Abstract：Objective To explore the individual and combined diagnosis value of serum procalcitonin and high sensitivity C-reactive protein in neonatal bacterial infectious pneumonia.Methods From January 2017 to January 2018，80 neonates with bacterial infectious pneumonia（infection group）and 60 healthy children（healthy control group）were selected and analyzed retrospectively.Serum PCT，hs-CRP levels were compared between the two groups.The diagnostic efficiency of each index in neonatal bacterial pneumonia was compared applying the receiver operating characteristic curve （ROC）.Results The levels of serum PCT and hs-CRP in the infection group were significantly higher than those in the healthy control group （t=41.405，15.315，P=0.000，0.000）.The ROC curve showed that the area under the curve（AUC）in diagnosis of neonatal bacterial pneumonia of PCT combined with hs-CRP was the highest（AUC=0.934，P=0.000），followed by PCT and hs-CRP（AUC=0.862，0.828，P=0.000，0.000）.AUC of combined diagnosis was higher than PCT（Z=2.788，P=0.005）and hs-CRP（Z=3.232，P=0.001）.The best cut-off point was PCT＞0.575 μg/L and hs-CRP＞8.639 mg/L.The accuracy of PCT combined with hs-CRP was higher than PCT and hs-CRP（χ2=3.968，6.130，P＜0.05），the sensitivity was higher than PCT and hs-CRP （χ2=5.331，5.331，P＜0.05），the specificity was higher than hs-CRP（χ2=5.714，P＜0.05），the negative predictive value was higher than PCT and hs-CRP （χ2=4.283，4.720，P＜0.05），and the other differences were not statistically significant （P＞0.05）.Conclusion PCT and hs-CRP combined diagnosis for neonatal bacterial infectious pneumonia has better diagnostic efficacy，diagnostic accuracy，sensitivity and specificity are higher.It is worthy of clinical promotion.
陈海涛. 血清降钙素原、超敏C反应蛋白单独及联合诊断新生儿细菌感染性肺炎的价值[J]. 中国当代医药, 2019, 26(6): 124-126.
CHEN Hai-tao. Individual and combined diagnosis value of serum procalcitonin and high sensitivity C-reactive protein in neonatal bacterial infectious pneumonia. 中国当代医药, 2019, 26(6): 124-126.
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