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Quick Search     Adv Search 2022 Vol. 29, No. 19 Published: 2022-07-08   5 Analgesic effect of serratus anterior plane combined with rectus sheath block in open hepatocellular carcinoma resection CAI Yuping ； CHEN Yuren； CHEN Xiao； XU Deming ； LIN Xinqiang Objective To study the analgesic effect of serratus anterior plane block combined rectus sheath block in patients undergoing radical operation of hepatic carcinoma. Methods A total of 60 liver cancer patients admitted to Affiliated Hospital of Putian University from October 2019 to May 2021 were selected as the research subjects, and they were divided into group S (n=30) and group C (n=30) according to random number table method. Group S was treated with serratus anterior muscle plane combined with rectus sheath nerve block combined with general anesthesia, while group C was treated with general anesthesia alone. Mean arterial pressure (MAP), heart rate (HR) and surgical volume index (SPI) were compared between the two groups before (T1), 5, 30 and 60 min after (T2-T4) and after (T5). Visual analogue scale (VAS) scores at rest and cough were compared between the two groups at 2, 6, 12 and 24 h postoperatively. The total amount of remifentanil, the pressing times of intravenous controlled analgesia (PCIA) within 12 and 24 h after operation and the incidence of postoperative adverse reactions were compared between the two groups. Results There were no significant differences in MAP, HR and SPI between two groups at T1, T5 (P>0.05). HR, MAP and SPI at T2-T5 were higher than those at T1, the differences were statistically significant (P<0.05). HR, MAP and SPI of T2-T4 in group S were lower than those in group C, and the differences were statistically significant (P<0.05). In the resting state, the VAS score of group S was lower than that of group C at 6 and 12 h after surgery, the difference was statistically significant (P<0.05). Under cough condition, VAS score of group S was lower than that of group C at 6, 12 and 24 h after operation, with statistical significance (P<0.05). The amount of Remifentanil in group S and the times of PCIA pressing 12 and 24 h after operation were less than those in group C, the differences were statistically significant (P<0.05). The total incidence of adverse reaction in group S was lower than that in group C, and the difference was statistically significant (P<0.05). Conclusion Serratus anterior plane block combined with rectus sheath block can effectively reduce surgical stress and the dosage of opioids with open hepatectomy, stabilize hemodynamic changes, provide definite analgesic effects, reduce the incidence of complications, and promote patients rapid recovery ,worthy of clinical research and application. 2022 Vol. 29 (19): 5-9 [Abstract] ( 27 ) HTML (1 KB)  PDF (555 KB)  ( 16 ) 10 Research on application of directional penetration of traditional Chinese medicine combined with Tofacib in ankylosing spondylitis FU Jianping； HU Juanjuan； WANG Qiang Objective To investigate the application value of traditional Chinese medicine directional penetration combined with Tofacitb in ankylosing spondylitis. Methods From February 2018 to August 2021, 70 patients with ankylosing spondylitis admitted to the Central Hospital of Xinyu Iron and Steel Group Co., Ltd. were selected as research objects, and divided into study group (n=35) and control group (n=35) according to the random number table method. The control group was treated with conventional antirheumatic drugs, while the study group was treated with traditional Chinese medicine directional penetration combined with Tofacitinib. The clinical efficacy, scores of visual analogue scale (VAS), Bath ankylosing spondylitis metroloty index (BASMI), Bath ankylosing spondylitis functional index (BASFI), Bath ankylosing spondylitis disease activity index (BASDAI), Pittsburgh sleep quality index scale (PSQI), generic quality of life inventory-74 (GQOL-74), erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α, interleukin-1β (IL-1β), interferon-gamma (IFN-γ), bone alkaline phosphatase (BALP), bone gamma-carboxyglutamic-acid-containing proteins (BGP), bone mineral density and total incidence of adverse reactions were compared between the two groups. Results The total effective rate of the study group was  higher than that of the control group, and the difference was statistically significant (P＜0.05). After 3 months of treatment, the scores of VAS, BASMI, BASFI, BASDAI and PSQI in the study group were lower than those in the control group, and the scores of GQOL-74 were higher than those in the control group, group, and the differences were statistically significant (P＜0.05). After 3 months of treatment, the levels of ESR, hs-CRP, TNF-α, IL-1β and BGP in the study group were lower than those in the control group, while the levels of IFN-γ, BALP and bone mineral density were higher than those in the control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Directional penetration of traditional Chinese medicine combined with Tofacitb in the treatment of patients with ankylosing spondylitis can improve the curative effect, enhance the spinal function, improve the quality of life and reduce the level of inflammation, which is safe and should be paid attention to clinically. 2022 Vol. 29 (19): 10-13转22 [Abstract] ( 25 ) HTML (1 KB)  PDF (916 KB)  ( 34 ) 14 Diagnostic value of CT perfusion imaging combined with mean arterial pressure in patients with severe craniocerebral trauma and its relationship with prognosis LI Shiqing； SONG Zengliang Objective To investigate the diagnostic value of CT perfusion imaging (CTP) combined with mean arterial pressure (MAP) in patients with severe craniocerebral trauma and its relationship with prognosis. Methods A total of 90 patients with severe suspected craniocerebral trauma who were admitted to the Department of Neurosurgery of the Third Hospital of Nanchang from April 2019 to February 2021 were selected as the research objects. All patients underwent routine head CTP examination after admission, and the final clinical examination results were used as "golden standard". The diagnostic value was analyzed and the MAP level was monitored. The patients were followed up for 6 months, and the Glasgow coma index score (GOS) was used as the prognostic scoring standard. The patients were evaluated at 1, 6 months after treatment, and the correlation analysis was completed. Results Among 90 patients with severe suspected craniocerebral trauma, 62 patients were finally diagnosed by clinical examination, with a diagnosis rate of 68.89%. 57 patients were finally diagnosed by head CTP examination, and the coincidence rate with the "gold standard" diagnosis was 85.56% [(53+24)/90]. The diagnostic sensitivity was 85.48% (53/62), the specificity was 85.71% (24/28). The levels of cerebral blood perfusion rate (CBF), cerebral blood volume (CBV) and MAP in severe craniocerebral trauma were lower than those in non-severe craniocerebral trauma, and the differences were statistically significant (P<0.05). The mean transit time (MTT) and the time to peak contrast (TTP) were longer than those of non-severe craniocerebral trauma, and the differences were statistically significant (P<0.05). The average GOS score of patients with severe craniocerebral trauma was (3.13±0.63). The results of correlation analysis showed that the GOS score of patients with severe craniocerebral trauma was negatively correlated with the levels of CBF, CBV and MAP, and positively correlated with MTT and TTP (P<0.05). Conclusion CTP has high diagnostic value in patients with severe craniocerebral trauma. Combined examination with MAP can guide clinical treatment and has a strong correlation with the prognosis of patients. 2022 Vol. 29 (19): 14-17 [Abstract] ( 24 ) HTML (1 KB)  PDF (551 KB)  ( 22 ) 18 Application effect of Pentoxifylline Injection in patients with transient ischemic attack YAN Jixi Objective To explore the application effect of Pentoxifylline Injection on transient ischemic attack (TIA). Methods A total of 94 TIA patients admitted to Wuchang Hospital Affiliated to Wuhan University of Science and Technology from May 2018 to May 2020 were selected as the research subjects, and they were divided into control group and experimental group by lottery, with 47 patients in each group. Patients in the control group were given routine TIA attack treatment, while patients in the experimental group were additionally treated with Pentoxifylline Injection on the basis of the contrpl group. The clinical efficacy, cerebral blood flow parameters (the average blood flow [Qmean], maximum flow rate [Vmax], minimum velocity [Vmin]), CT perfusion imaging parameters (mean traansit time [MTT], time to peak [TTP], cerebral blood volume [CBV], cerebral blood flow [CBF]), vascular endothelial function (vascular endothelial growth factor [VEGF], vascular endothelin-1 [ET-1], nitric oxide [NO]) before and after treatment, adverse reactions, recurrence rate of TIA, incidence of cerebral infarction of two groups were conpared. Results The total effective rate in experimental group was higher than that in control group, and the difference was statistically significant (P<0.05). After treatment, Qmean, Vmax and Vmin in the experimental group were higher than those in the control group, and the differences were statistically significant (P<0.05). After treatment, MTT and TTP of the experimental group were lower than those of the control group, while CBV and CBF were higher than those of the control group, the differences were statistically significant (P<0.05). After treatment, VEGF and ET-1 in experimental group were lower than those in control group, and NO was higher than that in control group, the differences were statistically significant (P<0.05). The recurrence rate of TIA and incidence of cerebral infarction in the experimental group were lower than those in the control group, the differences were statistically significant (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Pentoxifylline Injection in the treatment of patients with transient ischemic attack can effectively enhance the effective rate of clinical treatment, significantly improve the cerebral blood supply and vascular endothelial function, and reduce the recurrence rate of transient ischemic attack and the incidence rate of cerebral infarction in patients, with less side effects. 2022 Vol. 29 (19): 18-22 [Abstract] ( 21 ) HTML (1 KB)  PDF (550 KB)  ( 28 ) 23 Research progress in diagnosis and differential diagnosis of spinal tuberculosis LIU Jian； WANG Li′nan； MA Hongbao； LOU Caili； NIU Ningkui  Spinal tuberculosis is the most common extrapulmonary and osteoarticular tuberculosis caused by Mycobacterium tuberculosis. Its onset is hidden, early clinical symptoms and signs are not obvious, similar to other infectious diseases of the spine, it is difficult to diagnose, often lead to missed diagnosis, misdiagnosis, and even mistreatment. Patients cannot be diagnosed and treated in time. With the aggravation of the disease, they often visit the doctor when nerve injury, bone destruction, spinal instability, kyphosis and other complications, which increases the difficulty of clinical treatment and seriously affects the quality of work and life of patients. Early diagnosis and treatment are the key factors affecting the prognosis of spinal tuberculosis. With the rapid development of diagnostic technology and the continuous updating of treatment regimens, the level of diagnosis and treatment has improved significantly. However, the number of patients with spinal tuberculosis has increased in recent years due to drug resistance, infectious disease transmission and other factors. In order to improve the diagnostic level of clinicians for spinal tuberculosis, this paper reviewed the research progress of typical clinical symptoms and signs, auxiliary examination and differential diagnosis of spinal tuberculosis in recent years. 2022 Vol. 29 (19): 23-27转31 [Abstract] ( 35 ) HTML (1 KB)  PDF (491 KB)  ( 26 ) 28 Research progress on the role of sputum eosinophils in airway inflammation in bronchial asthma DENG Niangen； WANG Jun Bronchial asthma is one of the common specific diseases. It is often accompanied by symptoms such as asthma, shortness of breath, chest tightness and cough. Some patients will also develop chronic obstructive pulmonary disease. With prolonged disease duration, patients will experience irreversible airflow limitation and airway remodeling. Therefore, early diagnosis of the disease is necessary to avoid missed optimal treatment opportunities due to missed diagnosis and misdiagnosis. Sputum eosinophils (EOS) are inflammatory effector cells in bronchial asthma, and their changes are closely related to airway inflammation and airway remodeling in patients, so they are important in the diagnosis, treatment, and assessment of disease progression in patients with bronchial asthma. In order to clarify its value in the progress of airway inflammation in bronchial asthma, this paper discusses the research progress of the role of sputum eosinophils in airway inflammation in bronchial asthma. Workers in the same industry provide references. 