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Quick Search     Adv Search 2019 Vol. 26, No. 4 Published: 2019-02-08   4 Radiosensitization effect of elemene on cervical cancer HeLa cells ZENG Chun-sheng;ZENG Hong-xue;HUANG Zuo-chao;LIU Lian-bin;ZHANG Qun-gui;XU Qing-yun; LI Rong;YU Ying Objective To investigate the effect of elemene on radiosensitization of cervical cancer HeLa cells and provide evidence for its clinical application in radiotherapy of cervical cancer.Methods The untreated group of elemene was the control group，and the elemene treatment group was the treatment group.The proliferation，apoptosis and cell cycle distribution of HeLa cells were detected by colony formation assay and flow cytometry.The expression of Bax and Bcl-2 protein was detected by immunofluorescence.The implanted tumor model of HeLa cells in nude mice was used to give elemene emulsion and after different doses of radiation，the body weight and volume changes of implanted tumors were calculated，and the radiosensitizing effect of elemene emulsion on HeLa cells was analyzed.Results When the concentration of elemene was ≥40 μg/ml，it could significantly inhibit the proliferation of HeLa cells and promote apoptosis，and promote the regulation of Bax expression and inhibit the expression of Bcl-2.Under different radiation doses，HeLa cells or implanted tumors in the treatment group were significantly inhibited by growth inhibition compared with the control group.Conclusions Elemene can significantly increase the radiosensitivity of HeLa cells. 2019 Vol. 26 (4): 4-7 [Abstract] ( 98 ) HTML (44 KB)  PDF  (0 KB)  ( 19 ) 8 Effectiveness of Ziyin Qingre Decoction in the treatment of recurrent oral ulceration with yin deficiency and fire-excess syndrome   LIU Chun-zi1 LI Ping2 ZHANG Guo-ming1 MI Hong-tu2 Objective To study the effectiveness of Ziyin Qingre Decoction in the treatment of recurrent oral ulceration（ROU）with yin deficiency and fire-excess syndrome.Methods A total of 44 patients of ROU with yin deficiency and fire-excess syndrome treated in our hospital from August to December 2017 were selected as subjects.According to the different treatment methods，they were divided into study group and control group，22 cases in each group.Patients in the study group were treated with Ziyin Qingre Decoction，while those in the control group were treated with conventional therapy.The therapeutic effect was compared between the two groups.Results Before treatment，there were no statistically significant differences in the levels of inflammatory cytokines （interleukin-2 ［IL-2］，interleukin-8 ［IL-8］and tumor necrosis factor ［TNF-α］）between the two groups （P＞0.05）.After treatment，IL-2 levels were higher in the two groups than before treatment，and IL-8 and TNF-α levels were lower in the two groups than those before treatment，however，IL-2 levels was higher in the study group than that in the control group，and IL-8 and TNF-α levels in the study group were lower than those in the control group，the differences were statistically significant（P＜0.05）.Before treatment，there were no statistically significant differences in the levels of various immune cell indicators （CD3+，CD4+，CD8+and CD4+/CD8+）and plasma endothelin-1 between the two groups （P＞0.05）.After treatment，the levels of CD3+，CD4+，CD8+and CD4+/CD8+in both groups were higher than those before treatment，and the levels of plasma endothelin-1 were lower than those before treatment，but the levels of CD3+，CD4+，CD8+and CD4+/CD8+in the study group were higher than those in the control group，and the levels of plasma endothelin-1 were lower than those in the control group，the differences were statistically significant （P＜0.05）.Conclusion The Ziyin Qingre Decoction can remarkably improve the plasma endothelin-1 levels，reduce the inflammatory factors，stabilize the immune cell levels，promote the fast recovery and keep the favorable prognosis. 2019 Vol. 26 (4): 8-13 [Abstract] ( 109 ) HTML (41 KB)  PDF  (0 KB)  ( 13 ) 11 Myocardial injury marker in diagnosis of viral myocarditis:a Meta-analysis LI Yan-zhuo1 XU Lin1▲ ZHANG Qun-hui1,2 Objective To assess the myocardial injury marker in clinical diagnosis of viral myocarditis （VMC）.Methods From December 2012 to March 2018，Chinese biomedical literature database （CBM）and China national knowledge network （CNKI）and other databases were searched systematically for the research literature on myocardial injury markers to assist in the diagnosis of VMC.Newcastle-Ottawa Scale （NOS）was used for literature quality evaluation.Results A total of 9 studies were included in this study.The results of meta-analysis indicated that the sensitivity （SEN）of VMC diagnosis was 94%，and the 95%confidence interval was 0.87-0.98，indicating that the rate of missed diagnosis was 6%.The specificity （SPE）was 90%，and the 95%confidence interval was 0.83-0.95，indicating that the misdiagnosis rate was 10%.The positive predictive value was 9.8，and the 95%confidence interval was 5.4-17.7，it indicated that when the myocardial injury markers assist in the diagnosis of VMC was positive，suspicious patients were more likely to be diagnosed with VMC.Negative predictive value was 0.06，it indicated that the possibility of myocardial injury markers excluding suspicious patients as VMC was high.The diagnostic odds ratio was 159，it indicated that myocardial injury markers were 159 times more likely to assist in the diagnosis of VMC positive than negative.The area under the ROC curve was 0.97，it indicated that the diagnostic efficiency was high.Conclusion Myocardial injury marker is indeed valuable in auxiliary diagnosis of viral myoarditis.But much more studies are needed to approve these results. 2019 Vol. 26 (4): 11-14 [Abstract] ( 98 ) HTML (35 KB)  PDF  (0 KB)  ( 11 ) 15 Clinical diagnosis and treatment of hyperprolactinemia induced by antipsychotics in female psychotic patients YU Yun-xiang1LI Yu-chen2LI Xue-mei2 Objective To explore diagnosis and treatment of antipsychotics induced by hyperprolactinemia in female psychotic patients.MethodsRetrospective analysis of the data of 280 cases of hyperprolactinemia induced by antipsychotics in female psychotic patients who visited the gynecology clinic or hospitalized in our hospital during the period from June in 2013 to June in 2018，their age were from 18 to 45 years old，and their sex hormones including prolactin （PRL），follicular stimulating hormone （FSH），luteinizing hormone （LH），estradiol（E2），progestin （P）and testosterone （T）as well as thyroid hormones such as thyroid-stimulating hormone （TSH），free triiodothyronine （FT3）and free thyroxine （FT4）were also measured in this paper.Moreover;B-ultrasonography of uterus，accessories and endometrial thickness of these patients were conducted during this period.It was shown from the data collected that ultrasonic inspection of uterus and accessories，level of thyroid hormones （thyroid stimulating hormone ［TSH］，free triiodothyroid acid ［FT3］，free thyroxine ［FT4］）were normal and sex hormones （follicle-stimulating hormone ［FSH］，luteinizing hormone［LH］，estradiol ［E2］，progesterone ［P］，testosterone ［T］）were also normal.These patients were diagnosed to be hyperprolactinemia （HPRL）when the level of PRL among them was ＞30 ng/L.According to the different level of PRL，280 cases of female psychotic patients were then divided into three groups：Group Ⅰ （30 ng/ml＜PRL＜100 ng/ml），130 cases;Group Ⅱ （100 ng/ml＜PRL＜200 ng/ml），120 cases;Group Ⅲ （PRL＞200 ng/ml），30 cases.The total incidence of menstruation，abnormal uterine bleeding （AUB），lactation and follow-up treatment in the three groups were observed.In addition，30 patients were screened from 280 female mental patients of HPRL in this study.The patients′hospitalization time was more than 1 year，PRL ≤30 ng/L before were given prolactin-associated antipsychotic drugs，thyroid function was normal，and PRL＞100 ng/L after inpatient were given prolactin-associated antipsychotic drugs.Patients were defined as PRL＜30 ng/L before medication group and PRL＞100 ng/L after medication group.Thyroid function indexes （TSH，FT3，FT4）of patients in PRL＜30 ng/L before medication group and PRL＞100 ng/L after medication group were compared.The correlation between PRL and thyroid function indexes in 30 patients of hospitalization time was more than 1 year，PRL ≤30 ng/L before medication，and PRL＞100 ng/L after medication were analyzed.Results A-mong 130 patients in group Ⅰ，82 cases of patients （82/130，63.1%）with normal menstruation，48 cases of patients （48/130，36.9%）with chronic AUB，30 cases of patients （30/130，23.1%）with galactorrhea.Among 120 patients in groupⅡ，5 cases of patients （5/120，4.2%）with normal menstruation，100 cases of patients （100/120，83.3%）with chronic AUB，15 cases of patients （15/120，12.5%）with acute AUB，80 cases of patients （80/120，66.7%）with galactorrhea.A-mong 30 patients in group Ⅲ，27 cases of patients （27/30，90.0%）with chronic AUB，3 cases of patients（3/30，10.0%）with acute AUB，28 cases of patients （28/30，93.3%）with galactorrhea.The total incidence of AUB in group Ⅱ （115/120，95.8%）and group Ⅲ （30/30，100%）were higher than that in the group Ⅰ （48/130，36.9%），the differences were statistically significant（P＜0.01）.The incidence of galactorrhe in group Ⅱ（80/120，66.7%）and group Ⅲ （28/30，93.3%）were higher than that in the group Ⅰ （30/130，23.1%），the differences were statistically significant（P＜0.01）.The level of TSH in PRL＞100 ng/L after medication group was higher than in the PRL＜30 ng/L before medication group （P＜0.01）.The level of FT4in PRL＞100 ng/L after medication group was lower than in the PRL＜30 ng/L before medication group（P＜0.05）.There was no significant difference existed in the level of FT3between PRL＜30 ng/L before medication group and PRL＞100 ng/L after medication group （P＞0.05）.The correlation between PRL and thyroid function indexes in 30 patients of hospitalization time was more than 1 year，PRL ≤30 ng/L before medication，and PRL＞100 ng/L after medication were analyzed.The PRL was positively correlated with TSH in 30 patients of hospitalization time was more than 1 year，PRL ≤30 ng/L before medication，and PRL＞100 ng/L （r=0.750，P＜0.01），it was found that there was a negative correlation between PRL and FT4 （r=-0.549，P＜0.01），and no correlation was derived between PRL and FT3 （r=0.276，P＞0.05）.The AUB was observed to occur in 193 cases of HPRL in female psychotic patients，among them including 175 cases of patients （175/193，90.7%）with chronic AUB and 18 cases of patients （18/193，9.3%）with acute AUB.It was suggested that 160 cases of patients （160/193，82.9%）needed to be with the regular follow-up，31 cases of patients（31/193，16.1%）were treated with medicinal therapy of hemostatics，estrogen，and progestogen，and 2 cases of patients（2/193，1.0%）with surgical curettage.Conclusion The number of female patients with total AUB is surveyed with the increase of level of PRL during the period of their taking of antipsychotic medications.Most of female psychotic patients with chronic AUB such as oligomenorrhea or infrequent menstruation are advised to be with the regular followup，and patients with acute AUB are recommended to be treated with medicinal therapy of hemostatics progestogen，sequential therapy of estrogen-progestogen or surgical curettage.Reduction of dosage or discontinuation of antipsychotic medications in HPRL patients result in decreasing or returning to normal the level of PRL.The level of PRL and TSH is shown to fluctuate readily in patients with HPRL and the level of thyroid hormones is not affected in a short term by HPRL which play an effect on the increase of the level of TSH but the decrease of FT4in a long period of time （PRL＞100 ng/L）. 2019 Vol. 26 (4): 15-20 [Abstract] ( 113 ) HTML (59 KB)  PDF  (0 KB)  ( 18 ) 21 Research progress on new preparation and quality control of Semen Strychni LIU Xiao-mei1,2HOU Guo-ru1,2ZHANG Wei-hua1,2,3▲ LIANG Shan-fang2,3 Semen Strychni is a traditional Chinese medicine with definite curative effect on rheumatic stubborn paralysis，arthritis，bruise injury and carbuncle venom so far.However，its effective ingredient is also toxic，which greatly limits its clinical use.Since ancient times，many scholars have devoted their efforts to reducing the toxicity and increasing the efficiency of Semen Strychni in order to expand the clinical application.With the development of preparation technology，more and more scholars adopt new technology and new dosage forms to realize the attenuation and synergy of Semen Strychni.This review will summarize the research literature on the new preparation and quality control of Semen Strychni in recent years，so as to provide reference for the modernization of the preparation form and the standardization of quality control of semen strychni. 2019 Vol. 26 (4): 21-25 [Abstract] ( 104 ) HTML (47 KB)  PDF  (0 KB)  ( 13 ) 26 Research progress of new oral anticoagulants in the treatment of patients with atrial fibrillation SHU Chang-cheng1HOU Zhen-shi2▲ Atrial fibrillation is one of the common arrhythmic diseases，thromboembolic disease is the most common and dangerous complication of atrial fibrillation.Oral Warfarin，a traditional anticoagulant，is an effective measure to prevent thromboembolism in patients with atrial fibrillation，but its therapeutic window is narrow and easy to interact with a variety of drugs and foods.The new oral anticoagulant overcomes the above shortcomings of warfarin and can better prevent thromboembolic disease and bleeding risk in patients with atrial fibrillation.This article reviews the research progress of new oral anticoagulants in the treatment of patients with atrial fibrillation. 2019 Vol. 26 (4): 26-28 [Abstract] ( 89 ) HTML (34 KB)  PDF  (0 KB)  ( 13 ) 29 Clinical effect of water knife combined with electric skin graft knife in the treatment of dispigmented scar YE Hua SUN Jun-feng▲ WANG Xian-lin ZHOU Xiao-liang TU Jia-jin XU Ze-hua ZENG Hao Objective To investigate the clinical effect of water knife combined with electric skin graft knife in the treatment of dispigmented scars.Methods A total of 58 patients with dispigmented scars who were admitted to our hospital from August 2012 to August 2018 were selected.According to the random grouping method，they were divided into the control group and the research group，29 cases in each group.The control group was given electric skin graft knife to treat the patients with dispigmented scars.The research group was given water knife combined with electric skin graft knife to treat the patients with dispigmented scars.The effect of clinical treatment was compared between the two groups.Results The therapeutic effect of patients with dispigmented scar in the research group was higher than that in the control group （P＜0.05）.The recovery of patients with dispigmented scars in the research group was better than that in the control group （P＜0.05）.Conclusion Water knife combined with electric skin graft knife can effectively improve the therapeutic effect of patients in the treatment of dispigmented scars.It is worthy of clinical popularization and application. 2019 Vol. 26 (4): 29-31 [Abstract] ( 102 ) HTML (33 KB)  PDF  (0 KB)  ( 17 ) 32 Clinical effect of hemodialysis combined with hemoperfusion in the treatment of acute organophosphorus pesticide poisoning XU You-duiWANG Wen-zeLIN Wen-can HU Bin Objective To investigate the application effect of hemodialysis combined with hemoperfusion in the treatment of acute organophosphorus pesticide poisoning and the influence on serum tumor necrosis factor alpha （TNF-α），IL-1β （IL-1β），and high sensitive C reactive protein （hs-CRP）.Methods A total of 84 cases of acute organophosphorus pesticide poisoning in our hospital from January 2015 to April 2018 were selected as the research objects，according to the method of random number table，they were divided into the control group and the observation group，42 cases in each group.The control group was treated with routine emergency measures.On this basis，the observation group was treated with hemodialysis combined with hemoperfusion.The therapeutic effects，serum inflammatory factors and nutritional status of the two groups were compared.Results The incidence of multiple organ failure in the observation group was 7.14%，which was lower than 26.19%of the control group，with significant difference （P＜0.05）.The waking time of the observation group and the time of hospitalization in the observation group were shorter than those in the control group，the amount of atropine use in the observation group was less than that in the control group，the difference was statistically significant（P＜0.05）.The levels of TNF-α，IL-1β beta and hs-CRP in the observation group after treatment were lower than those in the control group，the levels of serum albumin，hemoglobin and prealbumin in the observation group after treatment were higher than those in the control group，with significant difference （P＜0.05）.Conclusion The patients with acute organophosphorus pesticide poisoning by hemodialysis combined with hemoperfusion can effectively reduce the dosage of atropine，avoid multiple organ failure，and reduce the level of serum TNF-α，IL-1β and hs-CRP，improve the nutritional status of the patients，and promote the recovery of the patients. 