Abstract：Objective To explore the clinical effect of Edaravone combined with Vinpocetine Injection in the treatment of acute cerebral infarction(ACI).Methods Seventy patients with ACI treated in Lufeng People′s Hospital from January 2018 to March 2019 were selected as research subjects.They were divided into the control group and the observation group according to the random number table method,with 35 cases in each group.Patients in the control group were treated with Edaravone,and patients in the observation group were treated with Vinpocetine Injection on the basis of the control group.The clinical efficacy,incidence of adverse reactions,and neurological function(national institute of health stroke scale[NIHSS])score,inflammatory factors(tumor necrosis factor-α[TNF-α),and matrix metalloproteinase-3[MMP-3])and oxidative stress(superoxide dismutase[SOD],malondialdehyde[MDA])levels before and after treatmentwere compared between the two groups.Results The total effective rate of treatment in the observation group was 97.14%,which was higher than 77.14%in the control group,and the difference was statistically significant(P＜0.05).The NIHSS score of patients in the observation group after treatment was(9.61±1.80)points,which was lower than that in the control group of(12.36±2.19)points,and the difference was statistically significant(P＜0.05).The levels of TNF-αand MMP-3 in the observation group after treatmentwere(72.31±15.22)and(2.63±0.62)μg/L,which were lower than those in the control group for(95.24±18.45)and(4.11±0.89)μg/L,the differences were statistically significant(P＜0.05).The SOD level in the observation group after treatmentwas(39.62±3.50)IU/ml,which was higher than that in the control group for(32.81±2.17)IU/ml,and the MDA level was(9.95±1.16)μmol/L,which was lower than that in the control group for(13.34±1.11)μmol/L,the differences were statistically significant(P＜0.05).No serious adverse reactions occurred in both groups.Conclusion The combination of Edaravone and Vinpocetine Injection can effectively improve the neurological function of patients with ACI,enhance the treatment effect,reduce the level of inflammatory factors,regulate the oxidative stress response and speed up the recovery of patients.
杨育生; 刘振鹏; 黄耀忠. 依达拉奉联合长春西汀注射液治疗急性脑梗死的临床效果[J]. 中国当代医药, 2020, 27(9): 57-60.
YANG Yu-sheng; LIU Zhen-peng; HUANG Yao-zhong. Clinical effect of Edaravone combined with Vinpocetine Injection in the treatment of acute cerebral infarction. 中国当代医药, 2020, 27(9): 57-60.
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