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2018 Vol. 25, No. 19
Published: 2018-07-08
4
Influence of vitamin D on the mesenchymal transformation of alveolarⅡepithelial cells induced by TGF-β
1
in rats
1in rats[J]. 中国当代医药, 2018,25(19): 4-7')" href="#">
QI Yun-feng;HUO Ru-jie;LIU Dai;CHAO Wei-guan;TIAN Xin-rui
Objective
To investigate the influence of vitamin D (VD)on the mesenchymal transformation of alveolarⅡepithelial cells(RLE-6TN)induced by TGF-β
1
in rats.
Methods
RLE-6TN cells were cultured in vitro,and were divided into the control group(group A),the TGF-β
1
group(group B),the TGF-β
1
＋VD group(group C),the TGF-β
1
＋ICG001 group(group D),the TGF-β
1
＋VD＋ICG001 group(group E).The cells were treated with VD and/or VD＋ICG001 at first,and TGF-β
1
was added into the culture solution after 24 h,the Western blot was used to detected the α-SMA,Fibronectin (Fn)and E-cadherin protein levels after 48 h.
Results
Under the microscope,in group A,cells adhered to the wall and showed a paving stone with tight junctions.The gap in group B was significantly increased and the spindle was obviously deformed.The cells in groups C and group D showed more paving stone-like changes than those in group B,and the cells gap decreased.Most of the cells in the group E were mostly paved stone-like changes,the gap was smallest and morphology was close to the normal group.Western blot analysis showed that the expression levels of α-SMA and Fn in groupB,C,D,E were higher than that in group A,but the expression of E-cadherin was lower than that in group A,the differences were statistically significant(P＜0.05).The levels of α-SMA and Fn in group C,D,E were lower than that in group B,but the expression of E-cadherin was higher than that in group B,the differences were statistically significant(P＜0.05).The expression levels of α-SMA and Fn in group C and group D were higher than that in group E,but the expression of E-cadherin was lower than that in group E,and the differences were statistically significant(P＜0.05).There were no significant differences in the expression levels of α-SMA,Fn and E-cadherin between group C and group D (P＞0.05).
Conclusion
Vitamin D can inhibited the mesenchymal transition of alveolarⅡ epithelial cells induced by TGF-β
1
in rats.
2018 Vol. 25 (19): 4-7 [
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201
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8
Analysis of correlation factors of anovulatory dysfunctional metrorrhagia induced by menopausal transition
HUANG Ying-shan;LI Shi-rong;ZHOU Yong-li
Objective
To analyze the correlation factors of anovulatory dysfunctional metrorrhagia induced by menopausal transition.
Methods
Altogether 64 cases of patients with anovulatory dysfunctional metrorrhagia induced by menopausal transition who were treated in our hospital from January to December in 2017 were selected as the object of this research.Under the circumstances of informed consent,a self-made questionnaire was used to understand the patients′general information,medical history and related clinical information so as to analyze the correlation factors of anovulatory dysfunctional metrorrhagia induced by menopausal transition.
Results
The patients with anovulatory dysfunctional metrorrhagia induced by menopausal transition of two groups had statistically significant difference in the hyperlipidemia history,childbearing history,abortion history,lactation history,family history,body mass index and waist-to-hip ratio(P＜0.05).The hyperlipidemia history,family history,body mass index and waist-to-hip ratio were associated with anovulatory dysfunctional metrorrhagia induced by menopausal transition.The main manifestations were that the hyperlipidemia history,family history,growing body mass index and growing waist-to-hip ratio could increase the risk of anovulatory dysfunctional metrorrhagia induced by menopausal transition.
Conclusion
There are many relevant factors in the anovulatory dysfunctional metrorrhagia induced by menopausal transition,including the hyperlipidemia history,family history,growing body mass index and growing waist-to-hip ratio.Proactive prevention should be carried out to reduce the incidence of anovulatory dysfunctional metrorrhagia induced by menopausal transition.
2018 Vol. 25 (19): 8-11 [
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] (
189
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12
Clinical study of post-TLIF application of Teriparatide in the treatment of lumbar spondylolisthesis patients accompanied with osteoporosis
LIU Han-hui;ZHAO Xiao-dong;CHEN Guang-fu;FU Mei-qi
Objective
To observe the clinical efficacy of application of combination of Teriparatide and transforaminal lumbar interbody fusion (TLIF)in the treatment of lumbar spondylolisthesis accompanied with osteoporosis.
Methods
Altogether 62 cases of lumbar spondylolisthesis patients accompanied with osteoporosis who were treated in our hospital from January 2012 to December 2015 were selected as the subjects of this research and divided into the Teriparatide group(31 cases)and the control group(31 cases)according to the random method.All the recruited patients were treated with TLIF.Since the post-operative first day,The Teriparatide group was administered with subcutaneous injection of Teriparatide injection at the dose of 20 μg once a day for 6 months and oral medication of Caltrate D
3
tablets at the dose of 600 mg once a day.The control group only took orally 600 mg of Caltrate D
3
tablets once a day.During 1-year follow-up,all the patients were reexamined at post-operative 3,6,9 and 12 months.The Oswestry disability index(ODI)function score and imaging evaluation were compared between the two groups,the lumbar bone mineral density(BMD)and biomarker of bone metabolism such as β Cross Laps and N-MID Osteocalcin were determined.
Results
The postoperative ODI function scores of the two groups were lower than those before operation,with statistically significant difference (P＜0.05).At post-operative 3,6,9 and 12 months,the ODI score of the Teriparatide group was lower than that of the control group (P＜0.05).The incidences of pedicle screw loosening,interbody fusion cage sinking and new vertebral compression fractures of the Teriparatide group were lower than those of the control group,with statistically significant difference(P＜0.05).At post-operative 12 months,the fusion rate of the Teriparatide group was 96.67%,which was higher than that of the control group (89.66%),with statistically significant difference (P＜0.05).The fusion time of the Teriparatide group was(3.9±0.7)months,which was lower than that of the control group[(4.7±1.3)months],with statistically significant difference(P＜0.05).There was no significant difference in the BMD(L
1-4
)of the Teriparatide group between post-operative 3 months and before the operation (P＞0.05).At post-operative 6,9 and 12 months,the BMD (L
1-4
)of the Teriparatide group was higher than that before the operation and that of the control group,with statistically significant difference(P＜0.05).The BMD(L
1-4
)of the control group at each time point had no statistically significant difference(P＞0.05)compared with that before the operation.At each post-operative reexamination time point,the levels of serum β Cross Laps and N-MID Osteocalcin of the Teriparatide group were lower than those before the operation,with statistically significant difference(P＜0.05).The control group had no statistically significant difference in the levels of serum β Cross Laps and N-MID Osteocalcin(P＞0.05).
Conclusion
It is effective to treat lumbar spondylolisthesis associated with osteoporosis with application of combination of TLIF and Teriparatide.Teriparatide can effectively improve the lumbar spine bone mineral density,promote bone graft fusion and reduce the incidence of internal fixation displacement and vertebral compression fractures.
2018 Vol. 25 (19): 12-16 [
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178
)
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17
Study on the expression of bronchoalveolar lavage fluid and serum inflammatory mediators of patients with diffuse interstitial lung disease
ZHAN Zi-e;WU Sheng;TANG Wen-hui;LI You-heng
Objective
To study and analyze the expression levels of bronchoalveolar lavage fluid and serum inflammatory mediators of patients with diffuse interstitial lung disease.
Methods
A total of 96 patients with diffuse interstitial lung disease in our hospital from December 2009 to October 2017 were selected as the observation group,96 healthy persons at the same time were selected as the control group.Then the expression levels of bronchoalveolar lavage fluid and serum inflammatory mediators of two groups and observation group with different stages were compared,then the relationship between the detection indexes and diffuse interstitial lung disease were analyzed by the Logistic analysis.
Results
The expression levels of bronchoalveolar lavage fluid and serum inflammatory mediators of the observation group were higher than those of the control group,the expression levels of the observation group with higher stages were higher than those of patients with lower stages(P＜0.05).Logistic analysis showed those mediators all had close relationship to the diffuse interstitial lung disease (P＜0.05).
Conclusion
The expression levels of bronchoalveolar lavage fluid and serum inflammatory mediators of patients with diffuse interstitial lung disease are higher,and differences of patients with different stages are significant,so they can be as the reference indexes for diagnosis and treatment of disease.
2018 Vol. 25 (19): 17-19 [
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] (
203
)
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20
Clinical effect of Olanzapine in improving mental and behavioral disorder in patients with senile dementia
FENG Chun-yan
Objective
To observe the clinical effect of Olanzapine in improving mental and behavioral disorder in patients with senile dementia.
Methods
A total of 114 patients with senile dementia accompanied with mental and behavioral disorder treated by the Fourth People′s Hospital of Jingdezhen from January 2016 to October 2017 were selected and they were divided into the control group and observation group,and there were 57 cases in each group.The control group was treated with Risperidone,while the observation group was treated with Olanzapine.After 8 weeks of continuous drug use,the clinical effect between the two groups was compared.
Results
The total effective rate of the observation group was 92.98%,while that of the control group was 89.47%,and there was no significant difference between the two groups(P＞0.05).At 2,4 and 8 weeks after treatment,the BEHAVE-AD score of the patients in the observation group was(18.0±4.4),(10.1±3.8)and (7.0±3.3)points respectively,which were lower than those of the control group ([20.2±4.5],[13.7±4.0],[8.6±3.8]points)and before treatment([23.2±5.2])points,and the differences were statistically significant(P＜0.05).In patients of the control group,the BEHAVE-AD score at 2,4 and 8 weeks after treatment were all lower than those before treatment([22.9±5.0])points,and the differences were statistically significant(P＜0.05).The incidence of abnormal liver function,lethargy and fatigue after treatment in the observation group was 1.75%,8.77%and 7.02%respectively,and the control groups was 0.00,7.02%and 3.51%respectively,and there was no significant difference between the two groups(P＞0.05).The incidence of irritation,extrapyramidal reaction and insomnia in the observation group was 0.00,3.51%,1.75%respectively,which were lower than those of the control group(8.77%and 19.30%.14.04%)(P＜0.05),and the total incidence of side effect in the observation group was 22.81%,which was lower than that of the control group(52.63%),and the difference was statistically significant(P＜0.05).The ADL score of the observation group after treatment was(37.1±7.0)points,which was lower than that of the control group([40.7±8.5]points),and the difference was statistically significant(P＜0.05).
Conclusion
Olanzapine treating senile dementia accompanied with mental and behavioral disorder can effectively improve the pathological behavior of patients with Alzheimer disease,with significant clinical effect,fewer side effects and high safety.It is worthy of clinical promotion.
2018 Vol. 25 (19): 20-23 [
Abstract
] (
182
)
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24
Analysis the effect of hypoproteinemia on the prognosis of chronic heart failure
LIU Qian;WANG LI-zhong;CHEN Meng-na
Objective
To study of the effect of hypoproteinemia on the prognosis of patients with chronic heart failure.
Methods
94 patients who diagnosed with chronic heart failure withⅡ-Ⅳgrade of cardiac function were selected from March 2013 to March 2015 of the Department of Cardiovascular Medicine in General Hospital of China Aviation,and patients were divided into the 3 groups according to the level of serum albumin:48 cases in normal group,28 cases in mild hypoproteinemia and 18 cases in moderate and severe hypoproteinemia.A prospective study was carried out for 2 years after routine treatment of heart failure.The data were collected.The effect of serum albumin level on rehospitalization rate,case fatality rate and related indexes of cardiac function in patients with chronic heart failure were analyzed.
