超声三维斑点追踪成像评价心复宁Ⅳ号防治乳腺癌患者化疗所致心肌毒性的应用效果

Abstract
Figure/Table
References (17)
Related Citation (15)

Download: PDF (1078 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To evaluate the efficacy of conventional echocardiography and real-time three-dimensional speck tracking imaging (RT3D-STI) in the treatment of chemotherapy-induced cardiotoxicity in breast cancer patients with Xinfuning Ⅳ. Methods A total of 60 breast cancer patients admitted to Guangdong Clifford Hospital from January 2020 to May 2021 who received surgical treatment and postoperative chemotherapy were selected as the research subjects. According to different treatment methods, they were divided into control group and study group, with 30 patients in each group. The control group was treated with 6-cycle Cyclophosphamide plus Epirubicin chemotherapy, and the study group was treated with Xinfuning Ⅳ on the basis of the control group. All patients underwent conventional echocardiography and RT3D-STI examination before chemotherapy and after 2, 4 and 6 cycles of chemotherapy, and the results of conventional ultrasound parameters and RT3D-STI parameters were analyzed. Results After 6 cycles of chemotherapy, the peak value of early mitral diastolic myocardium movement (Em), peak value of early mitral diastolic myocardium flow rate (E)/peak value of late mitral diastolic myocardium flow rate (A) and peak value of Em/late mitral diastolic myocardium movement (Am) in study group were higher than those in control group, and the differences were statistically significant (P<0.05). After 2 cycles of chemotherapy, the left ventricular torsion angle (LVtw) of patients in the study group was higher than that in the control group, and the myocardial composite index (MCI) was lower than that in the control group. After 4 cycles of chemotherapy, LVtw was higher than that of the control group, while 3D strain (3DS), global longitudinal strain (GLS) and MCI were lower than those of the control group. After 6 cycles of chemotherapy, LVtw and 3D-LVEF were higher than those in the control group, while 3DS, GLS and MCI were lower than those in the control group, the differences were statistically significant (P<0.05). Conclusion Xinfuning Ⅳ can reduce the influence of cardiotoxicity caused by chemotherapy, and promote the successful completion of chemotherapy by monitoring the patients′ left ventricular myocardial stress parameters uesing RT3D-STI.

Key words： Breast cancer Xinfuning Ⅳ Real-time three-dimensional speck tracking imaging Left ventricular function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHAO Xia
	ZHUANG Lei
	CHEN Pengfei
	ZENG Liyuan

Cite this article:

ZHAO Xia,ZHUANG Lei,CHEN Pengfei, et al. Evaluation of the efficacy of Xinfuning Ⅳ in prevention of cardiotoxicity induced by chemotherapy in breast cancer by conventional echocardiography and real-time three-dimensional speck tracking imaging[J]. 中国当代医药, 2022, 29(19): 119-123转128.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2022/V29/I19/119

1]	马媛媛，陈金玲，谭团团，等.二维斑点追踪成像联合实时三维超声心动图评价尿毒症患者左房功能的研究[J].临床超声医学杂志，2018，20（10）：18-22.
[2]	左洋萍，刘柳，曹礼庭，等.三维斑点追踪技术评价乳腺癌患者蒽环类药物化疗后迟发性左心功能变化[J].川北医学院学报，2020，35（5）：78-81.
[3]	孙勇.曹贵民教授治疗慢性心力衰竭的临床经验[J].临床医药文献电子杂志，2018，5（28）：94-95.
[4]	何璇，赵晓莉，王少春，等.斑点追踪分层应变技术评价蒽环类化疗药物对乳腺癌患者左室心肌纵向应变的影响[J].临床超声医学杂志，2018，20（6）：397-400.
[5]	张盼盼，芦桂林，黄磊，等.三维斑点追踪成像评价乳腺癌患者蒽环类药物化疗前后心室功能[J].中华超声影像学杂志，2017，26（1）：17-20.
[6]	陈剑琼，孙国平，吴芳芳，等.三维斑点追踪整体面积应变是乳腺癌蒽环类药物化疗患者早期心肌受损的良好预测指标[J].安徽医科大学学报，2018，53（11）：1767-1771.
[7]	谭娅，马会林，胡波，等.斑点追踪分层应变技术评价心血管危险因素对表柔比星化疗乳腺癌患者左室运动功能的影响[J].中华超声影像学杂志，2020，29（1）：25-30.
[8]	宋秀莲，林婷，陈环梅.利用二维斑点追踪成像技术评价化疗药物对乳腺癌患者左心功能损害的价值研究[J].国际医药卫生导报，2020，26（21）：3217-3220.
[9]	万梦婷，赵志玉，梅丹娥，等.左室压力-应变环定量评估蒽环类药物化疗对乳腺癌患者左室功能的影响[J].临床超声医学杂志，2021，23（4）：256-260.
[10]	王飞，赖玉琼，庞丹梅，等.三维斑点追踪技术可评价乳腺癌患者蒽环类药物治疗前后的心室功能改变[J].分子影像学杂志，2019，42（4）：434-438.
[11]	徐泽民，纪玉霞，陈丽敏，等.心复宁颗粒联合西药治疗冠心病的疗效观察[J].中国医院用药评价与分析，2017， 17（7）：924-925，928.
[12]	苗爱雨，智文祥，周瑾，等.二维斑点追踪成像技术结合心肌做功评价蒽环类药物对乳腺癌患者左心室功能的影响[J].中国癌症杂志，2020，30（10）：91-96.
[13]	方晓燕，程蕾蕾，潘向欧，等.三维斑点追踪显像技术评价食管癌患者同步放化疗中左心室功能的早期改变[J].中华超声影像学杂志，2018，27（7）：553-558.
[14]	刘晓丽，张文华，宋昕殊，等.应用三维斑点追踪技术评价蒽环类药物对乳腺癌化疗患者心肌损害及转归[J].中国超声医学杂志，2019，35（8）：696-699.
[15]	史文婷，肖秋梅，张相机，等.乳腺癌新辅助化疗疗效的影响因素研究[J].中国医药科学，2020，10（16）：130-133.
[16]	黄骏骢.吉西他滨联合顺铂治疗耐蒽环类及紫杉类晚期乳腺癌的效果[J].中国当代医药，2020，27（13）：58-60，70.
[17]	王燕，张平洋，刘琨，等.三维斑点追踪成像技术评价乳腺癌患者接受吡柔比星化疗后右心室心肌力学特性改变[J].南方医科大学学报，2018，38（9）：14-20.