Abstract：ObjectiveTo study the efficacy of Sini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris.Methods74 patients with variant angina pectoris in the Central Hospital of Zibo Mining Group Co.,LTD.from June 2014 to April 2017 were selected and divided into the combination group and the control group by random number table method,37 cases in each group.The combination group was treated with Sini Decoction combined with Isosorbide Mononitrate,the control group was treated with Isosorbide Mononitrate.During the course of treatment,the frequency and duration of angina pectoris in the two groups were observed.2 weeks after treatment,cardiac function indexes and serum cytokines were determined in the two groups.ResultsThe frequency of angina pectoris in the combined group was significantly less than that in the control group and the duration of each attack in the combined group was significantly shorter than that in the control group,with significant difference (P＜0.05).After 2 weeks of treatment,cardiac function indexes CO,EF of the combination group was significantly higher than that of the control group,with significant difference(P＜0.05);serum tumor necrosis factor alpha(TNF-α),interleukin-6(IL-6),intercellular adhesion molecule-1(ICAM-1)contents in the combination group was significantly lower than that in the control group,with significant difference(P＜0.05).ConclusionSini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris can reduce angina pectoris,improve heart function and inhibit inflammatory reaction.
谭明琴. 四逆汤联合单硝酸异山梨酯治疗变异性心绞痛的效果分析[J]. 中国当代医药, 2017, 24(29): 121-123.
TAN Ming-qin. Effect analysis of Sini Decoction combined with Isosorbide Mononitrate in the treatment of variant angina pectoris. 中国当代医药, 2017, 24(29): 121-123.
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