerve, SCV of median nerve and SCV of common peroneal nerve in observation group were higher than those in control group after treatment, with statistical significances (P<0.05). There were no obvious adverse reactions such as abnormal blood routine, liver and kidney function and coagulation function in the two groups. Conclusion The combination of α-lipoic Acid Injection and Mecobalamin Injection has a significant clinical effect in the treatment of diabetic peripheral neuropathy,which can effectively help improve symptoms and signs,and regulate the conduction velocity of the common peroneal nerve and median nerve, and has a high safety, without obvious adverse reactions during treatment.
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