蛋白基因产物9.5在子宫内膜样癌中的表达及其与临床病理特征的关系

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Abstract Objective To investigate the expression of protein gene product 9.5 (PGP 9.5) in endometrioid carcinoma and its relationship with clinicopathological characteristics. Methods From January 2017 to December 2020, 91 patients with endometrioid cancer and 20 healthy patients who were admitted to Ganzhou Maternity and Child Health Hospital were selected as the research objects, and their tissue specimens of endometrioid cancer and normal endometrium were collected.Tissue specimens were prepared and sectioned.PGP 9.5 was stained by immunohistochemical experiments and the results were interpreted. The expression of PGP 9.5 in normal endometrial tissue and endometrioid carcinoma tissue was compared. The cancer specimens were divided into high expression group and low expression group. The clinicopathological characteristics such as age, tumor diameter, histological grade, muscle invasion, cervical canal involvement, lymph node metastasis, vascular involvement, adnexal involvement, Federation International of Gynecology and Obstetrics (FIGO) staging, etc. were compared between the two groups. Results The results of immunohistochemical experiments showed that the positive expression rate of PGP 9.5 in normal endometrial tissues was lower than that in endometrioid carcinoma tissues, and the difference was statistically significant (P<0.05). The age of the two groups of patients were compared, and the difference was not statistically significant (P>0.05). The tumor diameter, histological grade, myometrial infiltration, cervical canal involvement, lymph node metastasis, vascular involvement, adnexal involvement, FIGO staging were compared between the two groups, and the differences were statistically significant(P<0.05).Conclusion The expression level of PGP 9.5 in endometrioid carcinoma tissues and normal endometrial tissues is different, indicating that the protein gene product has a role in the process of endometrial tissue transforming from normal to endometrioid carcinoma. Important regulatory role. Therefore, it can be used as an effective predictor of the prognosis of endometrioid carcinoma, providing new ideas and new methods for clinical treatment of endometrioid carcinoma, which can create certain social benefits.

Key words： Protein gene product 9.5 Endometrioid carcinoma Immunohistochemistry was used Gene expression;Clinical pathology

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