Results
The rate of rehospitalization and case fatality rate in patients with chronic heart failure with hypoproteinemia was higher than that in the normal group,and the difference was statistically significant(P＜0.05).The rate of rehospitalization and mortality in patients with moderate and severe hypoproteinemia with chronic heart failure was higher than that in the mild hypoproteinemia group,and the difference was statistically significant(P＜0.05).After 2 years,the N terminal pro brain natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDV)and 6 min walking distance in normal group were significantly improved compared with before treatment,and the difference was statistically significant(P＜0.05).After 2 years,the above indexes of the hypoproteinemia group were worse than those before treatment,and the difference was statistically significant(P＜0.05).The lower the albumin level,the worse the cardiac function index.
Conclusion
Patients with chronic heart failure and hypoproteinemia have a higher rate of rehospitalization and case fatality rate,and the lower the albumin level,the more serious the patient′s condition is and the worse the prognosis.
2018 Vol. 25 (19): 24-27 [
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] (
173
)
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28
Research progress on tissue engineered skin seed cells
ZHANG Guang-jing;WANG Zheng-xiang;FENG Shi-jun;AI Dong-fang
Study on skin tissue engineering has developed rapidly in recent years,the basic principle is that of normal skin tissue in vitro by sufficient cell numbers,a certain amount of cells were seeded into scaffolds of biodegradable as skin model has certain morphological and functional differentiation.Tissue engineered skin substitutes contain epidermis substitutes,dermis substitutes,and full skin substitutes.The full layer skin model consists of three main aspects：seed cells,biodegradable dermis scaffolds and tissue engineered skin in vitro.However,skin necrosis caused by burns,such as large skin defects,tissue trauma,congenital giant nevus and other diseases,is an important clinical problem.Due to the lack of skin donor site,the external skin model is urgently needed to solve these difficult problems.One of the most important parts of tissue engineered skin is the seed cells,and the progress of their related research is reviewed.
2018 Vol. 25 (19): 28-31 [
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164
)
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32
Research progress on the relationship between schizophrenia and infection
ZHU Dong-jian;LIN Ju-da
Schizophrenia is a complicated disease,and the current diagnosis is mainly based on symptomatology,and treatment is difficult to achieve the desired effect.The study on the pathogenesis of schizophrenia has been the focus of various scholars,and infection may be one of the causes of schizophrenia.This article reviews the research on infection and schizophrenia based on the published articles both at home and abroad in recent years,and tells the relationship between Toxoplasma,viruses,bacteria,and other infectious agents and schizophrenia,and attempts to explore the pathogenesis.
2018 Vol. 25 (19): 32-35 [
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196
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36
The clinical research of long-term postoperative cholecystectomy syndrome after two types of cholecystectomy
ZHANG Wen;WANG Min;HUANG Yong-sheng
Objective
To analyze the clinical efficacy of Long-term postoperative cholecystectomy syndrome after two types of cholecystectomy.
Methods
Sixty patients who underwent cholecystectomy from March 2016 to March 2018 in our hospital were selected as subjects.They were randomly divided into control group and treatment group,with 30 cases in each group.The control group adopted traditional methods,open cholecystectomy therapy,and the treatment group used laparoscopic cholecystectomy therapy.The blood loss and total length of hospital stay,operation time and ambulation time and other indicators,as well as the incidence of postoperative syndrome between the two groups were compared.
Results
The bleeding volume,total length of hospital stay,operation time,and time of ambulation in the treatment group were significantly lower than those in the control group,the differences were statistically significant(P＜0.05).The incidence of cholecystectomy syndrome in the treatment group was 6.67%,which was significantly lower than that in the control group for 30.00%,the difference was statistically significant(P＜0.05).
Conclusion
Performing endoscopic cholecystectomy for patients undergoing cholecystectomy has a significantly better therapeutic effect than open cholecystectomy,and it also contributes to the reduction of postoperative syndrome.
2018 Vol. 25 (19): 36-38 [
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] (
206
)
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39
Comparison of the clinical effects of total areolar approach and chest/breast approach during endoscopic thyroidectomy
WANG Chao;LI Xiao-hui;ZHANG Jian;CHEN Qia-ming;WANG Jin-xiang;PANG Shan
Objective
To investigate the clinical effects of total areolar approach and chest/breast approach during endoscopic thyroidectomy.
Methods
From February 2014 to December 2016,60 patients underwent endoscopic thyroid surgery in our hospital were selected as the subjects,and divided into two groups by random number table method,with 30 cases in each group.Patients in control group performed with endoscopic surgery via chest/breast approach,and patients in research group performed with total areolar approach.The intraoperative amount of bleeding,operation time,postoperative total volume of drainage,drainage time,postoperative persistent pain time,time to take food again,postoperative hospital stay,hospitalization costs,satisfaction on incision beauty,and incidence of complications including subcutaneous effusion,transient hoarseness,wound hematoma,subcutaneous emphysema,neck paresthesia,and swallowing discomfort were compared between the two groups.
Results
The intraoperative amount of bleeding,operation time,postoperative drainage,drainage time,pain duration after surgery,time to take food again,postoperative hospital stay,and hospitalization expenses between the two groups were not displayed statistical differences(P＞0.05).There was no statistical difference in the incidence of complications like subcutaneous effusion,transient hoarseness,wound hematoma,subcutaneous emphysema,neck paresthesia,and swallowing discomfort and so forth(P＞0.05).The total satisfaction on incision beauty in the research group(100.00%)was higher than that in the control group(80.00%)(P＜0.05).
Conclusion
The clinical efficacy and safety of endoscopic thyroidectomy via total areolar approach and chest/breast approach are similar,but the former has a better cosmetic effect.
2018 Vol. 25 (19): 39-41 [
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] (
172
)
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42
Obsevation clinical effect of ultrasound-guided stellate ganglion block combined with drugs in the treatment of cervicogenic headache
DONG Sha-na
Objectives
To study the clinical effect of ultrasound-guided stellate ganglion block (SGB)combined drugs in the treatment of cervicogenic headache (CEH).
Methods
Thirty patients of CEH treated in our hospital from June to December in 2017 were selected as the subjects,and divided into control and observation groups,with 15 cases in each group.The control group was treated with drug therapy,and the observation group performed ultrasound-guided stellate ganglion block therapy on the basis of drug therapy in the control group.The results were compared between the two groups.
Results
After treatment,the total effective rate of the observation group was 93.33%,significantly higher than that in the control group for 73.33%,the difference was statistically significant(P＜0.05).There was no significant difference in VAS score between the two groups before treatment(P＞0.05).After treatment,the VAS score of the observation group([3.62±0.21]points)was significantly lower than the control group ([5.13±1.20]points),the difference was statistically significant(P＜0.05).No serious adverse reactions were observed in both groups.
Conclusion
Ultrasound-guided by stellate ganglion block combination of drugs in the treatment of neck source sex have a headache effect significantly,can effectively alleviate symptoms of pain,has the high security,which is worth popularizing applied to clinical.
2018 Vol. 25 (19): 42-44 [
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169
)
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45
Effect of non-invasive ventilator in the treatment of chronic obstructive pulmonary disease complicated with respiratory failure
WU Shan-yan;GAN Lu;ZANG Li-mei;WANG Qiang
Objective
To analyze the therapeutic effect of non-invasive ventilator in the treatment of chronic obstructive pulmonary disease (COPD)and respiratory failure (RF).
Methods
A total of 90 COPD patients complicated with RF treated in our hospital from January 2014 to June 2016 were selected as the subjects,and divided into research group and control group by random number table method,45 cases in each group.In the control group,routine treatments such as trachea dilation,oxygen uptake,cough relieving,and phlegm eliminating were used,while in the research group,on the basis of the control group,non-invasive ventilator was added.The oxygen partial pressure (PaO
2
),respiratory rate(RR),oxygen saturation (SaO
2
),and heart rate (HR)before and after treatment,and occurrence of adverse reactions were observed in the two groups.
Results
HR after treatment in the research group ([93.82±10.37]times/min)was lower than that in the control group([119.28±18.47]times/min).The SaO
2
in the research group([99.04±4.87]%)was higher than that in the control group([79.08±2.22]%),RR in the research group([22.07±1.89]times/min)was lower than that in the control group ([29.81±1.98]times/min),PaO
2
in the research group ([66.07±2.97]mmHg)was higher than that in the control group([50.12±2.11]mmHg),the differencse were statistically significant(P＜0.05).The incidence of adverse reactions in the research group(13.33%)was much lower than that in the control group(35.56%),the difference was statistically significant(P＜0.05).The hospital stay([9.1±1.2]d),hospitalization cost([8798.1±102.8]yuan),and amount of re-admission ([0.23±0.12]times)in the research group were less than those in the control group ([13.2±2.1]d,[9879.4±1129.2]yuan,and [1.98±0.89]times),the differences were statistically significant(P＜0.05).
Conclusion
Non-invasive ventilator therapy for patients with COPD and RF can significantly improve the clinical symptoms,enhance the efficacy of treatment,and reduce the occurrence of adverse reactions,which is worthy of widespread promotion in clinic.
2018 Vol. 25 (19): 45-47 [
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200
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48
Clinical observation of Thymalfasin for injection on incidence of infections in maintenance hemodialysis patients
ZHOU Yang;YE Fan;YIN Jin-feng
Objective
To observe the therapeutic effect of Thymalfasin for injection on incidence of infections in maintenance hemodialysis patients.
Methods
From January 2015 to December 2016,60 patients treated with maintenance hemodialysis in our hospital were selected as objects,and divided into control group and observation group by random number table method,with 30 cases in each group.The control group received routine treatment.The patients in the observation group were treated with the Thymalfasin for injection on the basis of treatment in the control group,1.6 mg each time,subcutaneous injection,2 times a week for one year.The incidence of infections,the time of intravenous antibiotics,the incidence of serious complications and the nutritional status of the two groups in 1 year were compared.
Results
The incidence of infections,the time of intravenous antibiotics,the incidence of serious complications in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The levels of hemoglobin and albumin in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).
Conclusion
The Thymalfasin for injection can prevent and treat the infections in maintenance hemodialysis patients effectively.
2018 Vol. 25 (19): 48-50 [
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177
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51
Clinical effect observation of Sacubitril/valsartan treating chronic cardiac insufficiency
ZHOU Hong;HUANG Si-bing
Objective
To investigate the clinical effect of Sacubitril/valsartan treating chronic cardiac insufficiency.
Methods
A total of 30 cases with chronic cardiac insufficiency treated in our hospital from June to October 2017 were selected as the research subjects.All patients were treated by Sacubitril/valsartan on the basis of the conventional therapy.Standardized continuous treatment lasted for 3 months.The total effective rate for treatment of the patients was observed.The cardiac function indexes,plasma N terminal pro brain natriuretic peptide (NT-proBNP)level and quality of life were compared before and after treatment in patients.
Results
After treatment,15 cases were markedly effective,13 cases were effective,2 cases were invalid,and the total effective rate was 93.33%.After treatment,the LVEF,FS and KCCQ score were significantly higher than those before treatment,and NT-proBNP level decreased significantly compared with that before treatment,and the difference between the two groups were statistically significant(P<0.01).The incidence of adverse reactions was 10.00%.
