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Quick Search     Adv Search 2023 Vol. 30, No. 21 Published: 2023-07-28   4 The pattern of medication use in the treatment of cough based on data mining of Peaceful Holy Benevolent Prescriptions ZHENG Runchen1 HU Shaozhen2 ZHANG Chuhan3 REN Xi4 Guide::  Objective Explore the characteristics and patterns of medication treating cough in Volume 46 of Peaceful Holy Benevolent Prescriptions,and provide reference for clinical medication for treating cough.Methods All formulas in Volume 46 of Peaceful Holy Benevolent Prescriptions were entered into Excel,and the frequency of individual drugs in the formula was counted.Association rule analysis and system cluster analysis were used to analyze the drug association rules and core drug combinations.Results A total of 150 prescriptions were included,involving 176 drugs.The most frequently used drugs were almonds,liquorice,aster,ginger,mulberry white,Fritillaria cirrhosa,Schisandra chinensis, etc. The most common medicinal pairs were licorice and almonds,licorice and ginger,almonds and aster.The common drug combinations found based on association rules were licorice cinnamon,Schisandra chinensis(94.4% confidence),licorice tangerine peel(22.0% support).Through cluster analysis,two core main formulas were identified,namely Gancao Ganjiang Tang and Xingren Ziwan Wan.Conclusion Based on the frequency of medication and association rules,it can be concluded that Peaceful Holy Benevolent Prescriptions includes medication for treating cough,which mainly focuses on warming the lungs,lowering qi,resolving phlegm,and stopping cough.The medication tends to be sweet and warm.Based on the core prescription obtained from system clustering analysis,Gancao Ganjiang Tang is used as an addition or subtraction for cold cough,and Xingren Ziwan Wan is used as an addition or subtraction for hot cough,providing a reference for the treatment of cough medication ideas. 2023 Vol. 30 (21): 4-07转22 [Abstract] ( 24 ) HTML (1 KB)  PDF (1085 KB)  ( 386 ) 8 Study on serum inflammatory factors and T lymphocyte subsets in Alzheimer's disease by repetitive transcranial magnetic stimulation combined with cognitive training DONG Jingwen DU Yujie WANG Lixin CHEN Xiling Guide::  Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) combined with computerized cognitive training(CCT)on serum inflammatory factors and T lymphocyte subsets in Alzheimer's disease(AD).Methods A total of 76 patients with mild AD who met the inclusion criteria and treated in the Second Affiliated Hospital of Zhengzhou University from October 2020 to May 2022 were selected as the study objects.They were divided into treatment group and control group by random number method,with 38 patients in each group.Patients in the treatment group were treated with rTMS combined with CCT,and patients in the control group were treated with transcranial magnetic pseudo-stimulation combined with CCT.After treatment,the cognitive functions of the two groups were compared by the mini-mental state examination(MMSE)and the Alzheimer's disease assessment scale-cognition(ADAS-COG).The levels of interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),interferon-γ (IFN-γ),killer T cells (TC),helper T cells (TH)and regulatory T cells (Tregs)before and after treatment were compared between the two groups.Results The levels of IL-6 and TNF-α in the treatment group were lower than those in the control group,and the differences were statistically significant(P＜0.05).TH and Tregs levels in the treatment group were higher than those in the control group after treatment,and the differences were statistically significant(P＜0.05).After treatment,the ADAS-COG score of the treatment group was lower than that of the control group,and the MMSE score was higher than that of the control group,with statistical significances (P＜0.05).There were no significant differences in IFN-γ and TC levels between the two groups after treatment (P＞0.05).After treatment,the levels of IL-6 and TNF-α in the treatment group were lower than those before treatment,and the level of IL-6 in the control group was lower than those before treatment,the differences were statistically significant (P＜0.05).After treatment,TH and Tregs levels in the treatment group were higher than those before treatment,and the differences were statistically significant(P＜0.05).After treatment,the ADAS-COG scores of both groups were lower than those before treatment,and the MMSE scores were higher than those before treatment,with statistical significances(P＜0.05).Conclusion rTMS combined with CCT can reduce serum IL-6,TNF-α,increase serum TH,Tregs levels and improve cognitive function in AD patients. 2023 Vol. 30 (21): 8-13 [Abstract] ( 23 ) HTML (1 KB)  PDF (679 KB)  ( 160 ) 14 Effect of Roxadustat with intravenous iron in the treatment of renal anemia of maintenance hemodialysis patients HE Mengxi TANG Jianying MOU Jiao YANG Ying CHEN Yi YANG Lu SONG Xiaoyan Objective To observe the effect of Roxadustat combined with intravenous iron in the treatment of renal anemia of maintenance hemodialysis patients.Methods A total of 81 maintenance hemodialysis patients with renal anemia admitted to University Town Hospital Affiliated Chongqing Medical University Dialysis Center from January 2020 to September 2022 were selected as research objects,and they were divided into control group(41 cases)and observation group(40 cases)according to different treatment methods.The control group was treated with recombinant human erythropoietin combined with intravenous iron and the observation group was treated with Roxadustat combined with intravenous iron.The hematocrit(HCT),red blood cell count(RBC),hemoglobin(Hb),total iron binding capacity(TIBC),serum iron(SI),serum ferritin(SF)and C-reactive protein (CRP)were compared between the two groups.Results After treatment,the HCT,RBC,Hb,TIBC,SI and SF of the two groups were higher than those before treatment,the HCT,RBC,Hb,TIBC,SI and SF of the observation group were higher than those of the control group,and the CRP of the observation group was lower than that before treatment and that of the control group,with significant differences(P＜0.05).Conclusion The treatment of Roxadustat combined with intravenous iron can obviously improve the indicators of anemia in patients with uremia,significantly improve the iron metabolism index,and reduce the inflammatory factors. 2023 Vol. 30 (21): 14-17 [Abstract] ( 28 ) HTML (1 KB)  PDF (612 KB)  ( 230 ) 18 Effect of Periplaneta Americana gel on preventing skin injury caused by radiation therapy QUE Suyun1 YANG Tao2 MA Xuanlei1 CUN Yufang1 HE Jiangtao2 YANG Kun3 Objective To investigate the effect of Periplaneta Americana gel on skin injury caused by radiation therapy.Methods From January 2021 to August 2022,110 patients with head and neck tumors and breast cancer treated by the first course radiotherapy in People's Hospital of Dali Prefecture were selected as the research objects.They were divided into drug group(55 cases)and blank control group(55 cases)by drawing lots.The drug group used Periplaneta Americana gel to smear on the skin in the radiation field,and the blank control group used blank gel to smear on the skin in the radiation field.The incidence of acute radiation dermatitis,the effective rate of acute radiation dermatitis,the degree of pain relief,the curative effect and adverse reactions of chronic radiation dermatitis were observed.Results The incidence of acute radiation dermatitis in the drug group was lower than that in the blank control group,and the difference was statistically significant(P＜0.05).The effective rate of the treatment of acute radiation dermatitis in the drug group was higher than that in the blank control group,and the difference was statistically significant(P＜0.05).The pain score of the drug group was lower than that of the blank control group,and the difference was statistically significant (P＜0.05).The incidence of chronic radiation dermatitis in the drug group was lower than that in the blank control group at 90 days after radiotherapy,and the difference was statistically significant (P＜0.05).Conclusion Periplaneta Americana gel has a good effect on the prevention and treatment of radiation dermatitis,can alleviate the pain of patients,and provide guarantee for the smooth treatment of radiotherapy patients. 2023 Vol. 30 (21): 18-22 [Abstract] ( 22 ) HTML (1 KB)  PDF (670 KB)  ( 190 ) 23 Simultaneous determination of four active ingredients in commercial Moutan Cortex formula granules by high performance liquid chromatography WANG Jin FU Meifang LI Huaiwei Objective To establish a method for simultaneous determination of the content of four active ingredients(gallic acid,catechin,paeoniflorin,paeonol) in Moutan Cortex formula granules,and to determine the content of the four active ingredients in 22 batches of Moutan Cortex formula granules sold in Shandong Province,and to analyze the influence of different extraction processes on the content of active ingredients.Methods Agilent ZORBAX SB-C18 column was used,with acetonitrin-0.2% phosphoric acid solution as the mobile phase,gradient elution,flow rate 1.0 ml/min,detection wave length 230 nm,column temperature: 35℃,injection volume: 10 μl.Results There were good linear relationships of gallic acid,catechin,paeoniflorin and paeonol to peak area in the range of 1.07-107.34 μg/ml (R2=0.999),1.08-108.12 μg/ml(R2=0.998),1.01-101.14 μg/ml(R2=0.999)and 1.04-104.24 μg/ml(R2=0.999),respectively.The average recovery rates were 95.26%,94.66%,95.54%,95.57%,and the RSD were 0.2%,0.5%,0.2%,0.3%,respectively.In 22 batches of commercial samples,the concentrations of gallic acid,catechin,paeoniflorin and paeonol were 6.028-21.996 mg/g,0.032-0.209 mg/g,11.147-26.269 mg/g and 0.215-11.499 mg/g,respectively.Conclusion The content determination method is fast and simple,which can provide a scientific method and basis for standardizing and controlling the quality of Moutan Cortex formula granules. 2023 Vol. 30 (21): 23-27 [Abstract] ( 27 ) HTML (1 KB)  PDF (725 KB)  ( 106 ) 28 Research progress of traditional Chinese medicine rehabilitation treatment after brachial plexus injury LIANG Dan YU Yiqing LIU Xinying XIAO Bin Brachial plexus injury is one of the world's medical treatment challenges,which can cause sensory dysfunction and muscle atrophy in the upper limbs.It has a high prevalence in the young and middle-aged working population,with a complex and diverse range of conditions that can cause great distress and obstacles to patients' lives.In recent years,microsurgery techniques in hand surgery have made great progress,and post-operative neuropathic pain,muscle atrophy and nerve regeneration have become the focus of post-operative rehabilitation therapy,but the efficacy of post-operative rehabilitation therapy is variable and there is still room for further development.Chinese medicine rehabilitation therapy has certain advantages in the treatment of brachial plexus nerve injury and has received increasing attention.Both internal Chinese medicine and non-pharmacological external Chinese medicine treatments such as acupuncture and massage are used in clinical practice to treat post-operative rehabilitation of brachial plexus nerve injuries,which can help eliminate inflammation and oedema,prevent joint contracture,promote nerve regeneration and restore nerve function.The aim of this paper is to summarise the traditional Chinese medicine treatment methods for post-operative brachial plexus nerve injury and to provide reference for comprehensive traditional Chinese medicine rehabilitation after brachial plexus nerve injury. 