Abstract：Objective To study the clinical effect of laparoscopic cholecystectomy in the treatment of acute cholecystitis (AC). Methods A total of 52 patients with AC treated in our hospital from June 2017 to June 2018 were selected as study subjects. The patients were randomly divided into two groups according to the random number table method, each had 26 cases. Patients in the control group underwent open cholecystectomy, patients in the experimental group underwent laparoscopic cholecystectomy. The immune function indexes, perioperative indexes, serum lipase (LPS), serum amylase (AMY) , and serum alkaline phosphatase (ALP) levels between the two groups were compared. Results Tn the postoperative, the levels of CD3+, CD4+, CD4+/CD8+experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The perioperative index of the experimental group in the postoperative group was less than that of the control group, the operation time and abdominal drainage time were shorter than those in the control group, and the amount of surgical bleeding was less than that in the control group, the differences were statistically significant (P＜0.05), The levels of LPS, AMY, and ALP in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusions Laparoscopic cholecystectomy is effective in treating AC, and can effectively alleviate postoperative immune function suppression, reduce LPS, AMY,ALP and promote patient recovery.
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