Conclusion
Sacubitril/valsartan treating chronic cardiac insufficiency can improve cardiac function and decrease the level of NT-proBNP in patients,and it is safe and reliable,and it can significantly improve their quality of life.It is worthy of clinical promotion.
2018 Vol. 25 (19): 51-53 [
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152
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54
Effect comparison of Propafenone and Amiodarone treating arrhythmia
LIU Jia-chao;HE Zhong-hao;CHEN Jian-fang;YANG Ze-bin
Objective
To compare the effect of Propafenone and Amiodarone treating arrhythmia.
Methods
A total of 72 patients with arrhythmias treated in our hospital from February 2015 to December 2017 were selected.The patients were divided into control group and observation group using the random digital table method,and there were 36 cases in each group.The control group was treated with Propanone,while the observation group was treated with Amiodarone.Continuous treatment lasted for 5 weeks,the therapeutic effect,heart rate variability (HRV)parameter and drug safety were compared between the two groups.
Results
The total effective rate in the observation group was 97.2%,which was higher than that in the control group (77.8%)(P＜0.05).The HRV parameter in the observation group was higher than that in the control group (P＜0.05).The incidence of adverse reactions in the observation group was 5.6%,which was lower than that in the control group(22.2%)(P＜0.05).
Conclusion
Amiodarone has more advantages compared with Propafenone in the treatment of arrhythmia.It can take into account both the clinical efficacy and the safety of medications.It can help patients correct their arrhythmia problems,and can be given priority when excluding medication contraindications.
2018 Vol. 25 (19): 54-56 [
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196
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Application effect of clinical emergency treatment method in patients with chronic congestive heart failure
WU Xian;XUE Xin-yu;QIAO Xiao-xue;GAO Peng
Objective
To explore the application effect of clinical emergency treatment method in patients with chronic congestive heart failure.
Methods
Altogether 50 patients with chronic congestive heart failure treated in our hospital from January 2016 to December 2017 were selected as the research subjects and they were divided into the control group (25 cases)and the study group (25 cases)according to the different treatment method.The control group was treated with routine hospitalization therapy，while the study group was treated with emergency treatment method.The therapeutic effect and the related indexes before and after treatment between the two groups were compared.
Results
The total effective rate of the study group(96.00%)was higher than that of the control group(82.00%)with statistically significant difference(P<0.05).There was no statistically significant difference of diastolic pressure index,systolic pressure index and heart rate before treatment between the two groups (P>0.05)and there was no statistically significant difference of diastolic pressure index,systolic pressure index and heart rate after treatment between the two groups(P>0.05).The average treatment cost of the study group was lower than that of control group (P<0.05).
Conclusion
Clinical emergency treatment applied in patients with chronic congestive heart failure can obviously improve the clinical treatment effect and can significantly improve the blood pressure and heart rate of patients,and significantly reduce the cost of treatment,which is worthy of clinical promotion and application.
2018 Vol. 25 (19): 57-59 [
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172
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Clinical research of intraoperative sufficient Atropine preconditioning to inhibit reperfusion of vagus nerve reflex during emergency PCI in treatment for acute inferior wall myocardial infarction
LU Qian;LIU Juan-feng;DONG Meng-shu;XU Hui-lin
Objective
To investigate clinical effect of intraoperative sufficient Atropine preconditioning to inhibit reperfusion of vagus nerve reflex during emergency PCI in treatment for acute inferior wall myocardial infarction.
Methods
All of 104 patients with acute inferior wall myocardial infarction were selected in our hospital from October 2014 to October 2017,and all patients were treated emergency PCI operation.All patients were divided into two groups according to the random number table method,and there were 52 case in each group.The control group received the routine treatment while the observation group received the intraoperative sufficient Atropine preconditioning.Electrocardiogram and myocardial injury indexes were analyzed in the two groups.Reaction of reperfusion and treatment time were compared between two groups.
Results
ST segment drop amplitude in the observation group was bigger than that of control group (P＜0.05).Creatine kinase isoenzyme,troponin,incidence of bradycardia,incidence of ventricular tachycardia,incidence of hypotension,incidence of asis syndrome,incidence of conduction block,incidence of temporary pacing in the observation group were lower than control group (P＜0.05).Left ventricular ejection fraction in observation group was higher than control group(P＜0.05).Opening window time and postoperative out of bed activity time in observation group were earlier than control group,and hospitalization time in the observation group was shorter than that of the control group (P＜0.05).
Conclusion
Intraoperative sufficient Atropine preconditioning to inhibit reperfusion of vagus nerve reflex during emergency PCI has significant effect in treatment for acute inferior wall myocardial infarction,which can improve myocardial function and safety.
2018 Vol. 25 (19): 60-62 [
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174
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63
Effect research of Tirofiban Hydrochloride Sodium Chloride Injection combined with cardiovascular intervention treating acute myocardial infarction
LIN Hai-yun;HUANG Yong-kun;W0 Wei-hao
Objective
To investigate the effect of Tirofiban Hydrochloride Sodium Chloride Injection combined with cardiovascular intervention treating acute myocardial infarction.
Methods
Sixty patients with acute myocardial infarction treated in our hospital from June 2015 to December 2017 were selected as study objects and they were randomly divided into the two groups,and there were 30 patients in each group.The control group was treated with cardiovascular intervention.The observation group was treated with Tirofiban Hydrochloride Sodium Chloride Injection on the basis of the control group.The clinical effect and short-term prognosis indexes between the two groups were compared.
Results
TIMI blood flow grading in the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference between the two groups in the activation of platelet before treatment(P＞0.05),after treatment,the CD62P,CD63 and positive expression rate of MPA in the observation group was significantly better than that before treatment and the control group(P＜0.05).The incidence of recurrent acute myocardial infarction,sudden death,malignant arrhythmia,severe bleeding events were significantly lower than those of the control group,and the differences were statistically significant(P＜0.05).
Conclusion
The clinical effect of Tirofiban Hydrochloride Sodium Chloride Injection combined with cardiovascular intervention treating acute myocardial infarction is more significant,which can reduce the incidence of adverse prognosis,which has high safety and is worth popularizing and applying.
2018 Vol. 25 (19): 63-65 [
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133
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66
Effect resecrch of cognitive behavioral therapy in the treatment of insomniacs
LYU Yuan-yuan;CHEN Bao-chang;QIAO Sheng-yu
Objective
To explore the effect of cognitive behavioral therapy in the treatment of insomnia,and to provide reference for clinical treatment.
Methods
Ninety patients with insomnia treated in our hospital from March 2016 to September 2017 were selected as the subjects,and randomly divided into the control group and the observation group,with 45 cases in each group.The control group was treated with drug therapy,and the observation group was treated with cognitive behavior therapy on the basis of the control group.The sleep disorders and quality of sleep were compared between the two groups before and after treatment.
Results
After treatment,the SDRS score and PSQI score in the two groups were lower than those before the treatment,and the SDRS score and PSQI score in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the SDRS scores and PSQI scores between the two groups before treatment(P＞0.05).
Conclusion
Cognitivebehavioral therapy based on drug therapy can reduce sleep disorders and improve sleep quality in insomniacs,which is worthy of clinical application.
2018 Vol. 25 (19): 66-68 [
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145
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69
Effect of multi-sensory stimulation on excitatory agitation and quality of life in the patients with Alzheimer′s disease
WANG Zhao;ZHONG Yuan-hui;CHEN Sheng-lin;LIN Wei-quan;QI Yun-hang
Objective
To investigate the effects of multi-sensory stimulation on the symptoms of excitatory agitation and quality of life in the patients with Alzheimer′s disease.
Methods
A total of 100 patients with Alzheimer′s disease who were admitted to the Third People′s Hospital of Meizhou City and Psychiatric Hospital of Bureau of Civil Affairs of Guangzhou Municipality from April 2016 to March 2017 were selected by the continuous sampling method.The patients were randomly divided into study group and control group,with 50 cases in each group.Both groups were given conventional medical treatment.On this basis,the research group was further given multi-sensory stimulation such as music therapy and touch therapy.The effects of the two groups of treatment on improving symptoms of excitatory agitation(BPRS)and improving the quality of life in the patients with Alzheimer′s disease were compared.
Results
After the intervention,the excitatory agitation and quality of life scores were significantly improved in both groups.The MMSE and BPRS scores in the research group were significantly better than those in the control group,and the differences were statistically significant(P＜0.05).The Alzheimer′s Disease Quality of Life Scale (QOL-AD)score in the research group was higher than that in the control group,and the difference was statistically significant(P＜0.05).
Conclusion
Multisensory stimulation not only improves the symptoms of patients,but also greatly improves the patients′living conditions,effectively reduces patients′mortality rate and ensures their quality of life.It can also directly reduce the economic burden on the patient′s family and the mental stress of the caregiver.
2018 Vol. 25 (19): 69-72 [
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123
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73
Effect of Butylphthalide on plasma lysophosphatidic acid level in patients with acute watershed infarction and its short-term efficacy analysis
CHANG Bao-qiang;MA Ling-qiu
Objective
To explore the effect of Butylphthalide on plasma lysophosphatidic acid(LPA)level for acute watershed infarction(CWI)and its short-term treatment efficacy.
Methods
From January 2015 to December 2016,106 patients with CWI were selected as the subject,and devided into the routine treatment group and Butylphthalide group by random number table method,with 53 cases in each group.A total of 50 healthy subjects were selected as the control group.The routine treatment group was treated with conventional antiplatelet therapy.The Butylphthalide group was treated with the same routine procedure,within 48 h after the onset of the disease,the patients were given Butylphthalide injection 100 ml by intravenous drip times a day after operation for 14 d.Plasma lysophosphatidic acid(LPA)level was measured before and after treatment at 7 and 14 d,and the NIHSS scores were compared.
Results
The plasma LPA level in the routine treatment group and Butylphthalide group were significantly higher than that in control group (P＜0.01).The plasma LPA level in the Butylphthalide group was significantly higher than that in the routine treatment group at 7 d after treatment(P＜0.05).There was no significant difference in plasma LPA level among the three groups at 14 d after treatment(P＞0.05).The NIHSS scores of the butylphthalide group and routine treatment group at 14 d after treatment were higher than before(P＜0.01),and the NIHSS scores of the Butylphthalide group was significantly higher than that in the routine treatment group (P＜0.05).The effective rate and obvious effective rate at 14 d after treatment in Butylphthalide group was higher than those in control group,the differences were statistically significant(P＜0.05).
Conclusion
The level of plasma LPA in the early stage of acute CWI in patients improves,suggesting that the platelet is activated in vivo.The application of Butylphthalide on the basis of routine therapy can decrease the level of plasma lysophosphatidic acid and reduce the neurologic impairment.
2018 Vol. 25 (19): 73-76 [
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159
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77
Diagnostic value of PSA and related parameters for prostate cancer with PSA＜4.0 ng/ml
HUANG Shun-tan;TANG Shun-li;SUN Gang
Objective
To investigate the diagnostic value of prostate specific antigen (PSA)and its related parameters for prostate cancer with PSA＜4.0 ng/ml.
Methods
A total of 320 cases of prostate biopsy with PSA＜4.0 ng/ml admitted to the 6th affiliated hospital of Guangzhou medical university and Zhongshan hospital of Guangdong medical university from January to December 2016 were retrospectively analyzed.According to the pathological results of the biopsy,they were divided into 53 cases of prostate cancer(PCA)and 267 cases of benign prostatic hyperplasia (BPH).The total prostate specific antigen(tPSA),free prostate specific antigen(fPSA),f/t PSA and pathological data were collected and divided into 5 intervals of 0.01-0.08,0.09-0.16 and 0.17 according to the f/t PSA ratio.
