Effect of Tiotropium Bromide combined with Montelukast on pulmonary function,inflammatory cells in sputum and expression of inflammatory factors in patients with chronic obstructive pulmonary disease
HUANG Sui-hua DONG Jing-jun DENG Jie-fang
Department of Respiratory Medicine,Bao′an District Central Hospital of Shenzhen City,Guangdong Province,Shenzhen 518101,China.
Abstract：Objective To investigate the effect of Tiotropium Bromide combined with Montelukast on lung function,inflammatory cells in sputum and expression of inflammatory factors in patients with chronic obstructive pulmonary disease (COPD).Methods A total of 86 COPD patients admitted to our hospital from April 2017 to March 2018 were selected and divided into control group and observation group with 43 cases in each group by random number table method.The control group was treated with Theophylline Sustained-release Tablets orally,while the study group was treated with Tiotropium Bromide combined with Montelukast.The levels of forced expiratory volume (FEV1),vital capacity (FVC),ratio of forced expiratory volume to vital capacity (FEV1/FVC),sputum myeloperoxidase (MPO),interleukin (IL)-8,leukotriene B4 (LTB4),neutrophils and eosinophils were compared before and after the intervention.Results Before the intervention,there was no statistical difference between the two groups(P＞0.05).After the intervention,the lung function related indexes of the two groups were higher than those before the intervention,and the differences were statistically significant(P＜0.05).The lung function related indexes of the patients in the study group were higher than those of the control group,and the differences were statistically significant(P＜0.05).Before the intervention,there was no statistically significant difference in sputum inflammatory factors between the two groups (P＞0.05).After the intervention,the sputum inflammatory factors of the two groups of patients were lower than those before the intervention,the differences were statistically significant(P＜0.05),and the sputum inflammatory factors of the patients in the study group were lower than those of the control group,the differences were statistically significant(P＜0.05).Before the intervention,there was no statistically significant difference between the two groups in inducing sputum inflammatory cells(P＞0.05).After the intervention,the induced sputum inflammatory cells in the two groups were lower than those before the intervention,and the difference was statistically significant(P＜0.05).The induced sputum inflammatory cells in the study group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Tiotropium Bromide combined with Montelukast can significantly improve the pulmonary function of COPD patients,reduce the level of inflammatory factors in sputum and reduce inflammatory cells in sputum.
黄穗华;董敬军;邓杰方. 噻托溴铵与孟鲁司特联合治疗对慢性阻塞性肺疾病患者肺功能、痰液炎性细胞及炎性因子表达的影响[J]. 中国当代医药, 2018, 25(23): 85-87转94.
HUANG Sui-hua;DONG Jing-jun;DENG Jie-fang. Effect of Tiotropium Bromide combined with Montelukast on pulmonary function,inflammatory cells in sputum and expression of inflammatory factors in patients with chronic obstructive pulmonary disease. 中国当代医药, 2018, 25(23): 85-87转94.
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