2022 Vol. 29 (19): 28-31 [Abstract] ( 28 ) HTML (1 KB)  PDF (452 KB)  ( 57 ) 32 Comparison on the differences of T cell subsets in pulmonary tuberculosis patients during active and quiescent stages LI Yong  Objective To explore the differences of T cell subsets in pulmonary tuberculosis patients during active and quiescent stages. Methods A total of 33 pulmonary tuberculosis patients in active stages admitted to Yingtan City People′s Hospital from January 2019 to March 2021 were retrospectively selected as the active group, while 33 patients with pulmonary tuberculosis in quiescent stages in the same period were selected as the quiescent group. The levels of CD3+, CD4+, CD8+ and CD4+/CD8+ T cell subsets in all objects were detected by flow cytometry. The value of the CD3+, CD4+, CD8+ and CD4+/CD8+ T cell subsets and combined detection in the differential diagnosis of pulmonary tuberculosis in active and quiescent stages were analyzed by receiver operating characteristic (ROC) curves. Results The levels of CD3+, CD4+ and CD4+/CD8+ T cell subsets in the active group were lower than those in the quiescent group, while the level of CD8+  T cell subsets in the active group was higher than that in quiescent group, the differences were statistically significant (P＜0.05). The results of ROC curve analysis showed that the area under curve (AUC) values under the ROC curve of CD3+, CD4+, CD8+, CD4+/CD8+ T cell subsets and combined detection in the differential diagnosis of pulmonary tuberculosis in active and quiescent stages were 0.592, 0.632, 0.657, 0.816 and 0.897, respectively. Conclusion The immune function is declined in pulmonary tuberculosis patients in active stages. In clinical practice, peripheral blood T lymphocyte subsets can be applied in the differential diagnosis of pulmonary tuberculosis in active and quiescent stages. 2022 Vol. 29 (19): 32-34 [Abstract] ( 25 ) HTML (1 KB)  PDF (756 KB)  ( 16 ) 35 Effects of oral calcium dosage and time on sodium citrate response during platelet collection from blood donors LIANG Lihua； CHEN Chaohong ； CHEN Cunyi； LIANG Jiezhen； LIAO Junyan ； LIANG Ting ； LIANG Weiying Objective To investigate the effect of oral calcium time and dose on sodium citrate reaction during platelet collection by blood donors. Methods A total of 400 blood donors who participated in platelet donation from April 2020 to March 2021 in Zhaoqing were selected as the research objects, they were divided into A, B, C, D group by random number table method, with 100 cases in each group. Group A was the control group, no intervention measures were taken before and during collection. Group B took 20 ml calcium orally 30 min before collection. In group C, 20 ml calcium was taken orally 10 min before collection. In group D, 20 ml calcium was taken orally 10 min before blood collection, 10 ml calcium was added in the middle of collection and 10 min before the end of collection. The incidence of sodium citrate reaction in four groups were observed until the end of collection. The effects of different oral calcium time and dose on the response of blood donors to sodium citrate were compared. Results There was significant difference in the incidence of sodium citrate reaction among the four groups, and the difference was statistically significant (P<0.001). The incidence of sodium citrate reaction in group A and group B was higher than that in group D, the differences were statistically significant (χ2=19.198, P＜0.001; χ2=10.288, P=0.001). There were no significant differences in the incidence of sodium citrate reaction between group A and group B, between group A and group C, between group B and group C, and between group C and group D (χ2=1.754, P=0.185; χ2=5.570, P=0.018; χ2=1.276, P=0.259; χ2=4.712, P=0.030). Conclusion Taking blood 10 min after taking 20 ml of calcium, and taking 10 ml of calcium in the middle of collection and 10 min before the end of blood collection can effectively reduce sodium citrate reaction. 2022 Vol. 29 (19): 35-37 [Abstract] ( 27 ) HTML (1 KB)  PDF (610 KB)  ( 22 ) 38 Etiological analysis of elderly patients with community-acquired pneumonia in emergency department WANG Jiao Objective To study the common etiology and infection characteristics of community-acquired pneumonia in elderly patients in emergency department. Methods A total of 79 elderly patients who were diagnosed with community-acquired pneumonia in the emergency department of Beijing Jingmei Group General Hospital from March 2020 to October 2021 were retrospectively analyzed. Qualified sputum samples were taken, common etiology was analyzed, the clinical characteristics of patients with mixed infection and single bacterial infection were compared. The variables with statistically significant difference in univariate analysis were included in logistic multivariate regression analysis. Results The detection rate of Gram-negative bacilli such as Klebsiella pneumoniae and Pseudomonas aeruginosa were higher in elderly patients with community-acquired pneumonia. Acinetobacter baumannii has a high drug resistance rate. The results of univariate analysis showed that mixed infection was related to dependence on gastric tube, urinary tube, bedridden status, history of antibiotic abuse, respiratory disease, type 2 diabetes, and infection rate of multi-drug resistant bacteria, and the differences were statistically significant (P<0.05). Multivariate analysis results of logistic regression model showed that type 2 diabetes (β=2.166, OR=8.723, 95%CI=2.195-34.671), multi-drug resistant bacteria infection (β=1.749, OR=5.746, 95%CI=1.166-28.323) were independent risk factors for mixed infection (P<0.05). Conclusion The bacteria isolated from community-acquired pneumonia in elderly patients gradually appear to have a bacterial spectrum similar to that of hospital-acquired pneumonia bacteria. Type 2 diabetes and multi-drug resistant bacteria infection are independent risk factors for mixed infection. 2022 Vol. 29 (19): 38-41 [Abstract] ( 26 ) HTML (1 KB)  PDF (666 KB)  ( 23 ) 42 Correlation between urine liver-type fatty acid binding protein, interleukin-18 levels and the degree of renal injury in patients with hepatitis B cirrhosis XU Jiao; ZHANG Ying; WANG Yuanyuan; ZHU Feng Objective To study the correlation between urine liver-type fatty acid binding protein (L-FABP), interleukin-18 (IL-18) levels and the degree of renal injury in patients with hepatitis B cirrhosis. Methods The clinical data of 90 patients with hepatitis B cirrhosis complicated with renal injury who were admitted to Dalian Public Health Clinical Center from February 2020 to June 2021 were retrospectively analyzed. According to the relevant staging criteria of acute kidney injury (AKI), 40 patients in AKI Ⅰ were included in the mild group, and 50 patients in AKI Ⅱ and Ⅲ were included in the severe group. Meanwhile, the clinical data of 40 patients with hepatitis B cirrhosis but without renal injury were selected as the control group. The levels of L-FABP and IL-18 in the urine of the three groups were detected and compared, and the relationship between the levels of L-FABP and IL-18 in the urine of patients with hepatitis B cirrhosis and the degree of renal injury was analyzed. Results The levels of urine L-FABP and IL-18 of patients in the severe group were higher than those in the control group and the mild group, the differences were statistically significant (P＜0.05). The levels of urine L-FABP and IL-18 of patients in the mild group were higher than those in the control group, the differences were statistically significant (P＜0.05). Spearman correlation analysis showed that the levels of urine L-FABP and IL-18 were positively correlated with the degree of renal injury in patients with hepatitis B liver cirrhosis (P＜0.05). Conclusion For patients with hepatitis B cirrhosis, the more severe the renal injury, the higher the levels of urine L-FABP and IL-18. 2022 Vol. 29 (19): 42-44转48 [Abstract] ( 24 ) HTML (1 KB)  PDF (640 KB)  ( 18 ) 45 Application effect of cold liquid prefilled hemostatic device in radial artery puncture of coronary angiography XIAO Min ；ZHOU Guifang； LUO Xiaoqin； JIA Haina；PENG Yang Objective To explore the application effect of low temperature combined with compression dual hemostasis in radial artery puncture of coronary angiography. Methods A total of 308 patients who underwent coronary angiography through radial artery puncture in the Department of Cardiology of Nanfang Hospital from August 2020 to January 2021 were selected as research objects, and they were divided into the test group 1 (103 cases), the test group 2 (103 cases) and the control group (102 cases) according to the random number table method. The test group 1 was pre charged with cold saline hemostasis, the test group 2 was pre charged with cold alcohol hemostasis, and the control group was compressed with conventional hemostasis. The incidence of bleeding or hematoma at the puncture site, the swelling of the palm on the surgical side, pain degree, compression time and the rate of radial artery occlusion were compared among the three groups. Results The degree of the swelling of the palm on the surgical side and pain degree of the test group 1 were lower than those of the test group 2, and the differences were statistically significant (P＜0.05). There were no significant differences in the incidence of bleeding or hematoma at the puncture site, the compression time and the rate of radial artery occlusion between the two groups (P＞0.05). The incidence of bleeding or hematoma at the puncture site, the degree of the swelling of the palm on the surgical side, and the degree of pain in the test group 1 and the test group 2 were lower than those of the control group, the differences were statistically significant (P=0.003, P＜0.001, P＜0.001, respectively), while there were no significant differences in compression time and radial artery occlusion rate among test group 1, test group 2 and the control group (P＞0.05). Conclusion Cold liquid prefilling hemostasis device used for hemostasis at the puncture site of the radial artery during coronary angiography can effectively reduce bleeding and swelling at the puncture site after operation, reduce pain, and provide long-term cold compress with low-temperature medium for better effect. 2022 Vol. 29 (19): 45-48 [Abstract] ( 34 ) HTML (1 KB)  PDF (619 KB)  ( 26 ) 49 Application effect of blood preservation solution in intermittent hemodialysis in patients with high risk of bleeding LIN Yangzhen；HUANG Xiaoling；LUO Zhaojian Objective To explore the application effect of blood preservation solution in intermittent hemodialysis in patients with high risk of bleeding. Methods A total of 96 patients with high risk of bleeding tendency who underwent intermittent hemodialysis treated into Jiangmen Central Hospital from October 2020 to June 2021 were selected as the research objects, and the patients were divided into the observation group and the control group according to random number table method, with 48 cases in each group. The control group was treated with modified heparin free anticoagulation, and the observation group was treated with two-stage anticoagulation with blood preservation solution. The pH value, and the levels of blood sodium, blood potassium, free calcium and thromboplastin time before and after treatment were compared between the two groups, the anticoagulant effect in the two groups was evaluated, and the complications in the two groups were recorded. Results The effective rate of dialyzer and venous kettle coagulation in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). After treatment, there was no significant difference in the level of free calcium between the two groups (P＞0.05). The pH value and the levels of blood sodium level in the observation group after treatment were higher than those in the control group, and the blood potassium level in the observation group was lower than those in the control group, the thromboplastin time in the obsertation group was shorter than that in the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Compared with the improved heparin free anticoagulation, two-stage blood preservation solution anticoagulation can significantly improve the anticoagulation effect, reduce adverse reactions, and have better safety and reliability in the intermittent hemodialysis treatment of patients with high risk of bleeding. 