Results
There was no significant difference between the two groups in tPSA and fPSA values (P＞0.05).The f/t PSA value in PCA group was lower than that in BPH group,the difference was statistically significant(P＜0.05).The PCA detection rates of the two groups of patients in f/t PSA 0.09-0.16,0.17-0.24,0.25-0.32 were statistically significant(P＜0.05),while the PCA detection rates of the two groups of patients in f/t PSA 0.01-0.08,0.33-0.40 were not statistically significant(P＞0.05).
Conclusion
PSA and PSA-related parameters have a good diagnostic value for the patients with prostate cancer with PSA＜4.0 ng/ml.
2018 Vol. 25 (19): 77-79 [
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153
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80
Analysis of the influence of hemodialysis on the quality of life in patients with end-stage renal disease
HE Tong-lin
Objective
To study the effect of hemodialysis on the quality of life in patients with end-stage renal disease.
Methods
Twenty-four patients with end-stage renal disease admitted to our hospital from July 2016 to January 2017 were selected as research objects,and divided into control group and observation group by drawing lots,with 12 cases in each group.The control group was treated with peritoneal dialysis while the observation group was treated with hemodialysis.The kidney disease quality of life short form (KDQOL-SF)scores,and complication rates between the two groups were compared.
Results
There was no significant difference in social function,emotional condition and physiological function between the two groups(P＞0.05).The patients′satisfaction with treatment and the overall quality of life after treatment in the experimental group were both higher than those in the control group,and the difference was statistically significant(P＜0.05).The total incidence of complications after treatment in the experimental group was lower than that in the control group,the difference was statistically significant(P＜0.05).
Conclusion
Hemodialysis is a reliable method for improving the quality of life of patients with end-stage renal disease.
2018 Vol. 25 (19): 80-82 [
Abstract
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166
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83
Effect and safety analysis of disposable circumcision stapler in treating phimosis and redundant prepuce
LI Jian-xin
Objective
To investigate the curative effect and safety analysis of disposable circumcision stapler in treating patients with phimosis and redundant prepuce.
Methods
A total of 192 patients with phimosis and redundant prepuces who were treated in our hospital from March 2016 to October 2017 were selected as the research objects.They were divided into group A,group B and group C,with 64 cases in each group by random counter.Among them,group A was treated with A disposable circumcision stapler,group B was treated with circumcision,and group C was treated with traditional circumcision.The operation time,intraoperative blood loss,VAS scores at 24 h after operation,appearance satisfaction and complications were compared among the three groups.
Results
The operation time of patients in group A was shorter than that in groups B and C,and the blood loss during operation was less than that in groups B and C,and the VAS scores at 24 h after operation were lower than those in groups B and C,while the scores of appearance satisfaction were higher than those in groups B and C,the difference was statistically significant（P＜0.05）.The total incidence of complications in group A was lower than that in groups B and C （P＜0.05）.
Conclusion
One-off circumcision segmenting in the treatment of patients with phimosis and overlong circumcision has significant clinical effect.It can shorten the operation time,reduce the amount of blood loss during the operation,and the degree of postoperative pain and the occurence of complications are reduled,Besides,the safety is high.
2018 Vol. 25 (19): 83-85 [
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153
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86
The clinical effect of clavicle plate for the treatment of distal clavicular fracture
FU Wen-feng
Objective
To explore the clinical effect of clavicular belt tripping plate in the treatment of distal clavicle fracture.
Methods
From April 2015 to June 2017,52 patients with the distal fracture of NeerⅡclavicular bone received by our hospital were selected as the research data,and the number list method was randomly divided into two groups：control group and observation group,26 cases in each group.The control group was treated with hook plate,and the observation group was treated with double-strap trip plate,and the clinical effect of patients treated with different methods was compared.
Results
The degree of shoulder pain in the observation group was significantly better than that in the control group (P＜0.05）;the shoulder joint abduction activity in the observation group was significantly better than that in the control group,with statistical difference (P＜0.05）;the shoulder function in the observation group was significantly better than that in the control group (P＜0.05）.
Conclusion
Clavicular plate for the treatment of distal clavicle fracture can not only reduce the limitation of shoulder joint activity,but also improve the pain of shoulder joint.
2018 Vol. 25 (19): 86-88 [
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102
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89
Clinical effect of internal fixation combined with vertebroplasty in the treatment of spinal fractures
ZHANG Lei;LIU Jian-feng
Objective
To investigate the effect of internal fixation combined with vertebroplasty in the treatment of spinal fractures.
Methods
A total of 68 patients with spine fractures treated in our hospital from June 2015 to June 2017 were selected as the subjects of this study,they were randomly divided into the conventional group and the experimental group,34 cases in each group.The patients in conventional group were treated with internal fixation alone,while the participants in the experimental group were treated with internal fixation combined with vertebroplasty.The therapeutic efficacy in the two groups was compared.
Results
The excellent and good rate in the experimental group was better than that in the conventional group with a significant difference (P＜0.05）.There was significant difference in the Cobb angle and the compression ratio of injured vertebral bone between after treatment and before treatment(P＜0.05).The Cobb angle in the experimental group was higher compared with that in the conventional group,the compression ratio of injured vertebral bone was lower than that in the conventional group,which were displayed statistical significance(P＜0.05）.
Conclusion
Internal fixation+vertebroplasty for patients with spinal fractures can obtain a remarkable effect.It is convenient for the improvement of clinical symptoms and is worthy of widespread promotion.
2018 Vol. 25 (19): 89-91 [
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121
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92
Comparison of the effect of internal fixation with hollow nail and total hip arthroplasty in the treatment of femoral neck fracture
LI Zhong-hui;WENG Yang-hua;LAI Xiao-min
Objective
To compare the effect of internal fixation with hollow nail and total hip arthroplasty in the treatment of femoral neck fracture.
Methods
A total of 74 cases of femoral neck fracture treated in our orthopaedics department from June 2012 to June 2014 were selected and randomly divided into internal fixation group groups(n=37)and permutation group (n=37).The internal fixation group was treated by internal fixation with hollow screws,permutation group was treated with total hip replacement.The postoperative conditions，and postoperative follow up for 12 months Harris hip joint function and quality of life of two groups of patients were campared.
Results
The operation time in permutation group was longer than that of the internal fixation group(P＜0.05）,the intraoperative blood was more than that of internal fixation group(P＜0.05）.The bed time of the permutation group was significantly faster than that of the internal fixation group(P＜0.05）,fracture healing time was significantly faster than that of the internal fixation group(P＜0.05）,hospitalization time was significantly shorter than that in the internal fixation group(P＜0.05）,the postoperative complication rate was significantly lower than that in the internal fixation group(P＜0.05）.The permutation group excellent and good rate of hip joint function was significantly higher than that in the internal fixation group at 12 months after operation (P＜0.05）;The mental health,emotional function,life activity,physical pain,physical function,physical function,social function and overall health score of the permutation group were higher than those in the internal fixation group after 12 months,the differences were statistically significant(P＜0.05）.
Conclusion
Total hip replacement for treatment of femoral neck fracture is better than that of the hollow pin internal fixation,and it can improve the function and quality of life of the patients.
2018 Vol. 25 (19): 92-94 [
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108
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95
Application effect observation of percutaneous vertebroplasty for the treatment of osteoporotic spinal fractures in the elderly
WANG Zi-gang;SHENG Wen-hui
Objective
To investigate the effect of percutaneous vertebroplasty on elderly osteoporotic spinal fractures.
Methods
A total of 100 elderly patients with osteoporotic spinal fractures admitted to our department from June 2015 to December 2016 were divided into conservative group and surgical group according to a random number table method,50 patients in each group.In the conservative group,conservative treatment was used,while in the latter,percutaneous vertebroplasty was performed.The clinical efficacy,pain degree，and bone mineral density (BMD)were compared between the two groups after treatment.
Results
The total effectiveness rate after treatment in the surgical group was 92.00%,higher than that in the conservative group accounting for 78.00%with a statistical difference (P＜0.05）.The visual analogue scale (VAS)scores after treatment in both groups were lower than before treatment,and VAS score in the surgical group was lower compared with that in the conservative group with a significant difference (P＜0.05）.The BMD in the surgical group 24 and 48 week after treatment was greater than that in the conservative group with statistical significance (P＜0.05）.
Conclusion
Percutaneous vertebroplasty in the treatment of osteoporotic spinal fractures in the elderly can obtain a favorable effect by effectively relieving pain and improving BMD,which is worthy of clinical application and promotion.
2018 Vol. 25 (19): 95-97 [
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133
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Safety analysis of minimally invasive percutaneous plate fixation in the treatment of limb fractures
HUANG Han-dao
Objective
To explore the safety of minimally invasive percutaneous plate fixation for the treatment of limb fractures.
Methods
A total of 40 patients with limb fractures admitted to our hospital from January 2016 to December 2017 were selected.They were divided into control group(n=20)and research group(n=20)according to the treatment protocol.In the control group,open reduction with compression plate was used,while in the research group,minimally invasive percutaneous plate fixation was adopted.The efficacy and safety of the corresponding treatment protocols as interventions in the two groups were compared.
Results
In the research group,the operation time was(91.35±9.32)min,shorter than that of the control group([115.66±10.94]min)(P<0.05).The hospital stay in the research group was(14.22±5.31)d,shorter than that in the control group([19.92±6.36]d)(P<0.05).The time of fracture healing in the research group were(14.32±4.98)d,shorter than that in the control group([22.46±5.22]d)(P<0.05).Intraoperative blood loss in the research group were(88.31±12.66)ml,lesser in the control group([270.14±50.64]ml)(P<0.05).The excellent and good rate of the joint function recovery in research group was 90.00%,higher than that of the control group accounting for 60.00%(P<0.05).The incidence of complications in the research group was 5.0%,much lower than that of the control group accounting for 30.00%,the difference was statistically significant(P<0.05).
Conclusion
Compared with open reduction,the minimally invasive percutaneous plate fixation for patients with limb fractures is effective.The operation is better and the incidence of complications is lower.It has higher safety and is easier to accept by patients,which is worth promoting in clinical practice.
2018 Vol. 25 (19): 98-100 [
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129
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101
Effect analysis of individualized physical exercise therapy intervention on adolescent idiopathic scoliosis
LI Yan-feng;ZOU Hui
Objective
To explore the clinical effects of individualized physical exercise therapy intervention on adolescent idiopathic scoliosis.
Methods
A total of 208 patients with adolescent idiopathic scoliosis who were admitted to our hospital from January to December in 2016 were selected as subjects.According to the specific morphology of scoliosis,the participants were divided into four types such as 3C(n=37),4C(n=54),N3N4(n=60),and single lumbar/thoracolumbar scoliosis(n=57).The individualized physical exercise therapies were targeted on different types of scoliosis.The improvement of Cobb angles,trunk rotation,and score of body pain before and after interventions were compared.
Results
Before intervention，patients′trunk rotation was mostly concentrated at 3°-4°,while after therapy,the rotation was at 1°-2°.After the intervention,the average Cobb angle was (8.4±2.1)°,significantly lower than before the intervention,(27.3±5.4)°.The patient′s body pain score was(2.7±1.4)points,greatly lower than the pre-intervention,(8.6±2.3)points with a significant difference(P<0.05).
