阿托伐他汀钙联合依折麦布片治疗冠心病的临床效果

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摘要目的探讨阿托伐他汀钙联合依折麦布片治疗冠心病的临床效果。方法选取2016年5月～2019年3月我院收治的160 例冠心病患者作为研究对象，按照随机数字表法分为对照组与试验组，每组各80 例。两组患者均进行常规冠心病治疗，对照组患者在常规治疗的基础上给予阿托伐他汀钙片以强化治疗，试验组患者在对照组患者的治疗方案基础上，加用依折麦布片进行治疗。两组患者均持续治疗4 周。比较两组患者的临床治疗效果、治疗前后心功能指标[左心室射血分数（LVEF）、左心室舒张末期内径（LVDD）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白I（cTnI）]、血脂指标及不良反应发生情况。结果试验组患者的治疗总有效率高于对照组，差异有统计学意义（P＜0.05）；治疗后，试验组患者的高密度脂蛋白胆固醇（HDL-C）高于对照组，低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）及三酰甘油（TG）水平低于对照组，差异均有统计学意义（P＜0.05）；试验组患者的LVEF、cTnI 高于对照组，差异有统计学意义（P＜0.05）；试验组患者的LVDD、CK-MB 低于对照组，差异有统计学意义（P＜0.05）；试验组患者的不良反应总发生率低于对照组，差异有统计学意义（P＜0.05）。结论相比单独使用阿托伐他汀钙进行强化治疗，阿托伐他汀钙联合依折麦布片对于冠心病的疗效显著，对患者心功能及血脂代谢功能的改善起促进作用，具有较高的安全性，值得临床推广使用。

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	倪承祉
	唐丽冬

关键词 ：阿托伐他汀钙, 依折麦布片, 冠心病, 联合治疗, 临床疗效

Abstract：Objective To explore the clinical effect of Atorvastatin Calcium combined with Ezeimaibu in the treatment of coronary heart disease.Methods From May 2016 to March 2019,160 patients with coronary heart disease treated in our hospital were selected as the subjects,and divided into control group and experimental group according to random number table method,with 80 cases in each group.The patients of the two groups were treated with routine coronary heart disease,on the basis of routine treatment,patients in the control group were given Atorvastatin Calcium Tablets for intensive treatment,while patients in the experimental group were treated with Ezetimib Tablets on the basis of the treatment plan of the control group.Both groups were treated for 4 weeks.The clinical treatment effects of the two groups were compared.The indexes of cardiac function (left ventricular ejection fraction [LVEF],left ventricular enddiastolic diameter [LVDD],creatine kinase isoenzyme [CK-MB],cardiac troponin I [cTnI],blood lipid before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant (P＜0.05).After treatment,the high density lipoprotein cholesterol (HDL-C) of the experimental group was higher than that of the control group,and the low density lipoprotein cholesterol (LDL-C),total cholesterol (TC) and triglyceride (TG) of the experimental group were higher than those of the control group,and the differences were statistically significant (P＜0.05).The levels of LVEF and cTnI in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05).The LVDD and CK-MB in the experimental group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Compared with the intensive treatment with Atorvastatin Calcium alone,Atorvastatin Calcium combined with Ezetimibe Tablets has a significant effect on coronary heart disease.It can promote the improvement of cardiac function and blood lipid metabolism in patients with coronary heart disease.It is safe and worthy of clinical application.

Key words： Atorvastatin Calcium Tzetimibe Tablets Coronary heart disease;Combined therapy;Clinical efficacy

作者简介: 倪承祉（1972-），男，本科，副主任医师，研究方向：心力衰竭、冠心病的进展

引用本文:

倪承祉; 唐丽冬. 阿托伐他汀钙联合依折麦布片治疗冠心病的临床效果[J]. 中国当代医药, 2020, 27(1): 40-43.
NI Cheng-zhi; TANG Li-dong. Clinical effect of Atorvastatin Calcium combined with Ezeimaibu in the treatment of coronary heart disease. 中国当代医药, 2020, 27(1): 40-43.

链接本文:

http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I1/40

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