2022 Vol. 29 (19): 49-52 [Abstract] ( 25 ) HTML (1 KB)  PDF (618 KB)  ( 81 ) 53 Evaluation value of combined monitoring of bispectral index and neuron-specific enolase in the prognosis of patients with traumatic brain injury QIAN Wuqiang; ZHAO Ping; SHI Xiaofen; TANG Jianlei; CUI Weiyan Objective To explore the diagnostic value of combined monitoring of bispectral index (BIS) and neuron-specific enolase (NSE) in the prognosis of patients with traumatic brain injury. Methods A total of 60 patients with raumatic brain injury from March 2020 to July 2021 in Wujin Hospital Affiliated to Jiangsu University were selected as the research subjects. According to the Glasgow outcome scale (GOS), they were divided into the good prognosis group (n=23) and the poor prognosis group (n=37). All patients received BIS monitoring and NSE level detection. The BIS value and NSE level of the two groups of patients were compared, and the correlation between BIS value and NSE index and prognostic score, as well as the predictive value of BIS value and NSE index on the prognosis of traumatic brain injury were analyzed. Results The BIS level in the good prognosis group was higher than that in the poor prognosis group, while the NSE level in the good prognosis group was lower than that in the poor prognosis group, and the differences were statistically significant (P＜0.05). The results of correlation analysis showed that the BIS value was positively correlated with the prognostic GOS score (r=0.712, P=0.001), and the NSE level was negatively correlated with the prognostic GOS score (r=-0.606, P=0.001). Combined monitoring of BIS value and NSE index (AUC=0.93) had higher sensitivity and specificity than those of single BIS value (AUC=0.81) and NSE index (AUC=0.77) in predicting poor prognosis of traumatic brain injury. Conclusion Both BIS value and serum NSE level can reflect the prognosis quality of patients with traumatic brain injury. The lower the BIS value, the higher the NSE index, the worse the prognosis quality, and the combined monitoring is more conducive to improving the monitoring sensitivity and specificity, which is worthy of clinical promotion. 2022 Vol. 29 (19): 53-55转60 [Abstract] ( 22 ) HTML (1 KB)  PDF (707 KB)  ( 39 ) 56 Application effect of nutritional management with high protein proportions in patients with craniocerebral injury and hyponatremia ZHONG Youdi； WANG Xingling； PAN Chaoyong Objective To explore the application effect of nutritional management with high protein proportions in patients with craniocerebral injury and hyponatremia. Methods A total of 98 patients with craniocerebral injury complicated with hyponatremia diagnosed in the Second People′s Hospital of Zhaoqing City from January 2018 to December 2020 were collected, and they were divided into the trial group (49 cases) and the control group (49 cases) according to the random number table method. The trial group was given nutritional management with high protein proportions, the total protein volume was 2.0-2.2 g/(kg·d). The control group was given nutritional management for the conventional proportions, the total protein volume was 1.0-1.5 g/(kg·d). Both groups were given an equal heat supply, and both groups lasted for 14 days. The time required for correction of hyponatremia, the recurrence rate of hyponatremia, serum albumin level, lymphocyte count, 24-hour urine volume, urea nitrogen level, creatinine level, time of hospital stay and mortality during hospitalization were compared between the two groups. Results The correction time required for hyponatremia in the trial group was shorter than that the control group, the recurrence rate of hyponatremia in the trial group was lower than that in the control group, with significant statistic differences (P＜0.05). The 24-hour urine volume in the trial group was less than that in the control group, the serum albumin levels, and lymphocyte counts in the trial group were higher than those the control group, with significant statistic differences (P＜0.05). There were no significant statistic differences in the levels of urea nitrogen, creatinine, time of hospital stay and mortality during hospitalization between the two groups (P＞0.05). Conclusion Nutritional management with high protein proportions can improve short-term efficacy, nutritional status, and immunity recovery in patients with craniocerebral injury and hyponatremia, and short periods of high protein proportions supply does not cause kidney damage. 2022 Vol. 29 (19): 56-60 [Abstract] ( 25 ) HTML (1 KB)  PDF (671 KB)  ( 30 ) 61 Efficacy of Salkubazol Valsartan Sodium in the treatment of heart failure in patients with valvular disease and its effect on serum miRNA-21 ZHOU Qilin ； HUANG Bo ； ZHOU Wanming ； MA Zhanzhong； WANG Li Objective To investigate the therapeutic effect of Sacubitril Valsartan Sodium Tablet on chronic heart failure in patients with valvular disease and its effect on the level of serum miRNA-21. Methods A total of 84 patients with valvular disease and heart failure admitted to the Outpatient Department of Cardiovascular Medicine of Yuebei People′s Hospital from March 2018 to May 2021 were selected as the study subjects. The random number table method was used for grouping and double-blind, and patients were divided into treatment group and control group, with 42 patients in each group. Patients in both groups were treated with Furosemide, Spironolactone and Bisoprolol. Patients in the treatment group were treated with Sacubitril Valsartan Sodium and patients in the control group were treated with Telmisartan. Both groups were treated for 5 months. The 6-min walking distance and serum miRNA-21 level were compared between the two groups before and after treatment. Results The 6 min walking distance of the treatment group was longer than that of the control group at 2, 3, 4 and 5 months of treatment, and the difference was statistically significant (P<0.001). The 6-min walking distance of the two groups in the 5 month of treatment were longer than those before treatment, and the differences were statistically significant (P<0.001). The serum miRNA-21 level in treatment group was lower than that in control group at 3, 4 and 5 months of treatment, the difference was statistically significant (P<0.001). The serum miRNA-21 levels in the two groups at 5 months of treatment were lower than those before treatment, the differences were statistically significant (P<0.001). Conclusion Sacubitril Valsartan Sodium has a significant effect on the prolongation of 6 min walking distance in patients with cardiac valvular heart failure, and this effect may be related to the down regulation of miRNA-21 expression. 2022 Vol. 29 (19): 61-64转69 [Abstract] ( 31 ) HTML (1 KB)  PDF (575 KB)  ( 12 ) 65 Clinical effect of Nicorandil combined with Coenzyme Q10 in the treatment of chronic heart failure GENG Erdong Objective To investigate the effect of Nicorandil combined with Coenzyme Q10 in patients with chronic heart failure. Methods A total of 80 patients with chronic heart failure admitted to Beijing Wangfu Hospital of Integrated Traditional Chinese and Western Medicine from October 2018 to November 2020 were selected as the research subjects. The patients were divided into control group and experimental group by random number table method, with 40 patients in each group. Both groups received conventional treatment of heart failure, the control group was given Coenzyme Q10, the experimental group was given Nicorandil based on the control group. After 4 months of treatment, the changes of 6 min walking distance (6MWD), resting heart rate (HR), left ventricular ejection fraction (LVEF), superoxide dismutase (SOD), C-reactive protein (CRP), tumor necrosis factor (TNF-α), serum brain natriuretic peptide (BNP) and the incidence of adverse reactions were compared between two groups. Results There were no significant differences in 6MWD, HR and LVEF between the two groups before treatment (P>0.05). After treatment, 6MWD of the experimental group was longer than that of the control group, HR was lower than that of the control group, and LVEF was higher than that of the control group, with statistically significant differences (P<0.05). There were no significant differences in SOD, TNF-α, CRP and BNP between the two groups before treatment (P>0.05). After treatment, SOD level in experimental group was higher than control group, TNF-α, CRP and BNP levels were lower than control group, the differences were statistically significant (P<0.05). After treatment, the grading of cardiac function in experimental group was better than that in control group, the total effective rate was higher than that of control group, the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Nicorandil combined with Coenzyme Q10 can reduce the level of serum inflammatory cytokines and improve the state of oxidative stress in patients with chronic heart failure. 2022 Vol. 29 (19): 65-69 [Abstract] ( 28 ) HTML (1 KB)  PDF (597 KB)  ( 14 ) 70 Effect of Trimetazidine combined with Metoprolol in the treatment of coronary heart disease with heart failure SU Heng； ZHU Jun ； WANG Guangyan Objective To investigate the effect of Trimetazidine combined with Metoprolol on the prognosis of patients with coronary heart disease and heart failure. Methods A total of 79 patients with coronary heart disease and heart failure admitted to Affiliated Hospital of Jiangnan University from February 2017 to February 2020 were selected as the study subjects, and divided into observation group (40 cases) and control group (39 cases) by random number table method according to the treatment sequence. The control group was treated with Metoprolol, and the observation group was treated with Trimetazidine on the basis of the control group. Cardiac function indexes, 6 min walking test results, serum N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) levels and the incidence of adverse reactions were compared between the two groups before and after treatment. Results After treatment, the left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) in the observation group were lower than those in the control group, and the left ventricular ejection fraction (LVEF) was higher than that in the control group, and the 6 min walking distance was longer than that in the control group, the differences were statistically significant (P<0.05). After treatment, NT-proBNP in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P>0.05). Conclusion Metoprolol combined with Trimetazidine in the treatment of coronary heart disease complicated with heart failure can further improve the heart function of patients, regulate the level of NT-proBNP, and the medication is safe and reliable. 2022 Vol. 29 (19): 70-73 [Abstract] ( 24 ) HTML (1 KB)  PDF (541 KB)  ( 24 ) 74 Effect of stress inoculation training on the health literacy and perceived stress of patients with coronary heart disease GE Lili； ZHANG Hui； SU Yang； ZHANG Lan； SHEN Yanji Objective To explore the effect of stress vaccination training on the health literacy and perceived stress of patients with coronary heart disease. Methods A total of 70 patients with coronary heart disease were selected as the research objects, who admitted to Rizhao Traditional Chinese Medicine Hospital from May to November 2020, and were divided into a control group and an observation group by random number table method, with 35 cases in each group. Both groups of patients were treated with conventional drugs, the control group received routine nursing, and the observation group received stress vaccination training. Total nursing satisfaction, health literacy and perceived stress scores were compared between the two groups. Results The total nursing satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). There were no significant differences in the scores of health literacy and perceived stress between the two groups before intervention (P>0.05). There were no significant differences in the scores of health literacy and perceived stress in the observation group after 1 month of intervention compared with those before intervention (P>0.05). After 2 and 3 months of intervention, the health literacy scores of the observation group were higher than those before intervention, and the perceived stress scores were lower than those before intervention, and the differences were statistically significant (P<0.05). The scores of health literacy and perceived stress in the control group after 1, 2 and 3 months of intervention were not significantly different from those before intervention (P>0.05). There were no significant differences in the scores of health literacy and perceived stress between the two groups after 1 month of intervention (P>0.05). After 2 and 3 months of intervention, the scores of health literacy in the observation group were higher than those in the control group, and the scores of perceived stress were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion The application of stress vaccination training in patients with coronary heart disease improved the patients′ total nursing satisfaction, the health literacy level of the patients was improved and the perceived stress was reduced after 2 months of the intervention. 