Conclusion
Individualized physical exercise therapy as an intervention for adolescent idiopathic scoliosis can not only effectively improve patient′s spine deformity,but also reduce the pain of the spine.Therefore,it has a good therapeutic effect.
2018 Vol. 25 (19): 101-103 [
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116
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104
Application value of transvaginal four-dimensional hysterosalpingography in the diagnosis of infertility
LI Gui-hong;ZHANG Hong;LUO Liu-ping;CHEN Chun-xia
Objective
To explore the application of transvaginal four-dimensional hysterosalpingography(TVS 4D-Hy-CoSy)in the diagnosis of infertility.
Methods
A total of 100 patients with infertility who were treated in our hospital from January to June in 2017 were selected as the research subjects.All patients were preformed with TVS 4D-HyCoSy examinations and the results were compared with those using laparoscopic dye-fluid test.
Results
A total of 200 fallopian tubes were detected in 100 infertile patients after examinations.TVS 4D-HyCoSy examination showed that 110 tubes in patency,60 tubes in patency but not smooth,and the remaining 30 tubes in complete obstruction.Laparoscopic dyefluid examination indicated that the number of tubal patency,patency but not in total,and complete obstruction was 112,60,and 28.Set the laparoscopic dye-fluid examination as standard,the accordance rate of TVS 4D-HyCoSy in detecting tubal patency was 98.21%,and 100.00%for patency but not in total,and 92.86%for complete obstruction.The difference between the two examinations was not significant(P＞0.05).During the examination,there were 6 cases occurred with obvious pain and 1 case with mild pain in the TVS 4D-HyCoSy examination.The incidence of adverse reactions was 7.00%.Compared with laparoscopic dye-fluid examination,the difference was not significant(P＞0.05).
Conclusion
The use of TVS 4D-HyCoSy in the examination of infertility patients can effectively display the specific shapes of the uterus and fallopian tube,and can accurately determine its patency,which is an effective clinical examination method and is worthy of promotion.
2018 Vol. 25 (19): 104-106 [
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140
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107
Comparison of clinical efficacy of Mifepristone and laparoscopic myomectomy treating uterine fibroids
LIN Qi-yu
Objective
To study the clinical effect of Mifepristone and laparoscopic myomectomy for uterine fibroids.
Methods
A total of 64 patients with uterine fibroids received treatment in our hospital from February to December 2017 were selected.They were divided into group A (Mifepristone group)and group B (laparoscope group)through the random number table method,32 cases in each group.Patients in group A were treated with Mifepristone,and hysteromyomectomy was performed under laparoscope in group B patients.The total efficiency,quality of life of the two groups were observed and recorded.
Results
The total effective rate in group A was 78.1%,and the total effective rate was 93.8%in group B,and the difference between the two groups was statistically significant(P＜0.05).The emotional function of patients of group A was obviously higher than that of group B patients,the difference was statistically significant(P＜0.05),whereas physical function，cognitive function,physical health,social function and role function of group B was better than that in group A of patients,patients with statistically significant difference (P＜0.05).
Conclusion
Compared with mifepristone,laparoscopic myomectomy has a high success rate,and good clinical effect.However,the use of Mifepristone for drug therapy has the ability to significantly improve the patient′s prognosis.
2018 Vol. 25 (19): 107-109 [
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158
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Changes of hemorheological and platelet-related parameters in women with pregnancy-induced hypertension
XU Yan-lei;MI Mei-yan;ZHANG Jun-na;QIANG Zhe
Objective
To analyze the changes of hemorheological and platelet-related parameters in women with pregnancy-induced hypertension.
Methods
A total of 90 pregnant women with gestational hypertension were selected and equally divided into three groups according to different disease conditions：severe preeclampsia group,preeclampsia group,pregnancy-induced hypertension group,30 cases in each group.Another group of 30 pregnant women with late pregnancy were classified into normal late pregnancy group during the same period.The cases were collected was from January 2,2015 to February 10,2016.The hemorheological and platelet-related parameters in pregnant women from different groups were analyzed.
Results
The erythrocyte aggregation index (EAI),K value of erythrocyte sedimentation rate(ESR),low-sheared reduction viscosity,and low-sheared viscosity of whole blood in the severe preeclampsia group were all higher than those in the other three groups with significant differences(P<0.05).The EAI in the pregnancy-induced hypertension group was higher than the normal late pregnancy group and the preeclampsia group with statistical significance(P<0.05).In the normal late pregnancy group,platelet distribution width and mean platelet volume were lower than those in the other three groups with statistical differences (P<0.05).The platelet count was lower in the normal late pregnancy group than that in the pregnancy-induced hypertension group with a significant difference(P<0.05).
Conclusion
There are abnormal platelet and hemorheological changes in women with pregnancy-induced hypertension.The indexes mentioned above are of great significance for the prevention and treatment of hypertensive disorders during pregnancy as well as its monitoring.
2018 Vol. 25 (19): 110-112 [
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123
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113
Clinical effect of applying forceps in a secondary cesarean section
ZHAO Jing
Objective
To explore the clinical effect of using forceps in a secondary cesarean section.
Methods
This study selected 126 women undergoing re-cesarean section from February 2016 to December 2017.The patients were divided into two groups according to different treatment methods.The patients in the observation group were forceps during a secondary cesarean section.In the control group,fetal head delivered was assisted by the operator′s hands in a secondary cesarean section,63 cases in each group.The fetal head delivery time,neonatal Apgar score,and incidence of complications such as uterine incision tear,neonatal intracranial hemorrhage,and uterine rupture were observed and assessed.
Results
The fetal head delivery time in the observation group was (115.36±13.42)min,shorter than that in the control group ([132.05±16.45]min)with a statistical significance (P<0.05).The neonatal Apgar score of the pregnant women in the observation group was(8.45±1.56)points,higher than that in the control group([6.05±0.78]points),which was displayed a significant difference (P<0.05).The total incidence of maternal complications in the observation group was 0.00%,much lower than that in the control group accounting for 9.52%with statistical significance(P<0.05).
Conclusion
The application of forceps in a secondary cesarean section is of great significance.It can reduce the incidence of complications after maternal and child delivery on the basis of solving difficult delivery of fetal head,which is worthy of promotion.
2018 Vol. 25 (19): 113-115 [
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127
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Clinical value of Enoxaparin Sodium in preventing deep venous thrombosis after cesarean section
LI Qi;JIA Xiao-jun;TAI Hai-feng;CHEN Qian;TANG Hui-jun
Objective
To investigate the clinical value of Enoxaparin Sodium in preventing deep venous thrombosis after cesarean section.
Methods
A total of 102 women undergoing cesarean section with high risk of deep venous thrombosis were recruited from November 2015 to November 2017 in our hospital.They were randomly divided into two groups,51 cases in each group.Only the study group was given Enoxaparin Sodium,and the occurrence of deep venous thrombosis and coagulation function in the two groups were compared and analyzed.
Results
There was no deep venous thrombosis occured in the study group.In the control group,11 cases(21.57%)developed deep venous thrombosis,and the total incidence of thrombosis was significantly higher than that of the study group(P<0.05).The levels of D-dimer,fibrinogen,prothrombin time(PT),activated partial thromboplastin time(APTT),and platelets(PLT)were similar between the two groups before cesarean section without statistical significance(P＞0.05).The levels of D-dimer and fibrinogen six days after cesarean section significantly decreased compared with those before in the study group,while the aforementioned two indicators increased greatly in the control group.The levels of PT,APTT and PLT of both groups increased.The levels of D-dimer and fibrinogen of the study group were much lower than theose of the control group,and the levels of PT,APTT and PLT weresignificantly higher,indicating statistical difference in coagulation function between the two groups(P<0.05).
Conclusion
Enoxaparin Sodium has the advantages of drug monitoring-free,long half-life,absence of adverse reactions such as bleeding,easy absorption,and appropriate price,etc.It can effectively prevent the occurrence of deep venous thrombosis after cesarean section and is worthy of wide application in clinical practice.
2018 Vol. 25 (19): 116-118 [
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216
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119
Efficacy and safety of hormone replacement combined with local drug use in perimenopausal women with atrophic vaginitis
ZHONG Yan-pei
Objective
To observe the effect of hormone replacement combined with local medication in the treatment of female atrophic vaginitis in perimenopausal women,to analyze the clinical value of hormone replacement combined with local medication,and to analyze its safety.
Methods
A total of 100 cases of perimenopausal women with atrophic vaginitis in our hospital from February 2014 to February 2017 were studied,patients were randomly divided into two groups,50 cases in each group.The control group was treated with local medication.The experimental group was treated with hormone replacement combined with local medication,and the effect and surface of the two groups were treated.The percentage of cells,the thickness of the endometrium,the estradiol,oestrogen and the incidence of adverse reactions after treatment were compared,and the clinical value after treatment were,and the clinical safety were also analyzed.
Results
The total effective rate of the experimental group was higher than the control group,the difference was statistically significant(P<0.05).The percentage of surface cells,the thickness of endometrium,estradiol and oestrogen after treatment were perfected,and the experimental group was higher than those in the control group,the differences were statistically significant(P<0.05);the adverse reaction rate was compared with the experimental group,the difference was statistically significant(P<0.05).
Conclusion
For the patients with perimenopausal atrophic vaginitis,the use of hormone instead of local medication is safer and more effective and suitable for future clinical related treatment.
2018 Vol. 25 (19): 119-121 [
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141
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122
Application of CT multi-directional scanning in carpometacarpal joint trauma
CHEN Bai-ling;LIANG Wei-qiang;XUE Guo-xiang
Objective
To analyze the application effect of CT multi-directional scanning in carpometacarpal joint trauma.
Methods
52 patients with carpometacarpal joint trauma who were admitted to our hospital from March 2014 to July 2016 were selected as the research subjects.Multiple X-ray and CT examinations(cross-sectional,coronal,sagittal,etc.)were provided,and the application effects of the two examination methods were analyzed.
Results
Of the 52 patients with carpometacarpal joint trauma,66 fractures and 6 instabilities/dislocations were diagnosed;the rate of definite diagnosis of fractures,instability,and dislocation detected by CT was higher than that of X-ray,and the differences were statistically significant(P<0.05);there was no statistically significant difference in the rate of definite diagnosis of axial scan fractures between the two examinations(P＞0.05).However,the diagnostic accuracy and missed diagnosis rate of fractures by quasi-coronal scan,and quasi-sagittal scan,as well as the diagnosis rate of instability/dislocation by axial scan，quasicoronal scan,and quasi-sagittal scan were more accurate than those by X-rays,and the differences were statistically significant(P<0.05).
Conclusion
During the CT scans on carpometacarpal joint trauma,CT quasi-coronal scan,and quasisagittal scan should be performed on the basis of the cross-sectional scan.All-round examination of the anatomical relationship between the various bones of the wrist is performed to improve the detection rate of minor fractures/dislocations and thus provide important reference data for clinicians.
2018 Vol. 25 (19): 122-124 [
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149
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125
Comparison of color Doppler ultrasound and magnetic resonance imaging in the diagnosis of focal nodular hyperplasia of the liver
WANG Xiao-bo;CHEN Zhong;DENG Lian-gui;LI Yun-hui
Objective
To compare the diagnostic value of ultrasonography and magnetic resonance imaging（MRI） in focal nodular hyperplasia of liver(FNH).