2019 Vol. 26 (4): 32-34 [Abstract] ( 98 ) HTML (34 KB)  PDF  (0 KB)  ( 19 ) 35 Clinical effect of 75%Ethanol catheter locks in the treatment of tunneled hemodialysis catheter-related blood stream infection CHEN Xue-xun1ZHANG Cheng-yin2ZHANG Yun-xia1MA Lin1GUO Min1WU Wen-bin2▲ Objective To investigate the clinical effect of 75%Ethanol catheter locks in the treatment of tunneled hemodialysis catheter-related blood stream infection.Methods A total of 62 cases of maintenance hemodialysis patients with central venous catheter-related blood stream infections from August 2016 to March 2018 in Affiliated Hospital of Weifang Medical University were selected as the research objects，according to different sealing methods，they were divided into the control group （18 cases），the Cefuroxime group （22 cases）and the Ethanol group （22 cases）.The control group was sealed with 50 mg/ml Heparin alone.The Cefuroxime group was sealed with Heparin （50 mg/ml）and Cefuroxime （20 mg/ml），while the Ethanol group was sealed with 75%Ethanol.The changes of body temperature，C-reactive protein （hs-CRP），white blood cell count （WBC），neutrophil count （NEU），neutrophil percentage （NEU%）and catheter dysfunction before and after catheter closure were detected.The clinical efficiency and the incidence rate of catheter dysfunction were compared among the three groups.Results The total clinical effective rate of the Ethanol group （95.5%）was higher than that of the Cefuroxime group （81.8%），the difference was statistically significant （P＜0.05）.The total clinical effective rate of the Ethanol group （95.5%）was higher than that of the control group （72.2%），the difference was statistically significant（P＜0.05）.The total effective rate of the Cefuroxime group （81.8%）was higher than that of the control group （72.2%），the difference was statistically significant （P＜0.05）.The total incidence rate of catheter dysfunction in the Ethanol group （12.1%）was lower than that in the Cefuroxime group （27.3%），the difference was statistically significant （P＜0.05）.There was no significant difference in the total incidence rate of catheter dysfunction between the Ethanol group （12.1%）and the control group （13.0%）（P＞0.05）.The total incidence rate of catheter dysfunction in the Cefuroxime group （27.3%）was higher than that in the control group （13.0%），the difference was statistically significant （P＜0.05）.Conclusion 75%Ethanol sealing and Cefuroxime sealing have good effect in the treatment of catheter blood stream infection，the effect of 75%Ethanol sealing is better than that of Cefuroxime sealing，and the incidence rate of catheter dysfunction is low. 2019 Vol. 26 (4): 35-38 [Abstract] ( 102 ) HTML (37 KB)  PDF  (0 KB)  ( 17 ) 39 Clinical effect of pulsed high volume hemofiltration in the treatment of acute respiratory distress syndrome DENG Xiu-fan QIU Han-zhong PAN Jian CHEN Zhao-yun MA Jun-wu OU Xiang-lin XIE Zhang-ke ZHU Zhan-dong Objective To explore the clinical effect of pulsed high volume hemofiltration in the treatment of acute respiratory distress syndrome.Methods A total of 52 patients with acute respiratory distress syndrome admitted to the ICU of our Hospital from February 2016 to March 2018 were enrolled.The patients were divided into the experimental group and the control group according to the random number table methods，with 26 cases in each group.The control group received conventional treatment plus conventional dose hemofiltration.The experimental group received routine treatment plus pulsed high-volume hemofiltration.The dynamic changes of vital signs and blood gas indexes before and after treatment were compared between the two groups.Results After 8 h and 24 h of treatment，the arterial pressure in the two groups was higher than that before treatment，and body temperature，respiratory rate and pulse rate after 8 h and 24 h of treatment were lower than those before treatment，the difference was statistically significant （P＜0.05）.The arterial pressure in the experimental group after 8 h and 24 h of treatment was higher than those in the control group，and body temperature，respiratory rate and pulse rate in the experimental group after 8 h and 24 h of treatment were lower than those in the control group，the difference was statistically significant （P＜0.05）.After 8 h and 24 h of treatment，the pH value and oxygen index in the two groups were higher than those before treatment，with significant difference （P＜0.05）.The oxygen index in the experimental group after 8 h of treatment was higher than that in the control group，with significant difference （P＜0.05）.Conclusion In the treatment of acute respiratory distress，pulsed high-volume hemofiltration can help improve the patients′vital signs and regulate their blood gas index，it is worthy of clinical popularization and application. 2019 Vol. 26 (4): 39-41 [Abstract] ( 106 ) HTML (31 KB)  PDF  (0 KB)  ( 11 ) 42 Clinical effect of early repair of skull defect after traumatic brain injury CEN Wei-peiLI Shi-zhuo ZHAO Yong-yao ZHU Yi-tuan ZHAN Chuan-wei Objective To investigate the clinical efficacy of early skull repair on patients with skull defect after traumatic brain injury.Methods A total of 50 patients with skull defects after craniotomy were enrolled in our hospital from September 2015 to September 2017.The patients were divided into the early group and the regular group by a random number table method，with 25 cases in each group.In the regular group，the skull repair was performed 3-6 months after decompressive craniectomy，while in the early group，decompressive craniectomy was performed from 40 days to 3 months.The Glasgow outcome scale （GOS）scores were compared between the two groups at 3 months after surgery.The improvement of neurological deficits and postoperative complications were observed in the two groups.Results The total effectiveness rate in the early group was 88.00%，which was higher than that 76.00%in the regular group，with statistical difference （P＜0.05）.There was no significant difference in the preoperative neurological deficit degree expressing as China stroke scale （CSS）score between the two groups （P＞0.05）.The CSS scores of the two groups decreased after surgery （P＜0.05），and the CSS score of the early group was lower than that of the regular group，with significant difference （P＜0.05）.There was no significant difference in the total incidence of postoperative complications between the two groups （P＞0.05）.Conclusion Skull repair in patients with skull injury after brain trauma can improve the recovery of neurological deficits in patients and the prognosis in good safety，which is worthy of further clinical research. 2019 Vol. 26 (4): 42-44 [Abstract] ( 114 ) HTML (34 KB)  PDF  (0 KB)  ( 16 ) 45 Effect comparison of non-invasive ventilation with Bi-level positive airway pressure ventilator and low-flow oxygen by nasal cannula in the treatment of elderly patients with chronic obstructive pulmonary disease and respiratory failure YAO Shao-shu ZHONG Guan-jun HUANG Wei-xiaLI Shu-lan CHEN Wen-ying Objective To investigate the clinical application effect of non-invasive ventilation with Bi-level positive airway pressure （BiPAP）ventilator and nasal low-flow oxygen in the treatment of elderly patients with chronic obstructive pulmonary disease （COPD）and respiratory failure.Methods A total of 100 elderly patients with COPD and respiratory failure admitted to our hospital from April 2015 to April 2018 were enrolled as subjects.By a random number table method，all patients were divided into the study group and the control group，50 cases in each groups.Both groups were provided with basic treatment.In the control group，low-flow oxygen via nasal catheter was added，while in the study group，non-invasive ventilation with BiPAP ventilator was added.The clinical efficacy，acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ）score，arterial oxygen partial pressure （PaO2），potential of hydrogen （pH），arterial blood carbon dioxide partial pressure （PaCO2），respiratory rate （RR），heart rate （HR），and the incidence rate of complications were compared between the two groups.Results The total clinical effectiveness rate was 86.00%in the study group，which was higher than that of the control group accounting for 64.00%，with significant difference （P＜0.05）.There were no significant differences in the levels of pH，PaO2，PaCO2，HR，RR and APACHE Ⅱscores before intervention between the two groups （P＞0.05）.At 96 hours of intervention，the levels of pH and PaO2 between the two groups were higher than those before intervention，with significant differences （P＜0.05）.Meanwhile，the levels of PaCO2，HR，RR，and the APACHE Ⅱ scores of the two groups were lower than those before intervention，with statistical significance （P＜0.05）.After 96-hour intervention，the level of PaCO2，HR，RR and the APACHE Ⅱ score in the study group were lower than those in the control group，with statistical differences （P＜0.05）.The levels of pH and PaO2in the study group were higher than those in the control group at 96-hour intervention，which differed statistically（P＜0.05）.The total incidence rate of complications in the study group was 26.00%，which was higher than that in the control group accounting for 4.00%，with significant difference （P＜0.05）.Conclusion Non-invasive ventilation with BiPAP ventilator can obtain a definite effect on treating elderly patients with COPD and respiratory failure by significantly improving the clinical symptoms and blood gas indicators，but the incidence rate of complications is high，which should be paid attention for its complication management in clinical application. 2019 Vol. 26 (4): 45-47 [Abstract] ( 91 ) HTML (36 KB)  PDF  (0 KB)  ( 11 ) 48 Application effect of Dexamethasone Injection in patients with respiratory tract infection RONG Feng Objective To explore the application effect of Dexamethasone Injection in patients with respiratory tract infection.Methods A total of 120 patients with respiratory tract infection admitted to our hospital from May 2016 to May 2018 were selected as study subjects，and divided into the treatment group （60 cases）and the control group （60 cases）according to different treatment methods.Symptomatic treatment combined with Dexamethasone Injection was used in the treatment group，while the control group was only treated with simple control.Temperature recovery，adverse reactions，and quality of life SF-36 scores were compared between the two groups.Results The temperature recovery time and treatment time of the treatment group were shorter than those of the control group，and the differences were statistically significant（P＜0.05）.The total incidence rate of adverse reaction of the treatment group was higher than that of the control group，and the difference was statistically significant （P＜0.05）.Quality of life SF-36 score in the treatment group after treatment was higher than that in the control group，the difference was statistically significant （P＜0.05）.Conclusion Dexamethasone Injection can accelerate the recovery of body temperature and improve the quality of life in patients with respiratory tract infection.However，it is worth noting that the adverse reaction rate is relatively high and it is recommended to be used cautiously. 2019 Vol. 26 (4): 48-50 [Abstract] ( 117 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 51 Application value of combination of rapid shallow breathing index and N-terminal-pro-brain natriuretic peptide for ventilator weaning to chronic obstructive pulmonary disease patients with respiratory failure LIU LingWU Wen-jieWANG Yan-xin YANG JiXIONG Xin ZHAO Hui-min CHEN YangXUE Bin Objective To assess the value of combination of rapid shallow breathing index （RSBI）and plasma N-terminal-pro-brain natriuretic peptide （NT-proBNP）for ventilator weaning to chronic obstructive pulmonary disease （COPD）patients with respiratory failure.Methods A total of 78 COPD patients with respiratory failure admitted in our hospital from 1 January 2015 to 1 January 2018 were selected as the research objects，they were divided into the success group（61 cases）and the failure group （17 cases）according to the weaning outcome at the first time.The difference of RSBI and plasma NT-proBNP were compared between the two groups when offline conditions were reached.Logistic multiple regression analysis was used to analyze the significance of RSBI，NT-proBNP and their combined detection in guiding ventilator evacuation in COPD patients with respiratory failure.Results The RSBI of the success group and the failure group were （81.25±10.12）times/（min·L），（110.01±20.13）times/（min·L），respectively.The level of NT-proBNP in the success group and the failure group were （299.26±131.62）pg/ml and （1286.29±256.16）pg/ml，respectively.The levels of RSBI and NT-proBNP in the successful group were lower than those in the failure group，and the difference was statistically significant （P＜0.05）.Logistic multivariate regression analysis showed that the relative risks OR of RSBI，NT-proBNP and their combination for successful ventilator evacuation were 5.236，2.762 and 6.785，respectively （P＜0.05）.The combination of the two methods was more valuable in predicting ventilator evacuation.Conclusion Respiratory muscle reserve function measured by RSBI and cardiac function assessed by NT-proBNP can improve the success rate of ventilator evacuation in COPD patients with respiratory failure and mechanical ventilation. 2019 Vol. 26 (4): 51-53 [Abstract] ( 102 ) HTML (32 KB)  PDF  (0 KB)  ( 17 ) 54 Effect of thoracoscopic radical resection of lung cancer in the treatment of elderly patients with non-small cell lung cancer ZHANG Yong-xin Objective To explore the effect of thoracoscopic radical resection of lung cancer in the treatment of elderly patients with non-small cell lung cancer.Methods The clinical data of 100 elderly patients with non-small cell lung cancer in our hospital from September 2014 to December 2017 were retrospectively analyzed.According to the different treatment methods，they were divided into the control group and the experimental group，50 cases in each group.The control group was treated with thoracotomy，and the experimental group was treated by thoracoscopic radical resection of lung cancer，and the clinical efficacy of the two groups was compared.Results There were no significant differences in the levels of IL-10，TNF-α，IL-6 and CRP between the two groups before treatment （P＞0.05）.After treatment，the levels of IL-10，TNF-α，IL-6 and CRP in the two groups were significantly lower than those before treatment，and there was significant difference （P＜0.05）.After treatment，the levels of IL-10，TNF-α，IL-6 and CRP in the experimental group were significantly lower than those in the control group （P＜0.05）.The total effective rate of the experimental group was 96%，which was higher than that of the control group （86%），and the difference was significant （P＜0.05）.The total incidence rate of complication of the experimental group was 12%，which was lower than that of the control group （28%），and there was a significant difference （P＜0.05）.The amount of bleeding in the experimental group was significantly less than that in the control group，and the postoperative hospital stay in the experimental group was significantly shorter than that in the control group （P＜0.05）.Conclusion The overall effectiveness and safety of thoracoscopic radical resection of lung cancer in the treatment of elderly patients with non-small cell lung cancer are higher，and the recovery effect of patients is more ideal. 2019 Vol. 26 (4): 54-56 [Abstract] ( 102 ) HTML (32 KB)  PDF  (0 KB)  ( 18 ) 57 Clinical effect of Kangfuxin Solution combined with Somatostatin in the treatment of upper gastrointestinal hemorrhage of liver cirrhosis and its influence on hemodynamics ZHA Hong-qun MAO Pin-ting WEI LingWU QiZOU Hong Objective To explore the clinical efficacy of Kangfuxin Solution combined with somatostatin on cirrhotic portal hypertensive upper gastrointestinal bleeding and its influence on hemodynamics.Methods A total of 84 patients with cirrhotic portal hypertensive upper gastrointestinal hemorrhage admitted to the First People′s Hospital of Jiujiang City from January 2017 to June 2018 were selected and randomly divided into the case group and the control group，42 cases in each group.The control group was given conventional supportive therapy and Somatostatin，the case group was supplemented with Kangfuxin Solution on the basis of the control group.The clinical efficacy，hemostasis time，blood transfusion volume，rebleeding rate，hospitalization time，venous blood flow and adverse reactions were observed in the two groups.Results The total effective rate of the case group was 95.24%，which was higher than that of the control group （80.95%），and the difference was statistically significant （P＜0.05）.The hemostasis time and the hospitalization time in the case group were shorter than those in the control group，the transfusion volume was less than that of the control group，and the rebleeding rate in the case group was lower than that in the control group，and the differences were statistically significant （P＜0.05）.After treatment，the portal venous blood flow and splenic venous blood flow in the case group were less than those in the control group，and the differences were statistically significant（P＜0.05）.The total incidence of adverse reactions in the case group was 4.76%，which was lower than 23.81%in the control group，and the difference was statistically significant （P＜0.05）.Conclusion Kangfuxin Solution combined with Somatostatin in the treatment of cirrhotic portal hypertensive upper gastrointestinal bleeding has significant clinical effect，and can achieve faster hemostasis and lower incidence of adverse reactions，thus it is worthy of clinical promotion. 2019 Vol. 26 (4): 57-59 [Abstract] ( 91 ) HTML (34 KB)  PDF  (0 KB)  ( 15 ) 60 Expression and clinical significance of serum procalcitonin，serum amyloid A and hypersensitive C-reactive protein in elderly patients with fever LI Chang-juan Objective To explore the expression and clinical significance of serum procalcitonin （PCT），serum amyloid A （SAA）and hypersensitive C-reactive protein （hs-CRP）in elderly patients with fever.Methods A total of 85 cases of elderly patients with fever in our hospital from January 2016 to June 2018 were selected as the observation group，then 85 cases of elderly patients without fever at the same period were selected as the control group.The levels and positive rates of serum PCT，SAA and hs-CRP of the two groups were compared.Results The positive rates of serum PCT，SAA and hs-CRP in the observation group before treatment were significantly higher than those in the control group（P＜0.01）.The positive rates of PCT，SAA and hs-CRP in the observation group after cure were significantly lower than those before treatment（P＜0.01）.The levels of PCT，SAA and hs-CRP in the observation group were significantly higher than those in the control group before treatment （P＜0.05）.The levels of PCT，SAA and hs-CRP in the observation group after cure were significantly lower than those before treatment （P＜0.05）.Conclusion The expression of PCT，SAA and hs-CRP is higher in serum of elderly patients with fever.Combined detection of PCT，SAA and hs-CRP can be used as a reliable indicator for early detection of bacterial infection and its severity in these patients. 2019 Vol. 26 (4): 60-62 [Abstract] ( 109 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 63 Effect of Rosuvastatin combined with Ticagrelor in the treatment of patients with coronary heart disease undergoing percutaneous coronary intervention HUANG YiCHEN Wen-guang CUI Yue LI Chang-liMO Jie-chao Objective To analyze the effect of Rosuvastatin combined with Ticagrelor in the treatment of patients with coronary heart disease undergoing percutaneous coronary intervention.Methods Eighty patients with coronary heart disease who underwent percutaneous coronary intervention from April 2017 to April 2018 in our hospital were selected as research objects.The patients were divided into observation group （40 cases）and control group （40 cases）according to the computer random method.In the observation group，Rosuvastatin combined with Ticagrelor was adopted，and in the control group，conventional treatment was used.The total incidence rate of adverse cardiovascular events，total effective rate of treatment，fibrinogen （Fbg），platelet aggregation test （PAgT），prothrombin time （PT），hospitalization time，and symptom relief time were compared between the two groups.Results The total incidence rate of adverse cardiovascular events was 5.00%in the observation group，which was significantly lower than that in the control group accounting for 25.00%，and the difference was statistically significant （P＜0.05）.The total effective rate of treatment in the observation group was 87.50%，which was significantly higher than that in the control group accounting for 67.50%，and the difference was statistically significant（P＜0.05）.There were no significant differences in Fbg，PAgT and PT between the two groups before treatment（P＞0.05）.The Fbg and PagT after treatment in the two groups were lower than those before treatment，the PT was shorter than that before treatment，and the differences were statistically significant（P＜0.05）.The Fbg and PagT after treatment in the observation group were lower than those in the control group，the PT was shorter than that in the control group，and the differences were statistically significant （P＜0.05）.The hospitalization time and symptom relief time in the observation group were shorter than those in the control group，and the differences were statistically significant（P＜0.05）.Conclusion The application of Rosuvastatin combined with Ticagrelor can obtain a remarkable effect in the treatment of patients with coronary heart disease undergoing percutaneous coronary intervention and it is worthy of clinical application and promotion. 