2022 Vol. 29 (19): 74-77 [Abstract] ( 23 ) HTML (1 KB)  PDF (582 KB)  ( 28 ) 78 Clinical effect of Compound Danshen Dropping Pills combined with Tolvaptan in the treatment of patients with acute myocardial infarction and heart failure WU Xiaoqiu ； HUANG Bin ； LIANG Shiwei Objective To investigate the clinical effect of Compound Danshen Dropping Pills combined with Tolvaptan in the treatment of patients with acute myocardial infarction (AMI) complicated with heart failure and the effect on serum cardiac troponin I (cTnI), myoglobin (Myo) levels in patients. Methods A hundred patients with AMI and heart failure admitted to the Department of Cardiovascular Medicine of Chongzuo People′s Hospital from January 2019 to June 2021 were selected as subjects for retrospective analysis, and divided into control group (50 cases) and experimental group (50 cases) according to the different treatment methods. The control group applied the drug treatment of Toraputan alone, and the experimental group combined the Compound Danshen Dropping Pills based on the control group. The clinical efficacy, total incidence rate of adverse reactions (thirst, frequency of urine), remission duration of clinical symptoms (dyspnea, chest pain, lower limb edema), and serum cTnI levels, and serum Myo levels were compared between the two groups of patients. Results The total clinical effective rate of experimental group was higher than that of control group, and the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). The relief time of dyspnea, chest pain and lower limb edema in the experimental group was shorter than that in the control group, and the difference was statistically significant (P<0.05). Before treatment, there were no significant differences in serum cTnI and Myo levels between  the two groups (P>0.05). After treatment, the levels of serum cTnI and Myo in the two groups were lower than those before tretment, the differences were statistically significant (P<0.05). The levels of serum cTnI and Myo in experimental group were lower than those in control group after treatment, with statistical significances (P<0.05). Conclusion The application of Compound Danshen Drop Pills with Torvarutan for patients with AMI and heart failure can significantly improve their serum cTnI and  Myo levels, while improving the clinical treatment effect and shortening the remission time of dyspnea, chest pain and lower limb edema. 2022 Vol. 29 (19): 78-80转89 [Abstract] ( 22 ) HTML (1 KB)  PDF (930 KB)  ( 22 ) 81 Clinical effects of Magnesium Valproate combined with Paliperidone in the treatment of schizophrenia LI Shujuan； HU Jing； TU Gangying； LI Junyi  Objective To evaluate the clinical effects of Magnesium Valproate combined with Paliperidone in the treatment of schizophrenia. Methods A total of 86 patients with schizophrenia treated in Jiangxi Psychiatric Hospital from October 2020 to August 2021 were selected as research objects, and they were divided into control group (43 cases) and observation group (43 cases) according to random number table method. The control group was treated with Paliperidone, and the observation group was treated with Magnesium Valproate combined with Paliperidone. The course of treatment was three months. The clinical efficacy, positive and negative symptom score (PANSS), global assessment function (GAF) score, social disability screening schedule (SDSS) score, thiobarbituric acid reactive substances (TBARS), brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). After treatment, GAF score of the two groups was higher than that before treatment, PANSS score and SDSS score of the two groups were lower than those before treatment, and GAF score of the observation group was higher than that of the control group, PANSS score and SDSS score of the observation group were lower than those of the control group, the difference was statistically significant (P<0.05). After treatment, the levels of TBARS, TNF-α and IL-1β in two groups were lower than those before treatment, the level of BDNF in two groups was higher than that before treatment, and the levels of TBARS, TNF-α and IL-1β in the observation group were lower than those in the control group, the level of BDNF in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Magnesium Valproate combined with Paliperidone is effective in the treatment of schizophrenia. 2022 Vol. 29 (19): 81-84 [Abstract] ( 26 ) HTML (1 KB)  PDF (586 KB)  ( 21 ) 85 Expression and clinical significance of resistin, copeptin and oxidized low density lipoprotein in patients with acute ischemic stroke GAO Shanyu； YOU Nianxing▲ Objective To explore the expression and clinical significance of resistin, copeptin and oxidized low-density lipoprotein in patients with acute ischemic stroke. Methods A total of 85 patients with acute ischemic stroke who were admitted to Changshu Second People′s Hospital affiliated to Yangzhou University from June to December 2019 were selected as the acute ischemic stroke group. Eighty-five healthy people who underwent physical examination in Changshu Second People′s Hospital at the same time were selected as healthy control group. The acute ischemic stroke group collected venous blood within 24 hours of onset to detect serum resistin, copeptin, ox-LDL levels, and compared the serum resistin, copeptin, ox-LDL level, draw ROC curve to analyze the predictive value of resistin, copeptin, ox-LDL and the combined detection of the three indicators in acute ischemic stroke. Results The levels of resistin, copeptin and ox-LDL in acute ischemic stroke group were higher than those in healthy control group, the differences were statistically significant (P<0.05). The levels of resistin, copeptin and ox-LDL in patients with moderate and large area cerebral infarction were higher than those in patients with lacunar cerebral infarction, and the differences were statistically significant (P<0.05). The levels of resistin, copeptin and ox-LDL in patients with large cerebral infarction were higher than those in patients with moderate cerebral infarction, and the differences were statistically significant (P<0.05). The levels of resistin, copeptin and ox-LDL in patients with moderate and severe neurological impairment were higher than those in patients with mild neurological im 2022 Vol. 29 (19): 85-89 [Abstract] ( 23 ) HTML (1 KB)  PDF (767 KB)  ( 16 ) 90 Cognitive function training combined with daily living ability training in the treatment of patients with Alzheimer′s disease CAI Liangling； HUANG Zhenhe； YU Zhigang Objective To explore the effect of cognitive function training combined with daily living ability training in the treatment of patients with Alzheimer′s disease. Methods A total of 160 patients with Alzheimer′s disease admitted to the Department of Geriatrics, Union Medical College Shenzhen Hospital, Huazhong University of Science and Technology from January 2020 to January 2021 were selected as the research objects. The patients were divided into control group and experimental group according to random number table method, with 80 patients in each group. The control group underwent routine nursing intervention. On this basis, patients in the experimental group received cognitive function training combined with daily living ability training, the mini-mental state examination (MMSE) and the Barthel index (BI) were used to evaluate the changes of cognitive function and activities of daily living of two groups before and after intervention. The behavioral pathology in Alzheimer′s disease (BEHAVE-AD) and the training/intervention effects of the two groups were compared before and after the intervention. Results The MMSE score and BI score of the two groups before intervention were not statistically different (P>0.05). After 6 months of intervention, the MMSE score and BI score of the two groups of patients were higher than those before the intervention, and the scores of experimental group were higher than those of the control group, the differences were statistically significant (P<0.05). The BEHAVE-AD scores of the two groups before intervention were not statistically significant (P>0.05). After 6 months of intervention, the BEHAVE-AD score of the two groups was lower than that before the intervention, and the score of experimental group was lower than that of the control group, the differences were statistically significant (P<0.05). The total training efficiency of the experimental group was better than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Cognitive function training and daily living ability training for patients with Alzheimer′s disease can effectively improve the cognitive function of the patients and improve the ability of daily living of the patients. The training effect is significant and it is worthy of clinical application. 2022 Vol. 29 (19): 90-93 [Abstract] ( 24 ) HTML (1 KB)  PDF (613 KB)  ( 71 ) 94 Clinical effect of plasma infusion in the treatment of delayed encephalopathy after carbon monoxide poisoning JI Xiaotan； LU Qixiu； YAN Bingwang； WANG Lixiang； LIU Houlin Objective To observe the clinical effect of plasma infusion in the treatment of delayed encephalopathy after carbon monoxide poisoning (DEACMP). Methods A total of 70 patients with DEACMP admitted to Jining NO.1 People′s Hospital from July 2017 to May 2021 were selected as the research objects, and they were divided into the control group and the experimental group according to random number table method, with 35 cases in each group. The control group was treated with routine medical treatment, while the experimental group received plasma infusion therapy on the basis of the control group. The Montreal cognitive assessment (MoCA) score, clinical effect, daily living ability score were compared between the two groups. Results Before treatment, there were no significant differences in the scores of MoCA and daily living ability between the two groups (P>0.05). After treatment of 14 days, there was no significant difference in MoCA scores between the two groups (P>0.05). After treatment of 14 days, the MoCA scores of the two groups were higher than those before treatment (P<0.05). After treatment of three months, daily living ability score in the experimental group was higher than that in the control group and before treatment, the difference was statistically significant (P<0.05). The treatment total effective rate of in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion The combined use of plasma infusion therapy on the basis of routine medical treatment can effectively improve the cognitive function and daily living ability in DEACMP patients. 2022 Vol. 29 (19): 94-97 [Abstract] ( 28 ) HTML (1 KB)  PDF (585 KB)  ( 67 ) 98 Application effect of Paliperidone in the treatment of patients with schiz-ophrenia WANG Kai ； LIU Xihe ； JIANG Hong Objective To investigate the application effect of Paliperidone in the treatment of schizophrenia. Methods A total of 81 patients with schizophrenia treated in Beijing Daxing Xinkang Hospital from January 2018 to January 2021 were divided into observation group (n=41) and control group (n=40) according to the random number table method. The control group was treated with risperidone, and the observation group was treated with Palliperidone. The levels of fasting blood glucose (FBG), insulin, C-peptide (CP), triglyceride (TG) and cholesterol (CHOL) were compared between the two groups before treatment, 4 weeks after treatment and 8 weeks after treatment. At the same time, the results of positive and negative symptom rating scale (PANSS) at different time points were compared between the two groups. Results The insulin and CP levels in the observed group at 4 weeks after treatment were lower than those in the control group, and the insulin, CP, CHOL and TG levels in the observed group at 8 weeks after treatment were lower than those in the control group, the differences was statistically significant (P<0.05). There was no significant difference in PANSS scores between the two groups (P>0.05). Conclusion Pariperidone treated schizophrenia with comparable efficacy compared to Risperidone, but Pariperidone had less effect on glycolipid metabolism indicators in patients. 