经颅磁刺激治疗精神分裂症患者的效果

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摘要目的探讨经颅磁刺激治疗精神分裂症患者的效果。方法选取2016年3月～2018年3月我院收治的112例精神分裂症患者作为研究对象，应用双色球法将患者随机分为对照组和研究组，每组各56 例。其中对照组患者给予药物治疗，研究组患者在对照组基础上给予经颅磁刺激进行治疗。比较分析两组患者治疗后的临床效果及治疗前后的认知功能和精神症状情况。结果观察组患者的临床治疗总有效率为98.21%，高于对照组的78.57%，差异有统计学意义（P＜0.05）。两组患者治疗前的阳性症状、阴性症状、一般精神病理症状评分和阳性和阴性症状量表（PANSS）总分比较，差异无统计学意义（P＞0.05）。治疗后，两组患的阳性症状、阴性症状、一般精神病理症状评分和PANSS 总分均低于本组治疗前，且观察组患者的阳性症状、阴性症状、一般精神病理症状评分和PANSS总分低于对照组，差异有统计学意义（P＜0.05）。两组患者治疗前的视空间工作记忆（VSWM）、词汇流畅性（VFT）评分比较，差异无统计学意义（P＞0.05），治疗后，两组患者的VSWM、VFT 评分均高于本组治疗前，且观察组患者的VSWM、VFT 评分高于对照组，差异有统计学意义（P＜0.05）。结论精神分裂症患者采用经颅磁刺激进行治疗的效果显著，能够明显改善患者的精神症状，提高其认知功能，值得在临床上大力推广。

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	刘佳
	刘亚丽
	董鲜苗
	王美
	赵蕾

关键词 ：精神分裂症, 经颅磁刺激, 精神症状

Abstract：Objective To explore the effect of transcranial magnetic stimulation in the treatment of schizophrenia.Methods From March 2016 to March 2018, 112 patients with schizophrenia treated in our hospital were selected as the research objects.They were randomly divided into control group and study group by double color sphere method, with 56 patients in each group.Patients in the control group were given drug therapy, and patients in the study group were treated with transcranial magnetic stimulation on the basis of the control group.The clinical efficacy of the two groups after treatment was compared and analyzed.And the cognitive function and mental symptoms before and after treatment were compared between the two groups. Results The total effective rate of clinical treatment in the observation group was 98.21%, which was higher than that in the control group (78.57%), the difference was statistically significant (P＜0.05).Before treatment, there were no significant differences in the scores of positive symptoms, negative symptoms,general psychopathological symptoms and the total score of positive and negative syndrome scale (PANSS) between the two groups (P＞0.05).After treatment, the scores of positive symptoms, negative symptoms, general psychopathological symptoms and the total score of PANSS in the two groups were lower than those before treatment, and the scores of positive symptoms, negative symptoms, general psychopathological symptoms and the total score of PANSS in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).Before treatment, there were no significant differences in invisual spatial working memory (VSWM) and vocabulary fluency(VFT) scores between the two groups (P＞0.05).After treatment, the VSWM and VFT scores of both groups were higher than those before treatment, and the VSWM and VFT scores in the observation group were higher than those in the control group, with statistically significant differences (P＜0.05). Conclusion The effect of transcranial magnetic stimulation on schizophrenia is remarkable, which can obviously improve the mental symptoms and cognitive function of schizophrenia, which is worth popularizing in clinic.

Key words： Schizophrenia Transcranial magnetic stimulation Mental symptoms

基金资助:广东省科技计划项目（20170215）

引用本文:

刘佳；刘亚丽；董鲜苗；王美；赵蕾. 经颅磁刺激治疗精神分裂症患者的效果[J]. 中国当代医药, 2020, 27(15): 63-65转69.
LIU Jia； LIU Ya-li； DONG Xian-miao； WANG Mei； ZHAO Lei. Effect of transcranial magnetic stimulation in the treatment of patients with schizophrenia. 中国当代医药, 2020, 27(15): 63-65转69.

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http://dangdaiyiyao.com/CN/ 或 http://dangdaiyiyao.com/CN/Y2020/V27/I15/63

[1]	陆奕彬，何秀贞，杨茂增，等.低频重复经颅磁刺激与利培酮对首发精神分裂症总有效率、精神分裂症指标变化分析[J].河北医药，2017，39（5）：707-709.
[2]	Mccreadie RG.The Nithsdale Schizophrenia Surveys.Breastfeeding and schizophrenia：preliminary results and hypotheses[J].Brit J Psychiat，2018，170（4）：334-337.
[3]	徐清，程灶火，刘晓伟，等.重复经颅磁刺激对慢性精神分裂症患者认知功能和血清脑源性神经营养因子水平的影响研究[J].中国全科医学，2017，20（25）：3171-3177.
[4]	吴江.超低频经颅磁刺激对精神分裂症阴性症状的影响[J].中国临床心理学杂志，2018，26（1）：89-93.
[5]	Weinstein JJ，Chohan MO，Slifstein M，et al.Pathway-specific dopamine abnormalities in schizophrenia[J].Biol Psychiat，2017，81（1）：31.
[6]	席敏，周翠红，张瑞国，等.重复经颅磁刺激联合利培酮对首发精神分裂症患者海马白质完整性的影响[J].精神医学杂志，2017，30（3）：170-172.
[7]	世界卫生组织.疾病和有关健康问题的国际统计分类（ICD-10）[M].2 版.北京：人民卫生出版社，2008：61-62.
[8]	李启斌，陶领钢，石顺治，等.重复经颅磁刺激与无抽搐电休克联合利培酮治疗流浪难治性精神分裂症患者的临床对照研究[J].现代中西医结合杂志，2018，27（9）：918-921.
[9]	Abraham KR，Kulhara P.The efficacy of electroconvulsive therapy in the treatment of schizophrenia.A comparative study[J].Brit J Psychiat，2018，151（2）：152-155.
[10]	张旻，黄晓琳，张凤霞.重复经颅磁刺激在阿尔茨海默病治疗中的作用[J].内科急危重症杂志，2017，23（3）：177-181.
[11]	蒲丽，向波，梁雪梅，等.低频重复经颅磁刺激与无抽搐电休克治疗精神分裂症患者的疗效及白质完整性分析[J].实用医学杂志，2017，33（19）：3243-3247.
[13]	张琼，蔡军，葛聪聪，等.重复经颅磁刺激在精神分裂症中的临床研究新进展[J].中国康复，2017，32（4）：343-346.
[14]	刘丽华，薛晓斌，陆晓姿，等.高频重复经颅磁刺激对精神分裂症阴性症状的疗效研究[J].精神医学杂志，2017，30（2）：122-124.
[12]	Gage SH，Jones HJ，Burgess S，et al.Assessing causality in associations between cannabis use and schizophrenia risk：a two-sample Mendelian randomization study[J].Psychol Med，2017，47（5）：971-980.
[15]	刘晨亮，王惠玲，杨芳，等.重复经颅磁刺激对慢性精神分裂症患者认知功能影响的初步研究[J].现代生物医学进展，2017，17（22）：4372-4375.