2023 Vol. 30 (21): 28-33 [Abstract] ( 24 ) HTML (1 KB)  PDF (593 KB)  ( 580 ) 34 Research progress of traditional Chinese medicine in the treatment of sperm DNA integrity structure damage in male infertility ZHENG Xiaoting MA Ling ZHOU Yuliang YAO Wenliang CHEN Shenghui In recent years,with the in-depth study of the pathogenic factors related to male infertility,the male sperm DNA fragmentation index has become one of the new important indicators to evaluate male fertility and predict clinical outcomes.The abnormal integrity of sperm DNA structure directly affects the quality of embryos and clinical outcomes,and in severe cases,it can lead to repeated implantation failure and abortion.The understanding and research of similar male infertility in traditional Chinese medicine have been recorded for a long time,and the identification and treatment of sperm DNA damage with "turbiditism" as the pathogenesis has been increasingly recognized by scholars.It is believed that "turbiditism" has a direct correlation with the damage of sperm DNA integrity structure,and emphasizes that dampness,heat,blood stasis,stagnation and so on are collectively called turbiditism,which can damage the integrity of sperm DNA structure.It is believed that turbidization is not only a pathogenic factor but also a pathological product.It is emphasized that turbidization plays an important role in the repair of sperm DNA structural damage.Based on the literature review and the experience of drug use in reproductive andrology clinic,the author summarizes the treatment of infertility patients with sperm DNA damage with traditional Chinese medicine,and puts forward new ideas for the clinical use of traditional Chinese medicine in the diagnosis and treatment of infertility with sperm DNA damage. 2023 Vol. 30 (21): 34-37转47 [Abstract] ( 28 ) HTML (1 KB)  PDF (898 KB)  ( 268 ) 38 Research status of miRNA-mediated cardiovascular disease mechanisms CHENG Haoran QU Fuzheng ZHANG Juan Over the past few decades,cardiovascular disease due to atherosclerosis has become the single largest cause of death worldwide.At present,the number of overweight and obese people is increasing at a worrying rate,and the risk factors related to cardiovascular diseases such as hypertension,smoking,dyslipidemia,physical inactivity,obesity,diabetes,diet,and population aging and their interactions make cardiovascular diseases a major global problem.miRNAs are extremely conserved star molecules in human evolution,and in recent years of research,miRNAs and their congeners have been shown to be closely associated with leukemia,gastric cancer,cardiovascular disease and many other diseases.Among cardiovascular diseases,chronic heart failure is the terminal stage of a variety of cardiovascular diseases,among which atherosclerosis is the common pathological basis of coronary heart disease and other cardiovascular diseases.As atherosclerosis is a chronic inflammatory disease,the inflammatory response may be regulated by miRNA expression.Therefore,how to prevent and treat cardiovascular diseases from the expression and regulation of genes has become a research hotspot. 2023 Vol. 30 (21): 38-42 [Abstract] ( 23 ) HTML (1 KB)  PDF (556 KB)  ( 297 ) 43 Clinical application of endoscopic band ligation in colon diverticulum hemorrhage WEN Jianjun Objective To explore the therapeutic effect of endoscopic band ligation (EBL) on colon diverticulum hemorrhage.Methods A total of 72 patients with colon diverticulum hemorrhage admitted to the People's Hospital of Ganzhou from January to December 2021 were selected as the study objects.The patients were divided into EBL group(36 cases)and control group (36 cases) by random number table method.The control group received endoscopic metal clip hemostasis treatment,while the EBL group received EBL treatment.The operative index(operation time,intraoperative hemostatic time,length of hospital stay),blood coagulation indicators (activated partial thromboplastin time [APTT],prothrombin time[PT],plasma fibrinogen [FIB])before and 24 h after operation were compared between the two groups.Stress hormones(cortisol[Cor],norepinephrine [NE],adrenocorticotropin [ACTH]),acute phase proteins (C-reactive protein [CRP],α1-antitrypsin[α1-AT],serum amyloid A [SAA]),postoperative adverse events were recorded,the success rate of initial hemostasis,and the rate of late bleeding were followed up 1 year after surgery.Results The operation time,hemostasis time and hospitalization time in EBL group were shorter than those in the control group,with statistical significances(P＜0.05).APTT and PT in EBL group were shorter than those in control group,and FIB level was higher than that in control group,with statistical significances (P＜0.05).The levels of Cor,NE and ACTH in EBL group were lower than those in control group,with statistical significances (P＜0.05).The levels of CRP,α-1-AT and SAA in EBL group were lower than those in control group,with statistical significances (P＜0.05).There was no statistical significant difference in the incidence of adverse events between the two groups(P＞0.05).The successful rate of first hemostasis in EBL group was higher than that in the control group,and the late bleeding rate was lower than that in the control group,with statistical significances(P＜0.05).Conclusion EBL can effectively shorten the hemostasis time,operation time and hospital stay,improve the blood coagulation function and the expression of stress hormone,and has a good therapeutic effect on colon diverticulum hemorrhage. 2023 Vol. 30 (21): 43-47 [Abstract] ( 22 ) HTML (1 KB)  PDF (548 KB)  ( 76 ) 48 Effect of Zhibai Dihuang Decoction combined with western medicine on blood glucose level and insulin resistance in patients with type 2 diabetes mellitus LI Juanjuan FENG Suyun Objective To explore the effect of Zhibai Dihuang Decoction combined with western medicine on blood glucose level and insulin resistance in patients with type 2 diabetes mellitus.Methods A total of 62 patients with Yin-deficiency and fire-abundance type 2 diabetes mellitus admitted to Rushan Hospital of Traditional Chinese Medicine from June 2021 to June 2022 were selected as the study objects,and were divided into observation group (31 cases)and control group(31 cases)according to random number table method.The control group was treated with Metformin+Glimepiride Tablets,and the observation group was treated with Zhibai Dihuang Decoction on the basis of the control group.The clinical efficacy,blood glucose level,fasting islet level,insulin resistance index,traditional Chinese medicine syndrome score and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of observation group after treatment was higher than that of control group,the difference was statistically significant (P＜0.05).After treatment,the blood glucose level,fasting insulin level and insulin resistance index of observation group were lower than those of control group,and the differences were statistically significant (P＜0.05).The traditional Chinese medicine syndrome score of the observation group after treatment was lower than that of the control group,and the difference was statistically significant(P＜0.05).There were no obvious adverse reactions during treatment in both groups.Conclusion Zhibai Dihuang Decoction combined with western medicine in the treatment of type 2 diabetes mellitus is beneficial to improve the therapeutic effect,reduce the level of blood sugar and fasting insulin,improve insulin resistance index and clinical symptoms,and is worthy of further promotion and application. 2023 Vol. 30 (21): 48-51 [Abstract] ( 25 ) HTML (1 KB)  PDF (503 KB)  ( 31 ) 52 Influencing factors of intracranial hemorrhage induced by intravenous Alteplase thrombolytic therapy in patients with acute cerebral infarction YUAN Qihong1 XIN Yue2 LIU Yue1 ZHANG Chunmei1 Objective To investigate the influential factors of intracranial hemorrhage (ICH) induced by Alteplase intravenous thrombolytic therapy in patients with acute cerebral infarction.Methods A retrospective analysis was performed on 44 cases of acute cerebral infarction treated with intravenous thrombolysis in the First Affiliated Hospital of Qiqihar Medical College from January 2021 to November 2022.Relevant clinical data of patients were collected.According to the presence or absence of ICH after intravenous thrombolytic therapy with Alteplase,patients were divided into ICH group and ICH free group,and the influencing factors of ICH after thrombolytic therapy were analyzed.Results Among the 44 patients,14 had ICH after intravenous thrombolytic therapy with Alteplase (31.8%).Gender,age,smoking,alcohol consumption,diabetes,past antithrombotic drugs,onset-to-needle time (ONT),TOAST classification,National Institutes of Health stroke scale (NIHSS) score before thrombolysis,baseline blood glucose level,incidence of elevated low-density lipoprotein cholesterol,and incidence of hyperhomocysteine were compared between patients in the ICH and non-ICH groups,and there were no statistical significances (P＞0.05).There were significant differences in the incidence of hypertension and previous ischemic stroke between the two groups (P＜0.05).Multivariate logistic regression analysis showed that age,ONT and history of ischemic stroke were independent influencing factors for ICH after Alteplase thrombolysis (P ＜0.05).Conclusion The use of Alteplase in acute cerebral infarction patients with ICH is related to age,hypertension,ONT,ischemic stroke history and many factors,clinical attention should be paid to patients with these risk factors,timely intervention. 