Abstract：Objective To explore the effect of Esomeprazole combined with Somatostatin(SS)in the treatment of severe acute pancreatitis (SAP)and its effect on intestinal mucosal barrier function and inflammatory transmitter levels.Methods A total of 84 cases of patients with SAP treated in our hospital from October 2015 to October 2017 were selected as objects and randomly divided into the control group and the observation group,with 42 cases in each group.The control group was given conventional symptomatic support,and the observation group was given Esomeprazole combined with SS on the basis of the control group.The symptom indicators,overall treatment effects,intestinal mucosal barrier function and inflammatory transmitter levels were compared between the two groups after treatment.Results After treatment,the relief time of abdominal pain and abdominal distension,the exhaust recovery time and the serum amylase recovery time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P＜0.05).The rate of total clinical effective in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P＜0.05).The levels of D-lactic acid,DAO,endotoxin and L/M in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of D-lactic acid,DAO,endotoxin and L/M in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of IL-6,IL-8,CRP,and TNF-α in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P＜0.05).The levels of IL-6,IL-8,CRP,and TNF-α in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Esomeprazole combined with SS for SAP can improve the symptoms and the treatment effective rate,promote the recovery of intestinal mucosal barrier function and reduce the levels of inflammatory mediators,which is worthy of clinical application.
杨婷;吴建维;汤红玲;成彦霖. 埃索美拉唑联合生长抑素治疗重症胰腺炎的效果[J]. 中国当代医药, 2018, 25(23): 166-168.
YANG Ting;WU Jian-wei;TANG Hong-ling;CHENG Yan-lin. Effect of Esomeprazole combined with Somatostatin in the treatment of severe acute pancreatitis. 中国当代医药, 2018, 25(23): 166-168.
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