Abstract：Objective To investigate the infection characteristics and risk factors of aplastic anemia patients to provide the theoretical basis for effective prevention and treatment.Methods 330 patients with aplastic anemia treated in the Hematology Department of Affiliated Hospital of Southwest Medical University from May 2013 to May 2017 were selected as object.Retrospective investigation and analysis method was used to analyze the related infection characteristics and the related risk factors of patients.Data were analyzed by SPSS 17.0 software.Results Among 330 patients with aplastic anemia,128 cases had infections(38.8%),46 cases of hospital infection(35.9%),82 cases of community infection(64.1%),111 cases of single infection(86.7%),14 cases of double infection(10.9%),3 cases of multiple infection(2.4%).A total of 19 cases of pathogenic bacteria were trained,Gram-negative bacteria in 12 case(63.2%),Gram-positive bacteria in 4 cases(21.1%),fungal infections in 3 cases(15.7%).Single factor analysis showed that the hospitalization time,white blood cell count,neutrophils count,agranulocytosis duration,albumin content,invasive operation and the application of hormone were risk factors for infection in patients with aplastic anemia (P＜0.01).Multivariate analysis showed that the hospitalization time,agranulocytosis duration,albumin content,number of neutrophils were independent risk factors for aplastic anemia with infection (P＜0.01).Conclusion In clinic,positive and effective preventive measures should be taken according to the above risk factors to reduce the incidence of infection in patients with aplastic anemia.
Young NS，Maciejewski J.The pathophysiology of acquired aplastic anemia[J].N Engl J Med，1997，336（19）：1365-1372.
[3]
Schrezenmeier H，Korper S，Hochsmann B.Aplastic anemia：current state of diagnosis and treatment[J].Internist （Berl），2015，56（9）：989-999.
[8]
Boddu PC，Kadia TM.Updates on the pathophysiology and treatment of aplastic anemia：a comprehensive review[J].Expert Rev Hematol，2017，10（5）：433-448.
[9]
Young NS，Kaufman DW.The epidemiology of acquired aplastic anemia[J].Haematologica，2008，93（4）：489-492.
[10]
Marsh JC，Kulasekararaj AG.Management of the refractory aplastic anemia patient：what are the options?[J].Blood，2013，122（22）：3561-3567.
[11]
Solmaz S，Korur A，Yeral M，et al.Active invasive fungal infection in a patient with severe aplastic anemia[J].Exp Clin Transplant，2016.[Epub ahead of print]
Tichelli A，Schrezenmeier H，Socie G，et al.A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin （ATG），cyclosporine，with or without G-CSF：a study of the SAA Working Party of the European Group for Blood and Marrow Transplantation[J].Blood，2011，117（17）：4434-4441.
[14]
Kazuma Y，Ono Y，Yonetani N，et al.Successful treatment of an overwhelming infection with granulocyte transfusion in severe aplastic anemia patient undergoing allogeneic peripheral blood stem cell transplantation[J].Rinsho Ketsueki，2016，57（4）：440-444.
[15]
Quillen K，Wong E，Scheinberg P，et al.Granulocyte transfusions in severe aplastic anemia：an eleven-year experience[J].Haematologica，2009，94（12）：1661-1668.
[16]
Wang H，Wu Y，Fu R，et al.Granulocyte transfusion combined with granulocyte colony stimulating factor in severe infection patients with severe aplastic anemia：a single center experience from China[J].PLoS One，2014，9（2）：e88148.
[17]
Hochsmann B，Moicean A，Risitano A，et al.Supportive care in severe and very severe aplastic anemia[J].Bone Marrow Transplant，2013，48（2）：168-173.
Phillips R，Hancock B，Graham J，et al.Prevention and management of neutropenic sepsis in patients with cancer：summary of NICE guidance[J].BMJ，2012，345：e5368.
[21]
Torres HA，Bodey GP，Rolston KV，et al.Infections in patients with aplastic anemia：experience at a tertiary care cancer center[J].Cancer，2003，98（1）：86-93.
京公网安备 11010502046607号