Abstract：ObjectiveTo explore the long-term effect of intravenous thrombolytic therapy with recombinant tissue-type plasminogen activator(r-tPA)treating acute cerebral infarction.MethodsFrom January 2015 to January 2017,100 patients with acute cerebral infarction admitted into our hospital were selected as research objects.Using a random number table method,they were divided into the two groups,and there were 50 cases in each group.All participants were provided with conventional therapy.On the basis of routine treatment,Aspirin Enteric-coated Tablets was added in the control group,while in the observation group,r-tPA was adopted.The clinical effect,prognosis,neurological deficit score,and Barthel index were compared between the two groups.ResultsAfter 3-month treatment,the clinical effect of the observation group was significantly better than that of the control group,and the prognosis in the observation group was better than that in the control group after 3-month treatment(P＜0.05).Before treatment,there was no statistical difference in the score of neurological deficits or Barthel index between the two groups (P＞0.05).After therapy,the score of neurological deficits in the two groups were both lower than those prior treatment(P＜0.05),and Barthel index were significantly higher than those before treatment(P＜0.05).The score of neurological impairment was lower and Barthel index was higher compared with those in the control group (P＜0.05).Conclusionr-tPA intravenous thrombolysis is effective in the treatment of acute cerebral infarction,which can facilitate the recovery of neurological function as well as daily living ability,and helps improve the long-term prognosis of patients.
Eijiro O，Morio M，Kota W，et al.A case of spontaneous spinal epidural hematoma that mimicked acute cerebral ischemic stroke and was treated by a recombinant tissue-type plasminogen activator[J].Neurosurg Q，2012，22（2）：99-101.
Osaki M，Miyashita F，Koga M，et al.Simple clinical predictors of stroke outcome based on National Institutes of Health Stroke Scale score during 1-h recombinant tissue-type plasminogen activator infusion[J].Eur J Neurol，2014，21（3）：411-418.
Whiteley WN，Thompson D，Murray G，et al.Targeting recombinant tissue-type plasminogen activator in acute ischemic stroke based on risk of intracranial hemorrhage or poor functional outcome：an analysis of the third international stroke trial[J].Stroke，2014，45（4）：1000-1006.
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