2023 Vol. 30 (21): 52-56 [Abstract] ( 21 ) HTML (1 KB)  PDF (509 KB)  ( 237 ) 57 Clinical characteristics of hospitalized children with influenza A and B in Affiliated Suqian Hospital of Xuzhou Medical University WANG Jinna WANG Xu CHEN Hongdou Objective To analyze the epidemiological characteristics,clinical characteristics and the efficacy of Peramivir in hospitalized children with influenza A and B at the Affiliated Suqian Hospital of Xuzhou Medical University.Methods A total of 260 hospitalized children with influenza admitted to Affiliated Suqian Hospital of Xuzhou Medical University from January 2019 to August 2022 were retrospectively selected as the study objects,and were divided into influenza A group(130 cases)and influenza B group (130 cases)according to the results of influenza nucleic acid detection.All children were treated with intravenous Peramivir.The epidemiological characteristics of influenza A and influenza B in the two groups were analyzed,and the clinical symptoms,influenza complications,hematological indexes and clinical efficacy of Peramivir in the two groups were compared.Results Influenza B generally prevailed from November to March of the following year,influenza A mostly prevailed from November to January of the following year.However,the influenza A of 2022 outbroken in July.The proportion of fever and convulsions in influenza A group were higher than those in influenza B group,and the differences were statistically significant(P＜0.05).While the proportion of vomiting in influenza B group was higher than that in influenza A group,and the differences were statistically significant (P＜0.05).The proportion of neutropenia,febrile convulsion and leukopenia in influenza A group was higher than that in influenza B group,and the differences were statistically significant (P＜0.05).The proportion of pneumonia and viral encephalitis in influenza B group was higher than that in influenza A group,and the difference was statistically significant(P＜0.05).The lymphocyte percentage in influenza A group was lower than that in influenza B group,and the difference was statistically significant (P＜0.05).The time of fever symptom relief in influenza A group was shorter than that in influenza B group,and the difference was statistically significant (P＜0.05).The hospital stay of children with influenza B was longer than that of children with influenza A,and the difference was statistically significant (P＜0.001).Conclusion Children with influenza A were prone to fever and convulsions,and children with influenza B were more likely to vomit.The more frequent complications of influenza A were neutropenia,febrile convulsion and leucopenia.The more frequent complications of influenza B were pneumonia and viral encephalitis.The lymphocyte percentage in children with influenza A was lower than that in children with influenza B.The fever symptoms remission time and hospitalization time of children with influenza A treated with Peramivir were significantly shorter than those of children with influenza B. 2023 Vol. 30 (21): 57-62 [Abstract] ( 23 ) HTML (1 KB)  PDF (638 KB)  ( 102 ) 63 Study on the occurrence and risk factors of ventricular premature beats in the third trimester of pregnancy and its influence on the maternal and infant outcome YANG Wensi Objective To investigate the occurrence and risk factors of ventricular premature beats (VPB) in the third trimester of pregnancy and its influence on the maternal and infant outcomes.Methods Eighty pregnant women who underwent pregnancy examination in Xinyu Maternal and Child Health Hospital from October 2019 to October 2022 were selected as the study subjects.All of them underwent 12 lead ECG examination.They were divided into normal pregnancy group and combined with VPB group according to whether they were accompanied with VPB.Basic data such as age,body weight,delivery status,education level,hyperlipidemia,gestational hypertension,gestational diabetes,combined with primary heart disease,anxiety and depression were collected in the two groups.Univariate analysis was carried out first,and logistic regression analysis was performed for items with statistical differences to obtain independent risk factors affecting the occurrence of VPB in the third trimester.The outcomes of the two groups were compared.Results A total of 28 cases of premature ventricular beat were detected in 80 pregnant women in the third trimester,the incidence was 35.00% (28/80).The results of univariate analysis showed that there were statistically significant differences in age,body weight,hyperlipidemia,gestational hypertension,gestational diabetes,combined primary heart disease,anxiety and depression between the two groups(P＜0.05).Multivariate logistic analysis showed that age≥35 years old(β=2.920,OR=18.545,95%CI:5.203-66.107),body weight≥75 kg (β=1.310, OR=3.706,95%CI: 1.410-9.738),hyperlipidemia (β=1.870, OR=6.491,95%CI:2.329-18.092),gestational hypertension (β=1.852,OR=6.370,95%CI:2.257-17.978),gestational diabetes mellitus(β=1.848,OR=6.346,95%CI: 2.203-18.278),combined with primary heart disease (β=2.197,OR=9.000,95%CI:2.540-31.893),anxiety (β=1.746,OR=5.730,95%CI: 2.103-15.611),depression (β=1.819,OR=6.167,95%CI:2.233-17.032)were the high risk factors for the occurrence of VPB in the third trimester of pregnancy (P＜0.05).The total incidence of adverse maternal and infant outcomes in the group with VPB was higher than that in the normal pregnancy group,and the difference was statistically significant (P＜0.05).Conclusion The incidence of VPB in the third trimester of pregnancy is relatively high,which is closely related to age≥35 years,body mass ≥75 kg,hyperlipidemia,pregnancy induced hypertension,pregnancy induced diabetes,primary heart disease,anxiety,depression.VPB can increase the risk of adverse maternal and infant outcomes,and targeted prevention and treatment should be carried out as soon as possible. 2023 Vol. 30 (21): 63-66 [Abstract] ( 24 ) HTML (1 KB)  PDF (569 KB)  ( 38 ) 67 Effect of Ergometrine Maleate combined with Oxytocin on postpartum hemorrhage stress response YAO Xiaying CHEN Jing XU Fang Objective To explore the effect of Ergometrine Maleate combined with Oxytocin on the control of postpartum hemorrhage stress response.Methods A total of 84 parturients admitted to the Department of Obstetrics of First People's Hospital of Fuzhou from February 2020 to February 2022 were selected as the study objects and divided into study group and control group according to random number table method,with 42 cases in each group.The control group was treated with gluteal muscle injection of Oxytocin,and the study group was combined with Ergometrine Maleate on the basis of the control group.The postpartum blood loss at 1,2 and 24 h,the mean prenatal and postpartum arterial blood pressure,the levels of lipid peroxide (LPO),C-reactive protein (CRP),tumor necrosis factor-α (TNF-α),D-dimer and adverse reactions were compared between the two groups.Results The amount of postpartum blood loss in both groups was gradually reduced,and the amount of postpartum blood loss at 2 and 24 h were lower than that at 1 h,with statistical significances(P＜0.05).The postpartum blood loss at 1,2 and 24 h in the study group were lower than those in the control group,and the differences was statistically significant (P＜0.05).The mean arterial pressure at 1 h postpartum in the study group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The levels of LPO,CRP,TNF-α and D-dimer in the study group postpartum were lower than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of complications between the two groups (P＞0.05).Conclusion Ergometrine Maleate combined with Oxytocin can effectively reduce postpartum blood loss,reduce oxidative stress and inflammatory response,and play a positive role in maintaining postpartum blood pressure stability,and drug safety is good,worthy of promotion and application. 2023 Vol. 30 (21): 67-70 [Abstract] ( 25 ) HTML (1 KB)  PDF (571 KB)  ( 61 ) 71 Observation on the effect of Cyclophosphamide combined with Rituximab in the treatment of refractory nephrotic syndrome in children XIA Wei Objective To investigate the clinical effect of Cyclophosphamide combined with Rituximab in the treatment of refractory nephrotic syndrome in children.Methods A total of 98 children with refractory nephrotic syndrome who were treated in the Affiliated BenQ Hospital of Nanjing Medical University from July 2019 to July 2021 were selected as the research objects.They were divided into control group (n=49) and combination group (n=49) by random number table method.The control group was treated with glucocorticoid+Tacrolimus+Cyclophosphamide,while the combination group were treated with Rituximab on the basis of the control group.After treatment,the clinical efficacy of the two groups was evaluated,the renal function and immune function of the two groups were compared before treatment and 1 month after treatment,and the adverse reactions of the two groups were compared.Results The total effective rate of the combination group was 95.92%,which was higher than 81.63%of the control group,and the difference was statistically significant (P＜0.05).After 1 month of treatment,the levels of serum creatinine (SCr),blood urea nitrogen (BUN),urinary protein and β2-microglobulin (β2-MC)in the two groups were lower than those before treatment,and the differences were statistically significant (P＜0.05).After 1 month of treatment,the levels of SCr,BUN,urine protein and β2-MC in the combination group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The levels of CD20+B in the two groups after 1 month of treatment were lower than those before treatment,and the difference was statistically significant (P＜0.05),and the level of CD20+B in the combination group after 1 month of treatment was lower than that in the control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞0.05).Conclusion Clinical application of Cyclophosphamide combined with Rituximab in the treatment of children with refractory nephrotic syndrome can obtain better clinical efficacy,can effectively improve the level of renal function and immune function of children,and is helpful to the prognosis of children,without significantly increasing adverse reactions,which has clinical reference value. 2023 Vol. 30 (21): 71-75 [Abstract] ( 26 ) HTML (1 KB)  PDF (609 KB)  ( 89 ) 76 Effect of balancing culture media with different oxygen concentrations on the clinical outcomes of assisted reproduction LIN Yunhong CHEN Qingfen CHEN Gangxin HUANG Zhiqing WEI Huijuan Objective This study aims to investigate the impact of different oxygen concentrations on the clinical outcomes of assisted reproduction by balancing culture media.Methods Patients' data on assisted reproduction in the Center of Reproductive Medicine of Fujian Maternity and Child Health Hospital from March 2020 to September 2021 was retrospectively analyzed,with a total of 401 egg retrieval cycles meeting the inclusion criteria.They were divided into atmospheric oxygen balance group and 5% oxygen balance group based on the use of different oxygen concentration incubators.Among them,the atmospheric oxygen balance group had 201 cycles and the 5%oxygen balance group had 200 cycles.The in vitro embryonic development and clinical outcomes of patients of the two groups were compared and analyzed.Results There was no statistically significant difference in baseline data between the two groups of patients (P＞0.05).The normal fertilization rate and high-quality blastocyst formation rate of the atmospheric oxygen balance group were higher than those of the 5%oxygen balance group,and the differences were statistically significant(P＜0.05).There were no statistically significant differences between the two groups of patients in terms of multiple fertilization rate,D3 high-quality embryo rate,blastocyst formation rate,clinical pregnancy rate,implantation rate,abortion rate,neonatal pregnancy time,neonatal birth weight and neonatal birth length (P＞0.05).Conclusion During the routine cycles of in vitro fertilization and embryo transfer,using a regular incubator with atmospheric oxygen concentration to balance the culture medium may be beneficial for normal fertilization and high-quality blastocyst formation in patients. 