Effect of Ginkgolide Injection on platelet activation in patients with acute cerebral infarction
WU Qiong1 LIN Shao-hua2 FU Ying3
1.Department of Clinical Laboratory,the Second Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330000,China;
2.Department of Clinical Laboratory,People′s Hospital of Anfu County,Jiangxi Province,Anfu 343200,China;
3.Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Nanchang University,Jiangxi Province,Nanchang 330000,China
Abstract:Objective To investigate the effect of Ginkgolide Injection on platelet activation in patients with acute cerebral infarction (ACI).Methods A total of 112 patients with ACI treated in the Second Affiliated Hospital of Nanchang University from January 2016 to January 2018 were selected as the study subjects for retrospictive analysis.According to the different treatment methods,they were divided into the control group and the treatment group,56 cases in each group.The control group was treated with Aspirin and the treatment group was treated with Ginkgolide Injection.The levels of platelet membrane glycoprotein (PAC-1) and cluster of differentiation 62 platelet (CD62P) were compared between the two groups before and after treatment.The main adverse cardiovascular and cerebrovascular events in the two groups were analyzed.Results The total effective rate of the treatment group was 96.43%,which was higher than that of the control group (80.36%),the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in PAC-1 and CD62P levels between the two groups (P>0.05); after treatment,the levels of PAC-1 and CD62P in the two groups were lower than those before treatment,and the levels of PAC-1 and CD62P in the treatment group were lower than those in the control group,the differences were statistically significant (P<0.05).The total incidence of major adverse cardiovascular events in the treatment group was 3.57%,which was lower than that in the control group (14.29%),the difference was statistically significant (P<0.05).Conclusion Ginkgolides Injection can significantly improve the clinical efficacy of ACI patients,improve platelet activation,effectively prevent thrombosis and reduce the major adverse cardiovascular events.