2022 Vol. 29 (19): 98-100转104 [Abstract] ( 20 ) HTML (1 KB)  PDF (600 KB)  ( 35 ) 101 Application effect of transcranial direct current stimulation combined with core stability training in cerebral infarction patients with hemiplegia GU Lei ； WU Liang▲ Objective To explore the application effect of transcranial direct current stimulation combined with core stability training in cerebral infarction patients with hemiplegia. Methods A total of 98 patients with cerebral infarction hemiplegia admitted to Beijing Xiaotangshan Hospital from May 2019 to May 2021 were selected as the research objects, and they were divided into the control group (49 cases) and the observation group (49 cases) according to the random number table method. The control group was given core stability training, and the observation group was given transcranial direct current stimulation on the basis of the control group for four weeks. The degree of neurological deficit (National Institutes of Health stroke scale [NIHSS]), balance ability (Berg balance scale [BBS]), motor function (Fugl-Meyer assessment [FMA]), daily life ability (Barthel index [BI]) and quality of life (stroke impact scale [SIS]) before and after intervention were compared between the two groups. Results There were no significant differences in NIHSS, BBS, FMA, BI and SIS scores between the two groups before intervention (P>0.05). After intervention, NIHSS scores of the two groups were lower than those before intervention, and NIHSS score of the observation group was lower than that of the control group, the differences were statistically significant (P<0.05). After intervention, BBS, FMA, BI and SIS scores of the two groups were higher than those before intervention, and BBS, FMA, BI and SIS scores of the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). Conclusion Transcranial direct current stimulation combined with core stability training can reduce the degree of neurological deficit in hemiplegic patients with cerebral infarction, improve balance ability and limb motor function, and comprehensively improve the quality of life. 2022 Vol. 29 (19): 101-104 [Abstract] ( 20 ) HTML (1 KB)  PDF (585 KB)  ( 74 ) 105 with Uremic Clearance Granules and its effect on renal function indexes in patients with stage 3-5 chronic kidney disease YAN Huimin； TONG Wei ； QIU Guoping▲ Objective To investigate the curative effect of traditional Chinese medicine colon dialysis combined with Uremic Clearance Granules effect and on the renal function indexes in patients with stage 3-5 chronic kidney disease. Methods A total of 82 patients with stage 3-5 chronic kidney disease in the First People′s Hospital of Jiujiang City from January 2019 to January 2021 were selected as the objects, and they were divided into the routine group (41 cases) and the study group (41 cases) by random number table method. The routine group was treated with oral Uremic Clearance Granules, while the study group was treated with traditional Chinese medicine colon dialysis on the basis of the routine group. Chinese medicine symptom score before and after treatment, clinical efficacy after treatment, the levels of blood uric acid (UA), serum creatinine (SCr), blood urea nitrogen (BUN) before and after treatment, and occurrence of adverse reactions were compared between the two groups. Results After treatment, the main symptom score, secondary symptom score and total score of the two groups were lower than those before treatment, and the main symptom score, secondary symptom score and total score of the study group were lower than those of the routine group, the differences were statistically significant (P<0.05). The overall treatment efficiency rate of the study group was higher than that of the routine group, the difference was statistically significant (P<0.05). After treatment, the levels of blood UA, SCr, BUN in the two groups were lower than those before treatment, and the levels of blood UA, SCr, BUN in the study group were lower than those in the routine group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of total adverse reactions during treatment between the two groups (P>0.05). Conclusion Traditional Chinese medicine colon dialysis combined with Uremic Clearance Granules in the treatment of patients with stage 3-5 chronic kidney disease can improve clinical symptoms, improve curative effect and improve renal function, which is safe and has certain popularization value. 2022 Vol. 29 (19): 105-108 [Abstract] ( 28 ) HTML (1 KB)  PDF (414 KB)  ( 28 ) 109 Clinical effect of Tripterygium Glycoside Tablets combined with Canag-liflozin in the treatment of diabetic nephropathy ZHAI Bona ； HAO Jianrong Objective To investigate the clinical effect of Tripterygium Glycoside Tablets combined with Canagliflozin in the treatment of diabetic nephropathy (DN). Methods A total of 80 patients with DN admitted to Department of Nephrology in Beijing Jingmei Group General Hospital from January 2020 to June 2021 were selected as the research objects, and they were divided into the control group (n=40) and the observation group (n=40) according to different treatment methods. The retrospective analysis was used in this study. The control group was treated with Canagliflozin, and the observation group was treated with Tripterygium Glycoside Tablets combined with Canagliflozin. Both groups were treated for three months. The renal function (24-h quantitative of urinary protein [24-UP], blood urea nitrogen [BUN], serum creatinine [SCr]), liver function (alanine aminotransferase [ALT], aspartate aminotransferase [AST]) and white blood cell count (WBC) before and after treatment were compared between the two groups. Results After treatment, the levels of 24-UP, BUN and SCr in the two groups were lower than those before treatment, and the levels of 24-UP, BUN and SCr in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). There were no significant differences in ALT, AST, WBC between and within the two groups before and after treatment (P>0.05). Conclusion The effect of Tripterygium Glycoside Tablets combined with Canagliflozin in the treatment of DN patients is better than that of Canagliflozin alone, and it can improve their renal function to some extent. 2022 Vol. 29 (19): 109-111转115 [Abstract] ( 23 ) HTML (1 KB)  PDF (705 KB)  ( 34 ) 112 Clinical value of high frequency ultrasonography in diagnosing digestive tract malformation in children ZHANG Qian； WEI Jianhui ； JIANG Xiaodi； JIANG Nan； XU Haiying Objective To investigate the clinical value of high frequency ultrasonography in diagnosing digestive tract malformation in children. Methods Eighty children with suspected digestive tract malformation in Jiujiang Maternal and Child Health Hospital from January 2016 to September 2021 were selected as the research subjects. High-frequency ultrasound and X-ray examination were performed on all the children, and the value of diagnosis of digestive tract malformation was analyzed with the surgical results as the gold standard. Results Among the 80 cases, 75 cases were diagnosed with gastrointestinal malformation by operation. Including 22 cases of hypertrophic pyloric stenosis (27.50%), 20 cases of malrotation with midgut volvulus (25.00%), 20 cases of anal atresia (25.00%), 5 cases of intestinal duplication malformation (6.25%), 4 cases of intestinal atresia (5.00%), 2 cases of megacolon (2.50%), and 2 cases of duodenal flap stenosis (2.50%). The sensitivity, specificity and accuracy of high-frequency ultrasound were 96.00% (72/75), 80.00% (4/5) and 95.00% (76/80), respectively. And the Kappa value consistent with gold standard was 0.640. The sensitivity, specificity and accuracy of X-ray examination were 78.67% (59/75), 60.00% (3/5) and 77.50% (62/80), respectively. And the Kappa value consistent with gold standard was 0.168. Conclusion High frequency ultrasound diagnosis of digestive tract malformation has a high coincidence rate, in the diagnosis of hypertrophic pyloric stenosis, anal atresia, intestinal duplication malformation, hirschsprung′s colon has a certain advantage, the clinical diagnostic value is good. 2022 Vol. 29 (19): 112-115 [Abstract] ( 22 ) HTML (1 KB)  PDF (560 KB)  ( 24 ) 116 Analysis of correlation between Helsinki CT score and postoperative intracranial pressure in patients with traumatic brain injury ZENG Qingchang ； LUO Zhijun ； ZUO Jianfeng Objective To analyze the correlation between Helsinki CT score and postoperative intracranial pressure in patients with traumatic brain injury (TBI). Methods A total of 88 patients with TBI who were treated in Fengcheng Hospital of Traditional Chinese Medicine from August 2020 to August 2021 were retrospectively selected as research objects. Head CT examination and postoperative intracranial pressure (ICP) detection were performed on all patients. Epidural hematoma, subdural hematoma and pressure on suprasellar cistern were recorded after CT scan, and Helsinki CT was scored. The patients were divided into normal group (n=10), mild group (n=25), moderate group (n=31) and severe group (n=22) according to the ICP value within 24 h after surgery. The Helsinki CT score of patients with different ICP values was compared, and Spearman rank correlation analysis model was used to analyze the correlation between Helsinki CT score and ICP value. Results ICP in normal group was lower than those in mild group, moderate group and severe group, and the differences were statistically significant (P<0.05). ICP in mild group was lower than those in moderate group and severe group, and the differences were statistically significant (P<0.05). ICP in moderate group was lower than that in severe group, the difference was statistically significant (P<0.05). Spearman rank correlation results showed that Helsinki CT score was positively correlated with ICP value (P<0.05). Conclusion Helsinki CT score is significantly correlated with ICP, which can be used to clinically evaluate the disease condition of patients with TBI. 2022 Vol. 29 (19): 116-118 [Abstract] ( 23 ) HTML (1 KB)  PDF (467 KB)  ( 10 ) 119 Evaluation of the efficacy of Xinfuning Ⅳ in prevention of cardiotoxicity induced by chemotherapy in breast cancer by conventional echocardiography and real-time three-dimensional speck tracking imaging ZHAO Xia； ZHUANG Lei； CHEN Pengfei； ZENG Liyuan Objective To evaluate the efficacy of conventional echocardiography and real-time three-dimensional speck tracking imaging (RT3D-STI) in the treatment of chemotherapy-induced cardiotoxicity in breast cancer patients with Xinfuning Ⅳ. Methods A total of 60 breast cancer patients admitted to Guangdong Clifford Hospital from January 2020 to May 2021 who received surgical treatment and postoperative chemotherapy were selected as the research subjects. According to different treatment methods, they were divided into control group and study group, with 30 patients in each group. The control group was treated with 6-cycle Cyclophosphamide plus Epirubicin chemotherapy, and the study group was treated with Xinfuning Ⅳ on the basis of the control group. All patients underwent conventional echocardiography and RT3D-STI examination before chemotherapy and after 2, 4 and 6 cycles of chemotherapy, and the results of conventional ultrasound parameters and RT3D-STI parameters were analyzed. Results After 6 cycles of chemotherapy, the peak value of early mitral diastolic myocardium movement (Em), peak value of early mitral diastolic myocardium flow rate (E)/peak value of late mitral diastolic myocardium flow rate (A) and peak value of Em/late mitral diastolic myocardium movement (Am) in study group were higher than those in control group, and the differences were statistically significant (P<0.05). After 2 cycles of chemotherapy, the left ventricular torsion angle (LVtw) of patients in the study group was higher than that in the control group, and the myocardial composite index (MCI) was lower than that in the control group. After 4 cycles of chemotherapy, LVtw was higher than that of the control group, while 3D strain (3DS), global longitudinal strain (GLS) and MCI were lower than those of the control group. After 6 cycles of chemotherapy, LVtw and 3D-LVEF were higher than those in the control group, while 3DS, GLS and MCI were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion Xinfuning Ⅳ can reduce the influence of cardiotoxicity caused by chemotherapy, and promote the successful completion of chemotherapy by monitoring the patients′ left ventricular myocardial stress parameters uesing RT3D-STI. 2022 Vol. 29 (19): 119-123转128 [Abstract] ( 21 ) HTML (1 KB)  PDF (1078 KB)  ( 23 ) 124 Effect of pharmaceutical education carried out by clinical pharmacists on medication use and quality of life of patients with malignant tumors GE Dangen； TANG Jie Objective To explore the effect of pharmaceutical education carried out by clinical pharmacists on medication use and quality of life of patients with malignant tumors. Methods A total of 177 patients with malignant tumor treated in People′s Hospital of Liyang City from August 2020 to July 2021 were selected as research subjects, and they were divided into observation group (88 cases) and control group (89 cases) by random number table method. Patients in the control group received traditional education from medical staff, and patients in the observation group received detailed individualized medication education from clinical pharmacists. Medication knowledge score, cancer pain knowledge score, Morisky medication adherence scale (MMAS-4) score, total incidence of adverse drug reactions and quality of life rating scale (QOL) score of cancer patients were compared between the two groups. Results Before education, there were no statistically significant differences in medication knowledge, cancer pain knowledge and MMAS-4 score between the two groups (P>0.05). After education, scores of medication