2023 Vol. 30 (21): 76-79 [Abstract] ( 23 ) HTML (1 KB)  PDF (605 KB)  ( 39 ) 80 Effect of Levetiracetam combined with Oxcarbazepine in the treatment of children with epilepsy LIU Nan XIE Huiyuan LI Jian ZHU Jianping Objective To explore the effect of Levetiracetam combined with Oxcarbazepine in the treatment of children with epilepsy.Methods From August 2020 to July 2022,92 children with epilepsy admitted to the Department of Pediatrics of Boai Hospital Of Zhongshan were selected as the study subjects.They were divided into the control group(46 cases)and the study group (46 cases) according to random number table method.The therapeutic effect of EEG and immune function(immunoglobulin [Ig]: IgA,IgM,IgG,T lymphocyte subgroup: CD3+,CD4+) cognitive function (full intelligence quotient[FIQ],performance intelligence quotient [PIQ],verpal intelligence quotient [VIQ]),and adverse reactions of the two groups were compared.Results The total effective rate of EEG treatment in the study group was higher than that in the control group,the difference was statistically significant (P ＜0.05).Before treatment,there were no statistically significant differences in the levels of IgA,IgM,IgG,CD3+and CD4+between the two groups (P＞0.05).After treatment,the levels of IgA,IgM and IgG in the two groups were lower than those before treatment,and the levels of CD3+and CD4+were higher than those before treatment,the levels of IgA,IgM and IgG in the study group were lower than those in the control group,and the levels of CD3+and CD4+were higher than those in the control group,with statistically significant differences (P＜0.05).Before treatment,the scores of total intelligence quotient (FIQ),operational intelligence quotient (PIQ),computational language intelligence quotient(VIQ)in the two groups were not significantly different(P＞0.05).After treatment,the scores of FIQ,PIQ and VIQ in the two groups were higher than those before treatment,and the scores of FIQ,PIQ and VIQ in the study group were higher than those in the control group,with statistically significant differences (P＜0.05).After treatment,there was no statistically significant difference in total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Levetiracetam combined with Oxcarbazepine can effectively improve the epileptiform discharge of electroencephalogram in children with epilepsy,help regulate the immune function of children,reduce the damage to cognitive function of children,and is safe and reliable. 2023 Vol. 30 (21): 80-83 [Abstract] ( 24 ) HTML (1 KB)  PDF (570 KB)  ( 25 ) 84 Rapid sedative effect of Remimazolam Besylate in patients undergoing nerve block anesthesia YAN Miao LUO Xiaochun HUANG Jiancheng Objective To investigate the rapid sedative effect of Remimazolam Besylate in patients undergoing nerve block anesthesia.Methods From January to September 2022,a total of 60 patients undergoing nerve block anesthesia in Xiang'an Hospital of Xiamen University were selected as the research objects.According to the random number table method,they were divided into control group (30 cases)and comfort group (30 cases).The control group was sedation with Midazolam combined with Dexmedetomidine,and the comfort group was sedation with Propofol combined with Remimazolam Besylate.The pain of the two groups before operation and 12,24 h after operation were compared.The onset time and maintenance time of sensory and motor block,and recovery time were compared between the two groups.The heart rate,systolic blood pressure and diastolic blood pressure were compared between the two groups before anesthesia (T0),10 min after administration (T1),30 min after administration (T2),and immediately after the end of operation (T3).The incidence of perioperative adverse reactions in the two groups was recorded.Results There was no statistically significant difference in the mechanical pain threshold between the two groups before operation(P＞0.05).The mechanical pain thresholds of the two groups at 12 and 24 hours after operation were higher than those before operation,and those of the comfort group were higher than those of the control group,and the differences were statistically significant (P＜0.05).The onset time of sensory and motor block in the comfort group were shorter than those in the control group,and the maintenance time of sensory and motor block in the comfort group were longer than those in the control group,while the recovery time was shorter than that in the control group,and the differences were statistically significant(P＜0.05).There were no significant differences in heart rate,systolic blood pressure and diastolic blood pressure at T0 between the two groups (P＞0.05).At T1,T2 and T3,the heart rate of the comfort group were lower than those of the control group,and the systolic blood pressure and diastolic blood pressure were higher than those of the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Remimazolam Besylate has the advantages of rapid sedation,little effect on hemodynamics,and can reduce the intensity of postoperative pain in patients with nerve block anesthesia,and has high safety,which is worthy of application and promotion. 2023 Vol. 30 (21): 84-87转92 [Abstract] ( 29 ) HTML (1 KB)  PDF (754 KB)  ( 146 ) 88 Comparison of the effect of ultrasound-guided lumbosacral plexus block and spinal anesthesia in elderly patients undergoing total knee arthroplasty WANG Xi1 CHEN Jun1▲ LI Hua1 CHANG Yuchun1 ZHANG Li1 ZHOU Shibo2 Objective To compare the effect of ultrasound-guided lumbosacral plexus block and spinal anesthesia in elderly patients undergoing total knee arthroplasty.Methods A total of 76 patients who underwent total knee arthroplasty in the First People's Hospital of Zhaotong from September 2020 to March 2022 were selected as the research objects.According to the random number table method,they were divided into lumbosacral plexus block(LSPB)group(38 cases)and spinal anesthesia(SA)group(38 cases).The LSPB group was treated with ultrasound-guided lumbosacral plexus block,and the SA group was treated with spinal anesthesia.The mean arterial pressure(MAP)at admission(T1),5 min after anesthesia(T2),15 min after anesthesia (T3),skin incision (T4) and 60 min after skin incision (T5) were compared between the two groups.The duration of anesthesia,operation time,intraoperative blood loss and infusion volume were compared between the two groups.The visual analogue scale (VAS)scores of pain at 4,8,12 and 24 h after operation were compared between the two groups.The intraoperative consumption of Sufentanil,Ephedrine and Norepinephrine were compared between the two groups.The incidences of urinary retention,headache,nausea and vomiting at 72 h after operation were compared between the two groups.Results The MAP of LSPB group at T2,T3,T4 and T5 were higher than those of SA group,and the differences were statistically significant (P＜0.05).The VAS scores at 4,8,12 and 24 h after operation in LSPB group were lower than those in SA group,and the differences were statistically significant (P＜0.05).There were no significant differences in operation time and intraoperative blood loss between the two groups(P＞0.05).The duration of anesthesia in the LSPB group was longer than that in the SA group,and the infusion volume was less than that in the SA group,and the differences were statistically significant (P＜0.05).The intraoperative use of Ephedrine,Norepinephrine and infusion volume in LSPB group were lower than those in SA group,and the differences were statistically significant (P＜0.05).The incidence of headache,nausea and vomiting and urinary retention in the LSPB group were lower than those in the SA group 72 h after operation,with statistically significant differences (P＜0.05).There was no significant difference in the dosage of Sufentanil between the two groups (P＞0.05).Conclusion Ultrasound-guided lumbosacral plexus block has a good anesthetic effect in elderly patients undergoing total knee arthroplasty,with less influence on intraoperative blood pressure,better postoperative analgesia and fewer postoperative complications. 2023 Vol. 30 (21): 88-92 [Abstract] ( 26 ) HTML (1 KB)  PDF (452 KB)  ( 192 ) 93 The value of multi-slice spiral CT combined with procalcitonin and pressure (central venous-arterial) carbon dioxide in early assessment of acute pancreatitis severity SU Hongbing ZHOU Xinghui Objective To explore the value of multi-slice spiral CT (MSCT) combined with procalcitonin (PCT) and pressure (central venous-arterial) carbon dioxide (P[cv-a] CO2) in early assessment of acute pancreatitis (AP) severity.Methods A total of 129 AP patients admitted to Fengcheng People's Hospital from August 2019 to August 2021 were selected as the study subjects,all patients were confirmed through pathological examination,among them 62 cases of severe acute pancreatitis (SAP)were included in the SAP group,67 cases of mild acute pancreatitis (MAP)were included in the MAP group,at the same time,116 healthy individuals who underwent physical examinations at Fengcheng People's Hospital were selected as the control group.All subjects underwent MSCT,PCT and P(cv-a) CO2 testing.The levels of PCT and P(cv-a) CO2 in three groups were compared.Pathological examination was used as the diagnostic gold standard,the diagnostic efficacy of MSCT,PCT,P(cv-a)CO2 detection alone and combined detection in AP were analyzed.Results The levels of PCT and P(cv-a)CO2 in the SAP group were higher than those in the MAP group and control group,the levels of PCT and P(cv-a) CO2 in the MAP group were higher than those in the control group,the differences were statistically significant (P＜0.05).The sensitivity and accuracy of the combined detection of MSCT,PCT,and P(cv-a) CO2 were all higher than those of the three indicators tested separately,the differences were statistically significant(P＜0.05).Conclusion MSCT combined with PCT and P(cv-a) CO2 can effectively evaluate the severity of AP patients and has high application value for early diagnosis of AP.It can be widely used in clinical practice. 2023 Vol. 30 (21): 93-96 [Abstract] ( 28 ) HTML (1 KB)  PDF (497 KB)  ( 29 ) 97 Clinical application of multi-slice spiral CT three-dimensional reconstruction in the preoperative evaluation of total hip replacement for adult Crowe Ⅲhip dysplasia CUI Xiaorong1 SUN Xiaobo2 ZHU Xiaoming2 LI Xiangyang1 LI Shiliang2 ZHONG Liangyu2 LIU bangyu1 MING Changsheng1 Objective To explore the clinical value of multi-slice spiral CT three-dimensional reconstruction in the preoperative total hip replacement for adult Crowe Ⅲhip dysplasia.Methods A total of 40 patients(40 hips)with Crowe Ⅲhip dysplasia admitted to the Fourth Department of Orthopaedics,Ganzhou Hospital of Traditional Chinese Medicine from September 2021 to December 2022 were selected as the study subjects,they were divided into the experimental group and the control group according to the computer generated random number method,with 20 cases in each group.The experimental group used multi-slice spiral CT three-dimensional reconstruction method preoperative,the control group underwent digital radiography (DR) anteroposterior and lateral photography preoperative.The detection of preoperative lesions,determination of true acetabulum,compliance of prostheses,surgical time,intraoperative bleeding and changes in length of both lower limbs preoperative and postoperative were compared between the two groups of patients.Results The detection rate of femoral head necrosis and joint capsule hydrops,the determination rate of true socket and the anastomosis rate of prosthesis in the experimental group were higher than those in the control group,the differences were statistically significant (P＜0.05).The surgical time of the experimental group patients was shorter than that of the control group,the intraoperative blood output was less than that of the control group,the differences were statistically significant (P＜0.05).There was no statistically significant difference in the length of the lower limbs between the two groups of patients preoperative (P ＞0.05).Postoperative,the difference in length between the two groups of patients' lower limbs was smaller than that preoperative,the difference in length of both lower limbs in the experimental group was smaller than that in the control group,the differences were statistically significant(P＜0.05).Conclusion The preoperative multi-slice spiral CT three-dimensional reconstruction can fully evaluate the preoperative aseptic necrosis of the femoral head and the joint cavity effusion,can reconstruct three-dimensional images to improve the determination rate of the true acetabulum,which provides sufficient basis for the preoperative formulation of acetabular reconstruction methods,reasonable selection of the size and model of the prosthesis,has important clinical significance in shortening the operation time,reducing intraoperative bleeding and reducing the length difference between the lower limbs postoperative. 