Methods
A total of 158 patients diagnosed as focal nodular hyperplasia of liver by biopsy of liver cells or pathological examination after operation from July 2001 to October 2016 were selected as the subjects，all patients were examined by ultrasound,MRI,and combination of both tests,and the result of pathological examination as the standard,the differential diagnosis and diagnosis of focal nodular hyperplastic lesions of the liver was compared.
Results
The pathological results confirmed that 158 cases of focal nodular hyperplasia of the liver in this study,27 cases of lesions was≥50 mm,31 cases was≥30 mm but<50 mm,44 cases was≥10 mm but<30 mm,56 cases was<10 mm;The sensitivity,specificity and accuracy of ultrasound in the diagnosis of focal nodular hyperplastic lesions of the liver were 91.04%,91.21%,and 91.14%,respectively,the sensitivity,specificity and accuracy of ultrasound combined with MRI in the diagnosis of focal nodular hyperplastic lesions of the liver were 95.52%,96.70%,and 96.20%,respectively.The accuracy rate of ultrasound and MRI in diagnosis of nodules≥10 mm,the difference was not statistically significant(P＞0.05);However,in the comparison of the diagnostic accuracy of 10 mm nodules,the diagnostic accuracy of MRI was significantly higher than that of ultrasonic diagnosis,and the difference was statistically significant(P<0.05).
Conclusion
For the diagnosis of focal nodular hyperplasia of the liver,ltrasound can be used for early screening,and combined with magnetic resonance imaging can improve the accuracy of diagnosis and reduce the rate of misdiagnosis and missed diagnosis.Therefore,ultrasound diagnosis has an irreplaceable role in the diagnosis of focal nodular hyperplasia of the liver.
2018 Vol. 25 (19): 125-128 [
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118
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129
Correlation between bilateral carotid artery intima-media thickness and risk factors
LIU Ting
Objective
To study the difference of intima media thickness of bilateral carotid artery and analyze the risk factors and correlation of carotid intima-media thickness.
Methods
A total of 68 healthy volunteers from December 2016 to December 2017 in our out-patient department were investigated by questionnaire.The thickness of bilateral carotid artery intima media was measured by color Doppler ultrasonography,the thickness of the left and right carotid artery intima media was compared,and the risk factors for the thickening of carotid intima media thickness were analyzed by Logistic linear regression analysis,and the correlation between carotid intima media thickness and risk factors was analyzed.
Results
The left carotid artery intima-media thickness of all age groups were higher than those of the right carotid artery intima-media thickness(P＜0.05).After single factor and multiple factor Logistic linear regression analysis,age,smoking index,blood sugar,blood pressure,blood lipid,serum CD40,CD40L and MMP-9 were the risk factors for the intima-media thickness of bilateral carotid artery intima.After correlation analysis,it was found that age,smoking index,blood sugar,blood pressure,blood lipidm,serum CD40,CD40L and MMP-9 were all positively correlated with the thickness of bilateral carotid endarteri.
Conclusion
The thickness of the left carotid artery intima-media is generally higher than that of the right side.The thickness of the carotid endarteri is affected by age,smoking index,blood glucose,blood pressure,blood lipid,serum CD40,CD40L,MMP-9 and so on.
2018 Vol. 25 (19): 129-131转134 [
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152
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132
Application value of 64-slice spiral CT in the diagnosis of mediastinal lung cancer
CHENG Liang;GU Chun-yan;LI Long-jun;HAO Quan;DONG Wen-sheng
Objective
To analyze the application value of 64-slice spiral computed tomography(CT)in the diagnosis of mediastinal lung cancer.
Methods
A total of 50 suspected patients with mediastinal lung cancer treated in our hospital from February 2016 to February 2017 were selected.All patients were performed with 64-slice spiral CT examinations.The postoperative pathological outcomes were used as the gold standard for diagnosis.The diagnostic sensitivity,specificity,and accuracy of 64-slice spiral CT were analyzed.The detection rate of 64-slice spiral CT for different types of lung cancer was also analyzed.
Results
The diagnostic sensitivity,specificity and accuracy of the 64-slice spiral CT examinations were relatively high,and there was no statistical difference compared with postoperative pathological findings(P＞0.05).The detection rates of different types by 64-slice spiral CT examinations were not displayed statistical significance compared with those in postoperative pathological findings(P＞0.05).
Conclusion
The application of 64-slice spiral CT in the diagnosis of mediastinal lung cancer is of great value.It has high diagnostic sensitivity,specificity and accuracy,and can accurately distinguish the status of mediastinal lung cancer.
2018 Vol. 25 (19): 132-134 [
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127
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135
The value of prenatal ultrasound combined with magnetic resonance in deformity of fetal central nervous system
DAI Lin;ZHANG Chun-quan
Objective
To analyze the clinical value of prenatal ultrasound combined with magnetic resonance (MRI)in the diagnosis of fetal central nervous system malformation.
Methods
From July 2016 to July 2017 in our hospital,86 pregnant women diagnosed by ultrasound and suspected fetal central nervous system abnormalities were studied.Fetal MRI was performed within 48 hours after routine ultrasound examination an examination.Ultrasound,magnetic resonance and follow-up results were compared.
Results
Among 86 pregnant women,34 cases were diagnosed by ultrasound and MRI,accounting for 39.53%,45 cases were diagnosed by MRI,ccounting for 52.33%,7 cases were corrected by MRI,accounting for 8.14%.The diagnosis of side effects of MRI in the diagnosis of lateral ventricle expansion was mainly in the large occipital cistern,accounting for 28.89%and 48.89%,respectively.The main correction of MRI was in the large occipital cistern,accounting for 57.14%.
Conclusion
In the field of prenatal examination,prenatal ultrasound as the main examination means,with a high detection rate,and MRI has a high diagnostic value,can be used as an auxiliary ultrasound examination to confirm the supplement,prenatal diagnosis should be flexible to use,will fully demonstrate their respective advantages.
2018 Vol. 25 (19): 135-137 [
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134
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138
Values and imaging features analysis of ultrasound in differential diagnosis of renal calculi and disease of kidney calcium latex
HE Miao-feng
Objective
To analyze the values and imaging features of ultrasound in differential diagnosis of renal calculi and disease of kidney calcium latex.
Methods
The ultrasonic diagnostic data of 126 cases of patients with renal calculi(the group A)and 32 cases of patients with disease of kidney calcium latex(the group B)from March 2016 to March 2017 in our hospital were analyzed retrospectively.The accuracy of ultrasonic diagnosis was calculated,and the differences of ultrasound imaging features were compared between the two groups.
Results
The accuracy rates of ultrasound diagnosis of renal calculi and disease of kidney calcium latex were 94.44%and 90.63%respectively,and there was no significant difference in the lesions diameter between the two groups(P＞0.05).The lesions in the group A were mostly found in renal calyx,calyx and renal pelvis but not in renal parenchyma,and the lesions in the group B were mostly found in the renal parenchyma but not in the renal pelvis (P＜0.05).The lesions in the group A were mostly clumpy shape without halfmoon shape while the lesions in the group B were mainly half-moom shap without arc-shaped band(P＜0.05).The number of acoustic shadowing,no ringing effect and having hydrocalycosis in the imaging of the group A was significantly higher than that of the group B,the differences were statistically significant(P＜0.05).
Conclusion
The accuracy of ultrasound is high in the diagnosis of renal calculi and disease of kidney calcium latex,and the difference in the ultrasound imageing features of the two is obvious,which is of great significance for the differential diagnosis of the two diseases.
2018 Vol. 25 (19): 138-140 [
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123
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141
Diagnostic value study of high frequency ultrasound imaging for placental implantation
HUANG Cui-ping;WEI Hong-yan;PANG Hui-xian;ZHANG Hai-yan;JIANG Ning-zhu;FAN Li-ping
Objective
To investigate the diagnostic value of high frequency ultrasound imaging for placental implantation.
Methods
From February 2016 to February 2018,50 patients with placenta implantation diagnosed in our hospital were reviewed and analyzed retrospectively.Low frequency and high frequency ultrasound imaging were used,and the results of the test were analyzed.
Results
Pathological examination revealed placenta implantation in 47 patients,with a detection rate of 94.00%.The detection rate of low frequency combined with high frequency was 88.00%,the sensitivity was 91.49%,the specificity was 66.67%,the positive predictive value was 97.73%,the negative predictive value was 33.33%,the false positive rate was 33.33%,the false negative rate was 8.51%and the diagnostic coincidence rate was 90.00%.The detection rate of Low frequency detection was 74.00%,the sensitivity was 74.46%,the specificity was 33.33%,the positive predictive value was 94.59%,the negative predictive value was 7.69%,the false positive rate was 66.67%,the false negative rate was 25.53%and the diagnostic coincidence rate was 72.00%.The specificity，sensitivity and coincidence rate of low frequency combined with high-frequency detection were significantly higher than those of low frequency detection alone,with a statistical difference(P<0.05).
Conclusion
For the diagnosis of placenta accrete,high frequency ultrasound imaging can improve the diagnostic specificity and sensitivity,reduce the incidence of false negative and false positives,and has high clinical application value.
2018 Vol. 25 (19): 141-143 [
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137
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144
Effect comparison of Diazepam,Phenobarbital and Midazolam in the treatment of pediatric convulsions
HUANG Shi-xuan;YANG Xue-qun;FANG Chun-hua
Objective
To investigate the efficacy of Diazepam,Phenobarbital and Midazolam in the treatment of convulsions in children.
Methods
A total of 90 children with pediatric convulsions treated in our hospital from November 2015 to November 2017 were selected as subjects.The children were divided into Phenobarbital group,Diazepam group and Midazolam group according to the difference in the order of treatment,30 cases in each group.The Phenobarbital group was treated with Phenobarbital,the Diazepam group was treated with Diazepam,and the Midazolam group was treated with Midazolam.The clinical treatment effects,drug onset time,and incidence of adverse reactions were compared of children in three groups.
Results
The total effective rate of clinical treatment of children in the Midazolam group was 90.00%,which was significantly higher than that in the Diazepam group(63.33%)and Phenobarbital group(73.33%),the differences were statistically significant(P＜0.05).The average onset time of drug of children in the Midazolam group was significantly shorter than that in the Phenobarbital group and Midazolam group,and the differences were statistically significant(P＜0.05).The overall incidence of adverse reactions of children in the Midazolam group(6.67%)was significantly lower than that in the Midazolam group(30.00%)and Phenobarbital group(26.67%),the differences were statistically significant(P＜0.05).
Conclusion
Children with convulsion received treament by Diazepam,Phenobarbital and Midazolam,both of which had certain therapeutic effects.However,the clinical effect of Midazolam is better,the incidence of adverse reactions is low,and the clinical effect is significant,which is worthy of being popularized.
2018 Vol. 25 (19): 144-146 [
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168
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147
Effect of Aspirin combined with Clopidogrel on cerebral hemodynamics and platelet parameters in patients with progressive stroke
ZENG Hai-ping;ZHANG Han-ye
Objective
To investigate the effect of Aspirin combined with Clopidogrel on cerebral hemodynamics and platelet parameters in patients with progressive stroke.