knowledge and cancer pain knowledge in the two groups were higher than those before education, and MMAS-4 score was lower than that before education, and the diffferences were statistically significant (P<0.05). After education, scores of medication knowledge and cancer pain knowledge in observation group were higher than those in control group, while MMAS-4 score was lower than that in control group, the differences were statistically significant (P<0.05). The total incidence of adverse drug reactions in observation group was lower than that in control group, the difference was statistically significant (P<0.05). Before education, there was no statistically significant difference in QOL scores between the two groups (P>0.05). After education, the scores of appetite, spirit, sleep, fatigue, pain, family understanding and cooperation, understanding of cancer, attitude of treatment, daily life, the side effects of treatment, facial expressions were higher than those before education, and the scores of observation group were higher than those of the control group, the differences were statistically significant (P<0.05). Conclusion Pharmaceutical education by clinical pharmacists in the treatment of malignant tumor patients can improve the mastery of medication use and cancer pain related knowledge and medication compliance, reduce the incidence of adverse drug reactions and improve the quality of life. 2022 Vol. 29 (19): 124-128 [Abstract] ( 24 ) HTML (1 KB)  PDF (440 KB)  ( 43 ) 129 Clinical effect of Aspirin combined with Clopidogrel in the treatment of acute cerebral infarction GAO Yuqiu ； WANG Huiran ； ZHANG Kai▲ Objective To analyze the effect of Aspirin combined with Clopidogrel in the treatment of patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction admitted to the Hongqi Hospital Affiliated to Mudanjiang Medical College from May 2019 to May 2020 were selected as the research objects, and they were divided into the reference group and the experimental group by drawing lots, with 50 cases in each group. The patients in the reference group received Aspirin. The experimental group was treated with Clopidogrel on the basis of the reference group. The therapeutic effect, the neurological function scores before and after treatment and the adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the reference group, and the difference was statistically significant (P<0.05). Before treatment, there was no statistically significant difference in neurological function scores between the two groups (P>0.05). After 1, 5 and 10 d of treatment, the neurological function scores of the two groups were lower than those before treatment, and the differences were statistically significant (P<0.05). After 1, 5 and 10 d of treatment, the neurological function scores of the experimental group were lower than those of the reference group, and the differences were statistically significant (P<0.05). The total adverse reaction rate of the experimental group was lower than that of the reference group, and the difference was statistically significant (P<0.05). Conclusion The application of Aspirin combined with Clopidogrel in the treatment of acute cerebral infarction can improve the therapeutic effect and neurological function, and reduce the adverse reactions rate, which is worthy of clinical promotion and application. 2022 Vol. 29 (19): 129-131转135 [Abstract] ( 18 ) HTML (1 KB)  PDF (754 KB)  ( 33 ) 132 Comparison of clinical application effect of floating needle therapy and conventional acupuncture in lumbar disc herniation LI Yong； CHEN Mingyu；LUO Jianping；LUO Sijing Objective To compare the clinical application effect of floating needle therapy and conventional acupuncture in lumbar disc herniation (LDH). Methods A total of 80 patients with LDH admitted to Pingxiang Maternal and Child Health Hospital from August 2020 to June 2021 were selected as the research subjects. They were divided into control group and experimental group by random number table method, with 40 cases in each group. Control group was treated with conventional acupuncture, experimental group was treated with floating needle. The therapeutic effect, pain relief and the incidence of adverse reactions were compared between the two groups. Results The  total effective rate in the experimental group was 95.00% (38/40), higher than 80.00% (32/40) in the control group, and the difference was statistically significant (P<0.05). After treatment, the Oswestry disability index (ODI) scores of the two groups were lower than those before treatment, and the ODI score of experimental group was lower than that in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Compared with conventional acupuncture, floating needle therapy can significantly improve the treatment efficiency and relieve pain. 2022 Vol. 29 (19): 132-135 [Abstract] ( 22 ) HTML (1 KB)  PDF (504 KB)  ( 24 ) 136 Influence of auricular acupuncture of press-needle on postoperative delirium in elderly patients with hip fracture CHEN Bin； HU Haitao ； YU Ping； FU Xinyao； DENG Luntong； LIU Yunjie； PEI Ziqin； WAN Da Objective To explore the influence of auricular acupuncture of press-needle on postoperative delirium in elderly patients with hip fracture. Methods A total of 50 elderly patients undergoing hip fracture surgery in Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine from September to December 2021 were selected as the research subjects, and they were divided into the observation group (n=25) and the control group (n=25) according to the random number table method. The control group was given routine anesthesia induction and maintenance therapy, while the observation group was combined with auricular acupuncture of press-needle on this basis. The incidence of postoperative delirium (Confusion Assessment Method [CAM]) was compared between the two groups. The vital signs (heart rate  [HR], mean arterial pressure (MAP)], blood glucose (Glu) and blood lactic acid (Lac) levels of the two groups before operation (T1), 5 minutes after operation (T2), 10 minutes after operation (T3) and after operation (T4) were observed. The dosage of anesthetic drugs (Propofol and Remifentanil) during operation was recorded. Results The incidence of postoperative delirium in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). The fluctuation ranges of perioperative HR, MAP, Glu and Lac in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The dosages of Propofol and Remifentanil in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Auricular acupuncture of press-needle can make the vital signs of elderly patients with hip fracture more stable, reduce the dosages of anesthetics, and effectively prevent the incidence of postoperative delirium. 2022 Vol. 29 (19): 136-138转142 [Abstract] ( 23 ) HTML (1 KB)  PDF (554 KB)  ( 42 ) 139 Effect of rehabilitation therapy of traditional Chinese medicine on limb function of patients with spastic hemiplegia after stroke TANG Lin Objective To explore the effect of rehabilitation therapy of traditional Chinese medicine on limb function of patients with spastic hemiplegia after stroke. Methods A total of 60 patients with spastic hemiplegia after stroke treated by Liaoning Provincial Disabled Persons Service Center from August 2020 to August 2021 were selected as the research objects. They were divided into control group and treatment group according to the random number table method, with 30 cases in each group. The control group received routine Western medical treatment and rehabilitation treatment, and the treatment group was treated with acupuncture, traditional Chinese medicine fumigation, traditional Chinese medicine massage and other traditional Chinese medicine rehabilitation measures on the basis of the control group. Both groups were treated for 30 days. The modified Ashworth muscle tone grading scores, Fugl-Meyer motor function scores and Berg balance scale scores of the two groups were compared. Results After treatment, the modified Ashworth muscle tone grading scores of the two groups were lower than those before treatment, and the scores of Fugl-Meyer motor function and Berg balance scale were higher than those before treatment, with statistically significant differences (P<0.05). After treatment, the improved Ashworth muscle tone grading score in the treatment group was lower than that in the control group, and the scores of Fugl-Meyer motor function and Berg balance scale were higher than those in the control group, with statistically significant differences (P<0.05). Conclusion Traditional Chinese medicine rehabilitation method is effective in the treatment of patients with spastic hemiplegia after stroke, which can promote the recovery of limb function and improve the rehabilitation effect. 2022 Vol. 29 (19): 139-142 [Abstract] ( 24 ) HTML (1 KB)  PDF (538 KB)  ( 13 ) 143 Clinical effect of Ningxin Tongbi Decoction combined with Allisartan Isoproxil on patients with unstable angina pectoris of coronary heart disease BI Minghui ； KE Zhifu ； ZHANG Guanghui Objective To explore the clinical effect of Ningxin Tongbi Decoction combined with Allisartan Isoproxil in the treatment of unstable angina pectoris of coronary heart disease. Methods A total of 150 patients with coronary heart disease unstable angina pectoris admitted to the Department of Cardiology, Xiamen Hospital of Traditional Chinese Medicine from July 2019 to September 2021 were selected as the research subjects. The group was divided into control group (n=75) and observation group (n=75) by random number table method. The two groups were treated with Allisartan Isoproxil, and the observation group was treated with Ningxin Tongbi Decoction. The total score of traditional Chinese medicine syndromes, myocardial ischemia, heart rate variability, angina pectoris after treatment and adverse reactions during treatment were compared between the two groups before and after treatment. Results The total score of traditional Chinese medicine syndrome in the observation group was lower than that in the control group after treatment, and the difference was statistically significant (P<0.05). The standard deviation of RR interval, mean standard deviation of RR interval and root mean square root difference of adjacent RR interval in the observation group were higher than those in the control group after treatment, the differences were statistically significant (P<0.05). The total myocardial ischemia load, QT dispersion and JT dispersion in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The frequency of angina pectoris and nitroglycerin dosage in the observation group were lower than those in the control group, and the duration was shorter than that in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Ningxin Tongbi Decoction combined with Alisartan Isoproxil can effectively improve the clinical symptoms and heart rate variability of patients with unstable angina pectoris of coronary heart disease. 2022 Vol. 29 (19): 143-146转154 [Abstract] ( 25 ) HTML (1 KB)  PDF (735 KB)  ( 11 ) 147 Clinical effect of Yiqi Huoxue Prescription add and subtract combined rehabilitation treatment in convalescent patients of ischemic stroke WU Jinjuan； MAO Ting； HUANG Miao； BAI Lijun Objective To explore the effect of Yiqi Huoxue Prescription add and subtract combined rehabilitation treatment on the efficacy in convalescent patients of ischemic stroke (IS). Methods From June 2019 to June 2020, a total of 86 IS convalescent patients admitted to Shahe Hospital of Changping District in Beijing City were selected as study subjects. They were divided into study group and control group by drawing lots method, with 43 cases in each group. The control group was received with routine rehabilitation treatment for IS. The study group was treated with Yiqi Huoxue Prescription add and subtract combined rehabilitation treatment. Before and after treatment, the serum hypersensitivity C-reactive protein (hs-CRP), brain-derived neurotrophic factor (BDNF), the National Institutes of Health stroke scale (NIHSS) score, Barthel index rating scale score, and Fugel-Meyer assessmen (FMA) rating scale score were compared between the two groups. Results There were no statistical differences in hs-CRP and BDNF between the two groups (P>0.05). After treatment, the hs-CRP levels in both groups were lower than those before treatment, while BDNF levels in both groups were higher than those before treatment, with statistically significant differences (P<0.05). The hs-CRP of the study group was lower than that in control group, and BDNF was higher than that in control group, with statistically significant differences (P<0.05). There were no statistical differences in the NIHSS score, the Barthel index, as well as the FMA score between the two groups (P>0.05). After treatment, the NIHSS scores in both groups were lower than those before treatment, while the Barthel index and the FMA score in both groups were higher than those before treatment, with statistically significant differences (P<0.05). The NIHSS score of the study group was lower than that in control group, and Barthel index and the FMA score were higher than those in control group, with statistically significant differences (P<0.05). Conclusion For patients with IS recovery, Yiqi Huoxue Prescription add and subtract combined rehabilitation treatment can improve the inflammatory status, contribute to the generation of nutritional nerve-related factors, promote the recovery of neurological defects, so as to improve their limb function and self-care ability. 