2023 Vol. 30 (21): 97-100 [Abstract] ( 23 ) HTML (1 KB)  PDF (498 KB)  ( 32 ) 101 Clinical value of transperineal pelvic floor ultrasound in the diagnosis of outlet obstructive constipation DAI Yujuan Objective To explore the value of transperineal pelvic floor ultrasound in the diagnosis of outlet obstructive constipation.Methods A total of 80 patients with constipation who visited the Zhongshan City People's Hospital in Guangdong Province from March 2022 to December 2022 were selected as the study subjects,all subjects underwent transperineal pelvic floor ultrasound diagnosis and X-ray defecography examination.The results of X-ray defecography were taken as the gold standard,the accuracy,sensitivity,specificity,positive predictive value and negative predictive value of transperineal pelvic floor ultrasound diagnosis were calculated.The accuracy of diagnosing for different conditions and patient satisfaction using of two diagnostic methods were compared.Results X-ray defecography showed positive results in 69 cases and negative results in 11 cases.Ultrasound diagnosis of the transperineal pelvic floor showed positive results in 71 cases and negative results in 9 cases.The results of X-ray defecography were taken as the gold standard,the consistency of transperineal pelvic floor ultrasound diagnosis was shown to be Kappa=0.951, P ＜0.001,indicated a high degree of consistency.The results of X-ray defecography were taken as the gold standard,the sensitivity of transperineal pelvic floor ultrasound diagnosis was 94.20% (65/69),specificity was 45.45% (5/11),negative predictive value was 55.56% (5/9),positive predictive value was 91.55% (65/71) and accuracy was 87.50% (70/80).There was no statistically significant difference in the diagnostic accuracy of two inspection methods for different conditions (P＞0.05).The satisfaction level of patients with X-ray defecography diagnosis was lower than that with transperineal pelvic floor ultrasound diagnosis,the difference was statistically significant (P ＜0.05).Conclusion In the diagnosis of outlet obstructive constipation,the diagnostic results of X-ray defecography are used as the gold standard.The sensitivity and consistency of the results of transperineal pelvic floor ultrasound diagnosis are high,the pelvic tissue can be clearly observed,patients' satisfaction is high,in clinical diagnosis,appropriate methods or joint diagnosis should be selected based on the patient's condition to improve diagnostic efficiency. 2023 Vol. 30 (21): 101-104 [Abstract] ( 25 ) HTML (1 KB)  PDF (486 KB)  ( 58 ) 105 Analysis of influencing factors of chronic hepatitis B combined with depression LIN Wenqing1 XIE Weining2 Objective To investigate the influencing factors of chronic hepatitis B combined with depression.Methods A population of chronic hepatitis B patients who admitted to the Department of Infectious Disease of Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to January 2023 were selected as the research subjects.By using a questionnaire survey,general information such as age,gender,weight,marital status,smoking and drinking history,education status,as well as traditional Chinese medicine constitution analysis,traditional Chinese medicine syndrome analysis and depression score were collected.Use logistic regression to analyze the influencing factors of chronic hepatitis B complicated with depression.Results A total of 365 patients were ultimately included in the study,including 96 patients with depression and 299 patients without depression.The results of univariate analysis showed that there were statistically significant differences in the comparison of depression among different types of traditional Chinese medicine constitution,traditional Chinese medicine syndrome differentiation and family history of depression(P＜0.05).The results of multivariate logistic regression analysis showed that Qi stagnation(OR=5.579,95%CI:2.063-15.087),blood stasis(OR=5.590,95%CI: 2.09-15.553),liver depression and spleen deficiency (OR=4.875,95%CI: 1.696-14.013),liver depression and phlegm obstruction (OR=6.515,95%CI:2.343-18.119),liver stagnation and Qi stagnation (OR=4.282,95%CI: 1.555-11.791)and family history of depression(OR=18.847,95%CI:5.416-65.584)were independent risk factors for chronic hepatitis B complicated with depression (P＜0.05).Conclusion Family history of depression,Qi stagnation,blood stasis,liver stagnation and spleen deficiency,liver stagnation and phlegm obstruction,liver stagnation and Qi stagnation are independent risk factors for chronic hepatitis B complicated with depression.It is necessary to pay attention to these high-risk factors in clinical practice and provide certain reference value for clinical intervention. 2023 Vol. 30 (21): 105-109 [Abstract] ( 24 ) HTML (1 KB)  PDF (531 KB)  ( 55 ) 110 Application value of seed-embedding at otopoints with the seed of cowherb combined with thunder-fire moxibustion after laparoscopic hysteromyomectomy WANG Chunhui WANG Haihua▲ ZHU Qian Objective To analyze the application value of seed-embedding at otopoints with the seed of cowherb combined withthunder-fire moxibustion in laparoscopic hysteromyomectomy.Methods A total of 62 patients who underwent laparoscopic hysteromyomectomy in Leping Hospital of Traditional Chinese Medicine from January to July 2022 were selected as the research objects,and they were divided into control group and observation group according to random number table method,with 31 patients in each group.Patients in the control group received routine intervention measures after surgery,and patients in the observation group were given seed-embedding at otopoints with the seed of cowherb combined with thunder-fire moxibustion on the basis of routine intervention after surgery.The psychological stress state,gastrointestinal function recovery and incidence of urinary retention were compared between the two groups.Results The observation group had lower self-rating anxiety scale (SAS) score and self-rating depression scale (SDS) score than those of the control group,the postoperative recovery time of peristalsis and anal exhaust time were shorter than those of the control group,the number of bowel sounds per minute was higher than that of the control group,and the incidence of urinary retention was lower than that of the control group,the differences were statistically significant(P＜0.05).Conclusion After laparoscopic hysteromyomectomy,seed-embedding at otopoints with the seed of cowherb combined with thunder-fire moxibustion can effectively relieve psychological stress state,promote rapid recovery of gastrointestinal function and reduce the occurrence of urinary retention,which has reliable clinical value. 2023 Vol. 30 (21): 110-113 [Abstract] ( 27 ) HTML (1 KB)  PDF (528 KB)  ( 91 ) 114 Application effect of self-made Changpu Yizhi Decoction combined with embedding needle therapy on the treatment of mild cognitive impairment after stroke LI Dingding SONG Weiwei Objective To explore the clinical effect of self-made Changpu Yizhi Decoction combined with embedding needle therapy in the treatment of mild cognitive impairment (MCI)after stroke.Methods A total of 80 patients with MCI after stroke treated in Rushan Traditional Chinese Medicine Hospital from January 2020 to September 2022 were selected as the study subjects,and they were divided into control group (40 cases)and observation group (40 cases)according to the random number table method.The patients in the control group were treated with Adibenzoquinone Tablets+conventional medicine,while the patients in the observation group were treated with Adibenzoquinone Tablets+conventional medicine+self-made Changpu Yizhi Decoction combined with embedding needle therapy.The clinical efficacy,traditional Chinese medicine syndrome score,cognitive function,quality of life and adverse reactions of the two groups were compared.Results The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).There were no statistically significant differences between the two groups before treatment in the traditional Chinese medicine syndromes scores,mini-mental state examination (MMSE)and stroke impact scale(SIS)scores (P＞0.05).After treatment,the scores and total scores of traditional Chinese medicine syndrome in the two groups were lower than those before treatment,and the scores and total scores of traditional Chinese medicine syndrome in the observation group were lower than those in the control group,and the scores of MMSE and SIS in the two groups were higher than those before treatment,and the scores of MMSE and SIS in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were no obvious adverse reactions in the two groups.Conclusion The treatment of MCI after stroke patients with self-made Changpu Yizhi Decoction combined with embedding needle therapy can improve cognitive function,relieve clinical symptoms,and improve the quality of life of patients,with significant effect and good safety,which is worthy of promotion. 2023 Vol. 30 (21): 114-117 [Abstract] ( 25 ) HTML (1 KB)  PDF (498 KB)  ( 119 ) 118 Analysis on the correlation between the innovation quality of single enrollment and career construction behavior in higher vocational medical colleges TIAN Meng Objective To explore the correlation between innovation literacy and career construction behavior of single enrollment in higher vocational medical colleges.Methods From June to September 2022,128 students from Heze Medical College were investigated by questionnaire.Results The total score of career construction behavior of single enrollment in higher vocational medical colleges was(4.11±0.75)point,and the total score of innovation literacy was(3.84±0.62)point.Pearson correlation analysis showed that the innovation literacy of single enrollment in higher vocational medical colleges was correlated with career construction behavior and its dimensions,and the differences were statistically significant (P＜0.05).Conclusion Higher vocational medical colleges should improve students' innovation literacy through multi-channel measures such as improving students' information literacy,strengthening students' innovation literacy throughout the teaching process,and improving the construction of career courses,so as to promote students to better carry out career construction,so as to enhance the employment competitiveness of medical single enrollment. 