铅中毒患儿驱铅治疗后外周血免疫球蛋白水平及细胞免疫功能的检测意义

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (520 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the significance of detecting peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning after antiplumbism. Methods A total of 50 children with lead poisoning admitted in Jiangxi Children′s Hospital from June 2019 to December 2020 were selected as research subjects. The levels of peripheral blood immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), T-lymphocyte subsets (CD3+, CD4+, CD8+) and natural killer (NK) cells CD16+ were compared before and after treatment. The levels of IgA, IgG and IgM in children with different prognosis were compared before and after treatment. Results The levels of IgA, IgG and IgM after treatment were higher than those before treatment, the differences were statistically significant(P<0.05). The levels of CD3+, CD4+ and CD16+ after treatment were higher than those before treatment, while the levels of CD8+were lower than those before treatment, the differences were statistically significant (P<0.05). The levels of IgA,IgG and IgM in cured group and non-cure group after treatment were higher than those before treatment, and the levels of IgA, IgG and IgM in cured group before and after treatment were higher than those in non-cure group, the differences were statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+ and CD16+ in cured group and non-cure group were higher than those before treatment, while the levels of CD8+ were lower than those before treatment, and the levels of CD3+, CD4+ and CD16+ in cured group before and after treatment were higher than those in the non-cure group, while the levels of CD8+ was lower than those in the non-cure group, the differences were statistically significant (P<0.05). Conclusion Peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning have detection significance, and peripheral blood immunoglobulin level and cellular immune function closely relate to the prognosis of children.

Key words： Lead poisoning Antiplumbism Peripheral blood immunoglobulin Cellular immune function Detection

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Zhi
	HE Qin
	LIN Yuanyuan
	LIU Xiaohui

Cite this article:

WANG Zhi,HE Qin,LIN Yuanyuan, et al. Significance of detecting peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning after antiplumbism[J]. 中国当代医药, 2022, 29(8): 95-98.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I8/95

[1]	薛文芳，张小鸥，王威，等.传统教育路径与互联网教育路径在儿童铅中毒排铅治疗中的效果[J].中国妇幼保健，2020，35（20）：3751-3753.
[2]	李旻明，颜崇淮.铅中毒对儿童神经心理发育的影响[J].中国妇幼保健，2018，33（24）：6073-6077.
[3]	冯灵美，施健，施斌.以腹痛和贫血起病的慢性铅中毒一例[J].中华消化杂志，2018，38（12）：858-859.
[4]	陈丽芳，陈咏芳，赖馨，等.一起铅中毒暴发事件中患儿铁代谢指标检测分析[J].检验医学与临床，2018，15（24）：3729-3730，3734.
[5]	王谦可，陈榕，李永财，等.顺德区龙江镇学龄前儿童血铅水平及影响因素研究[J].中国卫生检验杂志，2018，28（19）：2382-2384.
[6]	潘伟韶，庞国象，张素芬，等.儿童铅中毒采用静脉驱铅的疗效及预后影响因素分析[J].山西医药杂志，2020，49（3）：300-302.
[7]	Zhang XY，Carpenter DO，Song YJ，et al.Application of the IEUBK model for linking Children′s blood lead with environmental exposure in a mining site，south China[J].Environ Pollut，2017，231（Pt 1）：971-978.
[8]	李风峰，宋元玲，吕建东，等.喜炎平注射液联合布拉氏酵母菌散剂对肺炎继发腹泻患儿肠黏膜屏障状态和免疫功能的影响[J].河北医药，2020，42（2）：244-246，250.
[9]	Huang S，Hu H，Sánchez BN，et al.Childhood Blood Lead Levels and Symptoms of Attention Deficit Hyperactivity Disorder （ADHD）：A Cross-Sectional Study of Mexican Children[J].Environ Health Perspect，2016，124（6）：868-874.
[10]	Chibowska K，Baranowska-Bosiacka I，Falkowska A，et al.Effect of Lead（Pb）on Inflammatory Processes in the Brain[J].Int J Mol Sci，2016，17（12）：2140.
[11]	Li Q，Zhang P，Yu X，et al.Lead Transiently Promotes Granulocyte-Macrophage Progenitor Differentiation and Subsequently Suppresses Common Myeloid Progenitor Differentiation[J].Toxicol Sci，2017，160（2）：268-283.
[12]	Qi S，Zheng H，Chen C，et al.Du-Zhong （Eucommia ulmoides Oliv.）Cortex Extract Alleviates Lead Acetate-Induced Bone Loss in Rats[J].Biol Trace Elem Res，2019，187（1）：172-180.
[13]	闫凡，霍静雨.解毒清热汤对小儿疱疹性咽峡炎急性期免疫球蛋白及T 淋巴细胞亚群的影响[J].中国中医急症，2020，29（10）：1832-1835.
[14]	Souza-Fonseca-Guimaraes F，Cursons J，Huntington ND.The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy[J].Trends Immunol，2019，40（2）：142-158.
[15]	王振华，刘绘绘，马宁，等.NK 细胞表面CD160 分子表达及其介导NK 杀伤效应机制的初步研究[J].中国实验血液学杂志，2018，26（5）：1559-1564.
[16]	胡焕焕，姬国杰，赵青，等.人外周血与脐带血来源自然杀伤细胞大体系扩增培养比较[J].新乡医学院学报，2017，34（3）：177-179，183.
[17]	刘林娜，陈荣发，陈慧，等.淋巴细胞亚群检测在儿童肾病综合征患者中的应用价值[J].中国卫生检验杂志，2018，28（18）：2245-2247.
[18]	Mitra P，Sharma S，Purohit P，et al.Clinical and molecular aspects of lead toxicity：An update[J].Crit Rev Clin Lab Sci，2017，54（7-8）：506-528.