Effect of Guipazide combined with Xuesaitong in the treatment of ischemic cerebrovascular disease
QIN Xiao-xia1ZHANG Zhao-yong2 LIANG Zeng-bing1
1.Department of Pharmacy,People′s Hospital of Gaozhou,Guangdong Province,Gaozhou 525200,China;
2.Department of Neurology, People′s Hospital of Gaozhou, Guangdong Province, Gaozhou 525200, China
Abstract：Objective To explore the effect of Guipazide combined with Xuesaitong in the treatment of ischemic cerebrovascular disease.Methods Ninety patients with ischemic cerebrovascular disease treated in Department of Neurology of our hospital from February 2018 to February 2019 were selected as subjects.They were divided into two groups according random number table method.The control group was treated with routine drugs.On this basis, the observation group was treated with Guipazide combined with Xuesaitong.The clinical efficacy, the changes of hemorheological indexes, the degree of neurological deficit and the ability of daily living and the levels of serum inflammatory factors in the two groups were compared.Results The total effective rate of treatment in the observation group was 95.56%,which was higher than 77.78% in the control group (P<0.05).After treatment, the plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, fibrinogen and specific volume of blood cells in the observation group were lower than those in the control group (P<0.05).After treatment, the National Institute of Health stroke scale(NIHSS) score of the observation group was lower than that of the control group, while the Barthel index of the observation group was higher than that of the control group (P<0.05).The levels of hypersensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), tumor necrosis factor-α (TNF-α) in the observation group were lower than those in the control group, the level of IL-10 (IL-10) was higher than that of the control group (P<0.05).Conclusion The clinical effect of Guipiazide combined with Xuesaitong in the treatment of ischemic cerebrovascular disease is remarkable, which can effectively improve blood viscosity, inhibit platelet aggregation, improve cerebral blood circulation, reduce the level of inflammatory factors and repair damaged nerve function.
京公网安备 11010502046607号