Methods
A total of 60 patients with progressive cerebral apoplexy treated in our hospital from January 2016 to January 2017 were selected as the research subjects.They were randomly divided into the control group(n=30)and the observation group(n=30)according to the digital table method.The control group was treated with Aspirin alone,0.1 g/times,1 times/d,and the observation group was given Clopidogrel on the basis of the control group,75 mg/times,1 times/d.The duration of treatment was 15 days in both groups.The National Institutes of Health Stroke Scale(NIHSS)was used to evaluate the degree of neurological deficit in two groups before treatment,5 days after treatment and 2 months after treatment.Barthel Index (BI)was used to evaluate the self-care ability of the two groups of patients before and after treatment.Transcranial Doppler was used to assess the cerebral hemodynamics of two groups,including systolic peak blood flow velocity,mean blood flow velocity and pulsation indexes.The platelet inhibition rate of the two groups was detected by thrombus elastography,and platelet parameters were also detected,including platelet count(PLT),average platelet volume(MPV),platelet pressure product (PCT),platelet volume distribution width (PDW)and so on.
Results
The NIHSS score of 5 days after treatment and 2 months after treatment were lower than before treatment,and the BI index was higher than before treatment,the differences were statistically significant(P＜0.05).And the NIHSS scores in the observation group of 5 days after treatment and 2 months after treatment were all lower than those in the control group,the BI indexes in the observation group of 5 days after treatment and 2 months after treatment were higher than those in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in hemodynamic index between the two groups before treatment(P＞0.05).While 5 days and 2 months after treatment,the systolic peak blood flow velocity and mean blood flow velocity were higher in both groups than before treatment,and the pulsation index was lower than before treatment,the differences were statistically significant(P＜0.05).And the systolic peak blood flow velocity and mean blood flow velocity in the observation group of 5 days after treatment and 2 months were higher than those in the control group,and the pulsation index in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).After treatment,the PLT and PCT of the two groups were higher than before treatment,and MPV,PDW were lower than before treatment,the differences were statistically significant(P＜0.05).And the PLT and PCT in the observation group were higher than those in the control group,and MPV,PDW in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).
Conclusion
The combination of Aspirin and Clopidogrel can effectively improve cerebral hemodynamics and platelet parameters in patients with cerebral stroke,improve neurological function deficiency,improve the therapeutic effect,improve the quality of life of patients.
2018 Vol. 25 (19): 147-150 [
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112
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151
Application effect of WeChat platform for health guidance in patients with epilepsy
HUANG Xiao-di
Objective
To explore the effect of WeChat platform on health guidance in patients with epilepsy.
Methods
A total of 112 epilepsy patients who were discharged from January to October 2017 in our hospital were selected as subjects and randomly divided into control group and observation group,with 56 patients in each group.In the control group,a follow-up call was used for health instruction.In the observation group,WeChat platform was established to provide health guidance to family members.The follow up lasted 6 months.The drug compliance,rationality and total clinical treatment effectiveness rate were compared between the two groups.
Results
The total drug compliance rate(96.4%)and the total effective rate of clinical treatment (91.1%)of the patients in the observation group were significantly higher than those in the control group(83.9%,58.9%),the differences were statistically significant(P＜0.05).The rate of regular use(96.4%)and interval use(91.1%)in the observation group were higher than in the control group(76.8%,67.9%),the differences were statistically significant (P＜0.05).
Conclusion
WeChat platform providing health guidance to family members can improve patients′drug compliance,rational use of drugs,and clinical efficacy,which is of great significance to the control of patients with epilepsy.
2018 Vol. 25 (19): 151-153转157 [
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124
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154
Clinical effect of Otilonium Bromide combined with Flupenthixol Melitracen in treatment of diarrhea-predominant irritable bowel syndrome
YIN Chun-li
Objective
To observe the clinical effect of Otilonium Bromide combined with Flupenthixol Melitracen in treatment of diarrhea-predominant irritable bowel syndrome (IBS-D).
Methods
A total of 96 patients diagnosed with IBS-D in our hospital from January 2014 to December 2016 were randomly divided into the observation group(52 cases)and the control group (44 cases).The control group was treated with Otilonium Bromide,while the observation group was treated with Otilonium Bromide combined with Flupenthixol Melitracen.The course of each group was 4 weeks.After treatment,the efficacy of the two groups of patients was compared,and the mental and psychological states of the two groups of patients were analyzed and evaluated by the hospital anxiety-depression scale (HADS).
Results
The overall curative effect of the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).The total effective rate of the control group was 75.0%(33/44),and the total effective rate of the treatment group was 88.5%(47/52),comparison of total therapeutic efficiency between the two groups showed no statistically significant difference(P＞0.05).The anxiety score of the control group was(8.14±1.36)points before treatment and(6.42±1.67)points after treatment,the anxiety score of the observation group was(8.35±1.44)points before treatment and(5.38±1.28)points after treatment.The depression score of the control group was(9.56±1.93)points before treatment and(6.89±2.02)points after treatment.The depression score of the observation group was(9.68±1.81)points before treatment and(5.56±1.73)points after treatment.After treatment,the anxiety and depression scores of both groups were lower than those before treatment and those of the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).The incidence of adverse reactions was 4.5%in the control group and 5.8%in the treatment group,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).
Conclusion
The treatment of Otilonium Bromide combined with Flupenthixol Melitracen has a more pronounced effect on IBS-D patients and the symptoms of anxiety and depression can be improved significantly.
2018 Vol. 25 (19): 154-157 [
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127
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158
Effect comparison of Carboprost Tromethamine and Oxytocin in the treatment of postpartum hemorrhage
LIANG Jian-mei
Objective
To study and analyze the effect of Carboprost Tromethamine and Oxytocin in the treatment of postpartum hemorrhage.
Methods
A total of 100 patients undergone postpartum hemorrhage treatment in our hospital from February 2015 to December 2016 were selected as the study subjects,and were divided into observation group and control group according to the random number table method,50 cases in each group.In the observation group,Carboprost Tromethamine was adopted,and in the control group,Oxytocin was used.The total effectiveness rate,incidence of adverse reactions and levels of coagulation function indicators were compared between the two groups.
Results
The total effectiveness rate in the observation group was 96.00%,which was higher than that in the control group accounting for 82.00%with a statistical difference (P＜0.05).After treatment,the platelet and fibrinogen levels in the observation group were lower than those in the control group,and the prothrombin time and thrombo plastin time were shorter than those in the control group,which were displayed statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was 4.00%,which was much lower than that of the control group accounting for 18.00%with statistical significance (P＜0.05).
Conclusion
In the clinical treatment of postpartum hemorrhage,the use of Carboprost Tromethamine has a very high value with a favorable effect.It not only reduces the coagulation factors significantly,but also prevents the occurrence of adverse reactions,which is worthy of wide promotion in major grass-roots hospitals.
2018 Vol. 25 (19): 158-160 [
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117
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161
Clinical effect of intravenous thrombolysis with Alteplase combined with Clopidogrel and Aspirin treating acute ST segment elevation myocardial infarction
YANG Xia-tong;CHEN Ke-quan;SU Ning;FENG Jing-tao;TAN Zhi-xiong;CHEN Yang
Objective
To observe the clinical effect of intravenous thrombolysis with Alteplase combined with Clopidogrel and Aspirin treating acute ST segment elevation myocardial infarction.
Methods
A total of 66 patients with acute ST-segment elevation myocardial infarction admitted into our hospital from January 2016 to January 2018 were selected.All patients were treated by intravenous thrombolysis with Alteplase combined with Clopidogrel and Aspirin.The patients were divided into the 6 h group(n=45)and＞6-12 h group(n=21)according to the time of onset.Coronary recanalization rate after treatment and APACHEⅡscore at 24 h after thrombolysis were compared in patients between the two groups.
Results
The coronary recanalization rate (59.09%)in the 6 h group was significantly higher than that in the＞6-12 h group(18.18%)(P＜0.05),and the APACHEⅡ score at 24 h after thrombolysis were significantly different between the two groups(P＜0.05).
Conclusion
intravenous thrombolysis with Alteplase combined with Clopidogrel and Aspirin treating acute ST segment elevation myocardial infarction is safe and effective treating acute ST segment elevation myocardial infarction,and the sooner thrombolysis is performed,the better the prognosis of patients.
2018 Vol. 25 (19): 161-163 [
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148
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164
Investigation on the traditional Chinese medicine constitution identification for 60-year-old or older patients with “three high disease” of Luohu District in Shenzhen City
ZHANG Jing-fang;XU Cong-bin
Objective
To investgate the traditional Chinese medicine(TCM)constitution types for 60-year-old or older patients with “three high disease” (hyperlipidemia,hypertension and hyperglycemia)of Luohu District in Shenzhen City.
Methods
Through the cluster sampling methods,a total of 1246 senior citizens aged 60 or older in three streets of Luohu District were selected as subjects.From July 1
st
2016 to November 31
st
2017,TCM constitution identification surveys were carried out among 482 cases who received the physical examination and questionnaire survey with “three high disease”.
Results
A total of 482 cases of the TCM constitutions were as follows:93 cases of qi deficiency(19.29%),96 cases of yang deficiency(19.92%),58 cases of calm(12.03%),52 cases of yin deficiency(10.79%),42 cases of qi stagnation(8.71%),41 cases of phlegm-dampness(8.51%),38 cases of special constitution(7.88%),36 cases of damp-heat(7.47%),and 26 cases of blood stasis(5.39%).Constitution of qi deficiency and yang deficiency were the main types of TCM constitution in the “three high disease” patients,accounting for 39.21%.
Conclusion
The main types of TCM constitution of the “three high disease” patients of Luohu District were mainly qi deficiency and yang deficiency.Identification of constitution can provide the reliable basis for the prevention and clinical treatment of elderly patients with“three high disease”,so as to better improve the life quality of elderly patients and extend their life span.
2018 Vol. 25 (19): 164-166 [
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125
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167
Analysis and countermeasure of thyroid color doppler ultrasonography of young workers in a large general hospital in Chongqing City
YU Ping-ping;BAI Rui-xue;LIU Hua;XU Xiao-yang;MEI Ying;Qi Xiao-ya
Objective
To investigate the abnormalities of thyroid in workers under 45 in a large general hospital in Chongqing.
Methods
The results of thyroid ultrasonography of young workers under 45 who underwent the health examination in a large general hospital in Chongqing City in 2017 were retrospectively analyzed.
Results
A total of 1661 cases were examined,including 356 males and 1305 females.A total of 658 cases were detected with thyroid abnormalities,whose positive detection rate was 39.61%,including 102 males and 556 females,the positive detection rates 28.65%and 42.61%respectively.The thyroid abnormality positive detection rate of female subjects was significantly higher than that of males,and the difference was statistically significant(χ
2
=22.77,P<0.01).Thyroid abnormalities included 226 cases of thyroid nodules(21 of which were to be determined),199 cases of thyroid echo inhomogeneity,132 cases of thyroid cysts,81 cases of thyroid colloid cysts,10 cases of abnormalities of thyroid gland size,and 10 cases of thyroid adenomas.The detection rate of thyroid nodules and thyroid echo inhomogeneity of females subjects were significantly higher than those of males,and the differences were statistically significant(χ
2
=6.34,P<0.05;χ
2
=11.79,P<0.05).The comparsion of detection rate of thyroid cysts,thyroid colloid cysts and thyroid size showed no significant differences(P>0.05).Two cases of thyroid cancer were found in clinical follow-up,accounting for 0.30%of the thyroid abnormality rate and 0.12%of the examined population.
Conclusion
Thyroid color doppler ultrasound should be used as a routine check-up program for health examinations,which is of great significance for early detection,early diagnosis,and early treatment of thyroid diseases.