2023 Vol. 30 (21): 118-120转125 [Abstract] ( 26 ) HTML (1 KB)  PDF (863 KB)  ( 47 ) 121 Therapeutic compliance,self-efficacy and health education strategies in hypertensive patients CAI Xiaohong1 LIU Chunyan2 LIU Xiaomei1 Objective To investigate the treatment compliance and self-efficacy level of middle-aged and elderly patients with hypertension in Suzhou.Methods The therapeutic compliance and self-efficacy of hypertension patients in Xuefu community of Suzhou were investigated.Results There were 62 males and 57 females in 119 patients with hypertension.The mean age was(66.88±7.43)years old(range 45-92 years old).The 119 patients with hypertension had high compliance of 68.9% and low compliance of 31.1%.The total average score of the therapeutic compliance scale was (97.45±10.17).A total of 119 hypertensive patients had the following problems of medication and non-medication adherence: ①Poor medication behavior accounted for 26.9%-37.0%.②Poor compliance accounted for 17.6%-38.7%.③86.6%-89.1% of them had bad eating habits.④The proportion of poor living habits and behaviors was 74.8%-82.4%.⑤43.7%and 46.2%of the subjects did not follow the advice of alcohol limit and smoking cessation.⑥The poor ability of psychological adjustment and stress relief accounted for 79.8%-89.1%.⑦The proportion of patients with poor medication behavior was relatively low,while the proportion of patients with non-medication compliance was relatively high.The score rate of self-efficacy of 119 hypertensive patients was 82.9%and 53.78%of them had good self-efficacy.The overall level of self-efficacy was not high,and some patients had insufficient confidence in adhering to healthy living habits and behaviors,compliance with medication and self-regulation of blood pressure.Conclusion The treatment compliance of middle-aged and elderly patients with hypertension in Suzhou community is slightly higher than that in domestic research,but there is still the problem of non-compliance.The proportion of non-drug treatment compliance is higher than that of poor medication behavior.The level of self-efficacy is generally not high,and some patients are lack of confidence in the self-efficacy issues such as adherence to healthy living habits and behaviors,medication compliance and blood pressure self-regulation.Health education is needed to improve treatment compliance,self-efficacy level and self-confidence. 2023 Vol. 30 (21): 121-125 [Abstract] ( 23 ) HTML (1 KB)  PDF (539 KB)  ( 15 ) 126 Effect of data envelopment analysis for evaluation of hospital human resources efficiency PEI Jia1 LIANG Dawei1 GAO Siyuan2▲ Objective To explore the effect of data envelopment analysis(DEA)on human resources efficiency evaluation in hospital so as to provide suggestions for optimizing the allocation of hospital human resources.Methods The human resources allocation status and input-output data of Luoyang Orthopedic-Traumatological Hospital in Henan Province(Henan Provincal Orthopedic Hospital)from January 2012 to December 2021 was collected.From two dimensions of service and economy,the data envelopment method of BCC model and Spearman correlation analysis were used to evaluate the human resource efficiency of the hospital,and the invalid year was analyzed by projection.Results The average service efficiency of the hospital from 2012 to 2021 was 0.897,and the output efficiency of 4 years was relatively effective,accounting for 40%.In the ineffective years of DEA,the redundancy rate of health technicians was higher in 2016,reaching 17.74%.The redundancy rate of traditional Chinese medicine physicians/pharmacists was relatively high in 2015,reaching 19.33%.The average economic efficiency of the hospital from 2012 to 2021 was 0.745,and the output efficiency of 1 year was relatively effective,accounting for 10%.In the ineffective years of DEA,the redundancy rate of health technicians was higher in 2016,reaching 30.88%.The redundancy rate of TCM physicians/pharmacists was relatively high in 2014,reaching 30.92%.Conclusion There are redundant human resources in the hospital,and the redundancy of human resources in economic output was greater.It is necessary to optimize the scale of input-output and the structure of human resources to further improve the efficiency of hospital operation. 2023 Vol. 30 (21): 126-130 [Abstract] ( 23 ) HTML (1 KB)  PDF (541 KB)  ( 62 ) 131 Application effect of precision management of Da Vinci robotic surgical instruments in Disinfection Supply Center LOU Liqiong LIU Wei▲ GE Mingli LI Shuling HU Guofeng LONG Han AO Jieqi Objective To explore the application effect of precision management in the management of Da Vinci robotic surgical instruments in the Disinfection Supply Center.Methods A total of 1 742 Da Vinci robotic surgical instruments treated by Jiangxi Provincial People's Hospital from July to December 2022 were selected as research objects,and divided into control group (860 Da Vinci robotic surgical instruments from July to September 2022,including 86 robotic arms,36 endoscopes and 738 basic instruments)and the observation group (from October to December 2022,882 Da Vinci robotic surgical instruments,including 92 robotic arms,41 endoscopes and 749 basic instruments)successively by time.The control group's Da Vinci robotic surgical instruments were managed as common instruments.Precision management was applied to the Da Vinci robotic surgical instruments in the observation group,and the whole process from use,recovery to distribution of the Da Vinci robotic surgical instruments was carried out.The treatment steps of the two groups of instruments were the same.The qualified cleaning rate,instrument damage rate and clinical department satisfaction of two groups of Da Vinci robotic surgical instruments were analyzed.Results The qualified rate of instrument cleaning in observation group was higher than that in control group,the difference was statistically significant (P＜0.05).The rate of instrument damage in observation group was lower than that in control group,and the difference was statistically significant (P＜0.05).The total satisfaction of clinical departments in the observation group was higher than that in the control group,and the difference was statistically significant (P ＜0.05).Conclusion The precision management of Da Vinci robotic surgical instruments in Disinfection Supply Center can improve the quality of Da Vinci robotic surgical instruments,reduce the damage rate of Da Vinci robotic surgical instruments,improve the satisfaction of users,and ensure the safety of patients. 2023 Vol. 30 (21): 131-134 [Abstract] ( 25 ) HTML (1 KB)  PDF (589 KB)  ( 117 ) 135 Research on the construction of comprehensive management by objective assessment index system of health work under the background of new medical reform HUANG Yulu1 LI Wanchang2▲ JI Wenchao3 LU Ying4 QIN Can5 Objective To establish a set of reasonable and scientific comprehensive management by objective assessment index system of health work under the background of the new medical reform,which can provide reference for the assessment of health administrative departments.Methods Based on the consulting relevant medical reform policies and literatures in recent years,the index system was constructed by Delphi consultation method,and the weight of the index system was determined by boundary value method.Finally the comprehensive management by objective assessment index system of health work was formed.Results An index system was established,including four first-level indicators and nineteen second-level indicators.First-level indicators including corporate management,mandatory tasks of government,industry management and Party building,of which indicator weights were 0.368,0.265,0.158 and 0.209 respectively.Conclusion The index system is scientific and feasible,which can provide theoretical reference and practical guidance for the assessment of comprehensive management by objective system of local health work to a certain extent. 2023 Vol. 30 (21): 135-139转151 [Abstract] ( 27 ) HTML (1 KB)  PDF (986 KB)  ( 724 ) 140 Application effect of emergency department information transformation in optimizing the emergency service process HONG Minnv SHEN Xuejuan HUANG Xuejun WU Lili Objective To investigate the application effect of emergency department informatization transformation in optimizing emergency service process.Methods A total of 170 patients from January 2020 to December 2021 in the Department of Emergency,Xiamen Haicang Hospital was selected as the research objects,and 85 patients from January to December 2020 were selected as the control group to implement the routine treatment process,while 85 patients from January to December 2021 were selected as the experimental group and implemented the medical process after the implementation of information technology transformation.The accuracy of pre-examination and triage,missed diagnosis rate,misdiagnosis rate,specialist intervention time,test acquisition time,examination acquisition time,residence time,treatment compliance,rescue success rate,adverse event rate and satisfaction rate were compared between the two groups.Results The missed diagnosis rate,misdiagnosis rate and total incidence rate of adverse event in the experimental group were lower than those in the control group,and the accuracy rate and rescue success rate of pre-inspection and triage were higher than those in the control group,the differences were statistically significant (P ＜0.05).The specialty intervention time,test acquisition time,test acquisition time and retention time of experimental group were shorter than those of control group,and the differences were statistically significant (P＜0.05).The total treatment compliance and total satisfaction of experimental group were higher than those of control group,and the differences were statistically significant (P＜0.05).Conclusion The implementation of emergency department informatization transformation can improve patient compliance,reduce the waiting time of patients related to examinations,reduce the missed rate of pre-examination and triage and the rate of adverse events,improve the success rate of rescue,and ultimately improve the overall satisfaction of emergency patients. 