左乙拉西坦联合奥卡西平治疗癫痫患儿的效果

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Abstract Objective To explore the effect of Levetiracetam combined with Oxcarbazepine in the treatment of children with epilepsy.Methods From August 2020 to July 2022,92 children with epilepsy admitted to the Department of Pediatrics of Boai Hospital Of Zhongshan were selected as the study subjects.They were divided into the control group(46 cases)and the study group (46 cases) according to random number table method.The therapeutic effect of EEG and immune function(immunoglobulin [Ig]: IgA,IgM,IgG,T lymphocyte subgroup: CD3+,CD4+) cognitive function (full intelligence quotient[FIQ],performance intelligence quotient [PIQ],verpal intelligence quotient [VIQ]),and adverse reactions of the two groups were compared.Results The total effective rate of EEG treatment in the study group was higher than that in the control group,the difference was statistically significant (P ＜0.05).Before treatment,there were no statistically significant differences in the levels of IgA,IgM,IgG,CD3+and CD4+between the two groups (P＞0.05).After treatment,the levels of IgA,IgM and IgG in the two groups were lower than those before treatment,and the levels of CD3+and CD4+were higher than those before treatment,the levels of IgA,IgM and IgG in the study group were lower than those in the control group,and the levels of CD3+and CD4+were higher than those in the control group,with statistically significant differences (P＜0.05).Before treatment,the scores of total intelligence quotient (FIQ),operational intelligence quotient (PIQ),computational language intelligence quotient(VIQ)in the two groups were not significantly different(P＞0.05).After treatment,the scores of FIQ,PIQ and VIQ in the two groups were higher than those before treatment,and the scores of FIQ,PIQ and VIQ in the study group were higher than those in the control group,with statistically significant differences (P＜0.05).After treatment,there was no statistically significant difference in total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Levetiracetam combined with Oxcarbazepine can effectively improve the epileptiform discharge of electroencephalogram in children with epilepsy,help regulate the immune function of children,reduce the damage to cognitive function of children,and is safe and reliable.

Key words： Epilepsy in children Levetiracetam Oxcarbazepine Immunity Cognitive function

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