2019 Vol. 26 (4): 63-65转69 [Abstract] ( 100 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 66 Effect of emergency PCI green channel on the rescue effect of patients with acute ST-segment elevation myocardial infarction QIAN Jin1GONG Yu2▲ DING Zhi-wen1LI Feng-hua1YE Lv-qing Objective To explore the effect of emergency percutaneous coronary intervention （PCI）green channel on the rescue effect of patients with acute ST-segment elevation myocardial infarction （STEMI）.Methods A total of 126 patients with STEMI who underwent PCI through the green channel from October 2016 to June 2018 in our hospital were selected as the observation group，and 107 STEMI patients who underwent PCI before the green channel was established from October 2014 to September 2016 were selected as the control group.The rescue time，door to balloon（D-to-B）time，the compliance rate of D-to-B time，hospitalization time，and mortality were compared between the two groups.Results The time of triage evaluation，time of venous stasis and intravenous administration in the observation group were shorter than those in the control group，and the differences were statistically significant（P＜0.05）.The electrocardiogram monitoring time and total rescue time in the observation group were significantly shorter than those in the control group，and the differences were statistically significant（P＜0.01）.The D-to-B time of the observation group was shorter than that of the control group，and the difference was statistically significant （P＜0.01）.The compliance rate of D-to-B time in the observation group was significantly higher than that in the control group，and the difference was statistically significant （P＜0.01）.The hospitalization time of the observation group was shorter than that of the control group，and the difference was statistically significant （P＜0.05）.The mortality of the observation group was significantly lower than that of the control group，and the difference was statistically significant（P＜0.01）.Conclusion The establishment of emergency PCI green channel can significantly shorten the rescue time of STEMI patients，reduce the mortality，improve the overall quality of rescue，and has a good clinical promotion value. 2019 Vol. 26 (4): 66-69 [Abstract] ( 84 ) HTML (36 KB)  PDF  (0 KB)  ( 10 ) 70 Effect comparison of radiofrequency ablation and drugs in the treatment of ventricular arrhythmia HU Jin-zhu1HUANG Qiang-hui1JU Zhen-zhen Objective To compare the effect of radiofrequency ablation and drugs in the treatment of ventricular arrhythmia.Methods A total of 100 patients with ventricular arrhythmia without organic heart disease admitted to our hospital from March 2015 to September 2016 were selected as subjects.The patients were divided into the drug treatment group （50 cases）and radiofrequency ablation group （50 cases）according to the computer random grouping method.Patients in the drug treatment group were treated with Metoprolol Succinate or Propafenone，and patients in the radiofrequency ablation group were treated with radiofrequency ablation.The total effective rate of clinical treatment，QT dispersion （QTd）and corrected QT dispersion （QTcd）before and after treatment，and total incidence rate of adverse reactions were compared between the two groups.Results The total effective rate of clinical treatment in the radiofrequency ablation group was 90.0%，which was significantly higher than that in the drug treatment group accounting for 64.0%，and the difference was statistically significant（P＜0.05）.There were no significant differences in QTd and QTcd between the two groups before treatment （P＞0.05）.The QTd and QTcd of patients in the radiofrequency ablation group were significantly lower than those before treatment，and the differences were statistically significant（P＜0.05）.The QTd and QTcd of the patients in the drug treatment group were lower than those before treatment，but the differences were not statistically significant （P＞0.05）.The QTd and QTcd of patients in the radiofrequency ablation group were significantly lower than those in the drug treatment group，and the differences were statistically significant（P＜0.05）.The total incidence rate of adverse reactions was 2.0%in the radiofrequency ablation group，which was significantly lower than that in the drug treatment group accounting for 20.0%.Conclusion The clinical effect of radiofrequency ablation in the treatment of patients with ventricular arrhythmia is significantly better than that of drugs alone，and the incidence rate of adverse reactions is low，which is worthy of clinical promotion. 2019 Vol. 26 (4): 70-72 [Abstract] ( 105 ) HTML (32 KB)  PDF  (0 KB)  ( 15 ) 73 Effect of Aspirin combined with Clopidogrel in the treatment of acute myocardial infarction BAI Ni Objective To investigate the effect of Aspirin combined with Clopidogrel in the treatment of acute myocardial infarction.Methods From February 2014 to August 2017，a total of 88 patients with acute myocardial infarction admitted to our hospital were selected as research objects and they were divided into the observation group （44 cases）and the control group （44 cases）according to different treatment methods.In the control group，Aspirin alone was used，while in the observation group，Clopidogrel was added on the basis of the control group.The coagulation function indicators （activated partial prothrombin time ［APTT］，prothrombin time ［PT］，platelet［PLT］）and cardiac function indicators（left ventricular ejection fraction ［LVEF］，left ventricle end systolic diameter ［LVESD］），left ventricular end diastolic diameter ［LVEDD］）before and after treatment and incidence of cardiovascular events between the two groups were compared.Results There were no significant differences in coagulation function indicators between the two groups before treatment （P＞0.05）.The APTT and PT after treatment in the two groups were longer than those before treatment，the PLT was lower than that before treatment，and the differences were statistically significant（P＜0.05）.There were no significant differences in coagulation function indicators between the two groups after treatment （P＞0.05）.There were no significant differences in cardiac function indicators between the two groups before treatment（P＞0.05）.The LVEF after treatment of the observation group was higher than that before treatment，the LVESD and LVEDD were lower than those before treatment，and the differences were statistically significant（P＜0.05）.The LVEF after treatment in the control group was higher than that before treatment，the LVESD and LVEDD were lower than those before treatment，but the differences weren′t statistically significant （P＞0.05）.The LVEF after treatment in the observation group was higher than that in the control group，the LVESD and LVEDD were lower than those in the control group，and the differences were statistically significant（P＜0.05）.The incidence rates of composite endpoint，death，post-infarction angina pectoris，and recurrent myocardial infarction in the observation group were lower than those in the control group，and the differences were statistically significant（P＜0.05）.Conclusion The clinical effect of Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction is remarkable，and can be promoted and applied. 2019 Vol. 26 (4): 73-75转79 [Abstract] ( 119 ) HTML (33 KB)  PDF  (0 KB)  ( 15 ) 76 Clinical effect of Danhong Injection in the treatment of coronary heart disease with angina pectoris BI Peng Objective To investigate the clinical effect of Danhong Injection in the treatment of coronary heart disease with angina pectoris.Methods A total of 80 cases of coronary heart disease patients with angina pectoris in our hospital from April 2015 to April 2017 were selected as the objects，and the patients were divided into the control group （n=40）and the observation group （n=40）according to the treatment method.Patients in the control group underwent routine treatment，and patients in the observation group received conventional treatment combined with Danhong Injection.The therapeutic effect，blood lipids，C-reactive protein，improvement of electrocardiogram and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 90.0%（36/40），which was significantly higher than that in the control group accounting for 70.0% （28/40），and the difference was statistically significant （P＜0.05）.There were no significant differences in the levels of total cholesterol，triglyceride，low-density lipoprotein，high-density lipoprotein，and C-reactive protein between the two groups before treatment （P＞0.05）.The levels of total cholesterol，triglyceride，and C-reactive protein after treatment in the two groups were significantly lower than those before treatment，the levels of low-density lipoprotein and high-density lipoprotein were significantly higher than those before treatment，and the differences were statistically significant （P＜0.05）.The levels of total cholesterol，triglyceride，low-density lipoprotein，and C-reactive protein after treatment in the observation group were significantly lower than those in the control group，the level of high-density lipoprotein was higher than that in the control group，and the differences were statistically significant （P＜0.05）.The total improvement rate of electrocardiogram in the observation group was 70.0% （28/40），which was significantly higher than that in the control group accounting for 50.0% （20/40），and the difference was statistically significant （P＜0.05）.There was no significant difference in the incidence rate of adverse reactions between the two groups （P＞0.05）.Conclusion Danhong Injection can effectively improve the therapeutic effect and electrocardiogram of coronary heart disease patients with angina pectoris，and it does not increase the adverse reactions of patients. 2019 Vol. 26 (4): 76-79 [Abstract] ( 119 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 80 Effect comparison of Selegiline and Pramipexole respectively assisting on Levodopa and Benserazide Tablets in the treatment of middle and advanced Parkinson′s disease LAI Sui-pian CHEN Ju-tao LI Guan-dong Objective To compare the effect of Selegiline and Pramipexole respectively assisting on Levodopa and Benserazide Tablets in the treatment of middle and advanced Parkinson′s disease.Methods The clinical data of 50 patients with Parkinson′s disease admitted to our hospital from July 2014 to June 2017 were analyzed.According to different medication regimens，they were equally divided into control group （Selegiline combined with Levodopa and Benserazide Tablets）and observation group （Pramipexole combined with Levodopa and Benserazide Tablets），25 cases in each group.The unified parkinson′s disease rating scale （UPDRS）score and the Hamilton depression scale （HAMD）score before and after treatment were observed.The clinical effect and incidence of adverse reactions of the two groups were observed.Results The differences of UPDRS score and HAMD score between the two groups before treatment was not statistically significant （P＞0.05）.After treatment，the UPDRS score and HAMD score of the two groups were both lower than those before treatment（P＜0.05）.The UPDRS score and HAMD score of the observation group after treatment were both lower comarped with those in the control group （P＜0.05）.The total clinical effectiveness rate was higher in the observation group than that in the control group with statistical significance （P＜0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups （P＞0.05）.Conclusion For patients with middle and advanced Parkinson′s disease，the UPDRS score and the HAMD score are markedly improved with a better effect in Pramipexole combined with Levodopa and Benserazide Tablets compared with Selegiline combined with Levodopa and Benserazide Tablets. 2019 Vol. 26 (4): 80-82 [Abstract] ( 103 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 83 Effect of emergency mechanical thrombectomy in the treatment of acute moderate to severe cerebral infarction after failure of intravenous infusion of Alteplase HU Lie-ji Objective To investigate the effect of emergency mechanical thrombectomy in the treatment of acute moderate to severe cerebral infarction after failure of intravenous infusion of Alteplase.Methods Sixty patients with acute moderate to severe cerebral infarction admitted to our hospital from February 2016 to February 2018 were enrolled in the study.They were divided into control group （n=30）and observation group （n=30）according to random number table method.In the control group，after the treatment of intravenous Alteplase thrombolytic therapy，the blood vessels were not recanalized.After 24 hours，the secondary cerebral hemorrhage was excluded by CT examination，and symptomatic treatment such as lipid-lowering and anti-thrombosis was continued.In the observation group，after failure of intravenous Alteplase thrombolytic therapy，emergency mechanical thrombectomy was performed.After 24 hours，secondary cerebral hemorrhage was excluded by CT examination，and symptomatic treatment such as lipid-lowering and antithrombosis was continued.The Barthel index，national institutes of health stroke scale （NIHSS）score，and post-treatment complications before and after treatment at 14 d and 28 d were compared in the two groups.Results Before treatment，there were no significant difference in Barthel index and NIHSS score between the two groups （P＞0.05）.The Barthel index of the observation group was higher than that of the control group after treatment，and the NIHSS score was lower than the control group at 14 d and 28 d with statistical significance （P＜0.05）.The incidence of complications in the two groups did not display statistically significant（P＞0.05）.Conclusion Emergency mechanical thrombectomy in the treatment of acute moderate to severe cerebral infarction after failure of intravenous Alteplase thrombolysis can obtain a favorable effect and is worthy of extensive promotion in clinical practice. 2019 Vol. 26 (4): 83-85转88 [Abstract] ( 96 ) HTML (33 KB)  PDF  (0 KB)  ( 17 ) 86 Analysis of serum uric acid in chronic schizophrenia patients with longterm hospitalization and its relationship with delayed dyskinesia ZHOU FengLIN Min-qiangWANG You-qin WANG Ai-mei Objective To study the serum uric acid level in chronic schizophrenia patients with long-term hospitalization and its relationship with delayed dyskinesia.Methods A total of 160 patients with chronic schizophrenia admitted to our hospital from January 2017 to May 2018 were selected as the study group.Another 160 healthy people at the same period were selected as the control group.The detection rate of hyperuricemia and serum uric acid concentration were compared between the two groups.Patients in the observation group were divided into delayed dyskinesia group and non-delayed dyskinesia group according to whether they were accompanied with delayed dyskinesia.The effect of schizophrenia with delayed dyskinesia on serum uric acid was analyzed.Results The detection rate of hyperuricemia was 7.50%in the observation group and 13.75%in the control group，and the difference between the two groups was not statistically significant （P＞0.05）.The level of serum uric acid in the observation group was lower than that in the control group，and the difference was statistically significant （P＜0.05）.The serum uric acid level in patients with delayed dyskinesia was lower than that in patients with non-delayed dyskinesia，and the difference was statistically significant （P＜0.05）.Conclusion Long-term hospitalized schizophrenic patients have abnormal uric acid metabolism，especially those with delayed dyskinesia，which needs to be prevented. 2019 Vol. 26 (4): 86-88 [Abstract] ( 86 ) HTML (29 KB)  PDF  (0 KB)  ( 13 ) 89 Application effect of occupation recreational therapy in patients with Alzheimer′s disease LI Jin-nong LI Ye-hong LIANG Mei-ju SU Ming-yu Objective To explore the application effect of occupation recreational therapy in patients with Alzheimer′s disease.Methods Sixty-five patients with Alzheimer′s disease admitted to our hospital from August 2017 to May 2018 were selected as objects.According to the different interventions，they were divided into the routine group （n=32）and the occupation recreational group （n=33）.Routine nursing intervention was used in the routine group，while occupation recreational therapy was added in the occupation recreational.The scores of agitation behavior，social function and life quality between the two groups were compared before and after intervention.Results The scores of agitation behavior after the intervention in the two groups were lower than those before the intervention，scores of social function and life quality were higher than those before the intervention，and the differences were statistically significant （P＜0.01）.The agitation behavior score after the intervention in the occupation recreational group was lower than that in the routine group，and the scores of social function and life quality were higher than those in the routine group，with statistically significant significances （P＜0.05）.Conclusion The rehabilitation effect of occupation recreational therapy in elderly patients with Alzheimer′s disease is remarkable. 