2023 Vol. 30 (21): 140-143 [Abstract] ( 21 ) HTML (1 KB)  PDF (591 KB)  ( 146 ) 144 Clinical application effect of targeted management measures in urine test DONG Yunli Objective To explore and analyze the clinical application effect of targeted management measures in urine test.Methods A total of 66 patients with urinary tract infection who underwent routine urine examination in the Eastern Theater Air Force Hospital from March 2021 to April 2022 were selected as the study subjects.They were divided into control group(33 cases)and observation group (33 cases)by random number table method.Patients in the control group were managed by routine urine test,while patients in the observation group were managed by targeted management.The defect samples,test time,test times,satisfaction level and recognition degree of the two groups were compared.Results The proportion of improper collection time,contaminated,unqualified containers,unclear labeling,delayed delivery and insufficient sample size in the observation group were lower than those in the control group,with statistically significant differences (P＜0.05).The test time of the observation group was shorter than that of the control group,and the actual number of urine tests received was less than that of the control group,with statistically significant differences (P＜0.05).The total satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The total compliance of patients in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Targeted management measures for patients undergoing urine testing have significant effect,can improve the quality of urine sample management,shorten the time required for urine testing,and reduce the number of actual urine testing,which is suitable for clinical implementation and development. 2023 Vol. 30 (21): 144-146 [Abstract] ( 21 ) HTML (1 KB)  PDF (581 KB)  ( 16 ) 147 Establishment of digital virtual tooth shape database and its application research in teaching CAI Jian1 OUYANG Zhiqiang2▲ ZHU Meiling2 LIN Hongqin3 Objective To explore the establishment of digital virtual tooth shape database and its application effect in oral clinical teaching.Methods A retrospective study was conducted on 114 five-year undergraduate students majoring in stomatology in the Affiliated Stomatological Hospital of Nanchang University from January 2021 to December 2022.They were divided into control group(56)and experimental group(58)according to the teaching methods.The control group was taught by traditional presentation teaching method,and the experimental group was taught by digital virtual tooth shape database.The assessment results,learning effect,thinking ability and students' satisfaction with teaching work of the two groups were compared.Results Before teaching,there were no statistically significant differences between the two groups in the mastery of basic theoretical knowledge,comprehensive defense score of practical operation ability and learning motivation,practical operation learning ability,autonomous learning ability,inquiry learning ability score and thinking ability (P＞0.05).After teaching,the experimental group's basic theoretical knowledge mastery score,comprehensive defense score of practical operation ability and learning motivation score,practical operation learning ability score,inquiry learning ability score and students' satisfaction with teaching work were higher than those of the control group,and their thinking ability was better than that of the control group,with statistical significances(P＜0.05).Conclusion Establishing a digital virtual tooth shape database and applying it to oral clinical teaching can promote students to better grasp basic theoretical knowledge,improve their practical operation and thinking abilities,enhance learning effectiveness,and have a high degree of satisfaction with teaching work. 2023 Vol. 30 (21): 147-151 [Abstract] ( 22 ) HTML (1 KB)  PDF (620 KB)  ( 66 ) 152 Application effect of micro-lecture combined with flipped classroom in small lecture for ICU practice nursing students SHI Suzhou YANG Mei▲ TAN Wei PAN Lu Objective To explore the application effect of micro-lecture combined with flipped classroom in small lecture for ICU practice nursing students.Methods A total of 37 ICU nursing students in intership (referred to as nursing students)in Shenzhen Second People's Hospital from June to December 2020 were selected as the control group,and 38 ICU nursing students in Shenzhen Second People's Hospital from June to December 2021 were selected as the observation group.The control group used the traditional method for nursing lectures,while the observation group used the micro-lecture combined with flipped classroom mode for small lectures.The theoretical test scores,comprehensive performance and satisfaction of lecture were compared between the two groups.Results The scores of lecture theory test,comprehensive performance and satisfaction of nursing students in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion The use of micro-lecture combined with flipped classroom mode in ICU nursing lectures is conducive to nursing students to better grasp the theoretical content of lectures,improve the comprehensive performance of nursing students in the classroom and improve the satisfaction of nursing students with small lectures. 2023 Vol. 30 (21): 152-155 [Abstract] ( 22 ) HTML (1 KB)  PDF (620 KB)  ( 154 ) 156 Practice and evaluation of ideological and political education in Immunology and Pathogenic Biology based on the value-added of students' ideological and political literacy WANG Jinfeng1 JING Xuening1 SHEN Wei Immunology and Pathogenic Biology is one of the important professional basic courses in medical colleges and universities,which plays an important role in the cultivation of medical talents.In recent years,the teaching team has carried out the teaching practice and evaluation of ideological and political education in Immunology and Pathogenic Biology courses.Based on the goals of ideological and political education,the teachers' competency in ideological and political education has been improved,the ideological and political elements have been excavated and refined,the teaching design has been improved,the teaching links have been timely and appropriately integrated,the online and offline mixed teaching has been adopted in the teaching process,the exploratory experiments have been innovated,and the social practice activities relying on the curriculum have been carried out.In addition,the implementation of multiple whole-process teaching evaluation,ideological and political education throughout the whole teaching process,construction of online and offline,theoretical experiment,in-class and extra-class all-round education pattern.In addition to knowledge teaching and ability training,students' patriotic feelings are stimulated,scientific spirit is cultivated,medical professional ethics is cultivated,cultural self-confidence is improved,dialectical thinking is enhanced,and students' ideological and political literacy are added.It is a useful exploration for cultivating medical talents with both political integrity and ability in the new era. 2023 Vol. 30 (21): 156-161 [Abstract] ( 25 ) HTML (1 KB)  PDF (624 KB)  ( 230 ) 162 Application of blended teaching in emergency medicine for international students in China WANG Enyun CHEN Jingxia PAN Linlin WANG Min FAN Xuejuan CHEN Hongfen Blended teaching is under the original conventional teaching mode,making full use of Internet technology,scene simulation and other teaching methods to optimize the teaching classroom,so that the teaching content is more intuitive and easier to understand.With the opening of China's academic door,more and more foreign students come to China to study,and their majors are also more and more extensive,including medicine,Chinese,science and technology,education and so on.Among them,medical learning is one of the important courses,and emergency medicine is a branch and important part of the medical discipline.The most important stage for international students to learn medicine is the clinical practice stage.In view of the limited Chinese proficiency of most foreign students,in order to improve the communication between international students and their teachers,the traditional teaching methods cannot fully adapt to the learning of international students.This method can improve the teaching process of emergency medicine in a sense,and improve the learning enthusiasm of international students.It is beneficial to cultivate their clinical thinking ability and deepen their understanding of theoretical knowledge.Emergency medicine course is an important part of medical teaching.It studies the field first aid,monitoring on the way,hospital treatment of emergency patients, etc.Emergency medicine course involves a wide range of class hours,but the content is relatively difficult to master,so it is difficult to arouse the learning enthusiasm of international students.Therefore,it is urgent to speed up the reform of teaching methods for international students,strengthen the improvement of teaching methods,and improve the quality of emergency medicine teaching for international students.Based on this,this paper discusses the application of blended teaching in emergency medicine teaching for international students. 2023 Vol. 30 (21): 162-166 [Abstract] ( 28 ) HTML (1 KB)  PDF (622 KB)  ( 129 ) 167 A case report of coronary artery management using a novel type A aortic dissection HUANG Zhihui HE Haifeng Acute Stanford type A aortic dissection is a very dangerous disease with high mortality,which seriously threatens patients' lives.Surgery is considered as an effective method to treat acute Stanford type A aortic dissection,which significantly improves the survival rate of patients.The treatment modalities varies with the extent of dissection,but the aortic root management strategy of Stanford type A aortic dissection is undoubtedly very challenging for surgeons,especially Stanford type A aortic dissection which needs to treat coronary artery at the same time.This paper aims to report the successful treatment of a heavy patient with acute Stanford type A aortic dissection involving noncoronary sinus and aortic valve regurgitation in the emergency operation of cardiac surgery in Huizhou First People's Hospital,and to share the intraoperative experience and related literature.The patient was a 44-year-old male with a body mass index of 29.4 kg/m2.In the operation,the aortic valve and ascending aorta were replaced by valved vascular prosthesis,and then holes were punched in the valved vascular prosthesis corresponding to the left and right coronary arteries,and the autologous aorta and the valved vascular prosthesis were continuously sutured along the STJ plane of the ascending aorta to complete the coronary artery transplantation.The patient was discharged on foot 44 days after operation,and the follow-up for more than half a year showed good results. 2023 Vol. 30 (21): 167-171 [Abstract] ( 23 ) HTML (1 KB)  PDF (487 KB)  ( 134 ) 172 Percutaneous vertebroplasty is ineffective in treating osteoporotic vertebral compression fractures of the lumbar spine,and reoperation is performed：report of one case CHEN Wenxiang SUN Yuhang Tao Yewei MA Xinqiang CAI Jun GUO Haitao ZHANG Xiaowei ZHOU Zhanguo GUAN Tao Thoracic and lumbar osteoporotic compression fracture is a common orthopedic disease,this disease brings a lot of pain to patients,seriously affecting the quality of life,vertebroplasty has been very extensive in the treatment of this disease,most patients can be relieved of pain symptoms,get out of bed as soon as possible,but also encounter some cases with poor postoperative efficacy.This article introduces 1 case of osteoporotic vertebral compression fracture patients undergoing vertebroplasty treatment process,the first surgery is not effective,the patient's low back pain is not relieved,and then re-examined MRI.It was found that some of the bone cement was not dispersed to still have edema signals,and considered the possible reason for the poor efficacy as the poor filling and diffuse site of bone cement.After discussion,performed contralateral pedicle puncture and bone cement injection of the same vertebral body again,and the lower back pain was relieved after the second operation.The treatment process of this case suggests that only observe the distribution of cement by intraoperative C-arm machine fluoroscopy,because X-rays are generally only fluoroscopy in the positive lateral position,which may cause misjudgment. 