2022 Vol. 29 (19): 147-150 [Abstract] ( 22 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 151 Mediating effect of psychological stress and resilience on sleep quality and work stress in soldiers performing major tasks XIONG Fuxian； LIN Qingxi； LI Yiqing ； CAO Liyun ； ZENG Qinlin ；XIE Chenfan ； TANG Bin Objective To analyze the mediating effect of psychological stress and resilience between sleep quality and work stress of officers and soldiers performing major tasks. Methods From March 2019 to August 2021, 245 army officers and soldiers engaged in major tasks were selected as the research subjects. The perceived stress scale (PSS), psychological stress evaluating test (PSET), Pittsburgh sleep quality index (PSQI) and Connor-Davidson resilience scale (CD-RISC) were used. Pearson correlation model was used to analyze the correlation between mental stress and resilience on sleep quality and work stress of soldiers performing major tasks, and structural equation model was used to analyze the mediating effect between mental stress and resilience on sleep quality and work stress of soldiers performing major tasks. Results A total of 245 questionnaires were distributed, each including 4 scales, 13 invalid questionnaires were removed, and 232 valid questionnaires were finally collected. The total score of PSS was (28.17±6.27) points in 232 valid questionnaires. The total score of PSET scale was (25.34±2.64) points. The total score of PSQI scale was (15.44±1.60) points. The total score of CD-RISC was (75.67±8.67) points. Sleep quality was positively correlated with work stress (r=0.864, P<0.001). Work stress was positively correlated with psychological stress (r=0.933, P<0.001). Sleep quality was negatively correlated with psychological resilience (r=-0.834, P<0.001). Psychological stress was negatively correlated with psychological resilience (r=-0.864, P<0.001). Psychological resilience was negatively correlated with work stress (r=-0.813, P<0.001). Sleep quality was positively correlated with psychological stress (r=0.929, P<0.001). Psychological stress and resilience accounted for 78.09% of the total effect as mediating effect. Conclusion There is a significant correlation between psychological stress, psychological resilience and sleep quality and work stress. As mediating variables, psychological stress and psychological resilience can adjust the predictive effect of work pressure on sleep quality for officers and soldiers performing major tasks. Psychological stress and resilience, reduce work stress and improve sleep quality. 2022 Vol. 29 (19): 151-154 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 155 Inflnencing factors of repeated abortion in women receiving post-abortion care service LUO Lei ； CHEN Haixia ； ZHANG Xueyan； WANG Yan ； YAO Yan ； BIAN Yanli Objective To analyze the current situation of women with induced abortion after the post-abortion care service (PAC), and analyze the influencing factors of repeated abortions, so as to provide direction for the extension of PAC services in the later period. Methods From January 2018 to January 2020, 368 women who received PAC services after an artificial abortion in Huimin Hospital of Beijing were selected as the research subjects, and baseline data of aborted women were collected for analysis. Results The results of univariate analysis showed that the difference in age, education level, marital status, contraceptive methods, contraceptive and abortion knowledge between the first miscarriage group and the repeated miscarriage group were statistically significant (P<0.05). The results of multivariate analysis showed that age (β=0.003, OR=19.395, 95%CI=5.689-24.326), education level (β＜0.001, OR=14.268, 95%CI=5.326-18.632), marital status (β ＜0.001, OR=1.564, 95%CI=1.247-1.967), contraceptive methods (β=0.012, OR=1.410, 95%CI=1.094-1.829), knowledge of contraception and abortion (β=0.009, OR=2.373, 95%CI=1.326-4.068) were risk factors affecting the repeated abortion rate of women with induced abortion (P<0.05). Conclusion The post-abortion care service is mainly based on unmarried women, which has the characteristics of high repetitive abortion rate, poor knowledge of contraception and abortion, etc. It is necessary to strengthen the popularization of contraceptive knowledge in this population to reduce the incidence of induced abortion. 2022 Vol. 29 (19): 155-157转175 [Abstract] ( 18 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 158 Effect of link-based health education model on breast-feeding of primipara and neonatal nursing ability HU Qiao Objective To explore the influence of link-based health education model on the breastfeeding of primiparas and the nursing ability of newborns. Methods A total of 80 primiparas admitted to Nanchang First Hospital from June 2020 to December 2021 were selected as the research objects, and divided into observation group (n=40) and control group (n=40) according to random number table method. The control group received routine health education, and the observation group received link health education on the basis of the control group. The scores of knowledge related to puerperal period (puerperal activity, perineal care, emotion regulation during puerperal period, prevention and treatment of maternal and infant complications during puerperal period), neonatal care ability score (breastfeeding, neonatal jaundice observation, neonatal umbilical care), self-rating anxiety scale (SAS), self-rating depression scale (SDS), breastfeeding rate and nursing satisfaction were compared between the two groups. Results The scores of postpartum activities, perineum care, puerperal emotional regulation and prevention of puerperal complications in observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The scores of breast feeding, neonatal jaundice observation and neonatal umbilical nursing after nursing in observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). The SDS and SAS scores in observation group after nursing were lower than those in the control group, and the differences were statistically significant (P<0.05). The breastfeeding rate of observation group was 90.00%, higher than that of control group (70.00%), and the difference was statistically significant (P<0.05). The nursing satisfaction of observation group was 95.00%, higher than 77.50% of control group, and the difference was statistically significant (P<0.05). Conclusion The link health education model can improve the ability of breastfeeding and newborn care of primipara, which should be paid attention to clinically. 2022 Vol. 29 (19): 158-161 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 162 Effect of hierarchical nursing model based on GRACE scoring system on postoperative complications and negative emotions in patients with acute myocardial infarction CHEN Yanmei ； YU Ling▲ Objective To observe the effect of hierarchical nursing model based on global registry of acute coronary events (GRACE) scoring system on postoperative complications and negative emotions in patients with acute myocardial infarction (AMI). Methods A total of 127 patients with AMI who received percutaneous coronary intervention (PCI) in the First Affiliated Hospital of Nanchang University from June 2019 to March 2021 were selected as research objects and divided into control group (64 cases) and study group (63 cases) according to random number table method. The control group received routine nursing after PCI, and the study group received stratified nursing based on GRACE scoring system after PCI, and they were all nursed until discharge. The incidence of postoperative complications, negative emotions (Hamilton anxiety scale [HAMA], Hamilton depression scale [HAMD] score) and nursing satisfaction were compared between the two groups. Results The total incidence of complications in the study group was lower than that in the control group, and the difference was statistically significant (P<0.05). The HAMA and HAMD scores in the two groups after nursing were lower than those before nursing, and HAMA and HAMD scores in study group were lower than those in control group, the differences were statistically significant (P<0.05). The total nursing satisfaction of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion The hierarchical nursing model based on GRACE scoring system can reduce complications, relieve patients′ negative emotions and improve nursing satisfaction. 2022 Vol. 29 (19): 162-165 [Abstract] ( 23 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 166 Application value of self-efficacy intervention in orthopedic elderly patients WANG Liu ； LIU Yangyang ； ZENG Xuewen Objective To study the application value of self-efficacy intervention in orthopedic elderly patients. Methods A total of 100 orthopaedic elderly patients admitted to Pingxiang People′s Hospital from January 2019 to December 2020 were selected as the research subjects. They were divided into control group (n=48) and observation group (n=52) according to the hospitalization time, control group received routine nursing, observation group received self-efficacy intervention. The scores of general self-efficacy scale (GSES), exercise of self-care agency (ESCA) and quality of life (QOL) were compared between the two groups before and after intervention. Results After intervention, the scores of GSES, ESCA and QOL of observation group were higher than those of control group, and the differences were statistically significant (P<0.05). Conclusion Self-efficacy intervention can improve self-efficacy, self-care ability and quality of life of orthopedic elderly patients. 2022 Vol. 29 (19): 166-168 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 169 Application of objective-oriented standard procedure intervention on patients with mental disorders treated by modified electroconvulsive therapy YAO Yu Objective To observe the application of objective-oriented standard procedure intervention on patients with mental disorders treated by modified electroconvulsive therapy (MECT). Methods A total of 60 patients with mental disorders who underwent MECT in the Third People′s Hospital of Shangrao from August 2019 to August 2021 were selected as the research subjects. They were divided into observation group and control group according to the random number table method, with 30 cases in each group. The control group was given routine nursing intervention, while the observation group adopted objective-oriented standard procedure intervention. The incidence of arrhythmia in the two groups was compared before intervention and after 2 weeks of intervention. The changes in mental status (present state examination [PSE], brief psychiatric rating scale [BPRS]) of the two groups were observed, and the incidence of other adverse reactions within 2 weeks of intervention was compared between the two groups. Results After 2 weeks of intervention, the scores of PSE and BPRS in observation group were lower than those in control group, the differences were statistically significant (P<0.05). The total incidences of arrhythmia and other adverse reactions in observation group were lower than those in control group, the differences were statistically significant (P<0.05). Conclusion Objective-oriented standard procedure intervention can effectively prevent the arrhythmia and other adverse reactions, improve the mental symptoms and cognitive function, and enhance the treatment safety of patients with mental disorders undergoing MECT. 2022 Vol. 29 (19): 169-171转189 [Abstract] ( 20 ) HTML (1 KB)  PDF  (0 KB)  ( 13 ) 172 Effect of joint management mode on the treatment compliance, quality of life and pregnancy outcome of patients with gestational diabetes mellitus MA Xiaoyan； ZHANG Chonghua； ZENG Linli Objective To explore the effect of combined management mode of patients and their families in gestational diabetes mellitus (GDM). Methods A total of 62 patients with GDM treated in Fuzhou First People′s Hospital from January 2021 to January 2022 were selected as the research objects. They were divided into control group (31 cases) and observation group (31 cases) by random number table method. The control group was treated with routine nursing, and the observation group was treated with joint management mode of patients and their families on the basis of routine nursing. Both groups continued to intervene until the end of delivery. The treatment compliance, quality of life and pregnancy outcome were compared between the two groups. Results There were no significant differences in treatment compliance and quality of life between the two groups before intervention (P>0.05). After intervention, the scores of medication compliance, body mass control, diet control and proper exercise in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). After intervention, quality of life scale for patients with type 2 diabetes mellitus (DMQLS) score in the observation was higher than that of the control group, and the difference was statistically significant (P<0.05). The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion The combined management mode of patients and their families can improve the treatment compliance of GDM patients, improve the quality of life and reduce the occurrence of adverse pregnancy outcomes. 