2018 Vol. 25 (19): 167-169 [
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141
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The analysis of drug use in 132 383 outpatients with hypertension prescription
CUI Yan
Objective
To analyze the drug use in outpatients with hypertension.
Methods
From January to December 2017,132 383 outpatient prescriptions of patients diagnosed with hypertension and treated with hypotensive drugs in our hospital were collected for statistical analysis of the use of antihypertensive drugs and the treatment plans options.
Results
Among 132 383 patients′medication prescription,the proportion of patients aged 59 to 79 was the largest,which was 44.30% (58 652/132 383).Among them,the proportion of male patients was 59.43% (78 677/132 383),which was higher than female patients of 40.57% (53 706/132 383).Among the 9 types of antihypertensive drugs used in the outpatient service,the frequency of drugs use in the top three were calcium channel blocker(CCB),angiotensinⅡreceptor antagonist(ARB)and β-blockers.In addition,Amlodipine(24.45%),Metoprolol(12.82%)and Irbesartan(9.56%)had the highest rates of use in similar drugs.The use of single drug treatment accounted for 43.12%,and combined use of two or more drugs accounted for 56.88%.
Conclusion
The kinds of antihypertensive drugs used in our outpatient and the antihypertensive treatment schemes are basically in line with the Chinese guidelines for hypertension prevention and treatment and the requirements of individualized treatment programs.
2018 Vol. 25 (19): 170-172转180 [
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138
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Effect of psychological nursing intervention in the whole process in patients with combined spinal and hard anesthesia
LI Xue-hong;CHENG Bi-hua;CAI Zhi-xia
Objective
To explore the clinical effect of whole course psychological nursing intervention on patients with combined spinal and hard anesthesia.
Methods
A total of 120 surgical patients who underwent combined spinal and epidural anesthesia in our hospital from February 2015 to February 2016 were selected as research objects.They were divided into control group and observation group with 60 cases in each group by random number table method.Patients in the control group were given routine nursing while patients in the observation group were given psychological nursing intervention in the whole course.The stress response and patient satisfaction during the operation were compared between the two groups.
Results
Before the online translation intervention,there was no significant difference between the two groups in systolic blood pressure and heart rate(P＞0.05).After the intervention,the systolic blood pressure and heart rate indexes of the two groups were higher than those before the intervention.Moreover,the indexes of systolic blood pressure and heart rate in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).Before the intervention,there was no significant difference between the two groups(P＞0.05).After the intervention,the concentrations of adrenaline and norepinephrine in the two groups were higher than those before the intervention.Moreover,the concentrations of epinephrine and norepinephrine in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).The total nursing satisfaction of patients in the observation group was significantly higher than that in the control group (P＜0.05).
Conclusion
the whole psychological nursing intervention for patients undergoing combined spinal epidural anesthesia can relieve stress response during perioperative period,maintain stability of vital signs and improve patient satisfaction.
2018 Vol. 25 (19): 173-176 [
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118
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Application of Clinical Nursing Pathway in Nursing Care of Patients With Peptic Ulcer
ZHAO Mei-li;CHU Wei-hong;JIN Ji-ping
Objective
To study the application effect of clinical nursing pathway (CNP)in patients with peptic ulcer.
Methods
Eighty patients with peptic ulcer admitted to our hospital from June 2016 to May 2017 were selected as the research object,and were divided into control group and experimental group with 43 cases in each group by random number table method.Patients in the control group were given routine nursing during the treatment while patients in the experimental group were given clinical nursing path mode during the treatment.The nursing satisfaction,patients'mastery of disease knowledge,hospitalization days,hospitalization expenses and treatment effect of the two groups were compared.
Results
There was no statistically significant difference between the two groups(P＞0.05).The total satisfaction degree of the experimental group was higher than that of the control group,and the difference was statistically significant（P＜0.05）.The average score(8.7±1.2)of the patients in the experimental group was higher than that in the control group （7.9±1.1）,with statistically significant difference(P＜0.05).The average hospitalization time of the patients in the experimental group was shorter than that in the control group,and the average total hospitalization expense was lower than that in the control group,the difference was statistically significant(P＜0.01).
Conclusion
Clinical nursing pathway for patients with peptic ulcer can effectively improve nursing satisfaction,shorten hospitalization days and reduce hospitalization expenses,which is worthy of promotion in clinical practice.
2018 Vol. 25 (19): 177-180 [
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126
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181
Effect of rehabilitation nursing combined with acupuncture and moxibustion on recovery of posttraumatic sequelae after intracerebral hemorrhage
GUO Xiang-feng;SHAN Min;ZHUO Shu-yuan
Objective
To investigate the effect of rehabilitation nursing combined moxibustion on rehabilitation of postoperative sequelae after cerebral hemorrhage.
Methods
Fifty patients with hemiplegia after cerebral hemorrhage admitted to our hospital from January 2016 to January 2017 were selected as the research object,and divided into control group and observation group with 25 cases in each group by different random methods.The patients in the control group received routine rehabilitation nursing methods.based on the nursing in the control group,the patients in the observation group were given comprehensive rehabilitation nursing and acupuncture treatment.finally,the motor function and motivation of daily life of the patients before and 3,6 and 12 months after nursing were evaluated.
Results
Before nursing,there was no significant difference between the two groups(P＞0.05).The motor function scores of the two groups of patients at 3,6,12 months after treatment were all higher than those before nursing,and the motor function scores of the observation group of patients at 3,6,12 months after nursing were significantly higher than those of the control group,the difference was statistically significant(P＜0.05).Before nursing,there was no statistically significant difference in the scores of daily living ability between the two groups(P＞0.05).The scores of daily living ability of the two groups of patients at 3,6,and 12 months after nursing were all higher than those before nursing,and the scores of daily living ability of the observation group of patients at 3,6,and 12 months after nursing were all significantly higher than those of the control group,the difference was statistically significant(P＜0.05).
Conclusion
Early rehabilitation nursing combined with traditional Chinese acupuncture can significantly improve the daily life ability of patients with cerebral hemorrhage,accelerate the recovery of limb function,and which is worthy of clinical promotion.
2018 Vol. 25 (19): 181-183 [
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134
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184
Effect of pressurized cold nursing on pain and rehabilitation after knee replacement
OU Yin-yan;LIANG Yan-chang;SUN Yan-ying;HUANG Jia-ying
Objective
To investigate the influence analysis of cold pressurization on pain and rehabilitation after knee joint replacement.
Methods
A retrospective analysis of 100 patients undergoing knee replacement surgery in our hospital from June 2015 to December 2016 was carried out.According to different nursing measures,they were divided into two groups：pressurized cold therapy group and routine group,50 cases in each group.In the routine group,ice compress nursing was used after surgey,while in the pressurized cold therapy group,pressurized cold nursing was adopted.The postoperative pain VAS scores,drainage volume and knee functional grading were performed with statistical analysis.
Results
The pain VAS scores in the pressurized cold therapy group were all lower than those in the routine group at 12,24,and 48 h after operation with statistical differences(P<0.05).The drainage volume at 12,24,and 48 h after operation in the pressurized cold therapy group was lesser than those in the routine group,with statistical differences (P<0.05).The excellent and good rate in functional knee joint grading in the pressurized cold therapy group was higher than that in the routine group with statistical differences(P<0.05).
Conclusion
Pressurized cold nursing can effectively relieve pain,reduce drainage,and improve knee joint function after knee joint replacement,which is worthy of further promotion in clinical practice.
2018 Vol. 25 (19): 184-186转190 [
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125
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187
The study on family doctor contracted services model in intervention of patients with hypertension
HONG A-yuan;ZHANG Chun-zhen
Objective
To evaluate the effect of family doctors′contract-signing services model on blood pressure and life quality of patients with essential hypertension （EH）.
Methods
From July 2016 to January 2017,80 patients with hypertension in the community health service center of Huli street in Huli district of Xiamen were randomly divided into control group and experimental group with 40 patients in each group.The control group adopted routine nursing management,while the experimental group went up to the family doctor signing service mode on the basis of the control group.The blood pressure,quality of life and satisfaction evaluation of the two groups were observed respectively when the patients entered the group and 6 months after the intervention.
Results
There was no significant difference in blood pressure between the two groups before intervention（P>0.05）.After the intervention,the blood pressure of the two groups of patients was lower than that before the intervention,and the blood pressure of the patients in the study group was lower than that of the control group,the difference was statistically significant（P<0.05）.The quality of life scores of patients in the study group after intervention were all higher than those in the control group,and the difference was statistically significant(P<0.05）.The total satisfaction of patients in the study group after intervention was higher than that in the control group,the difference was statistically significant(P<0.05).
Conclusion
Family doctor contracted service model can lower the blood pressure,effectively improve the life quality of patients with EH and promote the satisfaction of patients.
2018 Vol. 25 (19): 187-190 [
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156
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191
Application of comprehensive nursing in relieving the degree of anus distention and anxiety in patients after PPH
YE Ping;HU Xin-chao
Objective
To explore and analyze the application of comprehensive nursing in alleviating the degree of anal distention and anxiety in patients after PPH.
Methods
Fifty-two patients with severe hemorrhoids who underwent PPH in our hospital from May 2016 to June 2017 were selected and randomly divided into control group and observation group by random number table method with 26 cases in each group.Patients in the control group received routine nursing intervention after surgery,while patients in the observation group received combined comprehensive nursing intervention on the basis of routine nursing intervention to compare the degree of anal swelling and psychological state of patients in the two groups after surgery.
Results
Before the intervention,there was no significant difference between the two groups in the degree of anal bulge(P＞0.05).On the 1
st
,3
rd
and 5
th
day after the intervention,the scores of anal distension in the two groups were lower than those before the intervention.Moreover,the score of anal bulge in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Before the intervention,there was no statistically significant difference in the scores of depression and anxiety between the two groups(P＞0.05).After the intervention,the scores of depression and anxiety in the two groups were lower than those before the intervention,and the scores of depression and anxiety in the observation group were lower than those in the control group,the difference was statistically significant(P＜0.05).
Conclusion
Comprehensive nursing for patients with rectal mucosal prolapse after PPH can effectively reduce the degree of anal distention and improve mental state,which is worthy of popularization and application.
2018 Vol. 25 (19): 191-193 [
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136
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194
The role of pressure ulcer assessment scale combined with grading nursing in reducing intraoperative pressure ulcer in long-term surgical Patients
MAI Hui-qiong;YUAN Yu-huan;LUO Ran-er
Objective
To explore the role of pressure ulcer assessment scale combined with grading nursing in reducing intraoperative pressure ulcer in long-term surgical patients.
Methods
A total of 138 patients who underwent long-term surgery in our hospital from June to December 2017 were randomly divided into group A and group B by random number table method,with 69 patients in each group.Patients in group A were given common spongy pads to prevent pressure sores during operation,while patients in group B were given operation pressure sores evaluation form combined with graded nursing on the basis of group A.The incidence of pressure sores and the satisfaction of nursing work were compared between the two groups.
Results
The total incidence of pressure sores in group B was lower than that in groupA （P＜0.05）.The satisfaction rate of nursing work in group B was higher than that in group A,the difference was statistically significant（P＜0.05）.
Conclusion
The operation pressure sore evaluation table combined with graded nursing can effectively reduce the incidence of pressure sores in long-term operation patients and obviously improve the satisfaction rate of nursing work.
2018 Vol. 25 (19): 194-196 [
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133
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