Abstract：Neonatal listeria infection is one of the important causes of neonatal abortion，premature birth and even stillbirth.Treatment of this disease is very difficult，with many sequelae and poor prognosis.In addition，there is no direct and effective method to cure neonatal listeria infection.By analyzing the etiology and understanding the pathogenesis，we can avoid contact and pay attention to prevention.Through clinical manifestations，early detection can be achieved，missed diagnosis and misdiagnosis can be avoided，and effective treatment can be summarized to improve the prognosis of this disease.In this paper，2 cases of neonatal infection with listeria were studied in the pediatric department of yichang central people′s hospital，and the clinical manifestations，laboratory examination and treatment were analyzed to improve the prognosis.
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