Abstract：Objective To systematically study relevant influence factors of aspirin resistance（AR）phenomenon in patients with acute cerebral infarction.M ethods Clinical data about 150 patients with acute cerebral infarction entering our hospital from December 2013 to December 2015 were selected for retrospective study.With the aid of thrombelastogram，wemeasured the blood platelet inhibition ratio in the induction pathway of patients′arachidonic acid（ASR）.AR meant that the blood platelet inhibition ratio was smaller than or equal to 20%；aspirin semi-resistance（ASR）meant that the blood platelet inhibition ratiowas between 20%and 50%；aspirin sensitivity（AS）meant that the blood platelet inhibition ratio was greater than 50%.By combining with the above standards，the above 150 patients were divided into different groups.Based on analysis of AR occurrence rate，characteristic differences among various groups were analyzed. Moreover，relevant risk factors of AR and ASR were summarized.Results Among patients of this group，the occurrence rate of AR was 34.0%（51/150）and the occurrence rate of ASR was 19.3%（29/150）.The high-sensitivity C-reactive protein（hs-CRP）level of AR+ASR group was obviously higher than that of ASgroup，and the difference presented statistical significance（P＜0.05）.According to Logistic regression analysis，risk factors of AR and ASR included blood platelet count and hs-CRP level.Conclusion By directing at patients with acute cerebral infarction，risk factors of AR include blood platelet count and inflammatory conditions.There is a need to regularly examine patients′blood routine and laboratory indexes，and to timely adjust clinicalmedication schemes.
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