Application of Ziprasidone for weight gain induced by Clozapine
LIN Xiao-ming YU Min LIANG Xiao-min HE Li-hua ZHANG Jie▲
Department of Psychiatry, Brain Hospital Affiliated to Guangzhou Medical University (Guangzhou Huiai Hospital),Guangdong Province, Guangzhou 510370, China
Abstract：Objective To investigate the application of Ziprasidone for weight gain induced by Clozapine in patients with schizophrenia.Methods A total of 80 patients with chronic schizophrenia were recruited from January 2017 to January 2018 in our hospital.Based on the random number table method, they were assigned to the study group (n=40)and the control group (n=40).The study group was treated with Ziprasidone combined with Clozapine, and the control group was treated with Clozapine.Body weight and body mass index were assessed between the two groups.Similarly,clinical efficacy and adverse drug reactions were assessed by using positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS), respectively.Results After 12 weeks of treatment, there was no significant difference in the rate of discontinuation between the two groups (P＞0.05).After 12 weeks of treatment, the body weight and body mass index of the patients and the total score of PANSS in the study group were lower than those in the control group, and the differences were statistically significant (P<0.05).There was no significant difference in the total score of TESS between the two groups (P>0.05).Conclusion Ziprasidone as a supplemental treatment is associated with weight loss in patients with schizophrenia who receiving the treatment of Clozapine.However, evidence-based medicine is needed to recommend it to clinical practice.
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