Objective To investigate the clinical effect of emergency clustering regimen in the treatment of acute heart failure (AHF).Methods Sixty patients with AHF treated in our hospital from January 2017 to January 2019 were selected.According to the random number table method,the patients were divided into routine treatment group (n=30)and emergency cluster treatment group (n=30).The routine treatment group was treated with conventional regimen,and the emergency cluster treatment group was provided with conventional regimen+emergency clustering regimen.The effects of treating,shortness of breath symptom relief time,total time of emergency treatment,hospital stay were compared; acute physiology and chronic health (APACHE) Ⅱscores,hypersensitive C-reactive protein (hs-CRP),left ventricular ejection fraction,arterial blood oxygen saturation,respiration rate mortality rate were compared between the two groups before and after treatment.Results The curative effect of the emergency cluster treatment group was higher than that of the routine treatment,the difference was statistically significant (P＜0.05).The time of shortage of breath relief,the total time of emergency treatment,and the hospital stay were shorted than those of the routine treatment,the differences were statistically significant (P＜0.05).The APACHEⅡscore,hs-CRP,and respiration rate of the emergency cluster treatment group were lower than those of the conventional treatment group,the left ventricular ejection fraction and arterial oxygen saturation were higher than those of the conventional treatment group,with statistical significances(P＜0.05).There was no significant difference in mortality between the two groups (P＞0.05).Conclusion The conventional regimen+emergency clustering regimen is effective in treating AHF,which can improve patients′ vital signs and cardiac function,accelerate recovery and shorten treatment.