2019 Vol. 26 (4): 89-91转95 [Abstract] ( 76 ) HTML (34 KB)  PDF  (0 KB)  ( 14 ) 92 Clinical effect of Edaravone combined with Clopidogrel Hydrogen Sulfate in the treatment of cerebral infarction SUN Yi-ming XU Xiao-lin DIAO Jian-xia XIE Li-liWANG CuiWANG Xiao-hong Objective To explore the clinical effect of Edaravone combined with Clopidogrel Hydrogen Sulfate in the treatment of cerebral infarction.Methods A total of 38 patients with cerebral infarction admitted to neurology department of our hospital from January to December 2017 were selected as research objects and according to their admission medical record number，they were divided into observation group （20 cases）and control group （18 cases）by random number table method.Patients in the control group received conventional treatment，like Aspirin，lipid-lowering drugs，and nutrient neuropharmaceuticals and patients in the observation group were treated with Edaravone combined with Clopidogrel Hydrogen Sulfate.One course of treatment was 7 days，with a total of 2 courses of treatment.The total effective rate of clinical treatment，neurological deficit score （NIHSS），viability score （BI），superoxide dismutase （SOD），and malondialdehyde （MAD）levels before and after treatment were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 90.00%，which was higher than that in the control group （61.11%），and the difference was statistically significant（P＜0.05）.There were no significant differences in NIHSS and BI scores between the two groups before treatment （P＞0.05）.The NIHSS scores of the two groups after treatment were lower than those before treatment，the BI scores were higher than those before treatment，and the differences were statistically significant （P＜0.05）.The NIHSS score of the observation group after treatment was lower than that of the control group，the BI score was higher than that of the control group，and the differences were statistically significant（P＜0.05）.There were no significant differences in the levels of SOD and MAD between the two groups before treatment（P＞0.05）.The SOD levels after treatment in the two groups were higher than those before treatment，the MAD levels were lower than those before treatment，and the differences were statistically significant （P＜0.05）.The level of SOD in the observation group was higher than that in the control group，the MAD level was lower than that in the control group，and the differences were statistically significant （P＜0.05）.Conclusion Edaravone combined with Clopidogrel Hydrogen Sulfate has better therapeutic effect on patients with cerebral infarction.It can effectively restore the patients′nerve function，and regulate SOD and MAD levels to enhance the body′s antioxidant capacity and improve the patients′life ability. 2019 Vol. 26 (4): 92-95 [Abstract] ( 91 ) HTML (35 KB)  PDF  (0 KB)  ( 14 ) 96 Differences in distribution of cerebral artery stenosis and related factors in patients with ischemic stroke at different ages GAO Hong-yu1WU Hong-liang1LIU Hong Objective To investigate the differences in distribution of cerebral artery stenosis and related factors in patients with ischemic stroke at different ages.Methods A total of 303 patients with acute ischemic stroke who were first diagnosed in our hospital from January 2014 to June 2017 were selected as the study subjects.According to age，they were divided into the older group （age≥80 years）（150 cases）and the elderly group （65 years＜age＜80 years）（153 cases）.The differences in distribution of cerebral artery stenosis and related factors were compared between the two groups.Results There was no significant difference in the incidence rate of intracranial arterial stenosis between the two groups （P＞0.05）.The incidence rate of extracranial arterial stenosis in the older group was 14.67% （22/150），which was lower than that in the elderly group accounting for 29.41% （45/153），and the difference was statistically significant（P＜0.05）.The proportions of history in type 2 diabetes mellitus，smoking，drinking and levels of fasting blood glucose，and triglyceride in the older group were lower than those in the elderly group，and the differences were statistically significant （P＜0.05）.The level of serum homocysteine in the older group was significantly higher than that in the elderly group，and the difference was statistically significant （P＜0.001）.Conclusion The incidence rate of extracranial artery stenosis in patients with ischemic stroke 80 years old and above is lower than that under 80 years old.There are differences in the distribution of related factors among stroke patients in different age groups. 2019 Vol. 26 (4): 96-99 [Abstract] ( 83 ) HTML (37 KB)  PDF  (0 KB)  ( 19 ) 100 Effect of physique art therapy on rehabilitation of patients with mental illness LI Xue-Jing GUO Yi▲ GAO Yun ZHU Shan-shan Objective To explore effect of physique art therapy on rehabilitation of patients with mental illness.Methods A total of 80 mental patients who were admitted to our hospital from March 2017 to March 2018 were selected as the research subjects，and were divided into research group and control group according to random number table method，40 patients in each group.Both groups were treated by routine therapy，the research group was given routine therapy and physique art therapy for 12 weeks.The positive and negative symptoms scale （PANSS），psychiatric rehabilitation scale （IPROS）and general self-efficacy scale （GSES）was used to evaluate patients before and after treatment.Results The scores of PANSS，PANSS-N，PANSS-G，IPROS of the research group were significantly lower than those of the control group and before treatment，and the scores of GSES of the research group were significantly higher than those of the control group and before treatment，the differences were statistically significant （P＜0.05）.The scores of PANSS，PANSS-N，PANSS-G，occupational therapy，attention to hygiene，care and interest in IPROS of the control group were significantly lower than those before treatment，the differences were statistically significant （P ＜0.05）.Conclusion Physique art therapy can improve the living ability and self-efficacy of mental patients，improve mental symptoms.It has positive effect on the patients′recoverg and return to society，worthy of promotion and applications. 2019 Vol. 26 (4): 100-102 [Abstract] ( 77 ) HTML (33 KB)  PDF  (0 KB)  ( 20 ) 103 Clinical effect of Argatroban combined with Urinary Kallindinogenase in the treatment of acute cerebral infarction HU Ying1SU Jing Objective To explore the clinical effect of Agathorban combined with Urinary Kallindinogenase in the treatment of acute cerebral infarction.Methods A total of 86 patients with acute cerebral infarction treated in Liaoyu Hospital of Dalian City in Liaoning Province for 4.5 to 48.0 hours from April 2014 to June 2016 were selected as the study subjects，they were divided into control group （43 cases）and treatment group （43 cases）according to random number table method，the control group was given Aspirin+Clopidogrel Dual Anti-platelet aggregation and routine treatment，the treatment group received intravenous administration of thrombin inhibitor Agathorban+Proteolytic Enzyme Urinary Kallindinogenase and routine treatment，blood routine and coagulation index activated partial thromboplastin time （APTT）were monitored in both groups during treatment.NIHSS and modified Rankin scale （mRS）were used to evaluate the degree of neurological impairment before treatment and 10 days after treatment，and the safety of medication was also evaluated.Results The scores of NIHSS and mRS in the treatment group were lower than those in the control group after treatment，the differences were statistically significant （P＜0.05）.The total effective rate of the treatment group was higher than that of the control group，the difference was significant（P＜0.05）.There were no significant differences in leucocyte and platelet levels between the two groups （P＞0.05）.The APTT of the treatment group was longer than that of the control group after treatment，the difference was significant （P＜0.05）.There were no gingival bleeding，blood in sputum，hematuria，hematemesis，tarry stool，or mild injury with long-term hemorrhage and coagulation in both groups.Conclusion In the routine treatment of acute cerebral infarction，the combined use of Agartraban and Urekrin is superior to Aspirin and Clopidogrel in dual anti-platelet aggregation plus routine treatment，which can significantly reduce scores of NIHSS and mRS，improve the degree of neurological recovery，and medication is safe. 2019 Vol. 26 (4): 103-106 [Abstract] ( 82 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 107 Effect comparison of ureteroscopy in reverse Trendelenburg stone lithotomy position combined with occluder and minimally invasive percutaneous nephrolithotomy in the treatment of upper ureteral incarcerated calculi LIU Cong LI Si-hua HUANG Li-liLAI Zai-chiFAN Han-gong Objective To compare the safety and effectiveness of ureteroscopy in reverse Trendelenburg stone lithotomy position combined with occluder and minimally invasive percutaneous nephrolithotomy in the treatment of upper ureteral incarcerated calculi.Methods Eighty five patients who underwent minimally invasive surgeries for upper ureteral incarcerated calculi （with stone position above the lumbar vertebra 4）in our hospital from January 1，2017 to December 31，2018 were selected as research objects.According to different treatment methods，they were divided into observation group （n=44）and control group （n=41）.The ureteroscope combined with occluder was used in the observation group，and holmium laser lithotripsy was given.In the control group，the minimally invasive percutaneous nephroscope was given，and the pneumatic ballistic lithotripsy was adopted.The success rate of the lithotripsy，stone clearance rate，operation time，hospitalization time，hospitalization cost and complications were compared between the two groups.Results The success rate of lithotripsy in the observation group was 95.4%，and the stone clearance rate was 95.2%，which were not significantly different from those in the control group respectively accounting for 100.0%and 97.6%（P＞0.05）.The operation time and hospitalization time in the observation group were shorter than those in the control group，the hospitalization cost and the total incidence of complications were lower than those in the control group，and the differences were statistically significant （P＜0.05）.Conclusion The ureteroscopy in reverse Trendelenburg stone lithotomy position combined with occluder and minimally invasive percutaneous nephrolithotomy are both effective methods for the treatment of incarcerated calculi in the upper ureter.The incidence rate of postoperative complications was lower and safety was higher in the ureteroscopy in reverse Trendelenburg stone lithotomy position combined with occlude，which is a better choice for the treatment of incarcerated calculi in the upper ureter. 2019 Vol. 26 (4): 107-110 [Abstract] ( 80 ) HTML (38 KB)  PDF  (0 KB)  ( 14 ) 111 Application effect of percutaneous nephrolithotomy in the treatment of patients with failed renal calculi under the therapy of extracorporeal shock wave lithotripsy WU Jin-guang Objective To investigate the application effect of percutaneous nephrolithotomy in the treatment of patients with failed renal calculi under the therapy of extracorporeal shock wave lithotripsy.Methods Sixty patients with failed renal calculi under the therapy of extracorporeal shock wave lithotripsy from February 2017 to February 2018 in our hospital were enrolled in this study.The patients were divided into the observation group （30 cases）and the control group （30 cases）according to the computer randomization.In the observation group，percutaneous nephrolithotomy was used，while in the control group，extracorporeal shock wave lithotripsy was used continuously.The hospitalization time，operation time，stone removal rate，total effective rate of treatment，and total incidence rate of complications were compared between the two groups.Results The hospitalization time of the observation group was （5.21±0.11）d，the operation time was （80.21±1.27）min，which were shorter than those of the control group accounting for （6.23±1.45）d and（90.11±1.25）min，and the differences were statistically significant （P＜0.05）.The stone removal rate of the observation group was 93.33%，which was significantly higher than that of the control group accounting for 66.67%，and the difference was statistically significant （P＜0.05）.The total effective rate of treatment in the observation group was 90.00%，which was significantly higher than that in the control group accounting for 63.33%，and the difference was statistically significant （P＜0.05）.The total incidence rate of complications in the observation group was 13.33%，which was significantly lower than that in the control group accounting for 26.67%，and the difference was statistically significant （P＜0.05）.Conclusion The application of percutaneous nephrolithotomy in the treatment of patients with failed renal calculi under the therapy of extracorporeal shock wave lithotripsy can obtain a remarkable effect，which can greatly increase the removal rate of stones as well as therapeutic effectiveness rate，and promote the early rehabilitation of patients with renal calculi. 2019 Vol. 26 (4): 111-113 [Abstract] ( 89 ) HTML (34 KB)  PDF  (0 KB)  ( 15 ) 114 Clinical effect of Drotaverine combined with Tolterodine in the treatment of bladder spasm after transurethral resection of prostate HONG Bo1HONG Yan2ZHUANG Juan3 Objective To investigate the clinical effect of Drotaverine combined with Tolterodine in the treatment of bladder spasm after transurethral resection of prostate.Methods Sixty patients with bladder spasm after transurethral resection of the prostate who were treated in Jiangxi Yingtan People′s Hospital Railway Branch from December 2016 to August 2018 were randomly selected as study objects and randomly divided into the treatment group （n=30）and the control group （n=30）.The control group was treated with Tolterodine，and the treatment group was treated with Drotaverine combined with Tolterodine.The number and duration time of bladder spasm after treatment were compared between the two groups.The overactive bladder symptom score （OABSS），bladder conditional awareness scale （PPBC）score，visual analogue scale （VAS）score，and quality of life （QOL）before and after treatment were compared between the two groups.Results There were no significant differences in the number and duration time of bladder spasm between the two groups at 24 h after treatment （P＞0.05）.The number of bladder spasm at 48 and 72 h after treatment in the two groups was fewer than that at 24 h after treatment，the duration time was shorter than that at 24 h after treatment，and the differences were statistically significant （P＜0.05）.The number of bladder spasm at 48 and 72 h after treatment in the treatment group was fewer than that in the control group，the duration time was shorter than that in the control group，and the differences were statistically significant （P＜0.05）.There were no significant differences in the scores of OABSS，PPBC and VAS between the two groups before treatment （P＞0.05）.The scores of OABSS，PPBC and VAS after treatment in the two groups were lower than those before treatment，and the differences were statistically sig-nificant（P＜0.05）.The scores of OABSS，PPBC and VAS after treatment in the treatment group were lower than those in the control group，and the differences were statistically significant （P＜0.05）.There was no significant difference in the score of QOL between the two groups before treatment （P＞0.05）.The scores of QOL after treatment in the two groups were higher than those before treatment，and the differences were statistically significant（P＜0.05）.The score of QOL after treatment in the treatment group was higher than that in the control group，and the difference was statistically significant（P＜0.05）.Conclusion Drotaverine combined with Tolterodine in the treatment of bladder spasm after transurethral resection of prostate has a satisfactory effect and high clinical value. 2019 Vol. 26 (4): 114-117 [Abstract] ( 66 ) HTML (37 KB)  PDF  (0 KB)  ( 15 ) 118 Application value of Wells score and D-dimer in the prediction of perioperative deep venous thrombosis of lower limbs in elderly patients with hip fracture XU Jin-ping LI Yun Objective To explore the application value of Wells score and D-dimer in the prediction of perioperative deep venous thrombosis （DVT）of lower limbs in elderly patients with hip fracture.Methods A retrospective analysis was made on 58 elderly patients with hip fracture treated in our hospital from January 2016 to July 2017，they were divided into non-occurrence group （36 cases）and occurrence group （22 cases）according to whether DVT of lower extremities occurred or not，wells score and D-dimer were measured in both groups.Serum D-dimer levels and Wells scores were compared between the two groups.Results The positive rate of Wells score＞1 in the occurrence group was 86.4%，which was higher than 5.6%in the non-occurrence group，the difference was statistically significant （P＜0.05）.The negative rate of D-dimer was 0.9%in the non-occurrence group，which was lower than 91.7%in the non-occurrence group，the difference was statistically significant （P＜0.05）.Conclusion Perioperative Wells score，D-dimer and lower limbs of elderly patients with hip fracture can be used for DVT clinical diagnosis. 2019 Vol. 26 (4): 118-120 [Abstract] ( 90 ) HTML (29 KB)  PDF  (0 KB)  ( 11 ) 121 Application effect of proximal row carpectomy in wrist surgery WU Yuan1ZHANG Zhi-ming2ZHOU You-shan1GUO Shi-wan1QIU Lin1YANG Yue-ming1 Objective To explore the application effect of proximal row carpectomy in wrist surgery.Methods A total of 98 patients with wrist surgery in Dayu People′s Hospital of Jiangxi Province from January 2015 to December 2017 were selected as the research objects，according to the different research methods，they were divided into control group and observation group，with 49 cases in each group.The control group was treated with routine operation，while the observation group was treated with proximal row carpectomy，the clinical excellent and good rate，postoperative pain score（VAS），wrist function score （Cooney）and hand grip strength were compared between the two groups.Results There were no significant differences in clinical recovery rate and Cooney score between the two groups （P＞0.05）.The VAS score of the observation group was lower than that of the control group，the difference was significant（P＜0.05）.The grip strength of the affected side in the observation group was higher than that in the control group，the difference was significant（P＜0.05）.Conclusion After proximal row carpectomy，wrist joint retains certain range of motion，which can effectively alleviate the pain of patients and partly preserve the wrist function of patients after operation. 