Abstract：Objective To investigate the clinical effect of Repaglinide combined with Metformin on the treatment of sulfonylurea secondary failure diabetes.Methods Fifty patients with sulfonylurea secondary failure diabetes admitted to our hospital from May 2016 to May 2018 were enrolled as the study subjects.They were divided into control group(25 cases) and observation group (25 cases) according to random number table method.Patients in the control group were treated with Metformin on the basis of sulfonylureas,and patients in the observation group were treated with Repaglinide and Metformin.The blood glucose control effect and adverse reactions were compared between the two groups.Results There were no significant differences in the levels of fasting plasma glucose (FPG),blood sugar 2 hours after meal(2 h PG) and glycosylated hemoglobin (HbA1c) between the two groups before treatment (P>0.05).The FPG and 2 h PG levels in the two groups after treatment for 3,6,and 12 weeks were lower than those before treatment,with statistical significance (P<0.01).The HbA1c levels in the two groups after 6 and 12 weeks of treatment were lower than those before treatment,the differences were statistically significant (P<0.05).The levels of FPG and HbA1c in the observation group were lower than those in the control group after 6 and 12 weeks of treatment,the differences were statistically significant (P<0.05).The 2 h PG levels in the observation group were lower than those in the control group after 3,6,and 12 weeks of treatment,the differences were statistically significant (P<0.01 ).The insulin (INS) levels after treatment in both groups were lower than those before treatment,and the C-peptide (CP) levels were higher than those before treatment,the differences were statistically significant (P<0.05).The INS level of the patients in the observation group after treatment was lower than that in the control group,and the CP level was higher than that in the control group,the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion The combination of Repaglinide and Metformin on the treatment of sulfonylurea secondary failure diabetes patients has better blood sugar control effect and better adverse reaction improvement,which is worthy of promotion.
王小霞. 瑞格列奈联合二甲双胍治疗磺脲类继发性失效糖尿病的临床效果[J]. 中国当代医药, 2020, 27(2): 52-55.
WANG Xiao-xia. Clinical effect of Repaglinide combined with Metformin on the treatment of sulfonylurea secondary failure diabetes. 中国当代医药, 2020, 27(2): 52-55.
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