Effect of Sevoflurane Inhalation combined with Anesthesia on inflammatory response and anesthetic effect in patients undergoing laparoscopic radical operation for cervical cancer
SUN Yang
Department of Anesthesiology, Jiangxi Maternal and Child Health Hospital, Jiangxi Province, Nanchang 330006, China
摘要目的 探讨七氟醚静吸复合麻醉对腹腔镜下宫颈癌根治术患者炎症反应及麻醉效果的影响。方法 回顾性分析2016年2月～2018年3月在我院拟行腹腔镜下宫颈癌根治术治疗的92 例患者的临床资料， 依据麻醉方式的不同分为观察组（七氟醚静吸复合麻醉）与对照组（丙泊酚静脉输注麻醉），每组各46 例。比较两组的麻醉效果、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）、心率（HR）。结果 两组的麻醉时间比较，差异无统计学意义（P＞0.05）；观察组的睁眼、自主呼吸恢复、定向力恢复及言语应答时间均短于对照组（P＜0.05）；观察组气腹后10 min与术后10 min 的IL-1β、TNF-α 水平均低于对照组，差异有统计学意义（P＜0.05）；麻醉前，两组的HR 比较，差异无统计学意义（P＞0.05）；气腹后10 min 与术后10 min，观察组的HR 低于对照组，差异有统计学意义（P＜0.05）；两组患者气腹后10 min、术后10 min 的IL-1β、TNF-α 水平均高于麻醉前，差异有统计学意义（P＜0.05）；对照组气腹后10 min 与术后10 min 的HR 均高于麻醉前（P＜0.05）；观察组气腹后10 min 的HR 高于麻醉前（P＜0.05）；观察组术后10 min 与麻醉前的HR 比较，差异无统计学意义（P＞0.05）。结论 腹腔镜下宫颈癌根治术患者经七氟醚静吸复合麻醉，其自主呼吸、言语应答等恢复时间较短，且对炎症反应以及HR 的影响相对较小。
Abstract：Objective To investigate the effect of Sevoflurane Inhalation combined with Anesthesia on patients undergoing laparoscopic radical operation for cervical cancer. Methods The clinical data of 92 patients undergoing laparoscopic radical operation for cervical cancer in our hospital from February 2016 to March 2018 were retrospectively analyzed. They were divided into the observation group (Sevoflurane Inhalation combined with Anesthesia) and control group (Propofol intravenous anesthesia), with 46 cases in each group. The effects of anesthesia, Interleukin-1 beta (IL-1β), Tumor necrosis factor-alpha (TNF-α) and heart rate (HR) were compared. Results There was no significant difference in anesthesia time between the two groups (P＞0.05). The time opening eyes, the time of recovery of spontaneous breathing, the time of recovery of orientation, and the time of speech response in the observation group were shorter than those in the control group (P＜0.05). The level of IL-1β and TNF-α in the observation group 10 minutes after pneumoperitoneum and 10 minutes after operation were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in HR between the two groups before anesthesia(P＞0.05). The HR in the observation group 10 minutes after pneumoperitoneum and 10 minutes after operation were lower than those in the control group, and the differences were statistically significant (P＜0.05). The level of IL-1β and TNF-α in the two groups 10 minutes after pneumoperitoneum and 10 minutes after operation were higher than those before anesthesia, and the differences were statistically significant (P＜0.05). The HR in the control group 10 minutes after pneumoperitoneum and 10 minutes after operation were higher than that before anesthesia (P＜0.05). The HR in the observation group 10 minutes after pneumoperitoneum was higher than that before anesthesia (P＜0.05). There was no significant difference in HR of the observation group before anesthesia and 10 minutes after operation (P＞0.05).Conclusion The recovery time of spontaneous breathing and speech response of patients undergoing laparoscopic cervical cancer radical operation under sevoflurane inhalation combined anesthesia is short, and the effect on inflammatory response and HR value is relatively small.
孙杨. 七氟醚静吸复合麻醉对腹腔镜下宫颈癌根治术患者炎症反应及麻醉效果的影响[J]. 中国当代医药, 2019, 26(9): 101-104.
SUN Yang. Effect of Sevoflurane Inhalation combined with Anesthesia on inflammatory response and anesthetic effect in patients undergoing laparoscopic radical operation for cervical cancer. 中国当代医药, 2019, 26(9): 101-104.
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