2019 Vol. 26 (4): 121-123 [Abstract] ( 79 ) HTML (34 KB)  PDF  (0 KB)  ( 4 ) 124 Effect of Zoledronic Acid in the treatment of osteoporosis in the elderly and its effect on bone pain relief LI Kun-yi Objective To explore the effect of Zoledronic Acid treatment on elderly patients with osteoporosis and its effect on bone pain relief.Methods Fifty-two elderly patients with osteoporosis admitted to our hospital from March 2015 to April 2017 were selected as the research objects，they were divided into control group （24 cases）and experimental group （28 cases）according to different treatment methods，the control group was treated with Calcium Cartonate and Vitamin D3Chewabie Tablets and Alfacalciferol soft Capsules，while the experimental group was treated with Calcium Carttonate and Vitamin D3Chewabie Tablets，Alfacalciferol soft Capsules and Zoledronic Acid.Pain score，serum calcium，phosphorus，alkaline phosphatase （ALP）levels and total incidence of adverse reactions were compared between the two groups.Results The pain score of the experimental group after 3 and 6 months of treatment was lower than that of the control group，the differences were statistically significant （P＜0.05）.After 6 months of treatment，the ALP level in the experimental group was （98.27±15.36）IU/L，which was lower than （142.27±19.36）IU/L in the control group，the difference was statistically significant （P＜0.05）.There were no significant differences in serum calcium and phosphorus levels between the two groups after 6 months of treatment （P＞0.05）.There was no significant difference in the total incidence of adverse reactions between the two groups （P＞0.05）.Conclusion Zoledronic Acid has a good effect on elderly patients with osteoporosis.It can significantly alleviate bone pain and has high safety. 2019 Vol. 26 (4): 124-126 [Abstract] ( 101 ) HTML (34 KB)  PDF  (0 KB)  ( 14 ) 127 Clinical effect of low dose Triamcinolone Acetonide pain-spot injection combined with silica gel heel pad in the treatment of calcaneodynia PAN Ming-huiYANG Xuan-huaHUANG Wan-rong Objective To explore the clinical effect of low dose Triamcinolone Acetonide pain-spot injection combined with silicone heel pad in treatment of calcaneodynia.Methods Sixty patients with calcaneodynia admitted to our hospital from January 2016 to December 2017 were selected as the study subjects，according to the random number table method，they were divided into study group and control group the study group and the control group，with 30 cases in each group，the study group was treated with low dose Triamcinolone Acetonide+2%Lidocaine 4 ml pain point injection combined with silicone heel pad，while the control group was treated with 40 mg Triamcinolone Acetonide+2%Lidocaine 4 ml pain point injection.The total effective rate，recurrence rate and visual analogue scale （VAS）were compared between the two groups.Results The total effective rate of clinical treatment in the study group （96.67%）was higher than that in the control group （80.00%）.The recurrence rate in the study group （3.33%）was lower than that in the control group （23.33%），the differences were statistically significant（P＜0.05）.The VAS score of the study group after treatment was （2.22±1.03）points，which was lower than （5.36±1.23）points of the control group，the difference was statistically significant （P＜0.05）.Conclusion The clinical effect of low dose Triamcinolone Acetonide pain-spot injection combined with silicone heel pad in the treatment of patients with calcaneal pain is remarkable，which can relieve the pain of patients and is worthy of clinical popularization and application. 2019 Vol. 26 (4): 127-129 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 15 ) 130 Clinical effect of clavicular hook plate internal fixation in the treatment of acromioclavicular joint dislocation LIU Jian-jun XIE Jing-bo YAN Qiu-yuan Objective To explore the clinical effect of clavicular hook plate internal fixation in the treatment of acromioclavicular joint dislocation.Methods Eighty patients with acromioclavicular joint dislocation admitted to our hospital from May 2014 to May 2017 were selected as the study subjects，they were divided into observation group （n=40）and control group （n=40）according to random number table method，patients in observation group were treated with clavicular hook plate internal fixation，while patients in control group were treated with Kirschner wire tension band internal fixation，the hospitalization time，operation related indexes，total effective rate of clinical treatment and complications were compared between the two groups.Results There was no significant difference in operation time and hospitalization time between the two groups （P＞0.05）.The incision length of the observation group was （8.00±0.85）cm，which was shorter than （10.00±0.76）cm of the control group，and the intraoperative bleeding volume was （70.66±8.06）ml，which was less than （82.52±8.54）ml of the control group，the differences were statistically significant（P＜0.05）.The total effective rate of the observation group was 97.50%，higher than 77.50%of the control group，the difference was significant（P＜0.05）.The total incidence of postoperative complications was 10.00%in the observation group，which was significantly lower than 35.00%in the control group，the difference was significant （P＜0.05）.Conclusion The treatment of acromioclavicular dislocation with clavicular hook plate internal fixation has the characteristics of short incision length and less bleeding during the operation.The clinical effect is remarkable.At the same time，the incidence of postoperative complications is low.This treatment method is worthy of clinical application. 2019 Vol. 26 (4): 130-132 [Abstract] ( 80 ) HTML (35 KB)  PDF  (0 KB)  ( 19 ) 133 The study of tangential fluoroscopy in detecting screw penetration in distal radius fracture WANG Jun-hong XIAO Zhi-man LIU Bin-wei Objective To explore the sensitivity and specificity of tangential fluoroscopy in detecting screw perforation in distal radius fractures.Methods From January 2016 to September 2017，patients with distal radius fracture treated by open reduction and volar plate internal fixation in our hospital were selected and divided into two groups according to the following two criteria according to intraoperative fluoroscopy.①A total of 131 patients with suspicious perforation of distal radius screw through the articular surface were selected as the anterolateral incision group by standard anterolateral fluoroscopy，and then the anterolateral incision fluoroscopy of distal radius was performed.②A total of 115 patients with suspicious screw penetration through the dorsal cortex were selected as the dorsal incision group by standard lateral fluoroscopy，and then the distal radius dorsal incision fluoroscopy was performed.Three-dimensional CT scans of wrist joints were performed in both groups about 3 days after operation.The sensitivity and specificity of the anterolateral and dorsal cuts were analyzed.At the same time，according to the results of three-dimensional CT scans，the number of screw penetrating the dorsal cortex was calculated，and which quadrant the screw penetrating the dorsal cortex was located.Results①The sensitivity and specificity of the tangential position for detecting the non-perforated and perforated articular surfaces of the screw were 98.26%and 81.25%respectively in the positive and lateral incision group，according to Gartland-Werley Wrist Function Score，the excellent and good rate was 79.05%.②The sensitivity and specificity of tangential screw detection in the dorsal section group were 99.01%and 85.71%respectively，which did not penetrate the dorsal cortex and penetrated the dorsal cortex.A total of 441 distal radius screws were inserted into the distal row （i.e.near the articular surface）.The screw positions were scanned by CT：the first room （48，10.88%），the second room （144，32.65%），38，the third room （163，36.96%），0，the fourth room （86，19.50%）and 9.Conclusion The tangent position is highly reliable for judging the screw penetrating the articular surface and the dorsal cortex of the distal radius fractur.The screw penetrating the dorsal cortex is mainly located in the second and fourth compartments，which has certain guiding significance for judging the length of the screw during the operation. 2019 Vol. 26 (4): 133-136 [Abstract] ( 69 ) HTML (33 KB)  PDF  (0 KB)  ( 16 ) 137 Clinical effect of different methods in the treatment of intrauterine adhesion HAI Na GUO Tian-qi Objective To study the clinical effect of different methods in the treatment of intrauterine adhesions （IUA）.Methods A total of 105 cases of IUA treated in our hospital from January 2013 to December 2016 were selected and divided into 3 groups according to the treatment method，35 cases in each group.The group Ⅰ received hysteroscopic adhesion separation combined with superior ring surgery.The groupⅡreceived hysteroscopic hysteroscopy combined with COOK balloon dilation for 14 days.The groupⅢwas treated with hysteroscopic adhesions separation and COOK balloon dilation for 7 days.All the three groups were treated with Estradiol Valerate combined with Diproprogesterone for 3 months.Before and after treatment in the three groups with the endometrial growth，menstrual volume，therapeutic effect，coagulation function related indexes and the occurrence of re-adhesion were compared.Results The total effective rate of clinical treatment in group Ⅱand Ⅲ were significantly higher than that in group Ⅰ （P＜0.05），but there was no significant difference between group Ⅱand Ⅲ（P＞0.05）.There was no significant difference in the score of each group before operation （P＞0.05）.The postoperative scores of group Ⅱand Ⅲ were lower than that of group Ⅰ，and the improvement rate of postoperative score was higher than that of group Ⅰ （P＜0.05）.The menstrual change rate of groupⅡand Ⅲ were significantly higher than that of group Ⅰ （P＜0.05），but there was no significant difference between group Ⅱand Ⅲ（P＞0.05）.Conclusion Hysteroscopy combined with balloon dilation in the treatment of IUA can significantly improve the therapeutic effect and improve the prognosis of patients with obvious clinical advantages. 2019 Vol. 26 (4): 137-139 [Abstract] ( 71 ) HTML (34 KB)  PDF  (0 KB)  ( 12 ) 140 Application effect of clasping knees with both hands in the second stage of labor of coccyx protruding women XIE Xu-juan LI Juan HAN Chun-ping LIU Gui-rong Objective To investigate the application effect of clasping knees with both hands in the second stage of labor of coccyx protruding women.Methods From February 2016 to March 2018，68 cases of puerpera with protruding tailbone were selected and randomly divided into control group （34 cases）and observation group （34 cases）.The second stage of labor，postpartum hemorrhage and newborn were compared between the two groups.Results The time of the second stage of labor in the observation group was shorter than that in the control group，the amount of blood loss at 2 hours after delivery in the observation group was significantly lower than that in the control group （P＜0.05）.The incidence of cervical laceration and neonatal asphyxia in the observation group was significantly lower than that in the control group （P＜0.05）.Conclusion In the parturition of the second stage of the parturition with the projection of the tailbone，it can obviously shorten the time of the second stage of labor，reduce the amount of postpartum bleeding，reduce the cervical laceration，and reduce the risk of neonatal asphyxia. 2019 Vol. 26 (4): 140-142 [Abstract] ( 84 ) HTML (32 KB)  PDF  (0 KB)  ( 18 ) 143 Application effect of clinical pathway in acute bronchitis patients in children with acute bronchitis HUANG Sheng-caiWANG He-ping FU Zhi-hua ZHOU You-shu LI Hai-yan Objective To explore application effect of clinical pathway of acute bronchitis in children with acute bronchitis.Methods A total of 105 cases of children with acute bronchitis treated in our hospital from January 2016 to March 2018 were selected，they were divided into control group and observation group according to random number table method，there were 53 cases in the observation group and 52 cases in the control group.The control group was given management and implementation to the traditional methods，the observation group was given patients clinical pathway and implementation，hospital stay，hospital expenses （including drug cost，inspection cost，cost of treatment），antibiotic use time and the degree of children and their families，children and families of cognitive level indicators such as changes of disease were compared between the two groups.Results Compared with the control group，the hospitalization time，antibiotic use time were both shorter in the observation group，hospitalization cost was lower than that in the the observation group，the differences were statistically significant（P＜0.05）.Compared with the control group，the nursing satisfaction and healthy education index were both higher in the observation group，the differences were statistically significant （P＜0.05）.Compared with the control group，the loss of asthma，the disappearance of cough and the disappearance of wheezing sound were shorter in the observation group，the differences were statistically significant（P＜0.05）.Conclusion The clinical application of the clinical pathway in patients with acute bronchitis is more effective and can improve the indicators of peri-hospitalization and better relieve symptoms. 2019 Vol. 26 (4): 143-145转149 [Abstract] ( 70 ) HTML (35 KB)  PDF  (0 KB)  ( 14 ) 146 Characteristics and treatment outcome analysis of children with Henoch-Schönlein purpura complicated with Mycoplasm pneumoniae infection CAI Mian-shan1FANG Bing-xiong2▲ HUANG Xu-dong1CHEN Jun3XIE Cheng1 Objective To explore and analyze the clinical characteristics and treatment outcome of children with Henoch-Schönlein purpura （HSP）complicated with Mycoplasma pneumoniae infection，and to analyze the correlation between the recurrence of HSP and Mycoplasma pneumoniae infection.Methods Altogether 180 cases of patients with HSP and who received treatment in Puning People′s Hospital from March 2016 to November 2017 were selected as research objects according to the double blind method，and were divided into 95 cases of Mycoplasma infection group and 85 cases of non Mycoplasma infection group according to DNA test results of patients with Mycoplasma pneumoniae.Then，the clinical characteristics were analyzed and patients were given the treatment，and the each indexes changes of biochemical test and blood routine test after the treatment of two groups of patients were compared，and the hospitalization time and recurrence of the two groups were observed.Results The levels of total cholesterol （TC），aspartate aminotransferase （AST）and alanine aminotransferase （ALT）in Mycoplasma infection group were higher than those in non Mycoplasma infection group （P＜0.05）.The levels of white blood cell count （WBC），red blood cell count（RBC），platelet count（PLT）and hemoglobin （Hb）in Mycoplasma infection group were higher than those in the non Mycoplasma infection group （P＜0.05）.The hospitalization time in the Mycoplasma infection group was longer than that in the non Mycoplasma infection group，and the recurrence rate was higher than that in the non-Mycoplasma infection group，the differences were statistically significant（P＜0.05）.Conclusion The recurrence of patients with HSP is influenced by the infection factors of Mycoplasma pneumonia，which it is necessary to detect Mycoplasma pneumoniae DNA in patients with HSP as early as possible，and timely diagnose and treat，so as to reduce the recurrence rate of patients with HSP. 2019 Vol. 26 (4): 146-149 [Abstract] ( 78 ) HTML (37 KB)  PDF  (0 KB)  ( 21 ) 150 Clinical effect of sequential therapy of Estradiol Valerate combined with Progesterone in the treatment of dysfunctional uterine bleeding HUANG Jing Objective To investigate the clinical effect of sequential therapy of Estradiol Valerate combined with Progesterone in the treatment of dysfunctional uterine bleeding.MethodsA total of 189 patients diagnosed with dysfunctional uterine bleeding in our hospital from May to October 2017 were selected as the research subjects.They were divided into control group （n=94）and combined group （n=95）according to random number table method.In the control group，Estradiol Valerate alone was used，while in the combined group，sequential therapy of Estradiol Valerate combined with Progesterone was adopted.The clinical effect of the two groups was compared and analyzed.Results The hospital stay，bleeding control time and hemostasis time were significantly shorter in the combined group than those in the control group with statistical significances （P＜0.05）.The endometrial thickness and uterine smooth muscle function scores in the combined group were significantly higher than those in the control group with statistical significances （P＜0.05）.The proportion of patients who recovered normal ovulation in the combined group was higher than that in the control group（P＜0.05）.The proportion of menstrual volume ＞80 ml was lower in the combined group than that in the control group with significant difference （P＜0.05）.There were no significant differences in the levels of follicle stimulating hormone（FSH），luteinizing hormone （LH），progesterone （P）and estradiol （E2） between the two groups before treatment（P＞0.05）.After treatment，in the combined group，the FSH and LH levels were significantly lower，while P and E2levels were significantly higher compared with those in the control group with statistical significances （P＜0.05）.Conclusion The application of sequential treatment of Estradiol Valerate combined with Progesterone can effectively control the symptoms of dysfunctional uterine bleeding and facilitate the recovery of uterine function.It has a high clinical application value and should be actively promoted. 2019 Vol. 26 (4): 150-152 [Abstract] ( 81 ) HTML (32 KB)  PDF  (0 KB)  ( 16 ) 153 Clinical effect of Intravenous Gamma Globulin in the prevention and treatment of recurrent abortion HUANG Yu HOU Ting-ting Objective To explore the clinical effect of Intravenous Gamma Globulin in the prevention and treatment of recurrent abortion （RSA）.Methods A total of 90 patients with RSA who were treated in our hospital from September 2014 to December 2017 were selected as observation group，46 patients who were treated with Intravenous Gamma Globulin according to their own willingness were selected as observation group 1，44 patients who chose traditional conservative treatment were selected as observation group 2，and the clinical treatment effects and adverse reactions of the two groups were observed.At the same time，90 healthy women who did pregnancy check-up in the hospital during the same period were selected as the control group.The level of gamma globulin in patients with RSA and healthy women were observed.Results The success rate of pregnancy and full term yield in the observation group 1 were significantly higher than those in the observation group 2 （P＜0.05）.The mortality of premature infant and abortion rate in the observation group 1 were significantly lower than those in the observation group 2 （P＜0.05），and the total incidence of adverse reactions in the two groups was not significantly different（P＞0.05）and the level of gamma interferon （IFN-γ）and natural killer （NK）in the observation group were significantly lower than those in the control group （P＜0.05）.The level of interleukin-10 （IL-10）in the observation group was significantly higher than that in the control group，the differences were statistically significant （P＜0.05）.Conclusion The level of IFN-γ in RSA patients is significantly different from that in healthy women.It can be used as an effective index to prevent RSA.Intravenous Gamma Globulin in the treatment of RSA can significantly improve the success rate of pregnancy and full term yield，and it has high safety and high clinical value. 