2023 Vol. 30 (21): 172-175转179 [Abstract] ( 27 ) HTML (1 KB)  PDF (1109 KB)  ( 69 ) 176 Study on the rehabilitation effect of transitional checklist-based nursing on patients of cardiac surgery ZOU Tuanyuan RAO Changxiu Objective To explore the application effect of transitional checklist-based nursing in patients undergoing cardiac surgery.Methods A total of 92 patients who underwent cardiac surgery in the First Affiliated Hospital of Nanchang University from October 2020 to October 2022 were selected as the study subjects.They were divided into control group and observation group by random number table method,with 46 patients in each group.The control group was treated with routine post-cardiac surgery nursing,while the observation group was treated with transitional checklist-based nursing.The time to get out of bed,hospital stay,weakness score,exercise endurance,cardiac rehabilitation exercise compliance and nursing level were compared between the two groups.Results The time to get out of bed and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant (P ＜0.05).After intervention,the score of fissile phenotype scale in observation group was lower than that in control group,and the 6-min walking distance was longer than that in control group,and the differences were statistically significant (P＜0.05).The compliance of cardiac rehabilitation exercise in the observation group was higher than that in the control group,and the difference was statistically significant (P ＜0.05).The satisfaction scores of clinical nursing ability,communication and coordination ability,nurse-patient cooperation ability and work confidence ability in the observation group were higher than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion The transitional checklist-based nursing can promote the postoperative rehabilitation of patients undergoing cardiac surgery,improve their exercise endurance and compliance with cardiac rehabilitation exercise,improve their weak state,and improve their nursing level. 2023 Vol. 30 (21): 176-179 [Abstract] ( 23 ) HTML (1 KB)  PDF (558 KB)  ( 63 ) 180 Intervention effect of narrative nursing on negative emotion and quality of life of nurses in emergency department ZHANG Lili CHEN Haizhu CHEN Jinxiu CHAI Jingyan YE Yongru Objective To explore the intervention effect of narrative nursing on negative emotion and quality of life of nurses in emergency department.Methods A total of 60 nurses in the Department of Emergency of Jiujiang University Affiliated Hospital from January to August 2022 were selected as the research objects.According to different time periods,they were divided into the control group (from January to April 2022, n=30) and the observation group (from May to August 2022,n=30).The negative emotions,empathy ability,job burnout and quality of life were compared between the two groups before and after intervention.Results The scores of negative emotions such as somatization,interpersonal relationship,physical compulsion,anxiety,depression and hostility in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total scores of perspective taking,emotional nursing and empathy ability of nurses in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The scores of depersonalization,no personal sense of achievement and emotional exhaustion of nurses in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The quality of life score of nurses in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Providing narrative nursing intervention for emergency nurses can help relieve the negative emotions of nurses,reduce job burnout,and improve empathy ability and quality of life. 2023 Vol. 30 (21): 180-183 [Abstract] ( 27 ) HTML (1 KB)  PDF (561 KB)  ( 148 ) 184 Application of target management in the Metabolic Management Center in the nursing of patients with diabetes and stroke ZHANG Huiling ZHANG Qingmei OUYANG Meihui LI Fen GAO Lin Objective To explore the application effect of Metabolic Management Center (MMC)target management in the nursing of patients with diabetes complicated with stroke.Methods A total of 80 patients with stroke complicated with type 2 diabetes admitted to Yichun People's Hospital of Jiangxi Province from January 2019 to August 2021 were selected as research objects.According to the sealed envelope lottery method,they were divided into control group (40 cases) and observation group (40 cases).The control group received routine nursing intervention of blood glucose.On the basis of the control group,the blood glucose target management was implemented in the observation group using the supporting facilities of MMC.Fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,body mass index (BMI),self-management behavior score and activity of daily living (ADL) score were compared between the two groups before intervention and 6 months after intervention.Results There were no statistically significant differences between the two groups in fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin level,BMI,waist circumference and abdominal circumference (P ＞0.05).After 6 months of intervention,the fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin level and BMI of the two groups were lower than those before the intervention,and the waist circumference and abdominal circumference of the two groups were shorter than those before the intervention,the differences were statistically significant(P＜0.05).After 6 months of intervention,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels of the observation group were lower than those of the control group,and the differences were statistically significant (P＜0.05).After 6 months of intervention,the BMI of the patients in the observation group was lower than that in the control group,and the waist circumference and abdominal circumference of the patients in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant differences in the scores of summary of diabetes self-care activities (SDSCA)and activity of daily living (ADL)between the two groups before intervention (P＞0.05).After 6 months of intervention,the SDSCA and ADL scores of the two groups were higher than those of the group before intervention,and the differences were statistically significant (P＜0.05).After 6 months of intervention,the SDSCA and ADL scores of patients in the observation group were higher than those in the control group,and the differences were statistically significant (P ＜0.05).Conclusion The application of MMC objective management in the nursing of patients with diabetes complicated with stroke can effectively control blood glucose,reduce body weight,improve patients'self-care ability and quality of life,which is worth promoting. 2023 Vol. 30 (21): 184-187转196 [Abstract] ( 24 ) HTML (1 KB)  PDF (959 KB)  ( 96 ) 188 Effect of early comprehensive nursing intervention on ICU syndrome,ICU environmental stress level,and psychological status in elderly patients ZHU Beibei1 HUANG Weilian2 QIU Yi2 HAN Jiayu1 Objective To study the effects of early comprehensive nursing intervention on elderly patients with intensive care unit (ICU)syndrome,ICU environmental stress level,and psychological state.Methods Sixty elderly ICU patients admitted to Second Affiliated Hospital of Gannan Medical University from January to December 2021 were selected as the research subjects.They were divided into control group(n=30)and study group(n=30)using an odd or even number method.In the control group,patients received routine care,while in the study group,patients received routine care combined with early comprehensive nursing.The incidence of ICU syndrome,the level of ICU environmental stress,and psychological status of the two groups were compared.Results After intervention,the incidence of ICU syndrome and intensive care unit environmental stressor scale (ICUESS)score in the study group were lower than those in the control group,the duration of stay in ICU in the study group was shorter than that in the control group,with statistical differences (P＜0.05).After intervention,the scores of positive emotional indicators of profile of mood state in the study group were higher than those in the control group,while the scores of negative emotional indicators were lower than those in the control group,with statistical significances(P＜0.05).After intervention,the scores of positive emotional indicators(POMS)in the study group and control group were higher than those before intervention in the corresponding group,while the scores of negative emotional indicators were lower than those before intervention in the corresponding group,with statistically significant differences(P＜0.05).The the short-form 36 item health survey questionnaire (SF-36) scores in all dimensions after intervention were higher than those of the control group,with statistically significant differences (P＜0.05).Conclusion Early comprehensive nursing can effectively improve patients'psychological state and reduce the occurrence of ICU syndrome. 2023 Vol. 30 (21): 188-191 [Abstract] ( 21 ) HTML (1 KB)  PDF (597 KB)  ( 39 ) 192 Chineseization and reliability and validity test of Bristol chronic obstructive pulmonary disease knowledge questionnaire HUANG Haina1 LIANG Guixing1 DING Meizhu2 DUAN Yunyu1 LIANG Cuiting1 Objective To translate Bristol chronic obstructive pulmonary disease knowledge questionnaire (BCKQ) into Chinese,and to test its reliability and validity.Methods The Chinese version of BCKQ was formed after translation and cross-cultural debugging.A total of 328 patients with chronic obstructive pulmonary disease (COPD)who were admitted to the Department of Respiratory Critical Care Medicine and the Chronic Disease Management Center of Guangdong Traditional Chinese Medicine Hospital from May 2021 to August 2021 were selected for survey to evaluate the reliability and validity of the Chinese version BCKQ.Results The correlation coefficient between the score of each item of the Chinese version BCKQ and the total score of the questionnaire were 0.132-0.511,Cronbach's α was 0.920,the half-reliability was 0.808,and the retest reliability was 0.924.After evaluation by 12 experts,the total content validity index of the Chinese version BCKQ was 0.833,and the content validity index of each item were 0.833-1.000.Conclusion The Chinese version of BCKQ has good reliability and validity,and can be used to evaluate the cognitive status of patients with COPD. 2023 Vol. 30 (21): 192-196 [Abstract] ( 26 ) HTML (1 KB)  PDF (606 KB)  ( 142 )

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