2022 Vol. 29 (19): 172-175 [Abstract] ( 21 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 176 Application effect of PDCA cycle management in high risk patients with lower extremity venous thromboembolism ZHU Dongmei； ZHANG Jiaxiong； LIU Yishang； LI Jianhong Objective To study the application effect of PDCA cycle management in high risk patients with lower extremity venous thromboembolism (VTE). Methods A total of 97 high risk patients with lower extremity VTE admitted to Department of Radiology and Intervention in Foshan Hospital of Traditional Chinese Medicine from June 2018 to June 2019 were selected as the control group, and 92 high risk patients with lower extremity VTE from June 2020 to June 2021 were selected as the observation group. The control group received VTE routine care, the observation group received PDCA cycle management including planning stage, doing stage, checking stage and action stage. The incidence of thrombosis, length of hospital stay, in-hospital mortality, satisfaction with hospitalization and anxiety were recorded of the two groups. Results The incidence of deep venous thrombosis in the observation group was lower than that in the control group, and the length of hospital stay in the observation group was shorter than that in the control group, the difference was statistically significant (P<0.05). There were no significant differences in the incidence of pulmonary embolism and in-hospital mortality between the two groups (P>0.05). The total satisfaction with hospitalization of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Before nursing, there was no significant difference in SAS scores between the two groups (P>0.05). After nursing, the SAS score of the two groups was lower than that before nursing, and the SAS score of the observation group was lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion Compared with the routine nursing, the PDCA cycle management can effectively reduce the incidence of VTE in high risk patients with lower extremity deep vein thrombosis, shorten the length of hospital stay, and improve the satisfaction of patients with nursing care. 2022 Vol. 29 (19): 176-178 [Abstract] ( 24 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 179 Application of personalized nursing combined with Natril Sulfas external application in promoting the recovery of gastrointestinal function in acute pancreatitis HUANG Min ； YANG Na ； YOU Yunye ； ZHOU Ying； FENG Yaqing Objective To explore the application of personalized nursing combined with Natril Sulfas external application in promoting the recovery of gastrointestinal function in acute pancreatitis. Methods A total of 80 patients with acute pancreatitis treated in the Central Hospital of Xinyu Iron and Steel Group Co., Ltd. from July 2020 to December 2021 were selected as the research objects. They were divided into control group and experimental group by random number table method, with 40 cases in each group. The control group adopted routine nursing intervention method, and the experimental group adopted personalized nursing+Natril Sulfas external application intervention method on the basis of routine nursing. The total clinical effective rate, gastrointestinal function score, duration of abdominal pain, recovery time of bowel sounds, length of hospital stay, incidence of adverse reactions and nursing satisfaction were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). The gastrointestinal function score of the experimental group was lower than that of the control group, and the difference was statistically significant (P<0.05). The duration of abdominal pain, recovery time of bowel sounds and hospital stay in the experimental group were shorter than those in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05). The nursing satisfaction of the experimental group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Personalized nursing+Natril Sulfas external application in the intervention of acute pancreatitis has high total effective rate, significant recovery of gastrointestinal function, short recovery time of bowel sounds and duration of abdominal pain, which can accelerate the recovery speed of patients, low adverse reactions rate and high nursing satisfaction. It is worthy of popularization and application. 2022 Vol. 29 (19): 179-182 [Abstract] ( 26 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 183 Effect of Green′s model-based health education on social avoidance in patients with enterostomy WANG Jingrong Objective To analyze the effect of Green′s model-based health education on social avoidance in patients with colostomy. Methods A total of 80 patients with enterostomy admitted to the Department of Oncology, Ji′an Central People′s Hospital from October 2019 to June 2021 were selected as the research objects, and divided into the control group and the observation group by random number table method, with 40 cases in each group. The patients in the control group were given routine health education, and the patients in the observation group were given the Green′s model-based health education. The social avoidance, stoma self-care ability and the incidence of stoma complications within 3 months after discharge were compared between the two groups. Results Eight weeks after the intervention, the social avoidance and distress scale (SADS) score of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Eight weeks after the intervention, the stoma self-care scale-general version (SSCS-GV) score of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Within 3 months after discharge, the total incidence of stoma complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Green′s model-based health education can reduce the social avoidance of colostomy patients, improve self-care ability, and reduce the occurrence of complications. 2022 Vol. 29 (19): 183-185 [Abstract] ( 21 ) HTML (1 KB)  PDF  (0 KB)  ( 17 ) 186 Application effect of the concept of rapid rehabilitation surgery in thoracoscopic surgical nursing of lung cancer LI Jinlong； LI Huan Objective To explore the application effect of the concept of rapid rehabilitation surgery in thoracoscopic surgical nursing of lung cancer. Methods A total of 80 patients with thoracoscopic lung cancer surgery admitted to the Affiliated People′s Hospital of Fujian University of Traditional Chinese Medicine from March 2019 to November 2020 were selected as the study subjects, and they were divided into control group and observation group by random number table method, with 40 cases in each group. The control group received routine nursing, and the observation group received rapid rehabilitation surgical concept intervention on the basis of routine nursing. The incidence of complications, perioperative indexes and lung function indexes were compared between the two groups. Results The total incidence of complications in observation group was lower than control group, the difference was statistically significant (P<0.05). The time of operation, time of getting out of bed, time of urinary tube extubation, time of chest tube extubation and length of hospital stay in the observation group were shorter than those in the control group, and the hospitalization cost in the observation group was lower than that in the control group, the differences were statistically significant (P<0.05). There were no significant differences in preoperative peak expiratory flow (PEF), 6 min walking distance and resting oxygen saturation (SpO2) between two groups (P>0.05). PEF, 6 min walking distance and SpO2 at rest in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion The intervention of patients undergoing thoracoscopic lung cancer surgery with the concept of rapid rehabilitation surgery can significantly reduce the rate of infection and complications, and promote improved lung function and postoperative recovery. 2022 Vol. 29 (19): 186-189 [Abstract] ( 18 ) HTML (1 KB)  PDF  (0 KB)  ( 11 ) 190 Application effect of oral care with traditional Chinese medicine combined with pat back along meridians in stroke patients XU Jia； WU Qiongying ； ZHANG Xiaowei Objective To explore the application effect of oral care with traditional Chinese medicine combined with pat back along meridians in stroke patients. Methods A total of 96 patients with stroke admitted to Department of Neurology in Wuxi Traditional Chinese Medicine Hospital from January 2018 to July 2020 were selected as the study subjects, and they were divided into the control group and the observation group according to random number table method, with 48 patients in each group. The control group received routine oral care, and the observation group received oral care with traditional Chinese medicine combined with pat back along meridians intervention, continuous intervention for seven days. The intervention effect, the incidence of stroke associated pneumonia (SAP), and oral bacteria count, halitosis before and after intervention were compared between the two groups. Results The total intervention effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). The incidence of SAP in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). After intervention, the oral bacterial count and halitosis score of the two groups were lower than those before intervention, and the oral bacterial count and halitosis score of the observation group were lower than those of the control group, the difference was statistically significant (P<0.05). Conclusion Oral care with traditional Chinese medicine combined with pat back along meridians can effectively improve the therapeutic effect, reduce the incidence of SAP and the number of oral bacteria, and improve halitosis. 2022 Vol. 29 (19): 190-192转196 [Abstract] ( 17 ) HTML (1 KB)  PDF  (0 KB)  ( 12 ) 193 Application value of cluster intervention in hemoperfusion in patients with acute pancreatitis with hyperlipidemia FAN Xiaoqian； DONG Yanfang Objective To explore the application value of cluster intervention in hemoperfusion in patients with acute pancreatitis with hyperlipidemia. Methods A total of 100 patients with acute pancreatitis with hyperlipidemia treated in the First Affiliated Hospital of Fujian Medical University from June 2020 to September 2021 were selected as the research objects. And they were divided into control group (n=50) and study group (n=50) by random number table method. The control group took routine nursing intervention, and the study group took cluster nursing. The recovery time, mental health score, quality of life score and complications were compared between the two groups. Results Before intervention, there were no statistical significances in scores of depression, anxiety and scores of mental health, cognitive function and physical function between the two groups (P>0.05). After intervention, the scores of depression and anxiety in the two groups were lower than before intervention, and the scores of anxiety and depression in the study group were lower than those the control group, the differences were statistically significant (P<0.05). After intervention, the scores of mental health, cognitive function and physical function of patients in the two groups were higher than those before intervention, and the scores of mental health, cognitive function and physical function of patients in the study group were higher than those in the control group, the differences were statistically significant (P<0.05). The length of hospital stay and the recovery time of lipase, amylase and leukocyte in the study group were shorter than those in the control group, and the differences were statistically significant (P<0.05). The total incidence of complications in study group was lower than that in control group, and the difference was statistically significant (P<0.05). Conclusion The cluster intervention in hemoperfusion of patients with acute pancreatitis with hyperlipidemia can improve the recovery time, improve the mental health level, improve the quality of life and reduce the incidence of complications. 2022 Vol. 29 (19): 193-196 [Abstract] ( 13 ) HTML (1 KB)  PDF  (0 KB)  ( 12 )

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