2019 Vol. 26 (4): 153-155 [Abstract] ( 86 ) HTML (32 KB)  PDF  (0 KB)  ( 15 ) 156 Clinical effect of oxygen flooding inhalation of Budesonide in the treatment of acute asthma attack in children TANG Lu-xiao Objective To study the effect of oxygen-driven aerosol inhalation of Budesonide in the treatment of acute asthmatic attacks in children and its effect on lung function.Methods 94 children with acute exacerbation of asthma admitted to our hospital from February 2017 to February 2018 were enrolled as subjects.According to the treatment methods，the patients were divided into the control group and the observation group，47 cases in each group.The patients in the control group were given conventional drug therapy，and the children in the observation group were given oxygen-driven aerosolized inhalation of Budesonide.The therapeutic effects，lung function，time to clinical symptom relief，length of hospital stay，and treatment satisfaction were compared between the two groups.Results After drug treatment，the total effective rate of the observation group was higher than that of the control group，and the difference was statistically significant （P ＜0.05）.Compared with before treatment，forced expiratory volume in one second （FEV1），peak expiratory flow（PEF）and forced vital capacity （FVC）were improved in both groups，and the degree of improvement in the observation group was higher than that of the control group，the differences were statistically significant （P＜0.05）.The dyspnea relief time，lung wheezing remission time，wheezing remission time，cough remission time and hospitalization time were all shorter in the observation group than those in the control group，and the differences were statistically significant （P＜0.05）.The treatment satisfaction of the observation group was higher than that of the control group，and the difference was statistically significant（P＜0.05）.Conclusion The treatment of children with acute asthmatic episodes by oxygen-driven nebulization and inhalation of Budesonide can effectively improve the clinical symptoms of children and improve the therapeutic effect.It is worthy of popularization and application. 2019 Vol. 26 (4): 156-158 [Abstract] ( 86 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 159 Clinical value of Dydrogesterone in the treatment of early threatened abortion CAI Jian-ming XU Yi Objective To investigate the application value of Dydrogesterone in the treatment of early threatened abortion.Methods Sixty patients with early threatened abortion from January 2017 to June 2018 in our hospital were enrolled in the study.They were divided into two groups by block randomization method，namely experimental group （n=30）and control group （n=30）.In the control group，Intramuscular Injection of Progesterone was used，while in the experimental group，oral administration of Dydrogesterone was given.The treatment success rate of the two groups for early threatened abortion patients was compared.The serum progesterone levels 6，7，8，9，and 10 weeks after treatment and the occurrence of adverse reactions were compared.Results The success rate of early threatened abortion patients in the experimental group was 86.67%，which was not significantly different from that in the control group accounting for 83.33% （P＞0.05）.The serum progesterone levels 7，8，9，and 10 weeks after treatment were higher compared with those 6 weeks after treatment in both groups （P＜0.05）.There was no significant difference in the serum progesterone level 6，7，8，9，and 10 weeks after treatment between the two groups （P＞0.05）.The incidence of adverse reactions did not display statistical significance between the two groups （P＞0.05）.Conclusion Patients with early threatened abortion receive dexamethasone treatment can obtain a favorable therapeutic effect，and its medication is simple，safe and reliable. 2019 Vol. 26 (4): 159-161 [Abstract] ( 100 ) HTML (31 KB)  PDF  (0 KB)  ( 12 ) 162 Effect of Budesonide in the treatment ofacute attack of children with asthma and its effect on pulmonary function of patients HUANG Huang Objective To investigate the effect of Budesonide suspension in the treatment of acute attack of asthma in children and its influence on pulmonary function.Methods Altogcther 50 children with acute attack of asthma in our hospital from March 2016 to January 2018 were selected and randomly divided into observation group （25 cases）and control group （25 cases）.The control group was treated with routine treatment.The observation group was treated with Budesonide.The therapeutic effects of the two groups were compared.The improvement time of clinical symptoms and the improvement of pulmonary function before and after treatment were compared.Results The effective rate of the observation group was 96.00%，which was significantly higher than that of the control group （72.00%），the difference was statistically significant（P＜0.05）.The cough relief time，the disappearance time of wheezing sound and the relief time of shortness of breath was significantly shorter than that of the control group （P＜0.05）.After treatment，the indexes of lung function in the observation group were also significantly higher than those in the control group，the differences were statistically significant （P＜0.05）.Conclusion Budesonide is effective in the treatment of acute asthma in children.It can quickly relieve the clinical symptoms，improve the pulmonary function and accelerate the recovery of children with asthma. 2019 Vol. 26 (4): 162-164 [Abstract] ( 82 ) HTML (31 KB)  PDF  (0 KB)  ( 15 ) 165 Influence of hypothyroidism on pregnancy outcome and fetus in pregnant women WU Hai-xia Objective To investigate the influence of hypothyroidism on pregnancy outcomes and fetuses in pregnant women.Methods From March 2017 to April 2018，52 patients with hypothyroidism during pregnancy and 52 healthy pregnant women were selected as subjects.The patients with hypothyroidism during pregnancy were classified into the observation group，and the healthy pregnant women were selected as the control group.The thyroid function，pregnancy outcomes and fetal conditions were observed in the two groups.Results With regard to thyroid function，the thyroid stimulating hormone （TSH）of the observation group was higher than that of the control group，and the level of free thyroxine （FT4）was lower compared with that in the control group with statistical differences （P＜0.05）.There were no significant differences in pregnancy outcomes such as the incidence of postpartum hemorrhage，placenta previa and placental abruption between the two groups （P＞0.05）.The incidence of preterm birth and anemia in the observation group was higher than that in the control group with statistical significance （P＜0.05）.There was no significant difference in fetal malformation between the two groups （P＞0.05）.The incidence of low birth weight and fetal distress in the observation group was higher than that in the control group （P＜0.05）.Conclusion Hypothyroidism in pregnant women can have adverse effects on pregnancy outcomes and fetal development，which can increase the incidence of fetal preterm birth and seriously harm the health of the fetus.Early screening，detection and treatment can avoid adverse effects on the fetus，and is of great importance in clinical practice. 2019 Vol. 26 (4): 165-167 [Abstract] ( 73 ) HTML (31 KB)  PDF  (0 KB)  ( 14 ) 168 Clinical effect of Bacillus Subtilis Binomial Living Bacteria Granules with Multivitamins preventing diarrhea complication in pneumonia cases XIE Ji-qing LI Juan Objective To study clinical effect of Bacillus Subtilis Binomial Living Bacteria Granules with Multivitamins preventing diarrhea complication in pneumonia cases.Methods Fifty children with pneumonia who were admitted to our hospital from January to June 2018 were selected as the subjects and divided into control group （25 cases）and observation group （25 cases）according to the random number table method.The control group received routine symptomatic treatment，the observation group was treated with Bacillus Subtilis Binomial Living Bacteria Granules.The incidence of secondary diarrhea，occurrence time of diarrhea，stopping time of diarrhea，times of defecation and adverse reactions were compared between the two groups.Results The incidence of secondary diarrhea in the observation group （4.00%）was lower than that in the control group （P＜0.05），the time of diarrhea in the observation group （［5.50±0.51］days） was later than that in the control group，stop time of diarrhea （［1.97±0.26］days） was shorter than that in the control group，with statistical difference （P＜0.05）.The number of defecation in the observation group was （2.23±0.79）time，which was significantly lower than that in the control group （P＜0.05），and there was no significant difference in the incidence of adverse reactions between the two groups （P＞0.05）.Conclusion Bacillus Subtilis Binomial Living Bacteria Granules can prevent the occurrence of secondary diarrhea in children with pneumonia fed artificially with high safety. 2019 Vol. 26 (4): 168-170 [Abstract] ( 83 ) HTML (32 KB)  PDF  (0 KB)  ( 17 ) 171 Effect of echocardiography in diagnosis and cardiac function evaluation for patients with chronic heart failure ZHANG Yan-fen Objective To investigate effect of echocardiography in diagnosis and cardiac function evaluation for patients with chronic heart failure（CHF）.Methods A total of 137 patients with CHF were selected in our hospital from January 2015 to January 2018 as observation group.137 health checkup people were selected at same period as control group.All people received echocardiography and cardiac function evaluation.Results Left ventricular ejection fraction（LVEF），cardiac index （CI） in the observation group were lower than that in the control group;while left ventricular end diastolic diameter（LVEDD），left atrial diameter（LV），HFEI score in the observation group were higher than those in the control group （P＜0.05）.LVEF，CI in patients with grade Ⅳ were lower than that patients with grade Ⅰ，Ⅱ，Ⅲ;while LVEDD，LV，HFEI scores in patients with gradeⅣ were higher than those patients with gradeⅠ，Ⅱ，Ⅲ （P＜0.05）.LVEF，CI in patients with grade Ⅲ were lower than those patients with gradeⅠ，Ⅱ;while LVEDD，LV，HFEI scores in patients with grade Ⅲ were higher than those patients with grade Ⅰ，Ⅱ （P＜0.05）.LVEF，CI in patients with gradeⅡwere lower than those patients with gradeⅠ;while LVEDD，LV，HFEI score in patients with gradeⅡwere higher than those patients with grade I （P＜0.05）.There were positive correlation between cardiac function classification and LVEF，CI（P＜0.05）.There were negative correlation between cardiac function classification and LVEDD，LV，HFEI score （P＜0.05）.Conclusion Echocardiography can be used in clinical diagnosis of CHF，which is closely related to cardiac function evaluation. 2019 Vol. 26 (4): 171-173 [Abstract] ( 77 ) HTML (30 KB)  PDF  (0 KB)  ( 13 ) 174 Clinical value of color Doppler ultrasound in diagnosis of hyperplasia of mammary glands BU Dan Objective To analyze the effect of color Doppler ultrasound in diagnosis of hyperplasia of mammary glands.Methods A total of 58 cases of hyperplasia of mammary glands admitted to our hospital from June 2017 to June 2018 were selected and diagnosed by case diagnosis.Color Doppler ultrasonography was used to diagnose and analyze the coincidence rate between ultrasonic diagnosis and pathological diagnosis.Results 12 cases of cystic hyperplasia of mammary gland，12 cases of hyperplasia of mammary lobule，11 cases of mammary gland tissue hyperplasia，10 cases of hyperplasia of mammary gland and 13 cases of mixed hyperplasia of mammary gland were found in the pathological diagnosis of 58 cases.11 cases of cystic hyperplasia of the breast were diagnosed by color Doppler ultrasound，the diagnostic coincidence rate was 91.67%，12 cases of mammary lobular hyperplasia，100.00%of diagnosis，10 cases of mammary gland tissue hyperplasia，90.90%of diagnosis，13 cases of mammary gland hyperplasia，76.92%of diagnostic coincidence，12 cases of mixed hyperplasia of mammary gland.The diagnostic accuracy of color Doppler ultrasonography was higher，which was not statistically different from pathology （P＞0.05）.Conclusion Color Doppler ultrasound diagnosis，in the diagnosis of breast hyperplasia has a high diagnostic coincidence rate，can provide important theoretical guidance for clinical diagnosis of breast diseases，has a high clinical value. 2019 Vol. 26 (4): 174-176 [Abstract] ( 75 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 177 Clinical effect of Pain and Diarrhea Formula hot package treating infantile diarrhea with spleen deficiency and dampness-trapped type ZHANG Zi-cai1ZHANG Zeng-xiu2SUN Ji-na1 Objective To evaluate the clinical effect Pain and Diarrhea Formula hot package treating infantile diarrhea with spleen deficiency and dampness-trapped type.Methods From January 2017 to March 2018，100 infantile diarrhea patients with spleen deficiency and dampness-trapped type treated in our hospital were selected as study objects.They were divided into the control group and observation group according to random control method，and there were 50 cases in each group.Both groups were given symptomatic treatment by routine western medicine，and the observation group was given auxiliary treatment of Pain and Diarrhea Formula hot package.The score of TCM symptoms，clinical efficacy and adverse reactions in the course of treatment were observed before and after treatment in the two groups，and the therapeutic effect was compared between the two groups.Results After 3 and 7 days treatment，the score of TCM symptoms in both groups were lower than those before treatment，and the differences were statistically significant （P＜0.05），and the score of TCM symptoms in the observation group were lower than those in the control group after 3 and 7 days treatment，and the differences were statistically significant （P＜0.05）.The therapeutic effect of the observation group were better than those of the control group after 3 and 7 days treatment，and the differences were statistically significant （P＜0.05）.There were no adverse reactions during the treatment of the two groups.Conclusion Clinical effect of Pain and Diarrhea Formula hot package treating infantile diarrhea with spleen deficiency and dampness-trapped type is significant，and it can significantly shorten the improvement time of clinical symptoms in children，and is worthy of promotion. 2019 Vol. 26 (4): 177-179 [Abstract] ( 66 ) HTML (35 KB)  PDF  (0 KB)  ( 16 ) 180 Application effect of Taohong Siwu Decoction and Wuling Powder in patients with calcaneal fracture PENG Wei-jun XIE Yi-lu Objective To explore the application effect of Taohong Siwu Decoction and Wuling Powder in patients with calcaneal fracture.Methods Seventy patients with calcaneal fracture treated in our hospital from June 2015 to December 2017 were selected as study objects.The patients were divided into the control group （35 cases）and the experimental group （35 cases）according to the random envelope method.Within perioperative period，routine treatment was used in the control group while the experimental group was treated with Taohong Siwu Decoction and Wuling Powder.The pain degree score，swelling degree score，incision healing effect and clinical related index were compared between the two groups.Results The pain and swelling degree score of the experimental group were lower than those of the control group，and the difference was statistically significant （P＜0.05）.The wound healing effect of the experimental group was better than that of the control group，and the difference was statistically significant （P＜0.05）.The appearing time of skin wrinkles and wound healing time in the experimental group were shorter than those in the control group，and the differences were statistically significant （P＜0.05）.Conclusion The treatment of calcane Siwu Decoction and Wuling Powder given in patients with calcaneal fracture has positive clinical significance for improving incision healing effect of perioperative period，improving pain degree and swelling degree.The clinical application value is higher and it is worthy of promotion. 2019 Vol. 26 (4): 180-182 [Abstract] ( 100 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 183 Effect of acupuncture combined with cognitive rehabilitation training in the treatment of stroke WANG Huan LIU Li-li Objective To investigate the effect of acupuncture combined with cognitive rehabilitation training in the treatment of stroke.Methods The clinical data of 106 patients with stroke who were admitted into the Department of Traditional Chinese Medicine in the Second People′s Hospital of Xiangzhou District in Zhuhai City from January 2017 to May 2018 were analyzed.They were divided into the control group （n=53，conventional cognitive rehabilitation training）and the observation group （n=53，acupuncture combined with cognitive rehabilitation training）according to different treatment measures.The cognitive function score，Fugl-Meyer score and Barthel index in patients of the two groups were observed before and after treatment.The clinical efficacy of in patients in the two groups was observed.Results There were no statistically significant differences in the cognitive function score，Fugl-Meyer score and Barthel index between the two groups before treatment （P＞0.05）.After treatment，the cognitive function score，Fugl-Meyer score and Barthel index in the two groups were higher than those before treatment and the cognitive function score，Fugl-Meyer score and Barthel index in the observation group after treatment were higher than those in the control group （P＜0.05）.The total effective rate of clinical treatment in the observation group was higher than that in the control group，and the difference was statistically significant （P＜0.05）.Conclusion Acupuncture combined with cognitive rehabilitation training in the treatment of stroke can significantly improve the cognitive function，limb function and quality of life in patients，and the effect is better，and it is worthy of clinical promotion and application. 