Abstract：Objective To investigate the effect of controlled low central venous pressure technique in laparoscopic hepatectomy.Methods A total of 100 patients undergoing laparoscopic hepatectomy in Department of Hepatobiliary and Pancreatic Surgery of our hospital from October 2014 to January 2019 were selected as the study subjects.They were randomly divided into control group and observation group,50 cases in each group.The patients in the control group underwent normal central venous pressure technique,and the patients in the observation group underwent controlled low central venous pressure technique.The surgical related indexes,liver and kidney function,and blood gas analysis indexes of the two groups were compared.Results The total amount of bleeding and intraoperative blood loss in the observation group were lower than those in the control group,and the liver cutting time was shorter than that in the control group,the differences were statistically significant (P<0.05).There were no significant differences in total bilirubin,serum creatinine,alanine aminotransferase and blood urea nitrogen levels between the two groups one day before surgery (P>0.05).At one day after surgery,total bilirubin and blood creatinine,alanine aminotransferase and blood urea nitrogen levels were higher than those one day before surgery,and which in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).At one day after operation,there were no significant differences in blood gas pH (pH) and oxygen saturation (SpO2) between the two groups (P>0.05).The oxygenpartial pressure (PaO2) and residual alkali (BE) of the observation group were lower than those of the control group,and the bicarbonate (HCO3-) was higher than that of the control group,the differences were statistically significant (P<0.05).Conclusion Controlled low central venous pressure technique can not only reduce the amount of bleeding,shorten the time of liver cutting,promote the recovery of liver and kidney function,but also reduce the influence on arterial blood gas index in laparoscopic hepatectomy.It is worthy of promotion in clinical practice.
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