2019 Vol. 26 (4): 183-185 [Abstract] ( 73 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 186 Cross-sectional survey of pulmonary rehabilitation awareness in chronic obstructive pulmonary disease at different levels of medical institutions in Panyu District of Guangzhou City ZHENG Xiang-yiCUI Jun-yu LI Xiu-ping HE Xi-zi Objective To understand the pulmonary rehabilitation awareness of chronic obstructive pulmonary disease（COPD）in various medical institutions in Panyu District of Guangzhou City.Methods From March to October in 2017，a questionnaire survey was conducted among 339 medical staff from respiratory specialists and community at all levels of medical institutions in the district.Data were input and statistical analysis was performed.Results The level of awareness of the severity of COPD airflow limitation was the highest in the tertiary hospitals （50.0%），and the lowest in the community （20.2%）.On the familiarity of the GOLD guidelines，the highest was in tertiary hospitals （22.7%）and the lowest in the community （1.6%）.The standard terminology used was up to 90.9%of tertiary hospitals.The highest awareness rate for the definite diagnosis of COPD was in tertiary hospitals （86.4%），and the lowest（58.7%）in the firstgrade hospital.The acknowledgement of lung function knowledge was most in tertiary hospitals （70.5%），and the lowest in the first-grade hospitals （30.4%）.The use of β-agonists to relieve shortness of breath was lowest in tertiary hospitals（34.1%）and highest in secondary hospitals （60.8%）.Inhaled drug varieties and usage understood in most in tertiary hospitals （52.3%），and lowest in primary hospitals （8.7%）.All medical institutions have the highest awareness of pursed lips breathing and abdominal breathing in various rehabilitation exercises.For upper and lower limb exercises，cycle ergometer，and treadmill exercise，the awareness rate of tertiary hospitals was higher than those of other medical institutions.Awareness of respiratory muscles was most in tertiary hospitals （72.8% ），and 19.5%of primary hospitals.Awareness of airway clearance technology was most in tertiary hospitals （77.3%），and lowest at primary hospi-tals （15.2%）.The return visits of various medical institutions mainly include re-visit to hospital （37.1%-84.1%）and telephone follow-up （26.1%-56.8%），and community visit was more than other medical institutions.Drug cost and absence of acknowledgement of treatment benefits were the main factors affecting the compliance of patients with COPD.72.7%～82.4%of all medical institutions would advise patients to quit smoking during each visit.Insufficient drugs，personnel，poor patient compliance，inadequate medical care，inadequate equipment，and backward information systems were the main reasons for community management of COPD.Conclusion Different levels of medical institutions in the Panyu District have different understanding of COPD pulmonary rehabilitation.Strenthening training for primary hospitals and communities should depend on the specific conditions，and give full play to the role of different medical institutions to jointly manage COPD. 2019 Vol. 26 (4): 186-191 [Abstract] ( 90 ) HTML (43 KB)  PDF  (0 KB)  ( 18 ) 192 Analysis of the investigation report on the prevalence of nosocomial infection in hospitalized patients in our hospital WU Mei-xia LUO Jing-xiang▲ LIN Si-bing Objective To investigate the prevalence of nosocomial infection in hospitalized patients in our hospital and provide reference for prevention and control of nosocomial infections.Methods A total of 729 inpatients received from 0：00-24：00 on April 24，2018 were investigated by cross-sectional survey to investigate the prevalence of nosocomial infection.Results On the day of investigation，there were 729 inpatients in the hospital.A total of 729 patients should be investigated，the actual investigation was 728 cases.The actual investigation rate was 99.86%.The prevalence rate of hospital infection was 2.33%.The infection rate of cases/times was 2.47%.The prevalence of the area one in the department of ICU was （44.44%）and neurosurgery （7.14%）.In the 234 inpatients of non-surgical department，the prevalence of nosocomial infection was 3.90%;among the 495 inpatients in the surgical department，the prevalence of nosocomial infection was 1.62%.The respiratory tract was the main infection site，and the infection rate was 38.89%.The pathogen detection showed that the infection rate of Gram-negative bacilli was the highest （67.86%）;the antibacterial drug use rate of all hospitalized patients on that day was 31.59%.Conclusion The prevalence of nosocomial infection in hospitalized patients in our hospital is in line with the national regulations on the prevalence of nosocomial infections，and the use of antibiotics is basically reasonable.The clinical examination should be strengthened and the management of antibiotics should be strengthened. 2019 Vol. 26 (4): 192-194 [Abstract] ( 71 ) HTML (30 KB)  PDF  (0 KB)  ( 10 ) 195 Analysis of the utilization of narcotic drugs in our hospital during 2012-2017 LIU Quan-yiYANG Liang-ruiZHENG Yang Objective To evaluate the current situation and trend of narcotic drugs used in our hospital，and to provide reference for scientific management and rational use of narcotic drugs.Methods From 2012 to 2017，the sales amount，drug frequency （DDDs），daily cost（DDC）and ranking ratio （B/A）of narcotic drugs for inpatients in the First Affiliated Hospital of Dali University were statistically analyzed.Results The consumption sum of narcotic drugs were increased year by year and used for postoperative analgesia in our hospital，mainly injection.Both consumption sum of Fentanyl Citrate Injection was took up the first place and DDDs was higher during 2012 to 2017.The consumption sum and DDDS was increased year by year of Sufentanil Citrate and Remifentanil Hydrochloride.The DDC of Hydroxycodone Hydrochloride preparation with different specifications was higher，B/A＜1.0，price were relatively high and the acceptance of patients was poor.The DDC of Morphine Hydrochloride Injection and Sufentanil Citrate Injection were lower，B/A＞1.0，the price is reasonable was higher，and the acceptance of patients was high.Conclusion The consumption sum of narcotic drugs in our hospital increase year by year.The utilization and management of narcotic drugs is basically in line with related standard and treatment criteria，but the management of narcotic drugs still needs to be strengthened in the future. 2019 Vol. 26 (4): 195-199 [Abstract] ( 71 ) HTML (38 KB)  PDF  (0 KB)  ( 12 ) 200 Retrospective survey and risk factors analysis of hypertension among the elderly in Kunlun community of Karamay City ZHANG Yan-hong；ZHOU Li-juan Objective To investigate the prevalence of hypertension and the risk factors of poor blood pressure control among the elderly in Kunlun，Karamay，in order to provide theoretical basis for community doctors to conduct lifestyle and drug intervention.Methods A total of 2630 patients with hypertension who visited Kunlun community from March 2011 to December 2017 were selected as research objects，detailed records of past medical history，behavior，eating habits and lifestyle were recorded，the prevalence and risk factors of hypertension were statistically analyzed.Results The prevalence rate of hypertension was 56.99%in the elderly in Kunlun community.The results of multivariate Logistic regression analysis showed that more than 10 cigarettes （OR=1.462），long term alcohol （OR=1.866），less than 2 times per week （OR=1.467），BMI＞28 kg/m2 （OR=1.958），abdominal obesity （OR=2.032），hypertriglyceridemia （OR=1.688），hypercholesterolemia （OR=1.203），high and low density lipoprotein cholesterolemia （OR=1.210），hyperuricemia（OR=1.928）were the high risk factors for poor control of hypertension （P＜0.05）.Conclusion Many factors lead to poor control of hypertension in the elderly in this community.A long-term and continuous supervision and intervention mechanism should be established to control hypertension in the community，improve the unfavourable lifestyle to reduce the risk of sudden cardio cerebrovascular events and enhance the quality of life. 2019 Vol. 26 (4): 200-202转206 [Abstract] ( 81 ) HTML (32 KB)  PDF  (0 KB)  ( 15 ) 203 Influence of continuous quality improvement nursing interventions in the standard rate and nursing satisfaction of abdominal catheter in the general surgery department YANG Dan ；LIN Qian-jun ；XIE Jian-ying Objective To study the influence of continuous quality improvement nursing interventions in the standard rate and nursing satisfaction of abdominal catheter in the general surgery department.Methods A total of 2880 cases of hepatobiliary surgery patients admitted to our hospital from January to October 2016 were selected as research objects.According to different management methods，they were divided into control group （371 cases）and observation group（2509 cases）.Patients in the control group received conventional nursing mode，while patients in the observation group received continuous quality improvement nursing mode.The results of normative investigation between the two groups were compared，and the total incidence of irregular events such as accidental tube detachment，irregular secondary fixation，and labeling and pasting of pipes were compared.The total nursing satisfaction between the two groups was compared.Results The total incidence of non-standard investigation （3.27%）in the observation group was significantly lower than that in the control group （49.06%），and the total nursing satisfaction （99.80%）in the observation group was significantly higher than that in the control group （92.99%），with statistically significant differences （P＜0.05）.Conclusion The continuous quality improvement nursing interventions can remarkably standardize and consolidate the indwelling criteria and skill operation procedures，improving the homogenous nursing modes，avoiding the patient-doctor disputes and increasing the patients′satisfaction.It shall be further developed in clinical practice. 2019 Vol. 26 (4): 203-206 [Abstract] ( 75 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 207 Application effect of nursing intervention model of Knowledge Attitude Belief practice in pregnant women with gestational diabetes TAN Hong-xia；WEN Juan；CHEN Lei-ning Objective To investigate the application effect of nursing intervention of Knowledge Attitude Belief practice（KABP）in pregnant women with gestational diabetes mellitus.Methods A total of 100 pregnant women with gestational diabetes who were routinely examined in our hospital from January to June 2018 were selected as the subjects，and divided into the control group and the intervention group according to the different ways of nursing intervention，with 50 cases in each group.The control group was given routine nursing intervention，and the intervention group was given nursing intervention of KABP.The differences in health behavior，blood glucose and weight control between the two groups of pregnant women were compared.Results The scores of healthy behaviors of pregnant women in the intervention group were higher than those in the control group，the fasting blood glucose and the 2 h postprandial blood glucose levels were lower than those in the control group，the weight gain during pregnancy and body mass index （BMI）before delivery of the intervention group were lower than those of the control group，and the differences were statistically significant （P＜0.05）.Conclusion The nursing intervention of KABP can help pregnant women establish good health behaviors，which is beneficial to pregnant women to better control blood glucose and body weight during pregnancy，thus improving pregnancy outcomes.This method is worthy of clinical application. 2019 Vol. 26 (4): 207-210 [Abstract] ( 76 ) HTML (37 KB)  PDF  (0 KB)  ( 14 ) 211 Application effect of multidisciplinary teamwork continuing nursing in patients with pulmonary tuberculosis complicated with type 2 diabetes mellitus ZHANG Jue Objective To explore the application effect of multidisciplinary teamwork continuing nursing in patients with pulmonary tuberculosis complicated with type 2 diabetes mellitus.Methods A tatal of 90 cases patients with pulmonary tuberculosis complicated with type 2 diabetes mellitus hospitalized in the infectious diseases department of our hospital from September 2013 to May 2017 were selected as the subjects，and randomly divided into experimental group and control group，with 45 cases in each group.The patients in the control group were given routine nursing，and the patients in the experimental group were given continuing nursing by multi-disciplinary team cooperation on the basis of the control group.The cure rate of pulmonary tuberculosis，the pass rate of blood sugar index and the total satisfaction degree were compared between the two groups.Results The cure rate of pulmonary tuberculosis and the pass rate of blood glucose in the experimental group were significantly higher than those in the control group，and the differences were statistically significant （P＜0.05）.The total satisfaction degree of the experimental group was 95.6%，which was significantly higher than that of the control group，and the difference was statistically significant （P＜0.05）.Conclusion Multidisciplinary teamwork continuing nursing mode combines the knowledge and skills of many professionals，provides a professional and scientific relief platform for tuberculosis patients with type 2 diabetes mellitus，obviously promotes the control and improvement of the patients′condition，is welcomed by patients，and is worthy of clinical promotion and use. 2019 Vol. 26 (4): 211-213 [Abstract] ( 62 ) HTML (31 KB)  PDF  (0 KB)  ( 3 ) 214 Application effect of psychological nursing intervention in improving pregnancy outcome in pregnant women and puerpera ZHANG Ping ；LUO Jia； XIA Yu-jie Objective To explore the application effect of psychological nursing intervention in improving the pregnancy outcome in pregnancy women and puerpera.Methods A total of 200 pregnant women and puerpera who were admitted to our hospital from March 2017 to March 2018 were selected as the subjects，and divided into control group （n=100）and observation group （n=100）according to the random number table method.The pregnant women and puerpera in the control group was given routine obstetric nursing intervention.The pregnant women and puerpera in the observation group were given psychological nursing intervention based on routine nursing intervention.The anxiety and depression improvement and nursing satisfaction before and after maternal nursing intervention were compared between the two groups，and the pregnancy outcomes of the two groups were followed.Results The self-rating anxiety scale （SAS）and self-rating depressive scale （SDS）scores in the two groups of pregnant women and puerpera after nursing intervention were significantly lower than those before the intervention，and the differences were statistically significant （P＜0.05）.The SAS and SDS scores in the observation group after nursing intervention were significantly lower than those in the control group，and the differences were statistically significant （P＜0.05）.The cesarean section rate，the incidence rate of neonatal asphyxia，the incidence rate of postpartum depression and the incidence rate of postpartum hemorrhage in the observation group were significantly lower than those in the control group，and the differences were statistically significant （P＜0.05）.The natural childbirth rate in the observation group was significantly higher than that in the control group，and the difference was statistically significant （P＜0.05）.The total nursing satisfaction in the observation group was significantly higher than that in the control group，and the difference was statistically significant （P＜0.05）.Conclusion Psychological nursing care in the department of obstetrics can effectively alleviate maternal anxiety and depression，which is conducive to reducing the rate of cesarean section，reducing the occurrence of adverse pregnancy outcomes such as neonatal asphyxia，postpartum hemorrhage and postpartum depression，and improving puerpera′s satisfaction.The effect is significant，and it can be widely promoted and further applied in clinical practice. 2019 Vol. 26 (4): 214-216 [Abstract] ( 78 ) HTML (33 KB)  PDF  (0 KB)  ( 14 ) 217 Application effect of comprehensive nursing intervention in the nursing of patients undergoing obstetrics and gynecology surgery LIU Heng Objective To analyze the application effect of comprehensive nursing intervention in the nursing of patients undergoing obstetrics and gynecology surgery.Methods A total of 100 patients undergoing surgery in the department of gynecology and obstetrics of our hospital from March 2017 to March 2018 were selected as study subjects，and they were divided into the control group and observation group by computer randomization coding method，with 50 cases in each group.The control group was given routine surgical nursing care.The observation group was given comprehensive nursing intervention.The postoperative pain，the number of days of painkiller application，length of hospital stays，quality of life，and satisfaction of nursing care were compared between the two groups.Results The pain scores in the observation group 1，3，7 days after surgery （［4.33±2.01］points，［2.26±1.12］points，［1.01±0.24］points）were lower than those in the control group （［6.32±2.15］points，［4.18±2.01］points，［3.32±1.05］points），and the differences were statistically significant （P＜0.05）.The days of application of analgesics was （4.12±0.64）days and length of hospital days was（19.58±2.05）days in the observation group，which were shorter than those in the control group （［7.54±0.36］days and［28.26±3.31］days），and the differences were statistically significant （P＜0.05）.The scores of general health （［85.59±2.13］points），mental health （［86.65±2.31］points），physical pain （［88.47±2.52］points），physiologic function （［87.59±3.01］points），and the total nursing satisfaction （98.00%）in the observation group after discharge were higher than those in the control group （［73.36±2.18］points，［75.58±2.21］points，［74.59±3.32］points，［76.52±2.01］points，84.00%），and the differences were statistically significant （P＜0.05）.Conclusion Comprehensive nursing intervention in the patients undergoing gynecology and obstetrics surgery can effectively alleviate pain，avoid long-term use of painkillers，and improve quality of life. 2019 Vol. 26 (4): 217-219 [Abstract] ( 71 ) HTML (33 KB)  PDF  (0 KB)  ( 18 ) 220 Application effect of intensive psychological nursing in nursing for orphans and disabled children in welfare homes HUANG Yan-fang；TAN Shao-zhen；HE Dong-mei Objective To analyze application effect of intensive psychological nursing in nursing for orphans and disabled children in welfare homes.Methods From March 2015 to August 2017，60 orphans and disabled children in the Guangzhou Social Welfare Institute were selected as the subjects.According to different nursing methods，they were equally divided into reference group and experimental group，with 30 cases in each group.In the reference group，participants were provided with regular nursing，while in the experimental group，intensive psychological nursing was added.The scores of mental health related factors，scores from autism behavior scale，scores of development and behavior scale，incidence of depression and self-injury before intervention and 3-month after intervention were compared between the two groups.Results After 3-month intervention，the scores of mental health related factors and autism behavior scale in the experimental group were significantly lower than those in the reference group，and the scores of development and behavior scale was higher than that in the reference group （P＜0.05）.The incidence rates of depression and self-injury after 3 months of intervention in the experimental group were lower than those in the reference group，with statistical significance （P＜0.05）.Conclusion Implementation of regular nursing combined with intensive psychological nursing for orphans and disabled children in welfare homes can obtain a favorable effect. 2019 Vol. 26 (4): 220-222 [Abstract] ( 79 ) HTML (34 KB)  PDF  (0 KB)  ( 16 ) 223 Application effect of clinical pathway nursing in hemodialysis patients LONG Rong-fang Objective To explore the application effect of clinical pathway nursing in hemodialysis patients.Methods A total of 84 cases of hemodialysis patients treated in our hospital from April 2015 to April 2017 were selected as the subjects.According to the different nursing methods，they were divided into the observation group and the control group，with 42 cases in each group.The patients in the control group took routine nursing measures，and the patients in the observation group took clinical path nursing，the two groups were all intervened for 1 months.The patients′satisfaction and the total incidence of complications were compared and analyzed between the two groups.Results The total incidence of complications in the observation group （9.52%）was significantly lower than that of the control group（33.33%），and the difference was statistically significant （P＜0.05）.The satisfaction scores of propaganda，environment，attitude，operation and treatment effect of the observation group were higher than those of the control group （P＜0.05）.Conclusion Clinical pathway nursing measures can effectively improve the quality of care of hemodialysis patients，reduce the total incidence of complications，and achieve the purpose of promoting curative effect. 2019 Vol. 26 (4): 223-225 [Abstract] ( 89 ) HTML (28 KB)  PDF  (0 KB)  ( 15 ) 226 Comparison of the effect of individualized postpartum pelvic floor rehabilitation nursing at different times in postpartum puerpera MA Liao-li；CHEN Shan-shan ；HU Ya-ling Objective To compare the effect of individualized postpartum pelvic floor rehabilitation nursing at different times in postpartum puerpera.Methods A total of 260 puerpera who were admitted to our hospital from February 2016 to June 2017 were selected as research subjects.According to different stages and nursing methods of individualized pelvic floor rehabilitation nursing，they were divided into group A，group B，group C and group D，with 65 cases in each group.Individualized pelvic floor nursing was used in group A from 42 to 56 days after delivery.Individualized pelvic floor nursing was used in group B from 57 to 70 days after delivery.Individualized pelvic floor nursing was used in group C from 71 to 91 days after delivery.Routine nursing care was used in group D from 42 to 56 days after delivery.The nursing effects were compared among the four groups.Results The pelvic resting pressure in group A，group B and group C was （58.71±3.11），（57.16±6.91），（58.18±3.11）cmH2O respectively，higher than that of（39.10±9.50）cmH2O in group D，and the differences were statistically significant （P＜0.05）.The pelvic floor systolic pressure in group A，group B and group C was （58.91±2.77），（59.32±3.63），（59.42±1.74）cmH2O respectively，higher than that of （43.92±2.81）cmH2O in group D，and the differences were statistically significant（P＜0.05）.The duration of type I muscle fibers in group A，group B and group C was （4.67±1.27），（5.13±1.50），（5.09±1.27）s respectively，longer than that of （3.12±0.91）s in group D，and the differences were statistically significant （P＜0.05）.The number of contraction of type Ⅱmuscle fibers in group A，group B and group C was 4.92±1.25，4.82±1.29，4.79±1.74 respectively，higher than that of 1.98±0.86 in group D，and the differences were statistically significant （P＜0.05）.There were no statistically significant differences in the above indices among group A，group B and group C （P＞0.05）.Conclusion The implementation of individualized pelvic floor rehabilitation nursing is beneficial to the recovery of postpartum pelvic floor function in puerpera.The selection of nursing timing has a less impact on the effectiveness of rehabilitation nursing care. 2019 Vol. 26 (4): 226-228 [Abstract] ( 68 ) HTML (31 KB)  PDF  (0 KB)  ( 16 ) 229 Application effect of comprehensive psychological nursing intervention on patients with mental disorders in compulsory medical treatment LIU Jia；PENG Shu-ying；XU Qu； HUANG Xin-li Objective To explore the effect of comprehensive psychological nursing intervention on patients with mental disorders in compulsory medical treatment.Methods A total of 100 patients with mental disorders hospitalized in Guangzhou compulsory medical institute from January 2014 to January 2017 were selected as the research subjects，and divided into the observation group and the control group according to the order of admission，with 50 cases in each group.The control group was given conventional medicine for symptomatic treatment and health education，and the observation group was given comprehensive psychological nursing intervention in psychologica，economic and knowledge level on basis of the patients in the control group.The mental symptoms，psychological and quality of life of the two groups were evaluated by Krawiecka symptom scale，SCL-90 symptom checklist and SF-36 scale，and the effects of nursing intervention were observed.Results The Krawiecka scores of the two groups after intervention were significantly lower than those before intervention，and those in the observation group were lower than those in the control group，the differences were statistically significant （P＜0.05）.The difference of the factors of SCL-90 before nursing intervention in the two groups was not statistically significant （P＞0.05）.The factors of the SCL-90 in the observation group were significantly lower than those in the control group after intervention，and the differences were statistically significant （P＜0.05）.The scores in the SF-36 scale of the observation group were significantly higher than those in the control group，and the differences were statistically significant （P＜0.05）.Conclusion The effective and comprehensive comprehensive psychological nursing intervention can help the patients get rid of the guilt，reduce the bad mood and help the recovery of the disease. 2019 Vol. 26 (4): 229-231 [Abstract] ( 98 ) HTML (33 KB)  PDF  (0 KB)  ( 14 ) 232 Application effect of surgical nursing pathway in laparoscopic hernia repair surgery SUN Yi Objective To explore the application effect of surgical nursing pathway in laparoscopic hernia repair surgery.Methods A total of 100 patients who underwent laparoscopic hernia repair from January to December in 2017 were selected as the subjects，and divided into study group and control group according to the random number table method，with 50 cases in each group.The control group was given routine nursing，and the study group was given routine nursing combined with surgical nursing pathway intervention.The nursing cooperation effects and nursing satisfaction were compared.Results There was no significant difference in the operation time between the two groups （P＞0.05）.The hospitalization time and the time to chronic severe pain disappearance in the study group were shorter than those in the control group，and the differences were statistically significant（P＜0.05）.The total incidence of adverse events in the study group was lower than that of the control group，and the difference was statistically significant （P＜0.05）.The total postoperative complication rate of the study group was lower than that of the control group，and the difference was statistically significant （P＜0.05）.The total nursing satisfaction of the study group was higher than that of the control group，and the difference was statistically significant （P＜0.05）.Conclusion The effect of surgical nursing intervention during the nursing cooperation of laparoscopic hernia repair surgery is exact. 2019 Vol. 26 (4): 232-234 [Abstract] ( 78 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 235 Application effect of prenatal care intervention in patients with pregnancy-induced hypertension syndrome HONG Ying-mei；YANG Xiao-zhen；MA Hua-xue Objective To explore the application effect of prenatal nursing intervention in patients with pregnancy-induced hypertension syndrome.Methods From May 2016 to June 2018，150 patients with pregnancy-induced hypertension syndrome were selected from the obstetrics clinic of our hospital.The patients were divided into the experimental group and the control group according to the random number table method，with 75 cases in each group.The patients in the control group were given routine nursing intervention.The patients in the experimental group were given prenatal care intervention on the basis of routine nursing.The rate of cesarean section，total incidence of adverse delivery outcome and quality of life were compared between the two groups.Results The rate of cesarean section and total incidence rate of adverse delivery outcome in the experimental group were significantly lower than those in the control group，and the differences were statistically significant（P＜0.05）.The quality of life score of the experimental group was significantly higher than that of the control group，and the difference was statistically significant(P＜0.05）.Conclusion Prenatal care interventions can improve the delivery outcome in patients with pregnancy-induced hypertension，improve their quality of life，which is worthy of clinical promotion and application. 2019 Vol. 26 (4): 235-237 [Abstract] ( 81 ) HTML (31 KB)  PDF  (0 KB)  ( 18 ) 238 Application effect of clinical treatment path in first-aid for patients with acute dyspnea LIU Ying Objective To explore the application effect of clinical treatment path in first-aid for patients with dyspnea.Methods A total of 128 patients with acute dyspnea admitted into our hospital from June 2015 to September 2017 were selected as the study objects and they were randomly divided into the routine group and study group using drawing lots，there were 64 cases in each group.The routine group was given routine first-aid treatment，while the study group was given first-aid treatment by clinical treatment pathway.The success rate of rescue，the cost of emergency treatment，the time of emergency rescue，the time of relieving dyspnea，the time of emergency detention and nursing satisfaction degree were compared in patients between the two groups.Results The success rate of rescue in the study group（84.38%）was significantly higher than that in the routine group （70.31%），and the difference was statistically significant （P＜0.05）.The emergency treatment cost of the study group was （985.0±116.8）yuan，which was significantly lower than that of the routine group （［1056.0±259.2］yuan），the time of emergency rescue，the time of relieving dyspnea，the time of emergency detention were shorter those than those of the routine group，and the differences were statistically significant（P＜0.05）.The total satisfaction degree of nursing after operation in the study group （76.56%）was significantly higher than that in the routine group （57.81%），and the difference was statistically significant （P＜0.05）.Conclusion Clinical treatment pathway can effectively improve the success rate of first-aid for patients with acute dyspnea，shorten the relief of dyspnea and emergency detention time.It is of great significance to reduce the cost of emergency treatment，improve the postoperative satisfaction degree of patients，and improve the quality of medical first-aid.It is worthy of clinical promotion and application. 2019 Vol. 26 (4): 238-240 [Abstract] ( 86 ) HTML (33 KB)  PDF  (0 KB)  ( 16 ) 241 The influence of clinical pathway nursing on perioperative negative emotion and nursing satisfaction degree of patients with uterine fibroids DENG Bing；WU Jian-xiu；LONG Shun-lan Objective To investigate the influence of clinical pathway nursing on perioperative negative emotion and nursing satisfaction degree of patients with uterine fibroids.Methods Eighty-two patients with uterine fibroids admitted to our hospital from December 2016 to December 2017 were selected as study objects and they were divided into the control group （n=41）and experimental group （n=41）according to a completely randomized method.In the control group，regular nursing way was used，while in the experimental group，the clinical pathway nursing way was adopted.The perioperative negative emotion and nursing satisfaction degree were compared in patients between the two groups.Results There were no significant differences in self-rating anxiety scale （SAS）and self-rating depression scale （SDS）scores in patients between the two groups before treatment （P＞0.05）.SAS and SDS scores in patients of the two groups after nursing were lower than those before nursing （P＜0.01）and SAS and SDS scores of the experimental group after nursing were lower than those of the control group （P＜0.05）.The total satisfaction degree of nursing in patients of the experimental group was 100.0%，which was higher than that in the control group accounting for 78.0%with a significant difference （P＜0.05）.Conclusion Clinical pathway nursing can effectively reduce the perioperative negative emotion of patients with uterine fibroids，improve the rehabilitation efficiency，significantly increase the nursing satisfaction of patients，promote the harmony of doctor-patient relationship，and it is worthy of promotion. 2019 Vol. 26 (4): 241-243 [Abstract] ( 80 ) HTML (31 KB)  PDF  (0 KB)  ( 14 ) 244 Preventive effect of moderate clustering nursing on pressure ulcer during operation in neurosurgical lateral position surgery WANG Ying Objective To explore the preventive effect of moderate cluster nursing on pressure ulcer during operation in neurosurgical lateral position surgery.Methods From January 2017 to January 2018，80 neurosurgical lateral position surgery patients were selected and they were divided into the experimental group and the control group according to the random number table method，there were 40 patients in each group.The control group received traditional nursing methods，while the experimental group received moderate cluster nursing method.The incidence of pressure ulcer，satisfaction degree with nursing and the cost of pressure ulcer protection were compared between the two groups.Results The total incidence rate of pressure ulcer in the experimental group was significantly lower than that in the control group，the cost of pressure ulcer protection was lower than that in the control group，and the total satisfaction degree was higher than that in the control group，and the differences were statistically significant （P＜0.05）.Conclusion Moderate cluster nursing can effectively reduce the incidence of pressure ulcer in neurosurgical lateral position surgery patients，reduce the cost of pressure ulcer protection，and improve patients′satisfaction degree with nursing，which is worthy of clinical promotion. 2019 Vol. 26 (4): 244-246 [Abstract] ( 92 ) HTML (33 KB)  PDF  (0 KB)  ( 17 ) 247 Application effect of evidence-based nursing intervention in patients with ulcerative colitis with anxiety NIU Hong-yan Objective To explore the application effect of evidence-based nursing intervention in patients with ulcerative colitis with anxiety.Methods Sixty-four patients with ulcerative colitis with anxiety who were admitted into our hospital from August 2015 to August 2017 were selected as study objects and they were divided into the control group（n=32）and the observation group （n=32）according to the randon number table method.The control group was given the routine nursing methods while the observation group was given evidence-based nursing methods.The total effective rate of treatment，anxiety score and nursing satisfaction degree score of patients were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group，and the difference was statistically significant （P＜0.05）.The anxiety score of the observation group was lower than that of the control group，and the difference was statistically significant （P＜0.05）.The nursing satisfaction score of the observation group was higher than that of the control group，and the difference was statistically significant （P＜0.05）.Conclusion The application of evidence-based nursing measures in the diagnosis and treatment of patients with ulcerative colitis with anxiety can effectively improve the prognosis of patients，reduce the anxiety symptoms of patients，improve the quality of life level of patients to a certain extent，and have a higher clinical value. 2019 Vol. 26 (4): 247-249 [Abstract] ( 74 ) HTML (31 KB)  PDF  (0 KB)  ( 17 ) 250 Application value of holistic nursing in patients undergoing transfusion due to thrombocytopenia ZHOU Li Objective To investigate the application value of holistic nursing in patients undergoing transfusion due to thrombocytopenia.Methods A total of 60 patients undergoing thrombocytopenic transfusion due to thrombocytopenia admitted to our department from September 2017 to September 2018 were selected as study objects and they were divided into the control group （n=30）and observation group （n=30）according to the random number table method.In the control group，routine nursing was used，and in the observation group，holistic nursing was added on the basis of routine nursing.The therapeutic effect，time of platelet level returning to norm，clinical treatment time，and nursing satisfaction degree were compared in patients between the two groups.Results The total effective rate of the observation group（90.00%）was significantly higher than that of the control group （66.67%）（P＜0.05）.The time of platelet level returning to norm，clinical treatment time in the observation group were significantly shorter than those in the control group （P＜0.05）.The total satisfaction degree of nursing in the observation group （93.33%）was significantly higher than that in the control group （73.33%）（P＜0.05）.Conclusion The effect of holistic nursing applied in patients undergoing thrombocytopenic transfusion due to thrombocytopenia is obvious，and it can shorten the treatment time and improve the nursing satisfaction degree of patients，which is worthy of promotion. 2019 Vol. 26 (4): 250-252 [Abstract] ( 65 ) HTML (30 KB)  PDF  (0 KB)  ( 12 )

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